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Topic: Leiomyosarcoma

	Basic Information
		Leiomyosarcoma is a cancer of smooth muscle cells.
		Remember: Leiomyosarcoma is a resistant cancer...not very responsive to chemotherapy or radiation.
		Gleevec is not effective in LEIOMYOSARCOMA tumors that are ckit positive, because LMS tumor reproduction is not being driven by the ckit.
	www.leiomyosarcoma.info /basic.htm (4638 words)

	Uterine Leiomyosarcoma
		Uterine leiomyosarcoma (LMS) is a rare form of cancer of the uterus, where smooth muscle tumors develop in the lining of the uterus.
		Uterine leiomyosarcoma is sometimes confused with the most common type of uterine cancer, called endometrial adenocarcinoma, because both cancers originate within the uterus.
		Leiomyosarcoma occurs in the smooth muscle of the uterus called the myometrium, while endometrial adenocarcinoma develops in the lining of the uterus (the endometrium).
	www.leiomyosarcoma-cancer.com /html/uterine-leiomyosarcoma.php3 (411 words)

	Leiomyosarcoma (Site not responding. Last check: )
		Leiomyosarcomas of soft tissues are an aggressive group of tumors with a high incidence of recurrence.
		Leiomyosarcoma of the somatic soft tissue is a rare malignant mesenchymal neoplasm that metastasizes to other organs in a subset of cases.
		One of the lesions arose in the stomach, one in the ileum, and 2 in the colon.
	www.thedoctorsdoctor.com:16080 /diseases/leiomyosarcoma.htm (4869 words)

	What is a leiomyosarcoma? : CancerBACUP (Site not responding. Last check: )
		A leiomyosarcoma is one of a family of cancers called soft tissue sarcomas.
		Leiomyosarcomas are so-called because they arise from cells very similar to those found in a type of muscle tissue called smooth muscle.
		Leiomyosarcomas usually start as a fairly rapidly growing, painless, swellings in the wall of an organ or a blood vessel.
	www.cancerbacup.org.uk /QAs/376 (453 words)

	Pathology and Pathophysiology of Uterine Smooth-Muscle Tumors
		Intravenous leiomyomatosis is distinguished from leiomyosarcoma by its lack of mitotic activity, atypia, and coagulative necrosis, and from endometrial stromal sarcoma by the demonstration that it is composed of smooth muscle.
		The leiomyosarcoma, a malignant tumor composed entirely of smooth muscle, is the malignant counterpart of the leiomyoma and is the most common pure sarcoma of the uterus.
		Most leiomyosarcomas irregularly invade the adjacent myometrium and have a cut surface that is pale with areas of hemorrhage and necrosis.
	ehp.niehs.nih.gov /members/2000/suppl-5/779-784robboy/robboy-full.html (5426 words)

	Leiomyosarcoma - Children's Hospital Boston
		Leiomyosarcoma accounts for 7 to 11 percent of all soft tissue sarcomas among adults and children.
		The exact cause of leiomyosarcoma is not entirely understood, however, studies have indicated that genetic alterations may play a role in the formation of all soft tissue sarcomas.
		A leiomyosarcoma may be localized, meaning it has not spread beyond the muscle tissue where it arose or beyond nearby tissues, or metastatic, meaning it has spread to lungs, bones or to other organs or structures of the body.
	www.childrenshospital.org /az/Site1098/mainpageS1098P0.html (1875 words)

	Gale Encyclopedia of Cancer: Leiomyosarcoma
		When leiomyosarcoma begins in an organ in the abdomen, such as the stomach or small bowel, the physician may be able to feel a large lump or mass when he examines the abdomen.
		Leiomyosarcomas on the arms and legs may be treated by amputation (removal of the affected limb) or by limb-sparing surgery to remove the tumor.
		Leiomyosarcomas of organs in the abdomen may also be treated with radiation and chemotherapy.
	www.findarticles.com /p/articles/mi_gGEC/is_0012/ai_2699001242 (1321 words)

