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Topic: Lamivudine

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	Epivir Online, Description, Chemistry, Ingredients - Lamivudine - RxList Monographs
		Lamivudine is a white to off-white crystalline solid with a solubility of approximately 70 mg/mL in water at 20
		Intracellularly, lamivudine is phosphorylated to its active 5'-triphosphate metabolite, lamivudine triphosphate (3TC-TP).
		Phenotypic analysis of baseline-matched on-therapy HIV-1 isolates from patients (n = 13) receiving lamivudine once daily showed that isolates from 12/13 patients were susceptible to zidovudine; isolates from 8/13 patients exhibited a 25- to 295-fold decrease in susceptibility to efavirenz, and isolates from 7/13 patients showed an 85- to 299-fold decrease in susceptibility to lamivudine.
	www.rxlist.com /cgi/generic3/lamivudine.htm (1050 words)

	AEGiS-RITA!: NRTI: LAMIVUDINE (Epivir) - March 2000
		Lamivudine tablets are film-coated, white, and diamond-shaped with the dosage "150" imprinted on one side and "GX CJ7" on the other side.
		Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI).
		Lamivudine resistance is associated with a mutation at position 184.
	www.aegis.com /pubs/rita/2000/RI000309.html (727 words)

	lamivudine - HIV: health and medical information about HIV and AIDS
		The reverse transcriptase uses lamivudine triphosphate instead of deoxycytidine triphosphate, and the lamivudine triphosphate interferes with the reverse transcriptase.
		Lamivudine does not kill existing HIV virus, and it is not a cure for HIV.
		Lamivudine also causes a decrease in blood cells, muscle pain and weakness, and nerve damage in the extremities (peripheral neuropathy).
	www.medicinenet.com /lamivudine/article.htm (634 words)

	Lamivudine - Drugs & Vitamins - Drug Library - DrugDigest
		Lamivudine is used to treat infections due to hepatitis B and human immunodeficiency virus (HIV).
		The doses of lamivudine are different depending upon the disease for which you are being treated.
		If you are receiving lamivudine for hepatitis B infection only, you should be tested for HIV prior to starting and during treatment to avoid inappropriate therapy for HIV.
	www.drugdigest.org /DD/DVH/Uses/0,3915,369\|Lamivudine,00.html (909 words)

	MedlinePlus Drug Information: Lamivudine
		Lamivudine is not a cure and may not decrease the number of HIV-related illnesses.
		Lamivudine (Epivir-HBV) is used to treat hepatitis B infection.
		Lamivudine is also used sometimes in combination with zidovudine (Retrovir, AZT) to treat health-care workers or other individuals exposed to HIV infection after accidental contact with HIV-contaminated blood, tissues, or other body fluids.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a696011.html (826 words)

	Combivir Online, Description, Chemistry, Ingredients - Lamivudine/Zidovudine - RxList Monographs
		Intracellularly, lamivudine is phosphorylated to its active 5' -triphosphate metabolite, lamivudine triphosphate (3TC-TP).
		Lamivudine: The in vitro activity of lamivudine against HIV-1 was assessed in a number of cell lines (including monocytes and fresh human peripheral blood lymphocytes) using standard susceptibility assays.
		In some patients treated with lamivudine alone or in combination with zidovudine, isolates have emerged with a mutation at codon 184, which confers resistance to lamivudine.
	www.rxlist.com /cgi/generic3/combivir.htm (1131 words)

	Lamivudine (Epivir) \| The New Mexico AIDS InfoNet
		Lamivudine is a nucleoside analog reverse transcriptase inhibitor, or nuke.
		Lamivudine should not be taken with emtricitabine (Emtriva, FTC) because these drugs are very similar and there is no additional benefit.
		Lamivudine + abacavir (Ziagen) + tenofovir (Viread) or lamivudine + ddI (Videx) + tenofovir (Viread): These combinations are linked to a high rate of treatment failure and should not be used without other ARVs.
	www.aidsinfonet.org /articles.php?articleID=415 (771 words)

	Lamivudine (Epivir), Drug Information Sheet, NIAID and Clinical Center HIV Program (Site not responding. Last check: 2007-10-17)
		Lamivudine is proven to work well only when taken in combination with other anti-HIV medications.
		Lamivudine is also available in a liquid form.
		If you are infected with hepatitis B, it is very important that you avoid abruptly stopping lamivudine because this may allow hepatitis B to multiply and damage your liver.
	www.niaid.nih.gov /dir/labs/lir/hiv/lamivudine.htm (371 words)

	ABACAVIR/LAMIVUDINE (MDXexchange)
		Lamivudine is well absorbed from the gastrointestinal tract, with peak serum levels occurring in about one hour; oral bioavailability is approximately 86%.
		Approximately 70% of an oral dose of lamivudine is excreted unchanged in the urine.
		At birth, the lamivudine concentration for the mother, umbilical cord, and neonate were similar, demonstrating the free passage of lamivudine across the placenta (Moodley et al, 1998).
	www.micromedex.com /products/updates/drugdex_updates/de/abacavir.html (6162 words)

