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Topic: Lamotrigine

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	Lamictal - Lamictal Side Effects - Lamictal Information - Canada Pharmacy - Canada Drugs
		Lamotrigine is thought to act at voltage-sensitive sodium channels to stabilize neuronal membranes and inhibit the release of excitatory amino acid neurotransmitters (e.g., glutamate, aspartate) that are thought to play a role in the generation and spread of epileptic seizures.
		Lamotrigine is metabolized predominantly in the liver by glucuronic acid conjugation.
		Lamotrigine was discontinued because of rash in 1.1% of adult patients in controlled studies and 3.8% of all patients in all studies.
	www.rxcarecanada.com /Lamictal.asp?prodid=997 (5283 words)

	Lamotrigine, L4
		Lamotrigine is known to inhibit glutamine release in vitro, and has been successfully applied to protect nerve cells in other experiments using animal models.
		The researchers studied the effects of lamotrigine on 28 people with HD; they also gave a placebo to 27 people with HD to control for psychological effects of treatment as well as to have a comparison group.
		Since lamotrigine is known to inhibit the release of glutamate, this group tested the safety of various doses of the drug and how well it was tolerated in HD patients.
	www.stanford.edu /group/hopes/treatmts/antiglut/l4.html (1781 words)

	lamotrigine for bipolar disorder
		Lamotrigine is another anti-seizure medication we psychiatrists have borrowed from the neurologists.
		The authors comment that a rapid dose increase was used in all three cases and that this might have influenced the apparent association of lamotrigine and the manic symptoms described.
		Conclusion: lamotrigine seems to be a different kind of mood stabilizer than Depakote or lithium, and has extremely low risk of side effects as long as you don't get the rash -- which is less likely if you go up very slowly on the dose.
	www.psycheducation.org /depression/meds/lamotrigine.htm (966 words)

	Lamictal Combined Tablets , SPC from the eMC
		Lamotrigine is a weak inhibitor of dihydrofolate reductase.
		Lamotrigine should not be used in pregnancy unless, in the opinion of the physician, the potential benefits of treatment to the mother outweigh any possible risks to the developing foetus.
		The half-life of lamotrigine is generally shorter in children than in adults with a mean value of approximately 7 hours when given with enzyme-inducing drugs such as carbamazepine and phenytoin and increasing to mean values of 45 to 50 hours when co-administered with sodium valproate alone (see Posology and Method of Administration).
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?documentid=4228 (4843 words)

	Lamotrigine
		Lamotrigine 200 mg/d Better than 50 mg/d: In a DB PC 7 week study of 192 bipolar I depressed patients, lamotrigine was found to be better than placebo by 3 weeks and the 200 mg/day dose more effective.
		Lamotrigine Helped, Gabapentin Didn’t in DB: In a small 45-patient DB PC study of 6 weeks each of 35 refractory bipolar patients and 10 refractory unipolar depressed patients, 51% on lamotrigine, 28% on gabapentin, and 21% on placebo had a positive response.
		Lamotrigine Equaled Lithium in Short, Small DB: In a DB study of 30 patients diagnosed Bipolar I manic phase, 4 weeks of treatment with Lithium 400 BID or lamotrigine 25 mg/day for 1 week, 50 mg/day for the 2nd week, then 100 my/day found that improvement was similar.
	www.modern-psychiatry.com /lamotrigine.htm (2735 words)

	Lamotrigine: A Significant Advance for Treatment of Bipolar Depression
		Lamotrigine should be the first-line treatment for bipolar 1 depressed patients with a previous history of severe manic episodes.
		Lamotrigine can be started at 12.5 mg to 25 mg daily and can be increased by 25 mg every 2 weeks during the first 6 weeks.
		In conclusion, lamotrigine is an excellent treatment for acute and maintenance treatment of bipolar depression, and it is in general well tolerated, with the exception of skin rash.
	www.angelfire.com /ga4/suicideawareness/375.html (1602 words)

	Lamotrigine (Site not responding. Last check: 2007-10-12)
		Lamotrigine is generally taken in conjunction with other anticonvulsants.
		It is thought to depress the activity of certain parts of the brain and suppress the abnormal firing of neurons that causes seizures.
		Lamotrigine is generally not recommended for use in children younger than age 16.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,703,00.html (603 words)

	Psychiatric Uses of Lamotrigine
		Lamotrigine received final approval for marketing in the USA on 27 December 1994 and was labeled for use as an anticonvulsant.
		Before lamotrigine is prescribed the patient should have a thorough medical evaluation, including blood and urine tests, to rule out any medical condition, such as thyroid disorders, that may cause or exacerbate a mood disorder.
		Lamotrigine seems to be effective in about two-thirds of people with bipolar mood disorders that have not responded to lithium or other mood-stabilizers.
	www.psycom.net /depression.central.lamotrigine.html (3526 words)

