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Topic: Lectin

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	BioMed Central \| Full text \| Determination of thermodynamic parameters of Xerocomus chrysenteron lectin interactions ...
		As the monosaccharide binding specificity is an important determinant of lectin function, we determined the affinity of XCL for the galactose moiety.
		Lectins are carbohydrate-binding proteins found in various organisms including fungi [1,2].
		Mushroom lectins have captured the attention of investigators on account of their antiproliferative, immunomodulatory, antitumor and cytotoxic activities, and more than 50 mushroom lectins have been reported [5].
	www.biomedcentral.com /1471-2091/6/11 (3194 words)

	Lectin - Wikipedia, the free encyclopedia
		Lectins are found in a variety of species from plants to insects to man.
		While the function of lectins in plants is believed to be the binding of glycoproteins on teh surface of cells, the role in animals also includes the binding of soluble extracellular and interecellular glycoproteins.
		Lectins are also known to play important roles in the immune system by recognising carbohydrates that are found exclusively on pathogens, or that are inaccessible on host cells.
	en.wikipedia.org /wiki/Lectin (404 words)

	Lectin Descriptions (Site not responding. Last check: 2007-10-11)
		Although "lectin" was originally coined to define agglutinins which could discriminate among types of red blood cells, today the term is used more generally and includes sugar-binding proteins from many sources regardless of their ability to agglutinate cells.
		Lectins have been found in plants, viruses, microorganisms and animals, but despite their ubiquity, their function in nature is unclear.
		The latter property may be a consequence of the structure of the lectin or the absence of a suitable receptor oligosaccharide on the cell surface.
	www.vectorlabs.com /Lectins/Ldescript.html (640 words)

	THE LECTIN STORY
		Lectins purified from the germinating seeds of wheat (Triticumspp.); bind to carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities.
		Lectins may bind to the gut wall and damage the gut lining, are not altered by digestive enzymes, and may alter gut permeability and pass through the gut into general circulation.
		Lectin intolerance means the inability to deactivate the toxic lectin (prevent its binding to your cells) in the confines of your own body, be it in the gut, artery, organ, gland or brain.
	www.krispin.com /lectin.html (4561 words)

	[No title]
		The D-galactoside binding lectin purified from sea urchin (Anthocidaris crassispina) eggs exists as a disulphide-linked homodimer of two subunits; the dimeric form is essential for hemagglutination activity [1].
		Although SUEL was first isolated as a D-galactoside binding lectin, it was latter shown that it bind to L-rhamnose preferentially [1, 2].
		Rhamnose-binding lectin (SAL) from catfish (Silurus asotus, Namazu) eggs.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000922 (451 words)

	Title of Invention: Lectin cDNA and transgenic plan ts derived therefrom
		Lectins from wheat, barley and rye (cereal lectins) are all dimers with 18 kD subunits which are synthesized as 23 kD precursors (Stinissen, H. et al, Planta 164:278-286 (1985)).
		Lectin was detected immunologically with anti-WGA antiserum or anti-WGA-B 172-186, an antiserum specific for the 15 amino acid pro-peptide at the carboxyl terminus of pro-WGA (Smith, J. J., et al., Plant Physiol (submitted) (1989)).
		It was concluded that (1) Barley lectin, which is expressed in specific cells of embryos and in the root caps of adult plants, is correctly processed and targeted to the vacuoles of transformed tobacco cells; and (2) Active lectin is produced in the transformed tobacco cells.
	www.nal.usda.gov /bic/Biotech_Patents/1994patents/05276269.html (7233 words)

	Mistletoe Lectin (Site not responding. Last check: 2007-10-11)
		Mistletoe lectin is considered to be the important component for the biological activities of the extracts.
		Lectins are proteins that bind to carbohydrates non-covalently (excluding antibodies).
		Lectins represent a heterogeneous group of proteins, which may differ from each other in several aspects, including their molecular structures, sugar specificities and biological activities.
	people.cryst.bbk.ac.uk /~ubcgx1d/project.html (1133 words)

	Budding-specific lectin induced in epithelial cells is an extracellular matrix component for stem cell aggregation in ...
		Budding-specific lectin induced in epithelial cells is an extracellular matrix component for stem cell aggregation in tunicates -- Kawamura et al.
		Budding-specific lectin induced in epithelial cells is an extracellular matrix component for stem cell aggregation in tunicates
		bioassy was ineffective in the presence of the lectin.
	dev.biologists.org /cgi/content/abstract/113/3/995 (331 words)

	Monitoring Lectin Levels In Commercial Soybean Meals (Site not responding. Last check: 2007-10-11)
		Investigating the possibility of monitoring lectin levels in commercial soybean meals indicated for poultry feeding using steam-heated soybean meal as a model.
		The objective of this study is to determine the optimum processing temperature and time to inactivate soybean lectins in soybeans.
		The urease activity was highly correlated (r> 0.73) with soybean lectin activity, indicating that urease activity could be used to monitor lectin activity in commercial soybean meals.
	www.soymeal.org /worldlitarticles_new/fasinayoandco-workers2003.html (169 words)

