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Topic: Lepromin


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In the News (Wed 21 Aug 19)

  
  Resource Library: Find information on Lepromin skin test at MerckSource
The manufacture of a product generally has the most complete information about that product.
The lepromin skin test is used to determine what type of leprosy a person has.
It involves the injection of a standardized extract of inactivated leprosy-causing bacteria under the skin.
www.mercksource.com /pp/us/cns/cns_hl_adam.jspzQzpgzEzzSzppdocszSzuszSzcnszSzcontentzSzadamzSzencyzSzarticlezSz003383zPzhtm   (450 words)

  
  LEPROSY   (Site not responding. Last check: 2007-09-14)
Their history and clinical features were recorded, lepromin test was done for reading at four weeks, and peripheral part of the hypoesthetic area was biopsied for histopathology and immunostaining.
Lepromin test, slit skin smears (SSS), skin biopsies (except PN cases) and nerve biopsies were performed and compared with FNAC.
Vaccination induced lepromin conversion in 100% of lepromatous leprosy cases and lepromin negative household contacts and augmentation of lepromin reactivity in 100% of lepromin positive household contacts, which was stable for the 15 weeks duration of follow-up.
www.jbtdrc.org /Sevamed_2002/Sevamed_On_CD/Abs/Abs_Leprosy.htm   (6773 words)

  
 International Journal of Leprosy and Other Mycobacterial Diseases: Cured tuberculoid patients have a greater life ...   (Site not responding. Last check: 2007-09-14)
Lepromin test was performed at various periods and recorded as nodule size (large x small diameter in mm), from which average diameter was calculated.
The age at death of patients with strong lepromin tests tended to be higher than that of those with negative lepromin tests, but it was not statistically significant.
Negative and strongly positive groups were compared for their age at death, and the latter group showed a tendency of higher age (1.8 yrs for male and 3.2 yrs for female), but it was not statistically significant.
www.findarticles.com /p/articles/mi_qa3754/is_200306/ai_n9283591/pg_2   (1524 words)

  
 Unlikely Medical Assistants
A reagent used for the prognosis of leprosy, lepromin derived from humans is scarce.
Lepromin from armadillos can be highly purified, is abundant, and is as reliable in its results.
Lepromin is injected in many patients with leprosy to predict the course the disease will take.
pandoras-box.org /my05037.htm   (1085 words)

  
 Tropical Medicine Central Resource
Lepromin is a crude, semistandardized extract of bacilli from a lepromatous nodule of an armadillo.
Unfortunately this is not a diagnostic test for leprosy, as many people who have never been exposed to this bacillus show a positive reaction, for example, due to tuberculosis, immunization with BCG, or even previous skin testing with lepromin.
The Mitsuda reaction is positive in cases of tuberculoid leprosy and borderline leprosy of the tuberculoid type, and therefore is helpful in classification and prognosis.
tmcr.usuhs.mil /tmcr/chapter34/lab.htm   (816 words)

  
 Indmedica - Indian Journal of Community Medicine
Average lepromin negativity among cases was 35.3%, among non-affected contacts was 15.3% and among controls was 7.8%, clearly showing that immunity was highest among controls and least among cases.
This shows that susceptibility to leprosy was highest among cases with average lepromin negativity of 35.3%, somewhat less among contacts, with 15.3% negative lepromin and least among controls with only 7.8% negative lepromin.
Among the affected contacts, 6 out of 8 borderline cases were lepromin negative (75%), 4 out of 130 tuberculoid cases were lepromin negative (3.1%) and the figure was 6 out of 34 for indeterminate type.
www.indmedica.com /journals.php?journalid=7&issueid=46&articleid=566&action=article   (1239 words)

  
 Dharmendra
By finding out an optimum dose of the protein to be used, the lepromin test could be made of diagnostic value, while the conventional lepromin is only of prognostic value, and has no diagnostic value at all.
In the second publication (Meyers et al) lepromins were prepared from A.F. bacilli in naturally infected animals, and tested in leprosy patients.
"Lepromins prepared from 6 armadillos with a naturally acquired leprosy-like-disease in Louisiana were assayed in 146 leprosy patients with lepromatous and non-lepromatous leprosy.
pandoras-box.org /my09020.htm   (1752 words)

