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Topic: Large ribosomal subunit

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regulatory subunit

large ribosomal subunit

small subunit ribosomal RNA

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	Ribosomal RNA - Wikipedia, the free encyclopedia
		Ribosomal RNA (rRNA) is the central component of the ribosome, the protein manufacturing machinery of all living cells.
		The function of the rRNA is to provide a mechanism for decoding mRNA into amino acids (at center of small ribosomal subunit) and to interact with the tRNAs during translation by providing petidyltransferase activity (large subunit).
		Ribosomal RNA characteristics are important in medicine and in evolution.
	en.wikipedia.org /wiki/Ribosomal_RNA (409 words)

	Pfam 20.0 : Ribosomal_L5_C (Site not responding. Last check: 2007-10-30)
		Ribosomes are the particles that catalyze mRNA-directed protein synthesis in all organisms.
		Many of ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilize its structure.
		Ribosomal protein L5 is one of the proteins from the large ribosomal subunit.
	pfam.wustl.edu /cgi-bin/getdesc?name=Ribosomal_L5_C (678 words)

	Archaeal Large Ribosomal Subunit Interactive Tour/UMASS Amherst
		The subunit was purified from a rather obscure organism, the archaea Haloarcula marismortui.
		Wool, I. G., Gluck, A., Endo, Y. Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation.
		The accession number of the NMR data of a small RNA with the sequence of a conserved part of the ribosomal RNA of the large subunit is 1VOP (12).
	www-unix.oit.umass.edu /~wdecatur/ribosome/index.htm (1615 words)

	Ribosomal Protein Gene in Yeast
		The MRPL28 gene in Saccharomyces cerevisiae encodes for a protein that is found on the large ribosomal subunit on the mitochondrial ribosome.
		Ribosomes are involved in the synthesis of proteins in cells, and can occur in three main subcellular locations - the cytosol, the endoplasmic reticulum, and the mitochondria.
		The study of the effects of changes in ribosomal proteins is a very important one, as ribosomal proteins are extremely far "upstream" in cellular pathways.
	www.bio.davidson.edu /courses/genomics/2001/lowry/mfygknown.html (696 words)

	[No title]
		L25899 Ribosomal protein L15; component of the large 60S ribosomal subunit molecular functionstructural protein of ribosomePGO:0003735Proteome9582194//molecular functionRNA bindingPGO:0003723Proteome9582194//biological processprotein biosynthesisPGO:0006412Proteome9582194//cellular componentribosomePGO:0005840Proteome9582194 Z97353 Data not found D10522 Involved in the crosslinking of actin filaments molecular functioncalmodulin bindingEGO:0005516Proteome1560845//molecular functionactin cross-linkingEGO:0003780Proteome1560845//biological processcell motilityNRGO:0006928Proteomena//cellular componentactin cytoskeletonPGO:0015629Proteome1560845//cellular componentplasma membraneNRGO:0005886Proteomena marcks is the most prominent cellular substrate for protein kinase c.
		J03464 Alpha 2 subunit of type I collagen; may be an extracellular matrix protein; member of the fibrillar collagen family of ECM proteins molecular functionstructural constituent of boneNRGO:0008147Proteomena//molecular functioncollagenNRGO:0005202Proteomena//biological processskeletal developmentPGO:0001501Proteome8841196//cellular componentcollagen type INRGO:0005584Proteomena type i collagen is a member of group i collagen (fibrillar forming collagen).
		V00503 Alpha 2 subunit of type I collagen; may be an extracellular matrix protein; member of the fibrillar collagen family of ECM proteins molecular functionstructural constituent of boneNRGO:0008147Proteomena//molecular functioncollagenNRGO:0005202Proteomena//biological processskeletal developmentPGO:0001501Proteome8841196//cellular componentcollagen type INRGO:0005584Proteomena type i collagen is a member of group i collagen (fibrillar forming collagen).
	www1.imim.es /courses/BioinformaticaUPF/P24/anotacions.txt (7796 words)

	InterPro: IPR005755 Ribosomal protein L13, archea and eukaryotic form
		Ribosomal protein L13 is one of the proteins from the large ribosomal subunit [ 4 ].
		In Escherichia coli, L13 is known to be one of the early assembly proteins of the 50S ribosomal subunit.
		Klein D.J. Moore P.B. Steitz T.A. The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR005755 (3316 words)

	[No title]
		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
		Ribosomal protein P1 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 3ara7
		Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
	www.ocimumbio.com /web/arrays/assets/downloads/OligoTestSets/Yeast/platefile_testset_yeast.html (2140 words)