	BioCarta - Charting Pathways of Life
		Although the initiating event activating the complement cascade is distinct in the lectin-induced pathway, from the C3 convertase onward the lectin induced complement pathway is the same as the classical complement pathway.
		Since antibodies are not required in the lectin-induced pathway, this aspect of the immune response is part of the innate immune response.
		The mannan-binding lectin pathway of complement activation: biology and disease association.
	www.biocarta.com /pathfiles/h_lectinPathway.asp (366 words)

	Lectin Histochemistry of Resected Adenocarcinoma of the Lung : Helix pomatia Agglutinin Binding Is an Independent ... (Site not responding. Last check: 2007-10-11)
		Lectin Histochemistry of Resected Adenocarcinoma of the Lung : Helix pomatia Agglutinin Binding Is an Independent Prognostic Factor -- Laack et al.
		Lectin Histochemistry of Resected Adenocarcinoma of the Lung
		Omission of the lectin or preincubation with 0.3 mol/L
	ajp.amjpathol.org /cgi/content/full/160/3/1001 (3598 words)

	Isolation and cloning of a C-type lectin from the hexactinellid sponge Aphrocallistes vastus: a putative aggregation ...
		lectin was identical with the corresponding region of the deduced
		Lane a, Purified lectin fraction (Fraction VI); lane b, analysis of endoglycosidase H (10 mU); lane c, analysis of the purified lectin after digestion with the enzyme endoglycosidase H in a 50 mM phosphate buffer.
		Muramoto, K. and Kamiya, H. (1986)The amino-acid sequence of a lectin of the acorn barnacle Megabalanus rosa.
	glycob.oxfordjournals.org /cgi/content/full/11/1/21 (5087 words)

	Cloning and characterization of a monocot mannose-binding lectin from Crocus vernus (family Iridaceae) -- Van Damme et ... (Site not responding. Last check: 2007-10-11)
		GNA [31], and the lectins from Hippeastrum hybrid [41].
		the Orchidaceae and Amaryllidaceae lectins clustering in the
		Misaki, A. and Goldstein, I.J. (1977) Glycosyl moiety of the Lima bean lectin.
	content.febsjournal.org /cgi/content/full/267/16/5067 (5962 words)

	Lectin Structure, Carbohydrate Binding and Ribosome Inactivating Protein (Site not responding. Last check: 2007-10-11)
		A lectin is any protein incorporating one or more (frequently two) sites highly specific for carbohydrate binding, occurring in the tissues of most living organisms.
		Lectins are of interest because of their wide variety of properties and potential applications for example in pharmacology, immunology, cancer therapy and agriculture, and occur also as a component of toxins such as type II RIP's.
		Nettle lectin (from Urtica dioica), one of the smallest known lectin proteins, has been crystallized both with and without bound NN'N''- chitotriose, and its structure is currently being determined.
	www.cryst.bbk.ac.uk /research/lectin/lectin-p1.html (428 words)

	Regulation of Adherence and Virulence by the Entamoeba histolytica Lectin Cytoplasmic Domain, Which Contains a beta 2 ...
		The Gal/GalNAc lectin is a heterodimeric molecule composed of a transmembrane heavy (170-kDa) subunit and a glycosylphosphatidylinositol-anchored
		the lectin migrated on SDS-PAGE as a 260-kDa heterodimer composed
		Petri, W.A., Jr., Smith, R.D., Schlesinger, P.H., Murphy, C.F., and Ravdin, J.I. Isolation of the galactose-binding lectin that mediates the in vitro adherence of Entamoeba histolytica.
	www.molbiolcell.org /cgi/content/full/9/8/2069 (5859 words)

	lectin
		A lectin is a sugar-binding protein of non-immune origin that agglutinates cells or precipitates glycoconjugates.
		The specificity of a lectin is usually defined by the monosaccharides or oligosaccharides that are best at inhibiting the agglutination or precipitation the lectin causes.
		Lectins occur in many types of organism; they may be soluble or membrane-bound; they may be glycoproteins.
	www.chem.qmul.ac.uk /iubmb/newsletter/misc/lectin.html (131 words)

	A mistletoe lectin (ML-1)-containing diet reduces the...
		At the highest daily intake (10 mg lectin) the degree of mitotic activity in tumors was reduced by 75% and the nuclear area had diminished by 21%.
		The overall level of lymphocyte infiltration (CD3 positive cells) in tumors from mistletoe lectin fed mice was increased by a factor of two.
		In 4/15 mice fed a mistletoe lectin diet for 11 days there was no longer evidence of viable tumor.
	www.cancerprev.org /Journal/Issues/28/1/4860 (328 words)

	Activation of the Lectin Complement Pathway by H-Ficolin (Hakata Antigen) -- Matsushita et al. 168 (7): 3502 -- The ...
		Two constituents of the initiation complex of the mannan-binding lectin activation pathway of the complement are encoded by a single structural gene.
		Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2.
		P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients.
	www.jimmunol.org /cgi/content/full/168/7/3502 (4207 words)