	Lamotrigine for epilepsy
		Lamotrigine is used to treat a broad range of seizures.
		Lamotrigine is used most often with other epilepsy drugs but may also be used alone to treat epilepsy.
		Lamotrigine has recently been approved for use in children ages 2 years and older who have Lennox-Gastaut syndrome and who have not responded to other drug treatment.
	www.webmd.com /hw/epilepsy/hw110556.asp (466 words)

	Focus on Lamotrigine - a new anti-epileptic
		Lamotrigine is an anticonvulsant that is chemically unrelated to any other anticonvulsant or mood regulating medication.Lamotrigine received final approval for marketing in the USDA on 27 December 1994 and is labeled for use as an anticonvulsant.
		Lamotrigine has had been successful in controlling rapid cycling and mixed bipolar states in people who have not received adequate relief from carbamazepine and/or valproate.It also appears that lamotrigine has significantly more antidepressant potency than either carbamazepine or valproate.
		Lamotrigine is has been placed in the FDA pregnancy Category C: "Animal studies have shown an adverse effect on the fetus but there are no adequate studies in humans; The benefits from the use of the drug in pregnant women may be acceptable despite its potential risks.
	www.priory.com /focus6.htm (1188 words)

	Lamictal Side Effects, Interactions and Information - Drugs.com
		Lamotrigine is used alone or in combination with other medications in the treatment of seizures.
		Lamotrigine is in the FDA pregnancy category C. This means that it is not known whether lamotrigine will be harmful to an unborn baby.
		Lamotrigine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants.
	lamictal.drugs.com (1683 words)

	Lamictal - Drugs & Vitamins - Drug Library - DrugDigest
		Lamotrigine is also used in adults and children who have generalized (major) seizures (convulsions) due to a special condition named Lennox-Gastaut syndrome.
		Lamotrigine is usually prescribed with other medications that also help to control the convulsions, although sometimes lamotrigine may be used by itself.
		Lamotrigine is also used in adults for a mental health condition called bipolar disorder.
	www.drugdigest.org /DD/DVH/Uses/0,3915,370\|Lamictal,00.html (1009 words)

	Buy Lamotrigine online in 25mg, 5mg dispersible tablet; cheap drug prices and information
		Lamotrigine is an anticonvulsant used alone or with other medicines to treat seizure disorders.
		Use of lamotrigine in children age 2 to 15 years of age is restricted to those having certain types of seizures (partial or Lennox-Gastaut type).
		Lamotrigine is also used in bipolar disorder to reduce the occurrence of mood problems.
	www.drugstore.com /qxdLamotrigine_332828_sespider/lamotrigine/lamotrigine.htm (333 words)

	Lamotrigine (Systemic) - MayoClinic.com
		Lamotrigine (la-MOE-tri-jeen) is used to help control some types of seizures in the treatment of epilepsy.
		Lamotrigine is not indicated for bipolar disorder in children under 18 years of age.
		Lamotrigine may be taken with or without food or on a full or empty stomach.
	www.mayoclinic.com /health/drug-information/DR202786 (1975 words)

	lamotrigine - Health and Medical Information produced by doctors - MedicineNet.com
		In patients taking valproic acid, the initial dose of lamotrigine is 25 mg every other day for two weeks, then 25 mg once daily for two weeks, slowly increasing the dose (by 25 to 50 mg per day) every one to two weeks) until a dose of 100 to 150 mg daily is reached.
		When lamotrigine is begun in patients already receiving valproic acid, the blood concentrations of valproic acid can decrease over a 3-week period.
		The risk in children (for whom lamotrigine is not approved) is as high as 1 in 50 to 1 in 100 patients.
	www.medicinenet.com /lamotrigine/article.htm (680 words)

	Epilepsy Drug Lamictal Appears Effective For Bipolar Depression (Site not responding. Last check: 2007-10-12)
		The article reported that lamotrigine demonstrated evidence of antidepressant activity compared to placebo in the treatment of major depressive episodes in patients with bipolar I disorder and that clinical improvement became evident as early as the third week of treatment.
		The dose of lamotrigine was increased gradually to reach the target dose of either 50 or 200 mg/day.
		Lamotrigine should ordinarily be discontinued at the first sign of rash, unless the rash is clearly not drug-related.
	www.pslgroup.com /dg/eb8ea.htm (874 words)

