| | CiteULike: Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function (Site not responding. Last check: 2007-11-01) |
 | | Interestingly, this method applies a Lamarckian model of genetics, in which environmental adaptations of an individual's phenotype are reverse transcribed into its genotype and become heritable traits (<I >sic</I >). |
 | | We consider three search methods, Monte Carlo simulated annealing, a traditional genetic algorithm, and the Lamarckian genetic algorithm, and compare their performance in dockings of seven protein-ligand test systems having known three-dimensional structure. |
 | | We show that both the traditional and Lamarckian genetic algorithms can handle ligands with more degrees of freedom than the simulated annealing method used in earlier versions of A<FONT SIZE="-1" >UTO</FONT >D<FONT SIZE="-1" >OCK</FONT >, and that the Lamarckian genetic algorithm is the most efficient, reliable, and successful of the three. |
| www.citeulike.org /article/77241 (680 words) |