  
 Table of Contents : Indian Journal of Dermatology, Venereology and Leprology : 1988 - 54(6)   (Site not responding. Last check: 2007-09-14)
In this study, 484 leprosy contact children were tested with Dharmendra lepromin and the early and late responses were recorded.
They were compared with lepromin reaction in 135 children who wereliving in the households where there were no leprosy cases.
Amongst contacts, the early lepromin was positive in 283 and negative in 201.
ijdvl.com /rss.asp?issn=0378-6323;year=1988;volume=54;issue=6;month=...   (937 words)

  
 Lepromin - Encyclopedia Glossary Meaning Explanation Lepromin   (Site not responding. Last check: 2007-09-14)
Here you will find more informations about Lepromin.
It involves the injection of a standardized extract of inactivated leprosy-causing bacteria (Mycobacterium leprae) under the skin.
There is an extremely small risk of an allergic reaction which may include itching and rarely hives.
www.encyclopedia-glossary.com /en/Lepromin.html   (251 words)

  
 International Journal of Leprosy and Other Mycobacterial Diseases: Efficacy of single-dose ROM therapy plus low-dose ...   (Site not responding. Last check: 2007-09-14)
Lepromin testing was performed employing standard WHO armadillo-derived lepromin.
Late lepromin responsiveness was recorded and graded as described by Jopling and McDougall (5).
At the end of the first 6 months bacteriological, histological and immunological (lepromin test) assessments were repeated.
www.looksmartscience.com /p/articles/mi_qa3754/is_200009/ai_n8923892   (1505 words)

  
 [No title]   (Site not responding. Last check: 2007-09-14)
The lepromin test is useful in determining the extent of host immune reactivity to Mycobacterium leprae.
0.1 ml of lepromin, prepared from a crude extract of organisms, is injected intradermally.
Histologic classification of tissue biopsied from the Mitsuda reaction probably has better clinical correlation than histology from a leprosy skin lesion.
www.skincareguide.com /content/page.asp?a=733&print=yes   (145 words)

  
 Leprae of Mycobacterium Infections
The lepromin test may give a positive result in tuberculous individuals and occasionally in healthy individuals.
Diagnosis is accomplished by demonstrating acid-fast bacilli in scrapings or fluid from ulcerated lesions.
The lepromin skin test is useful in determining whether or not the patient is in the lepromatous stage and thus the prognosis.
virology-online.com /Bacteria/Mycobacterium5.htm   (2053 words)

  
 International Journal of Leprosy and Other Mycobacterial Diseases: Susceptibility to Leprosy May Be Conditioned by an ...   (Site not responding. Last check: 2007-09-14)
There were no significant differences in the allelic and genotypic frequencies for alleles 2, 3, and 4 in relation to the Mitsuda test among patients and household contacts, nor between those with MB and PB forms.
However, individuals with a negative lepromin response associated with genotypes 22 and 23 presented a 7- and 8-fold greater chance of developing leprosy, respectively.
Therefore, the NRAMP1 gene promoter polymorphism exhibited an interaction with the lepromin response, suggesting that allele 2 of the NRAMP1 promoter is an independent genetic factor that predisposes cells to enable pathogen survival, probably due to its low efficiency in iron transport.
newssearch.looksmart.com /p/articles/mi_qa3754/is_200412/ai_n9482645   (1246 words)

  
 Clinical syndrome   (Site not responding. Last check: 2007-09-14)
A lepromin (leprosy skin test) is positive, indicating that the cell-mediated immune system is responding against M. leprae antigens.
Skin biopsy shows many actively proliferating M. leprae cells, and infective bacteria in nasal secretions mean these patients can transmit their infection to others.
The lepromin test is negative, indicating a lack of cell-mediated immune response against M. leprae antigens.
www.biodiversity.org.uk /ibs/envsci/resources/year3/env324/projectsold/cameron/disease1.htm   (355 words)