	Article : Primary Leiomyosarcoma of Inferior Vena Cava - An Unusual Entity; Author : A Ahluwalia ; Co-Author(s) : K ... (Site not responding. Last check: )
		Leiomyosarcoma of primary vascular origin is a rare tumor, which arises mainly from the inferior vena cava (IVC).
		Leiomyosarcoma of the inferior vena cava (IVC) is a rare malignant tumor originating from the smooth muscle of the media.
		Leiomyosarcoma with extravascular development may be much more difficult to differentiate from retroperitoneal tumors compressing or invading the IVC [7].
	www.ijri.org /articles/archives/2002-12-4/vascular_515.htm (933 words)

	Nikon MicroscopyU: Human Pathology Digital Image Gallery - Leiomyosarcoma
		Leiomyosarcoma is a soft tissue sarcoma that attacks smooth muscle cells, usually in the gastrointestinal tract, retroperitoneum, and uterus.
		The size and grade of leiomyosarcoma tumors are the primary determinants of prognosis, which is typically poor since the cancer is very difficult to detect until it is in an advanced state and begins to produce symptoms.
		Leiomyosarcoma at 20x Magnification - The treatment for leiomyosarcoma most commonly involves surgery, but radiation therapy and chemotherapy are also sometimes utilized, though they are ineffective against certain types of the disease, especially the type that involves tumor formation in the gastrointestinal tract.
	www.microscopyu.com /galleries/pathology/leiomyosarcoma.html (372 words)

	[No title]
		Presenting signs and symptoms of leiomyosarcomas of the head and neck structures are generally nonspecific because the primary lesions occur in diverse locations and are usually referable to the location in which they arise.
		The usual route of metastatic spread for leiomyosarcoma is theorized to be the bloodstream to the lungs.
		A leiomyosarcoma of the oral cavity with metastasis to lymph glands.
	www.bcm.edu /oto/grand/7893.html (1836 words)

	Final Diagnosis -- Case 107
		Leiomyosarcomas comprise approximately 7% of all soft tissue sarcomas.
		Superficial leiomyosarcomas are usually divided into the two subcategories of cutaneous and subcutaneous leiomyosarcomas due not only to their difference in location, but also due to their differences in prognosis and their likely site of origin.
		Cutaneous leiomyosarcomas, the type presented in this case, are believed to derive from precursor cells associated with the arrector muscles of the hair, the smooth muscle surrounding sweat glands or the genital dartos muscle.
	path.upmc.edu /cases/case107/dx.html (652 words)

	California Tumor Tissue Registry
		Primary leiomyosarcoma of the heart: a rare cause of obstruction of the left ventricle outflow tract.
		Leiomyosarcoma of the pulmonary veins with extension to the left atrium.
		Rapid progression of primary leiomyosarcoma with obstruction of the left ventricular outflow tract and mitral stenosis.
	www.cttr.org /cotm.php?p=cotm/aug_04i.htm (273 words)

	Echocardiography (Site not responding. Last check: )
		Case report: leiomyosarcoma of the descending thoracic aorta masquerading as aortic dissection.
		Leiomyosarcomas (LMS) of the heart are exceptional primary malignant tumours with a catastrophic prognosis and a mean survival measured in months.
		A case of left atrial leiomyosarcoma involving the interatrial septum and the right atrial free wall and presenting with syncope and atrial fibrillation, is described.
	www2.umdnj.edu /~shindler/leiomyo.html (2235 words)

	Military Medicine: Leiomyosarcoma of the Urinary Bladder in a Teenage Male
		Leiomyosarcoma is a rarely seen neoplasm of the bladder with a generally poor prognosis.
		Leiomyosarcoma of the bladder is rare, has a poor 5-year survival rate, and is most commonly seen in patients older than 50 years of age.
		Leiomyosarcoma is less aggressive with a better prognosis and better therapeutic response to local measures.
	www.findarticles.com /p/articles/mi_qa3912/is_200402/ai_n9408130 (1077 words)

