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Topic: Langerhans cell

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In the News (Wed 17 Jul 19)

  Ear Pathology Online: Langerhans Cell Histiocytosis of the Ear
Langerhans' cell histiocytosis is a rare disorder of unknown aetiology in which pathological Langerhans' cells accumulate and destroy local tissue.
Langerhan's cell histiocytosis is an uncommon granulomatous disease, characterized by the idiopathic proliferation of Langerhan's cells or their marrow precursors.
Langerhans' cell histiocytosis is a rare pathology that implies an abnormal proliferation of these kind of cells associated with granular infiltration that affects different structures of the human body, including the temporal bone.
www.surgical-pathology.com /ear_histiocytosis.htm   (2725 words)

  Langerhans cell - Wikipedia, the free encyclopedia
Langerhans' cells are immature dendritic cells containing large granules called Birbeck granules.
Generally, dendritic cells in tissue (such as Langerhans' cells) are active in the capture, uptake and processing of antigens.
Langerhans' cells are derived from the cellular differentiation of monocytes with the marker "Gr-1" (also known as "Ly-6c/G").
en.wikipedia.org /wiki/Langerhans_cell   (212 words)

 Langerhans Cell Histiocytosis
Langerhans cell histiocytosis (LCH) is a rare spectrum of disorders characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the various tissues and organs of the body (lesions).
Langerhans cell histiocytosis was selected by the Histiocyte Society to replace the older, less specific term histiocytosis X. Histiocytosis X encompassed three entities known as eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease that were characterized by the accumulation of histiocytes.
Langerhans cell histiocytosis was chosen because it is now known that Langerhans cells play the central role in the development of these disorders.
hw.healthdialog.com /kbase/nord/nord408.htm   (2872 words)

 Obstructing tracheal pulmonary Langerhans cell histiocytosis CHEST - Find Articles   (Site not responding. Last check: )
Pulmonary Langerhans cell histiocytosis, also known as pulmonary eosinophilic granuloma and pulmonary histiocytosis X, is an uncommon interstitial lung disorder that is characterized by the abnormal proliferation of Langerhans cells.
A biopsy specimen from the lesion was compatible with Langerhans cell histiocytosis, and therefore a second FOB was performed with full excision of the lesion using laser therapy with a Nd-YAG laser (30 W; total energy, 3,000 J).
Pulmonary Langerhans cell histiocytosis, or pulmonary eosinophilic granuloma, is an uncommon interstitial lung disorder that is characterized by the abnormal proliferation of Langerhans cells.
www.findarticles.com /p/articles/mi_m0984/is_2_128/ai_n15379448   (871 words)

 2004 Pulmonary Pathology Specialty Conference Handout - Case 5
Langerhans cell histiocytosis (LCH), also termed pulmonary eosinophilic granuloma or Langerhans' cell granulomatosis, is an interstitial lesion of uncertain etiology characterized by an abnormal proliferation of modified histiocytes (Langerhans cells).
Ultrastructurally Langerhans' cells contain unique pentilaminar inclusions (Birbeck or Langerhans' granules) within their cytoplasm, and for this reason electron microscopy was once considered the method of choice for establishing the diagnosis of LCH in difficult cases.
Three-dimenstional characterization of pathologic lesions in pulmonary Langerhans cell histiocytosis.
www.uscap.org /site~/93RD/SPECPULMH5.htm   (1815 words)

 Langerhans Cell Histiocytosis
Langerhans cell histiocytosis, previously named histiocytosis X, refers to a group of disorders with a wide spectrum of clinical manifestations, characterized by the proliferation and tissue infiltration of specific, bone marrow-derived, dendritic (Langerhans) cells.
Langerhans cell histiocytosis is a rare disease with an estimated annual incidence ranging from 2 to 5 cases per million people per year and a higher incidence in men.
Langerhans cell histiocytosis is essentially a benign, often self-limited disease and patients with unifocal bone lesions generally have an excellent prognosis.
www.orthosupersite.com /view.asp?rID=23095   (2136 words)

 Modern Pathology - Langerhans Cell Histiocytosis Involving the Thyroid and Parathyroid Glands
Langerhans cell histiocytosis (LCH) is a rare illness, and the disease afflicting the thyroid gland is very uncommon, even in the presence of multisystem involvement.
Currently, the preferred term is Langerhans cell histiocytosis (3, 4) replacing the term histiocytosis X because the Langerhans cell is believed to play a central role in the pathogenesis of this heterogeneous group of disease whose clinical manifestation ranges from benign, solitary bone lesion to fatal, multisystemic, life-threatening lymphoproliferative disorders (Litterer-Siwe syndrome) (2).
On an ultrastructural level (5), Birbeck or Langerhans granules, which represent invaginations of plasma membrane and laid the foundation that led to the suggestion that Langerhans cells are the progenitor of the LCH cells (14), are typically identified in LCH cells.
www.nature.com /modpathol/journal/v14/n2/full/3880266a.html   (2798 words)