	MedlinePlus Drug Information: Lamivudine (Systemic) (Site not responding. Last check: 2007-10-17)
		Lamivudine (la-MI-vyoo-deen) is used in the treatment of the infection caused by the human immunodeficiency virus (HIV) or hepatitis B virus.
		Lamivudine is taken together with zidovudine (AZT) or other medications used to treat HIV.
		Lamivudine is not a cure for the hepatitis B virus; the long-term effects of the drug on the infection and the liver are unknown at this time.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202791.html (1923 words)

	Howstuffworks "Lamivudine: A Profile of a HIV Drug"
		Lamivudine is used in the treatment of human immunodeficiency virus (HIV) infection.
		Lamivudine works by inhibiting the reproduction, or growth, of the virus, which slows down the progression of AIDS.
		Lamivudine is used in combination with other anti-AIDS drugs, such as zidovudine.
	health.howstuffworks.com /define-lamivudine.htm (758 words)

	Lamivudine - Wikipedia, the free encyclopedia
		Lamivudine (2',3'-dideoxy-3'-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor of the class nucleoside analog reverse transcriptase inhibitor (NARTI).
		Despite this, lamivudine is still used widely as it is well tolerated.
		Lamivudine is administered orally, and it is rapidly absorbed with a bio-availability of over 80%.
	en.wikipedia.org /wiki/Lamivudine (346 words)

	Simple FactSheet: Lamivudine/zidovudine (Combivir)
		Lamivudine is also approved for the treatment of hepatitis B (Epivir HBV).
		Lamivudine has few side-effects, mainly nausea, vomiting, headaches, and rare cases of hair loss.
		If you're going to use lamivudine, it's important to check for infection with hepatitis B. If you have active hepatitis B when you start lamivudine, you may feel sick for a month or two because liver cells infected with hepatitis B die off.
	www.aegis.com /factshts/network/simple/combi.html (960 words)

	Tenofovir + Lamivudine (3TC) for HBV/HIV Coinfection
		Lamivudine (3TC, is a potent inhibitor of both HIV and HBV and was approved by the FDA for use in chronic HBV infection in1998.
		Lamivudine is already commonly prescribed as an antiretroviral agent in the treatment of HIV (although at a higher dose of 150mg bd or 300mg od), and can be used as part of a HAART regimen for patients with dual infection.
		Individuals who were not currently receiving lamivudine but had received it in the past with evidence of virological failure and may therefore have developed 3TC-resistant HBV, recommenced lamivudine.
	www.natap.org /2006/CROI/CROI_72.htm (1008 words)

	Entecavir Better Than Lamivudine In Chronically Infected Hepatitis B Patients (Site not responding. Last check: 2007-10-17)
		Safety was comparable between the treatment groups, with similar incidence of serious adverse events (6 percent with entecavir, 8 percent with lamivudine) and total adverse events (75 percent with entecavir, 79 percent with lamivudine).
		ALT level elevations were observed in 3 percent of patients on treatment receiving entecavir compared to 5 percent on treatment receiving lamivudine and in 14 percent versus 22 percent of patients off treatment, respectively.
		Safety was comparable between the treatment groups, with similar incidence of serious adverse events (10 percent with entecavir, 8 percent with lamivudine) and total adverse events (85 percent with entecavir, 81 percent with lamivudine).
	www.pharma-lexicon.com /medicalnews.php?newsid=15698 (1072 words)

	Medical Dictionary: Lamivudine - WrongDiagnosis.com
		Lamivudine: a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV
		Lamivudine: A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV.
		Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP).
	www.wrongdiagnosis.com /medical/lamivudine.htm (346 words)

	Lamivudine Drug Information
		Lamivudine will not cure or prevent HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.
		Lamivudine with zidovudine (e.g., Combivir)-Should not be used at the same time that you are taking lamivudine tablets or oral solution
		Lamivudine tablets and oral solution for hepatitis B virus contain lower amounts of the drug than the tablets and solution for HIV.
	www.drugs.com /cons/Lamivudine.html (2187 words)

	abacavir and lamivudine Consumer Drug Information
		Abacavir and lamivudine is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS).
		Abacavir and lamivudine is not a cure for HIV or AIDS.
		The symptoms of an abacavir and lamivudine overdose are not known.
	www.drugs.com /mtm/abacavir_and_lamivudine.html (1686 words)