	Final Diagnosis -- Case 246
		Primary leiomyosarcoma of bone is a very rare malignancy, consisting of predominantly spindle cell neoplasm exhibiting smooth muscle differentiation thought to originate from either the smooth muscle cells of blood vessels or the mesenchymal myofibroblasts in bone (2).
		When one encounters a confirmed leiomyosarcoma involving a bone, exclusion of a metastasis from uterus or gastrointestinal tract is a prerequisite.
		The histologic analysis showed that the osseous leiomyosarcoma are most commonly of the classic type, followed by epithelioid, myxoid, and pleomorphic variants (3).
	path.upmc.edu /cases/case246/dx.html (906 words)

	Soft tissue, pelvic, and urinary bladder leiomyosarcoma as second neoplasm following hereditary retinoblastoma -- ...
		Leiomyosarcoma of the femur in a patient with a history of retinoblastoma.
		A high grade primary leiomyosarcoma of the bladder in a survivor of retinoblastoma.
		Post-radiation leiomyosarcoma of the orbit complicating bilateral retinoblastoma.
	jcp.bmjjournals.com /cgi/content/full/56/3/233 (1598 words)

	PRIMARY LEIOMYOSARCOMA OF THE THORACIC AORTA
		Leiomyosarcomas arise from the smooth muscle of the aortic wall, and may have intraluminal and extravascular components.
		Our case is one of a leiomyosarcoma of the descending thoracic aorta masquerading as aortic dissection on clinical and computed tomography (CT) features.
		The diagnosis of leiomyosarcoma arising from the aortic wall was based on histological analysis and confirmed immunohistochemical findings.
	www.kfshrc.edu.sa /annals/203_204/00-011R.htm (1090 words)

	AR Online » Current Issue » Leiomyosarcoma of the inferior vena cava
		Leiomyosarcoma of the inferior vena cava (IVC) (IVC sarcoma)
		Leiomyosarcoma of the IVC is an uncommon tumor ﬁrst reported by Perl in 1871.
		Histologically, leiomyosarcoma show a typical pattern of interlacing bundles of spindle-shaped cells with varying degrees of mitotic activity, and cellular and nuclear polymorphism.
	appliedradiology.com /case/case.asp?Id=65&IssueID=3&CatID=29&...&Quiz= (957 words)

	Leiomyosarcoma (LMS) : CancerBACUP (Site not responding. Last check: )
		Leiomyosarcomas are one of the commoner types of sarcoma to occur in adults.
		The treatment for leiomyosarcoma depends on a number of things including your general health, and the size and position of the tumour within the body.The results of your tests will help your doctor to decide on the best type of treatment for you.
		Treatment of a leiomyosarcoma is surgery, wherever possible, to remove the tumour.
	www.cancerbacup.org.uk /Cancertype/Softtissuesarcomas/Types/LMS (1940 words)

	Leiomyosarcoma of the Uterus
		The uterine leiomyosarcoma is a rare sarcoma arising from the smooth muscle cells found within the myometrium.
		From 12 epithelioid leiomyosarcomas, we selected 5 that had: 1) clear cell areas and 2) spindle cell areas that were at least focally positive for desmin and caldesmon.
		A leiomyosarcoma of the uterus in a 54-year-old woman exhibited striking involvement of large vessels of the myometrium and broad ligament on both gross and microscopic examination.
	www.thedoctorsdoctor.com /diseases/uterus_leiomyosarcoma.htm (2302 words)

	AR Online » 58Back Issues » June 2001 » Leiomyosarcoma in a patient with Wilms' tumor; a secondary ...
		Leiomyosarcoma in a patient with Wilms' tumor; a secondary primary tumor
		Patients with leiomyosarcoma usually present in the fifth and six decades of life with a male to female ratio of 3:1.
		Leiomyosarcoma occurs most commonly in the jejunum and ileum and is the most common neoplasm of Meckel's diverticula.
	www.appliedradiology.com /case/case.asp?Id=168&IssueID=58 (1002 words)

	Leiomyosarcoma Small Bowel (Site not responding. Last check: )
		Surgical resection and pathologic analysis established the diagnosis of leiomyosarcoma of small bowel.
		Leiomyosarcoma of the small intestine presenting as a pelvic mass: four cases.
		Leiomyosarcomas of the small intestine misdiagnosed as ovarian masses: report of three cases.
	home.earthlink.net /~radiologist/tf/040201.htm (307 words)