  
 International Journal of Leprosy and Other Mycobacterial Diseases: Immunotherapy of lepromin-negative borderline ...   (Site not responding. Last check: 2007-09-14)
Thus 8% of the borderline leprosy patients receiving Convit vaccine, 20% of the patients receiving BCG vaccine, and 60% of the patients administered killed M. leprae vaccine remained refractory to lepromin challenge, despite receiving four inoculations of the different vaccines.
A positive lepromin test in a tuberculoid patient is a yardstick of immunologic stability and finds the histopathologic concurrence in the formation of specific delayed hypersensitive granuloma composed of epithelioid cells, lymphocytes and giant cells in and around neurovascular complexes in the dermis.
The lepromin and LMI conversion rates were less in the LL patients (66% and 50%, respectively) (1) than those in the borderline leprosy patients (92% and 72%, respectively) (present study).
www.findarticles.com /p/articles/mi_qa3754/is_199703/ai_n8740237/pg_2   (1273 words)

  
 4P-S3-3
For early diagnosis, the Lepromin test, the Fluorescent Leprosy Antibody Absorption Technique (FLA-ABS), PCR and Gene probes are excellent tools.
In our five years follow-up study on 455 healthy childhood contacts of leprosy patients, we found children who were FLA-ABS positive and Lepromin negative to be at high risk of developing disease.
Again, in another study we observed r-RNA gene probes to be of immense diagnostic benefit particularly in early stages of disease, in smear negative cases and in those with inconclusive histopathology.
www.unepsa.org /china/ab/4P-S3-3.HTM   (175 words)

  
 International Journal of Leprosy and Other Mycobacterial Diseases: Why relapse occurs in PB leprosy patients after ...
This indicated that their cell-mediated immunity (CMI) was not competent enough to eliminate all leprosy bacilli, although they were able to form a DTH granuloma at the lepromin injection sites (6).
The lepromin test was performed by intradermal injection of 0.1 ml standard lepromin containing 1.6 x 10^sup 8^ heat-killed M. leprae (human) per ml; 3 weeks thereafter the Mitsuda reaction was recorded (7).
The histological characteristics of a typical lepromin granuloma are: the presence of Langhans' giant cells, epithelioid cells, extensive lymphoid-cell infiltrates, and circumscribed tuberculoid structure.
www.findarticles.com /p/articles/mi_qa3754/is_199806/ai_n8807124   (1312 words)

  
 Lepromin skin test Health Information Directory Diseases Conditions Resources   (Site not responding. Last check: 2007-09-14)
LEPROMIN SKIN TEST - A test for leprosy where an extract of infected tissue (antigen) is injected under the skin to determine if you have a current or recent leprosy infection.
Definition: The lepromin skin test is used to determine what type of leprosy a person has...
The lepromin skin test is used to determine what type of leprosy a person...
www.canada-rx-online.com /health-terms/Lepromin-skin-test.htm   (484 words)

  
 BDS
However, use of Mw as an adjunct therapy results in 100% absence of viable bacilli in all leprosy patients4.
Mw also converts significant number of lepromin negative patients to lepromin positivity, which is not seen with MDT alone.
This lepromin conversion is seen even in lepromin negative contacts of leprosy patients, and provide prophylaxis against Leprosy.
www.bangalorederma.com /apr02/myco.htm   (1044 words)

  
 Experience and lessons from the use of lepromin and Mycobacterium leprae-specific serology.   (Site not responding. Last check: 2007-09-14)
Experience and lessons from the use of lepromin and Mycobacterium leprae-specific serology.
Experience and lessons from the use of lepromin and Mycobacterium leprae-specific serology.Skin testing with lepromin, which produces a delayed-type hypersensitivity reaction, has been used in the classification of leprosy, and a good correlation has been found between immunological status and the reaction to lepromin.
More recently, skin testing with two soluble antigens of Mycobacterium leprae showed no difference of the mean size of the reaction between household contacts and non-contacts, indicating that these antigens are not useful for the diagnosis of leprosy.
www.pdg.cnb.uam.es /UniPub/iHOP/gp/8571365.html   (144 words)