Langerhans' cells are white blood cells in the immune system that normally play an important role in protecting the body against viruses, bacteria and other invaders.
Langerhans' cell histiocytosis is rare, affecting 1 in 250,000 children and 1 in 1 million adults in the United States.
People with Langerhans' cell histiocytosis may have a higher-than-average risk of developing cancer later in life, including lymphoma and leukemia The reason for this increased risk is not known.
www.intelihealth.com /IH/ihtIH/WSIHW000/9339/25698.html   (1300 words)

 Langerhans Cell Histiocytosis pg. 67--73
The Langerhans cell (LC) is considered to be a dendritic cell of the epidermis, making up 1--2% of epidermal cells, and is believed that it is derived from a multipotent bone marrow stem cell [4,6,10,25].
Langerhans cells in LCH lesions are clonal [29--33].
, and interleukin 11 in the osteolytic lesions of Langerhans cell histiocytosis.
www.uphs.upenn.edu /ortho/oj/2002/html/oj15sp02p67.html   (5338 words)

 Langerhans' Cell Histiocytosis: Histiocytic Syndromes: Merck Manual Professional
Langerhans' cell histiocytosis is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely.
Langerhans' cell histiocytosis (LCH) is a dendritic cell disorder.
These cells are identified by a pathologist experienced in the diagnosis of LCH according to their immunohistochemical charecteristics, which include cell surface CD 1a and S-100.
www.merck.com /mmpe/sec11/ch140/ch140b.html   (1180 words)

 HON Allergy Glossary Antigen-presenting cell (APC)
Dendritic cells are the principle APC involved in primary immune responses.
Their major function is to obtain antigen in tissues, migrate to lymphoid organs and activate T cells.
Langerhans Cells are dendritic cells specific to the skin.
www.hon.ch /Library/Theme/Allergy/Glossary/apc.html   (195 words)

 Paul Langerhans (www.whonamedit.com)
Langerhans attended the Gymnasium zum Grauen Kloster in Berlin and graduated at the age of sixteen.
In 1868 using the technique taught to him by Cohnheim, he stained a sample of human skin with gold chloride and described the dendritic cells in the skin which now bear his name and which from their morphology he believed to be nerve cells.
Langerhans and Hoffmann studied the intravital storage of cinnabar injected intravenously in rabbits and guinea pigs.
www.whonamedit.com /doctor.cfm/1987.html   (972 words)

 ScienceDaily: Source Of Crucial Immune Cell In The Skin Discovered
A tight network of cells covering the entire body is formed in the skin by a group of cells known as Langerhans cells.
Langerhans Cells Regulate Immune Reactions In The Skin (December 20, 2005) -- Researchers at Yale School of Medicine have demonstrated that Langerhans cells in the skin, which had been thought to alert the immune system to pathogens, instead dampen the skin's reaction to...
Embryonic stem cell -- Embryonic stem cells (ESCs) are stem cells derived from the undifferentiated inner mass cells of a human embryo.
www.sciencedaily.com /releases/2006/01/060130032032.htm   (1865 words)

 Rare diseases bullet 9: Adult pulmonary Langerhans' cell histiocytosis -- Tazi et al. 55 (5): 405 -- Thorax
Langerhans' cells accumulate between the bronchiolar epithelium (ep) and the muscle fibres (m) surrounding the bronchiolar mucosa.
of Langerhans' cells in distal bronchioles, the capacity of the
lineages of haematopoietic cells derived from the progenitor.
thorax.bmj.com /cgi/content/full/55/5/405   (6133 words)

 Langerhans cell histiocytosis (histiocytosis X, eosinophilic granuloma)
Langerhans cell histiocytosis patients have HLA Cw7 and DR4 types associated with specific clinical presentations and no increased frequency in polymorphisms of the tumor necrosis factor alpha promoter.
Cholestasis, sclerosing cholangitis, and liver transplantation in Langerhans cell Histiocytosis.
Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment.
www.uptodate.com /patients/content/topic.do?topicKey=whitecel/8445   (2801 words)

 BioMed Central | Full text | Langerhans cell histiocytosis on the penis: a case report
Histologically, the lesions consisted of diffuse infiltrates of Langerhans cells with indented or grooved nuclei and eosinophilic or pale cytoplasm.
Langerhans cells are modulated actively in response to certain chemical stimuli, human papillomavirus infection, and cervical intraepithelial neoplasia [6].
It is not proven that the distribution of Langerhans cells or various stimuli to the penis may be related to the rare nature of penile lesions or the good response to the treatment.
www.biomedcentral.com /1471-2490/6/28   (1192 words)