	Leiomyosarcoma (Site not responding. Last check: )
		Leiomyosarcoma of the soft tissue is divided into following groups:
		Leiomyosarcoma commonly occurs in the fifth to seventh decade.
		Secondary leiomyosarcomas arise from primary retroperitoneal or uterine leiomyosarcoma and present as dermal and subcutaneous nodules on the scalp or back.
	www.geocities.com /sampyroy2000/Leiomyosarcoma.html (422 words)

	eMedicine - Intestinal Leiomyosarcoma : Article by George Edward Martinez, MD
		Pathophysiology: Leiomyosarcomas apparently arise between the muscularis propria and muscularis mucosa layers of the bowel wall, though the exact histological source is in question.
		With curative resection, the 5-year survival rate of patients with a gastric leiomyosarcoma is 68-90%, whereas small intestine tumors are associated with a survival rate of 40-50%.
		Age: Leiomyosarcomas primarily are a disease of middle-aged persons, with the average age on presentation falling between the fifth and seventh decades of life.
	www.emedicine.com /med/topic1180.htm (2261 words)

	Sloan-Kettering - Leiomyosarcoma & Other Uterine Sarcomas
		Our doctors have developed a novel chemotherapy regimen that has demonstrated excellent efficacy in patients with leiomyosarcoma -- a sarcoma that arises within the uterine wall -- that has metastasized and cannot be removed surgically.
		The success of this regimen in leiomyosarcomas has led to additional research efforts, including a larger study of our treatment regimen by the Gynecologic Oncology Group.
		For patients with early-stage leiomyosarcoma of the uterus that has been completely removed surgically, we are evaluating chemotherapy based on the regimen that has shown high response rates in patients with metastatic disease, given in sequential fashion with radiation therapy and additional chemotherapy.
	www.mskcc.org /mskcc/html/13242.cfm (188 words)

	Caring Medical - Symptoms - Leiomyosarcoma
		A leiomyosarcoma is a cancer of smooth muscle cells, which are cells that make up the tissue of the uterus, stomach and intestines, the walls of the blood vessels and the skin.
		Tumors that arise from smooth muscle cells are most common in the wall of the uterus, where they are better known as uterine fibroids.
		A leiomyosarcoma usually starts as a fairly rapidly growing, painless swelling in the wall of an organ or blood vessel.
	www.caringmedical.com /symptoms/condition.asp?condition_id=1050 (351 words)

	Case#16
		Primary leiomyosarcoma of bone is extremely rare with approximately 50 cases reported in the literature.
		Common primary sites for leiomyosarcoma include the uterus, gastro-intestinal tract and soft tissues.
		Leiomyosarcoma lacks herringbone or storiform patterns of fibrosarcoma and MFH, stains negative with cytokeratin, and exhibits strong immunoreactivity with smooth muscle actin and muscle specific actin (HHF-35).
	www.umdnj.edu /tutorweb/case16.htm (228 words)

	1H-NMR Detectable Fatty Acyl Chain Unsaturation in Excised Leiomyosarcoma Correlate with Grade and Mitotic Activity -- ...
		Malignancy grading of soft tissue sarcoma and of leiomyosarcoma in particular is of prognostic importance.
		D/C cross-peak volume ratio as a function of leiomyosarcoma mean mitotic activity (mean mitoses/10 hpf).
		Doxorubicin is the most active chemotherapeutic agent for the treatment of leiomyosarcoma.
	www.jci.org /cgi/content/full/98/2/244 (3864 words)

	Leiomyosarcoma treatment information
		Get in touch with patients and care givers just like you from newly diagnosed to 25 year survivors.
		Stanford University and Lmsra.org (a group of leiomyosarcoma survivors) are currently doing LMS Micro array research work.
		By simply filling out a form, you can have one of your many samples sent to a leiomyosarcoma tissue bank and make it available to researchers working on better treatments and possibly a cure.
	www.leiomyosarcoma.net (406 words)

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