	The amino-acid sequence of the glucose/mannose-specific lectin isolated from Parkia platycephala seeds reveals three ... (Site not responding. Last check: 2007-10-11)
		The amino-acid sequence of the glucose/mannose-specific lectin isolated from Parkia platycephala seeds reveals three tandemly arranged jacalin-related domains -- Mann et al.
		lectin was composed of a single polypeptide chain.
		a mannose-specific lectin from tubers of the Jerusalem artichoke,
	content.febsjournal.org /cgi/content/full/268/16/4414 (3990 words)

	Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells -- Cambi et al. 164 (1): 145 ...
		C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.
		C-type lectin receptors on dendritic cells and Langerhans cells.
		The dendritic cell specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis-x.
	www.jcb.org /cgi/content/full/164/1/145 (7006 words)

	NEJM -- Mannose-Binding Lectin Variant Alleles and the Risk of Arterial Thrombosis in Systemic Lupus Erythematosus
		alleles of the mannose-binding lectin gene are associated with
		Jonsen, A., Gullstrand, B., Guner, N., Bengtsson, A.A., Nived, O., Truedsson, L., Sturfelt, G. Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus.
		Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus.
	content.nejm.org /cgi/content/abstract/351/3/260 (797 words)

	The Innate Immune System: The Complement System - The Lectin Pathway (Site not responding. Last check: 2007-10-11)
		The proteins circulate in an inactive form, but in response to the recognition of molecular components of microorganism, they become sequentially actived, working in a cascade where in the binding of one protein promotes the binding of the next protein in the cascade.
		The lectin pathway is mediated by mannan-binding lectin (also known as mannan-binding protein or MBP).
		MBP is a protein that binds to the mannose groups found in many microbial carbohydrates but not usually found in the carbohydrates of humans.
	www.cat.cc.md.us /courses/bio141/lecguide/unit2/innate/lectin.html (586 words)

	Evolution of the C-type lectin-like domain
		C-type lectin-like domains (CTLDs) of higher eukaryotes are protein modules originally identified as carbohydrate-recognition domains (CRDs) in a family of Ca -dependent animal lectins.
		Less closely related but still definitely homologous CTLDs have been identified in a variety of proteins that do not appear to have carbohydrate-binding activity.
		Dodd, RB and Drickamer, K (2001) Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity.
	www.imperial.ac.uk /research/animallectins/ctld/default.html (114 words)

	Phenotypic Variation of Helicobacter pylori Isolates from Geographically Distinct Regions Detected by Lectin Typing -- ... (Site not responding. Last check: 2007-10-11)
		be used to subtype certain lectin reaction patterns (10).
		Isolates with the latter lectin reaction pattern are unreactive
		Lectin typing of Pseudomonas aeruginosa strains of different serogroups, Habs and Fisher types.
	jcm.asm.org /cgi/content/full/40/1/227 (4338 words)

	Regulation of Toll-like receptor-2 expression by the Gal-lectin of Entamoeba histolytica -- KAMMANADIMINTI et al. 18 ...
		B inhibitor pyrrolidine dithiocarbomate (PDTC) at different concentrations or medium alone for 30 min before stimulating with lectin (500 ng/mL) for 2 h and Northern analysis.
		Values in parentheses indicate % of inhibition relative to that observed with lectin.
		Cells were stimulated with 500 ng/mL each of lectin or LPS for 30 min and 2 h and nuclear extracts were collected.
	www.fasebj.org /cgi/content/short/18/1/155 (1327 words)

	Purification and Characterization of a Neu5Acalpha 2-6Galbeta 1-4Glc/GlcNAc-specific Lectin from the Fruiting Body of ...
		Purification and Characterization of a Neu5Acalpha 2-6Galbeta 1-4Glc/GlcNAc-specific Lectin from the Fruiting Body of the Polypore Mushroom Polyporus squamosus -- Mo et al.
		A lectin has been purified from the carpophores of the mushroom Polyporus squamosus by a combination of affinity chromatography
		The Mushroom Marasmius oreades Lectin Is a Blood Group Type B Agglutinin That Recognizes the Galalpha 1,3Gal and Galalpha 1,3Galbeta 1,4GlcNAc Porcine Xenotransplantation Epitopes with High Affinity
	www.jbc.org /cgi/content/abstract/275/14/10623 (582 words)

	Technorati Tag: lectin
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	www.technorati.com /tag/lectin (186 words)

	IDR factfile for Mannan-binding lectin - associated serine protease 2 deficiency
		Mannan-binding lectin - associated serine protease 2 deficiency
		Mannan-binding lectin associated serine protease (MASP-2) is homologous to MASP-1 and the two C1q-associated serine proteases C1r and C1s.
		When mannan-binding lectin binds to carbohydrate structures on microorganisms, the manan-binding lectin pathway of the complement system is activated.
	dna.uta.fi /xml/idr/FF119.xml (298 words)

	Gateway to Lectins
		INTERLEC 21, 21st International Lectin Meeting - see some photos
		Thorkild's lectin page was chosen as HMS Beagle's "Web Pick of the Day" in May 1998 - updated regularly
		Go to the Lectin Subject Index with more than 1300 keywords to lectins
	plab.ku.dk /tcbh/lectin-links.htm (147 words)

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