 Langerhans cell histiocytosis in sequential discordant lymphoma -- Adu-Poku et al. 58 (1): 104 -- Journal of Clinical ...
Langerhans cell histiocytosis in sequential discordant lymphoma -- Adu-Poku et al.
Langerhans cell histiocytosis is a group of disorders characterised
of the Langerhans cell histiocytosis, its presence in the non-Hodgkin
jcp.bmjjournals.com /cgi/content/full/58/1/104   (1019 words)

 Langerhans Cell Histiocytosis
Langerhans cell histiocytosis (also called histiocytosis X) is a rare disorder that primarily affects children.
Langerhans cell histiocytosis historically was thought of as a cancer-like condition, but more recently researchers have begun to consider it an autoimmune phenomenon in which immune cells begin to overproduce and attack the body instead of fighting infection.
And because these symptoms could be caused by another condition not related to Langerhans cell histiocytosis, it is important to seek proper medical attention to receive an accurate diagnosis.
cms.clevelandclinic.org /childrenshospital/body.cfm?id=551   (691 words)

 eMedicine - Juvenile Xanthogranuloma (Nevoxanthoendothelioma) : Article by Caroline DS Piggott
Juvenile xanthogranulomas (JXGs) are benign; usually asymptomatic; self-healing; red, yellow, or brown papules and nodules composed of histiocytic cells that predominantly occur in infancy and childhood.
The consensus is that the cells of origin are dermal dendrocytes.
Because of the difficulty in diagnosing JXG and because of the transient presence of Touton giant cells in JXG lesions, these classic elements may not be present in every case.
www.emedicine.com /derm/topic202.htm   (2336 words)

 Langerhans' cell histiocytocis (LCH) in children : Cancerbackup
Langerhans' refers to Dr Paul Langerhans who first described the cells in the skin from which LCH develops.
Langerhans' cells are dendritic cells and are normally only found in the skin and major airways.
In LCH, the Langerhans' cells are abnormal and spread via the bloodstream into many parts of the body, including the bone marrow, skin, lungs, liver, lymph glands, spleen and pituitary gland.
www.cancerbackup.org.uk /Cancertype/Childrenscancers/Typesofchildrenscancers/Langerhanscellhistiocytocis   (1408 words)

 [No title]
A white blood cell that is stimulated in a laboratory to kill tumor cells.
Langerhans cell histiocytosis may also affect the pituitary gland (which makes hormones that control other glands and many body functions, especially growth).
Langerhans cell histiocytosis is most common in children and young adults.
www.cancer.gov /dictionary/db_alpha.aspx?expand=l   (6052 words)

 Differentiation of Langerhans cells in Langerhans cell histiocytosis -- Geissmann et al. 97 (5): 1241 -- Blood
Langerhans cell histiocytosis (LCH) consists of lesions composed of cells with a dendritic Langerhans cell (LC) phenotype.
Langerhans' cell histiocytosis: definitive diagnosis with the use of monoclonal antibody O10 on routinely paraffin-embedded samples.
Langerhans cells in Langerhans cell granulomatosis are not actively proliferating cells.
www.bloodjournal.org /cgi/content/full/97/5/1241   (5691 words)

 Langerhans' Cell Histiocytosis
Langerhans cell histiocytosis (LCH), or histiocytosis X, is a group of diseases characterized by proliferation of the Langerhans cell.
There may be destruction of the alveolar ridge with infiltration of the gums with LCH cells, resulting in the teeth floating from their sockets [2].
The Langerhans cells are recognized by their abundant, amphophilic cytoplasm and round or kidney bean-shaped nucleus.
dermatology.cdlib.org /DOJvol8num2/case_presentations/histiocytosis/namazi.html   (1048 words)

 CIGNA - Langerhans Cell Histiocytosis
Langerhans cell histiocytosis was chosen because it is now known that Langerhans cells play the central role in the development of these disorders.
Langerhans cell histiocytosis represents a spectrum of disorders whose symptoms and physical features vary greatly from case to case.
Cases of LCH that affect the lungs may be referred to as pulmonary eosinophilic granuloma or pulmonary Langerhans cell histiocytosis.
www.cigna.com /healthinfo/nord408.html   (3207 words)

 Langerhans cell histiocytosis. DermNet NZ
Langerhans cell histiocytosis (LCH) refers to a reactive (non-cancerous) increase in the number of Langerhans cells in the skin and other organs (see histiocytoses).
Langerhans cells are immune cells that are normally found within the epidermis where they act as antigen-presenting cells in an early warning system fighting foreign material such as bacteria.
Langerhans cell histiocytosis may develop at any age but most commonly occurs in childhood (1-3 years of age).
www.dermnetnz.org /dermal-infiltrative/langerhans.html   (874 words)

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