	Lamivudine News
		Treatment for chronic hepatitis B is limited by the emergence of resistance to lamivudine, the most common first-line antiviral drug.
		Treatment with lamivudine is effective, but limited by the development of drug-resistant virus when used as monotherapy.
		Two fixed dose triple combination water-dispersible tablets produced by generic manufacturer Ranbaxy providing half- and quarter-doses of nevirapine, lamivudine and stavudine for paediatric use are...
	www.topix.net /drug/lamivudine (790 words)

	Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors -- Ono-Nita et al. ...
		Wild-type HBV is susceptible to lamivudine, lobucavir, and adefovir.
		Genotypic resistance to lamivudine in a prospective placebo-controlled multicenter study in Asia of lamivudine therapy for chronic hepatitis B infection: incidence kinetics of emergence and correlation with disease parameters.
		Identification and characterization of mutations in hepatitis B virus resistant to lamivudine.
	www.jci.org /cgi/content/full/103/12/1635 (4364 words)

	Lamivudine (Site not responding. Last check: 2007-10-17)
		Lamivudine is used to treat human immunodeficiency virus (
		HIV) infection and is in a class of drugs known as antivirals.
		Controlled studies are needed to determine whether taking sho-saiko-to might enhance the beneficial effects of lamivudine.
	www.kroger.com /hn/Drug/Lamivudine.htm (295 words)

	[No title]
		LAMIVUDINE is an antiretroviral agent, which belongs to a class of drugs called "nucleoside reverse transcripts inhibitors" or “ NRTIs”.
		LAMIVUDINE mimics a nucleoside base, which blocks further construction of the virus.
		The goal is to decrease the amount of viruses in the blood (viral load) to as LOW as possible and for as LONG as possible.
	xweb.crha-health.ab.ca /clin/sac/lamivudi.htm (412 words)

	[No title]
		Lamivudine/zidovudine, also known as Combivir, is a combination of the two anti-HIV medicines, lamivudine (Epivir) and zidovudine (Retrovir).
		This medicine was developed because lamivudine and zidovudine are often prescribed together to treat HIV infection.
		The recommended dose of lamivudine/zidovudine for adults and adolescents at least 12 years of age is one tablet (150 mg of lamivudine and 300 mg of zidovudine) twice a day.
	www.aidsinfo.nih.gov /drugs/htmldrug_nt.asp?int_id=0285 (409 words)

	Simple FactSheet: lamivudine, 3TC (Epivir)
		Lamivudine, trade name Epivir (also known as 3TC), is an anti-HIV treatment in the class of drugs called Nucleoside Reverse Transcriptase Inhibitors (NRTIs).
		The body breaks down these drugs into chemicals that stop HIV from infecting uninfected cells in the body, but they do not help cells that have already been infected with the virus.
		GlaxoSmithKline, the maker of lamivudine (3TC, pivir), has a patient assistance program for people having problems getting the drug.
	www.atdn.org /simple/lami.html (751 words)

	Gilead -- New Data Demonstrate Antiviral Activity of Gilead's Hepsera in Patients with Lamivudine-Resistant Chronic ...
		Patients receiving Hepsera alone or in combination with lamivudine experienced statistically significant reductions in both serum hepatitis B virus (HBV) DNA and alanine aminotransferase (ALT, a measure of liver damage), compared with patients who received lamivudine only.
		Patients treated with lamivudine alone did not show significant virological, biochemical or serological benefit compared with their baseline values.
		In addition, ALT levels normalized in 53 percent of patients receiving Hepsera in combination with lamivudine (p<0.01) and in 47 percent of patients who switched to Hepsera monotherapy (p<0.01) compared to five percent of patients who continued lamivudine monotherapy.
	www.gilead.com /wt/sec/pr_1036369914 (1835 words)

	Healthopedia.com Drugs Information - Lamivudine : Proper Use (Epivir, Epivir-HBV, 3TC, Heptovir)
		Also, do not stop taking lamivudine or zidovudine without checking with your doctor first.
		Keep taking lamivudine for the full time of treatment, even if you begin to feel better.
		If you are using lamivudine oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately.
	www.healthopedia.com /drugs/detailed/lamivudine/proper-use.html (626 words)

	LAMIVUDINE a Commonly Used Medication (Site not responding. Last check: 2007-10-17)
		Increased levels of zidovudine; no dosage adjustment needed.
		Resistance to lamivudine promotes susceptibility to ZDV; this combination is recommended.
		TMP-SMX slows clearance of lamivudine; clinical implication uncertain
	www.hivdent.org /drugs/LAMIVUDINE.htm (134 words)

	Epivir brand lamivudine (3TC): a complete guide from AIDSmeds.com
		Lamivudine resistance common in patients coinfected with hepatitis B and HIV (5/17/06)
		Lamivudine slows progression of chronic hepatitis B with advanced fibrosis (10/6/04)
		Lamivudine plus zidovudine decreases vertical HIV transmission, but at a cost (4/24/01)
	www.aidsmeds.com /drugs/Epivir.htm (1900 words)

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