	A Novel SET Domain Methyltransferase Modifies Ribosomal Protein Rpl23ab in Yeast -- Porras-Yakushi et al. 280 (41): ...
		methyl-accepting substrate elutes with the large ribosomal subunit.
		The identity of the ribosomal subunits was determined by extracting RNA from 100 µl of the pooled sample and demonstrating the presence of the 25 S rRNA in the large subunit and the 18 S rRNA in the small subunit by gel electrophoresis (data not shown).
		B, protein (100 µg) from the large ribosomal subunit, small ribosomal subunit, and soluble protein fraction was fractionated by SDS gel electrophoresis on a gel prepared with 15% acrylamide and 0.52% N, N-methylene-bisacrylamide, followed by fluorography for 2 months.
	www.jbc.org /cgi/content/full/280/41/34590 (5471 words)

	Ribosome Tour for old chime
		The abridged tour of the large subunit is designed for a general audience.
		If you have more than a basic familiarity with the ribosome or have looked at the original set of papers describing the structures (1,2,3), you'd probably better spend your time and learn more by examining the comprehensive tour of the Archaeal Large Ribosomal Subunit.
		The original impetus for designing chime-based images of the large subunit was to accompany a series of presentations given in the Fall 2000 Molecular Biology Journal Club at the University of Massachusetts at Amherst.
	www.umass.edu /molvis/pipe/ribosome/intro.htm (1513 words)

	The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 A Resolution -- Ban et al. 289 (5481): 905 -- ... (Site not responding. Last check: 2007-10-30)
		The large ribosomal subunit catalyzes peptide bond formation and binds initiation, termination, and elongation factors.
		Ribosomal Proteins Cross-Linked to the Initiator AUG Codon of a mRNA in the Translation Initiation Complex by UV-Irradiation.
		Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron.
	intl.sciencemag.org /cgi/content/abstract/289/5481/905 (2221 words)

	Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR -- ...
		Ribosomes are the canonical example of ribonucleoprotein complexes in both prokaryotes and eukaryotes and are responsible
		/500 mM KCl/10% (wt/wt) sucrose/1 mM DTT], and the ribosomal
		The characterization of yeast large ribosomal subunit proteins is challenging because of the number of proteins to be characterized,
	www.pnas.org /cgi/content/full/99/9/5942 (4414 words)

	A novel site of antibiotic action in the ribosome: Interaction of evernimicin with the large ribosomal subunit -- ...
		Footprinting of Evn on Bacterial and Archaeal Ribosomes.
		Lane 1, unmodified control; lane 2, ribosomes modified with DMS in the absence of Evn; lanes 3 and 4, ribosomes modified with DMS in the presence of 10 µM or 50 µM Evn, respectively.
		The large ribosomal subunit is shown in a crown projection with the interface side of the 50S subunit toward the reader (28).
	www.pnas.org /cgi/content/full/98/7/3726 (4472 words)

	Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit (Site not responding. Last check: 2007-10-30)
		The 5Å-resolution electron-density map of the 50S ribosomal subunit shows well resolved density for the backbone of the two strands of duplex RNA and higher density features at the positions of phosphate groups.
		Bernabeu, C. and Lake, J. Nascent polypeptide chains emerge from the exit domain of the large ribosomal subunit: Immune mapping of the nascent chain.
		The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome.
	www.csb.yale.edu /people/steitz/backup/nature_art.html (4146 words)

	Binding Site of Macrolide Antibiotics on the Ribosome: New Resistance Mutation Identifies a Specific Interaction of ... (Site not responding. Last check: 2007-10-30)
		the ribosome with its subsequent hydrolysis by peptidyl-tRNA hydrolase.
		Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus.
		Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin.
	jb.asm.org /cgi/content/full/183/23/6898 (5023 words)

	Species Specificity in Ribosome Biogenesis: a Nonconserved Phosphoprotein Is Required for Formation of the Large ...
		In the protozoan parasite Trypanosoma brucei, the large rRNA,
		Isolation and characterization of yeast ribosomal RNA precursors and preribosomes.
		Molecular cloning of Trypanosoma brucei CK2 catalytic subunits: the alpha isoform is nucleolar and phosphorylates the nucleolar protein Nopp44/46.
	ec.asm.org /cgi/content/full/4/1/30 (3663 words)

	RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli -- SEMRAD et al. 10 (12): 1855 -- RNA
		RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli -- SEMRAD et al.
		In this assay the pre-mRNA of the thymidylate synthase (td)
		Franceschi, F.J. and Nierhaus, K.H. Ribosomal proteins L15 and L16 are mere late assembly proteins of the large ribosomal subunit.
	www.rnajournal.org /cgi/content/full/10/12/1855 (3309 words)