  
 Fabrications and falsifications
Contamination of lepromin was the most sensitive concern, since it is used throughout the world to perform skin tests on leprosy patients.
Its use in the preparation of lepromin is shown in Table 4.
Because of the delay in publishing, most leprologists were not aware of the significance of lepromin tests on armadillos for nine years.
www.uow.edu.au /arts/sts/bmartin/dissent/documents/Burchfield/alc06.html   (7507 words)

  
 Lepromin skin test   (Site not responding. Last check: 2007-09-14)
For a complete list of hospital classes and events, click here to connect to HealthConnection Online
Encyclopedia -> Test -> L -> Lepromin skin test
How Performed: An extract sample of inactivated leprosy-causing bacteria is injected just under the skin, usually on the forearm, so that a small lump pushes the skin up.
www.rwjhamilton.org /Atoz/Encyclopedia/article/003383.asp   (574 words)

  
 Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, hair loss, hair ...   (Site not responding. Last check: 2007-09-14)
Induction of lepromin positivity and immunoprophylaxis in household contacts of multibacillary leprosy patients: a pilot study with a candidate vaccine, Mycobacterium w.
The initial lepromin status as assessed in the group of 54 contacts having disease at the outset showed 24 out of 46 (52.2%) to be lepromin positive and 22 of 46 (47.8%) to be lepromin negative.
In the same group, among 24 lepromin positives, 22 (91.7%) had paucibacillary (PB) and 2 (8.3%) had multibacillary (MB) disease; among the lepromin negatives, 12 (54.5%) had PB and 10 (45.5%) had MB disease.
drugs-online-usa.com /ref-vaccine/vaccine-research-abs6.176.html   (1580 words)

  
 Armadillos - Page 2 of 3   (Site not responding. Last check: 2007-09-14)
Lepromin is a substance that is used as a diagnostic tool by doctors to predict the course of a leprosy infection in an individual human.
While this substance used to be rare, now it's known that even one seriously infected armadillo can produce enough lepromin for all the human cases in the world.
Apparently this new abundant source of lepromin has greatly accelerated research into a leprosy vaccine.
tanny.com /nature/armadillos/armadillos3.cgi   (407 words)

  
 IMMUNOLOGICAL IDENTIFICATION OF FOOT-PAD ISOLATES AS MYCOBACTERIUM LEPRAE BY LEPROMIN REACTIVITY IN LEPROSY PATIENTS -- ...
IMMUNOLOGICAL IDENTIFICATION OF FOOT-PAD ISOLATES AS MYCOBACTERIUM LEPRAE BY LEPROMIN REACTIVITY IN LEPROSY PATIENTS -- Shepard and Guinto 118 (2): 195 -- The Journal of Experimental Medicine
produced reactions that correlated with those of lepromin.
the lack of reactivity to lepromin of lepromatous patients appears
www.jem.org /cgi/content/abstract/118/2/195   (252 words)

  
 Lepromin
The lepromin skin test is used to determine what type of leprosy a person has.
This page was last modified 22:31, 15 Jan 2005.
The article about Lepromin contains information related to Lepromin, How the test is performed, Normal Values, Risks and Source.
www.arikah.net /encyclopedia/Lepromin   (335 words)

  
 Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in ...   (Site not responding. Last check: 2007-09-14)
Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships.
Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships.The Mitsuda test, which measures the specific immune response against intradermally injected lepromin, has a high prognostic value for susceptibility or resistance to the lepromatous form of leprosy.
A sib-pair linkage analysis between the Mitsuda response and the NRAMP1 gene was done among 20 nuclear families with leprosy (totaling 118 sibs) from Ho Chi Minh City, Vietnam.
www.pdg.cnb.uam.es /UniPub/iHOP/gp/2115731.html   (195 words)

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