	RemedyFind: patient ratings of Lamictal for Bipolar II Disorder
		Lamictal etc. (Lamotrigine) is one of the newest generation of anticonvulsant medications, and is approved for the treatment of epileptic seizures (U.S. FDA 1998), and for the long-term maintenance treatment of Bipolar I Disorder (June 2003).
		Lamotrigine is thought to act at voltage-sensitive sodium channels to stabilize neuronal membranes and inhibit the release of excitatory amino acid neurotransmitters (like glutamate and aspartate).
		Lamotrigine is the best studied anticonvulsant and has efficacy in acute bipolar depression and in longer term treatment of bipolar depression as well as rapid-cycling bipolar II disorder but not in acute mania.
	www.remedyfind.com /rm-2821-Lamictal.asp (1808 words)

	Lamotrigine - Patient UK
		Lamotrigine can be used on its own or alongside other medicines to control the convulsions (fits or seizures) in some forms of epilepsy by reducing the activity in the brain.
		Lamotrigine is available in tablet and dispersible tablet form.
		Lamotrigine may cause your skin to become more sensitive to sunlight than it is usually.
	www.patient.co.uk /showdoc/30002576 (612 words)

	MedlinePlus Drug Information: Lamotrigine
		Lamotrigine is used to treat certain types of seizures in patients who have epilepsy or Lennox-Gastaut syndrome (a disorder that causes seizures and often causes developmental delays).
		Lamotrigine is also used to increase the time between episodes of depression, mania (frenzied or abnormally excited mood), and other abnormal moods in patients with bipolar I disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods).
		Lamotrigine has not been shown to be effective when people experience the actual episodes of depression or mania, so other medications must be used to help people recover from these episodes.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a695007.html (1362 words)

	Lamotrigine in Rapid-Cycling Bipolar Disorder (Site not responding. Last check: 2007-10-12)
		Each received lamotrigine titrated to a minimum dose of 150 mg/day as monotherapy or in combination with other psychotropic agents.
		Lamotrigine was well tolerated by all patients; only one patient experienced several side effects, which were probably due to interaction between several psychotropic medications.
		Conclusion: Lamotrigine augmentation therapy and monotherapy appeared to have mood-stabilizing and antidepressant efficacy in the treatment of five rapid-cycling bipolar patients.
	www.psychiatrist.com /pasttoc/toc/december1997/522lamo.htm (278 words)

	Lamictal-lamotrigine
		There is now substantial evidence that lamotrigine is also useful in treating resistant depression, rapid cycling bipolar affective disorder, depressive episodes in bipolar affective disorder and in the maintenance phase or prophylaxis of bipolar affective disorder.
		Lamotrigine effective mood stabilizer for some with rapid-cycling bipolar disorder pharmiweb Of those in the lamotrigine group, 41% were stable without relapse for 6 months, compared with 26% of those in the placebo arm
		Lamotrigine Effective Mood Stabilizer for Some With Rapid-Cycling Bipolar Disorder medscape Dec 15,2000 though rashes occurred, none were considered serious.
	noetic.oathill.com /bipolar/lamictal.html (343 words)

	Lamictal, Lamotrigine - Buy Lamictal, Lamotrigine
		Lamotrigine should be used in children below the age of 16 ONLY if they have seizures related to the Lennox-Gastaut Syndrome.
		Lamotrigine is used in adults with epilepsy to control a type of seizure called partial seizures.
		It should not be construed to indicate that use of Lamictal, Lamotrigine is safe, appropriate, or effective for you.
	247-pharmacy.com /Lamictal.htm (193 words)

	Lamictal (lamotrigine) - The Good, The Bad and The Funny. From People Who Have Taken These Crazy Meds...and SCIENCE!
		Lamictal (lamotrigine) joins lithium in being one of only two meds to date approved to treat both the manic and depression phases of bipolar disorder and essentially to treat the mood swings themselves.
		Lamictal (lamotrigine) is the prima donna of anticonvulsants / mood stabilizers.
		Lamictal (lamotrigine) is one of the few meds approved for Lennox-Gastaut syndrome, an uncommon form of epilepsy that, among other symptoms, presents the atonic seizure, where all your muscles go utterly limp.
	www.crazymeds.org /lamictal.html (4359 words)

	Lamictal Online, Description, Chemistry, Ingredients - Lamotrigine - RxList Monographs
		LAMICTAL (lamotrigine), an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs.
		Lamotrigine is a white to pale cream-colored powder and has a pKa of 5.7.
		The tablets contain 2 mg (white), 5 mg (white), or 25 mg (white) of lamotrigine and the following inactive ingredients: flcurrant flavor, calcium carbonate, low-substituted hydroxypropylcellulose, magnesium aluminum silicate, magnesium stearate, povidone, saccharin sodium, and sodium starch glycolate.
	www.rxlist.com /cgi/generic/lamotrigine.htm (618 words)

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