	MrpL36p, a Highly Diverged L31 Ribosomal Protein Homolog With Additional Functional Domains in Saccharomyces cerevisiae ...
		Mitochondrial ribosomes were prepared from strain EHW419 (MRPL36::3xMYC, cox2-22) transformed with 2µ plasmids expressing the MYC-tagged MRPL36/mrpL36 alleles shown and analyzed as described in Fig 1.
		Fractions containing the large ribosomal subunit, as defined by the sedimentation of Mrp7p (data not shown), are marked (Large).
		, 2001 The large subunit of the mammalian mitochondrial ribosome: analysis of the complement of ribosomal proteins present.
	www.genetics.org /cgi/content/full/167/1/65 (5321 words)

	tRNA & Ribosomes
		Below is a summary of the composition of E. coli ribosomes and mammalian cytoplasmic ribosomes.
		Structures of the large and small subunits of bacterial and eukaryotic ribosomes have been determined, by X-ray crystallography and by cryo-electron microscopy with image reconstruction.
		At right the 30S ribosomal subunit of a thermophilic bacterium is displayed by RasMol in spacefill and ribbons, with rRNA in monochrome and protein chains in different colors.
	www.rpi.edu /dept/bcbp/molbiochem/MBWeb/mb2/part1/trna.htm (1470 words)

	All three functional domains of the large ribosomal subunit protein L25 are required for both early and late pre-rRNA ...
		All three functional domains of the large ribosomal subunit protein L25 are required for both early and late pre-rRNA processing steps in Saccharomyces cerevisiae -- van Beekvelt et al.
		20 Kruiswijk,T., Planta,R.J. and Krop,J.M. (1978) The course of the assembly of ribosomal subunits in yeast.
		30 Finley,D., Bartel,B. and Varshavsky,A. (1989) The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis.
	nar.oxfordjournals.org /cgi/content/full/29/24/5001 (5705 words)

	The Caulobacter crescentus CgtAC Protein Cosediments with the Free 50S Ribosomal Subunit -- Lin et al. 186 (2): 481 -- ... (Site not responding. Last check: 2007-10-30)
		Obg proteins are associated with the large ribosomal subunit.
		with the free mature or pre-50S ribosomal subunits, it is a
		The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively.
	jb.asm.org /cgi/content/full/186/2/481 (5155 words)

	Non-canonical Base Pair Database \| Summary10
		Note: the duplicated entries (with different data available) are grouped together in the table.
		U-A,4-carbonyl-N7 Atomic structure of the large ribosomal subunit
		C-A,amino-N3 Atomic structure of the large ribosomal subunit
	prion.bchs.uh.edu /bp_type/summary10.html (81 words)

	5S Ribosomal RNA Database -- Szymanski et al. 30 (1): 176 -- Nucleic Acids Research
		Ribosomal 5S RNA (5S rRNA) is an integral component of the large
		ribosomal subunit in all known organisms with the exception
		Recently, the crystal structure of the large subunit of the
	nar.oxfordjournals.org /cgi/content/full/30/1/176 (1663 words)

	50S Large Ribosomal Subunit (Site not responding. Last check: 2007-10-30)
		50S subunit of the ribosome from Haloarcula marismortui at 2.4 Angstrom resolution.
		The portions of this macromolecule composed of protein are shown in blue.
		The ribosomal RNA is shown with the bases in white and the phosphate backbone in red.
	chemistry.library.wisc.edu /biophysics/1JJ2image.htm (173 words)

	Baserga Lab Website
		The small-subunit processome is a ribosome assembly intermediate.
		The small subunit processome is required for cell cycle progression at G1.
		A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis.
	info.med.yale.edu /mbb/baserga/alum.html (1318 words)

	Supplementary Table 3
		The GRAM algorithm discovered 106 modules ranging in size from five (the minimum allowed) to 52 genes (a large set of co- expressed ribosomal genes).
		ribosomal large subunit assembly and maintenance rRNA primary transcript binding* nucleolus
		ribosomal large subunit assembly and maintenance protein binding* cytosol*
	www.nature.com /nbt/journal/v21/n11/extref/nbt890-S3.htm (2730 words)

	Large Subunit Ribosomal (Site not responding. Last check: 2007-10-30)
		Caution: Select and download them only if you have enough disk space to do so.
		Large subunit alignment in GenBank [787 Kb] or AE2 [809 Kb] format
		No phylogenetic tree based on the LSU alignment exists at this time.
	geta.life.uiuc.edu /RDP/data/lsu.html (199 words)

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