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Topic: Leucovorin

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	Leucovorin (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-14)
		Leucovorin (loo-koe-VOR-in) is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses.
		Leucovorin acts the same way in the body as folic acid, which may be low in these patients.
		Leucovorin is also used along with fluorouracil (a cancer medicine) to treat cancer of the colon (bowel).
	www.mayoclinic.com /health/drug-information/DR202321 (1089 words)

	ADAP drugs: leucovorin (Site not responding. Last check: 2007-10-14)
		Leucovorin is the active form of the B complex vitamin, folate.
		Leucovorin is also taken to decrease the bone marrow toxicity of sulfa drugs, and in combination with pyrimethamine to decrease the toxicity of toxoplasmosis treatment.
		Leucovorin should not be used to treat pernicious anemia because it does not counteract the central nervous damage that is the result of vitamin B12 deficiency.
	www.aegis.com /factshts/network/access/drugs/leuc.html (364 words)

	Hill Health Topics A-Z - Leucovorin : Examples (Site not responding. Last check: 2007-10-14)
		Leucovorin works differently depending on whether it is used with methotrexate (MTX) or fluorouracil (5-FU).
		Leucovorin is used with either methotrexate (MTX) for the treatment of ectopic pregnancy or fluorouracil (5-FU) for colon or breast cancer.
		Leucovorin enhances the binding of fluorouracil (5-FU) and prolongs the lifespan of 5-FU, increasing the anticancer effect.
	www.healthwise.net /hillhealth/Content/StdDocument.aspx?HWID=tv7106 (280 words)

	Leucovorin Encyclopedia of Cancer - Find Articles
		Leucovorin (also known as Wellcovorin and citrovorum factor) is a drug that can be used either to protect healthy cells from chemotherapy or to enhance the anti-cancer effect of chemotherapy.
		When leucovorin and methotrexate are used together, this therapy is often called leucovorin rescue because leucovorin rescues healthy cells from the toxic effects of methotrexate.
		Leucovorin is also used to treat megaloblastic anemia, a blood disorder in which red blood cells become larger than normal, and to treat accidental overdoses of drugs like methotrexate.
	www.findarticles.com /p/articles/mi_gGEC/is_0012/ai_2699001243 (664 words)

	leucovorin (oral and injectable) - [Medication] (Site not responding. Last check: 2007-10-14)
		Leucovorin is used to reduce the side effects of large doses of medications such as methotrexate (Rheumatrex), pyrimethamine (Daraprim), trimethoprim (Trimpex, Proloprim), and others that may reduce the effects of folic acid in the body.
		Leucovorin may also be used in the treatment of anemia caused by folic acid deficiency and with 5-fluorouracil (Adrucil) in the palliative treatment of patients with advanced colorectal cancer.
		Leucovorin is in the FDA pregnancy category C. This means that it is not known whether leucovorin will be harmful to an unborn baby.
	www.bcbswny.com /kbase/multum/d00275a1.htm (915 words)

	Leucovorin Indications, Dosage, Storage, Stability - Leucovorin - RxList Monographs
		Leucovorin calcium rescue is indicated after high-dose methotrexate therapy in osteosarcoma.
		Leucovorin is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists.
		Leucovorin Calcium Tablets, 15 mg are oval, convex, yellowish-white, engraved LL on left and 15 on right on one side, scored in half on the other side and engraved C to the left of the score and 35 to the right, each containing 15 mg of leucovorin as the calcium salt, supplied as follows:
	www.rxlist.com /cgi/generic/leucovorin_ids.htm (823 words)

	MedlinePlus Drug Information: Leucovorin Calcium
		Leucovorin also can prevent or treat the toxicities associated with a group of drugs known as folate antagonists.
		Leucovorin in combination with fluorouracil is also used to treat other types of gastrointestinal cancers.
		Keep leucovorin in the container it came in, tightly closed, and out of reach of children.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682336.html (529 words)

	leucovorin (oral and injectable) - Fort Lauderdale, Florida
		Leucovorin is used to reduce the side effects of large doses of medications such as methotrexate (Rheumatrex), pyrimethamine (Daraprim), trimethoprim (Trimpex, Proloprim), and others that may reduce the effects of folic acid in the body.
		Leucovorin may also be used in the treatment of anemia caused by folic acid deficiency and with 5-fluorouracil (Adrucil) in the palliative treatment of patients with advanced colorectal cancer.
		Leucovorin is in the FDA pregnancy category C. This means that it is not known whether leucovorin will be harmful to an unborn baby.
	www.browardhealth.org /110689.cfm (934 words)

	Product Label
		Leucovorin is one of several active, chemically reduced derivatives of folic acid.
		Leucovorin is a mixture of the diastereoisomers of the 5formyl derivative of tetrahydrofolic acid.
		The apparent bioavailability of leucovorin was 97% for 25 mg, 75% for 50 mg and 37% for 100 mg.
	www.accessdata.fda.gov /scripts/cder/onctools/labels.cfm?GN=leucovorin (1290 words)

	Leucovorin (Site not responding. Last check: 2007-10-14)
		Leucovorin is used to lessen the harmful effects of methotrexate (a cancer medication), when given in high doses.
		In addition, leucovorin may be used to prevent or treat certain kinds of anemia (a condition characterized by a decreased amount of hemoglobin, a protein in red blood cells).
		Leucovorin may be injected directly into your vein through an IV (intravenously), injected directly into your muscle (intramuscularly) through a needle and syringe or it may be given by mouth (orally) in a pill form.
	www.clevelandclinic.org /health/health-info/docs/1500/1586.asp?index=4866 (563 words)

	FDA Warning Letter, Xanodyne Pharmacal, Inc. (Methotrexate, Leucovorin, Amicar)
		It notes that "Deaths have been reported with the use of methotrexate in the treatment of malignancy, psoriasis, and rheumatoid arthritis." The PI for Leucovorin includes a warning that Leucovorin must not be administered intrathecally because such administration may be harmful or fatal to patients.
		Methotrexate in high doses followed by leucovorin rescue in combination with other chemotherapeutic agents is effective in prolonging relapse-free survival in patients with non-metastatic osteosarcoma who have undergone surgical resection or amputation for the primary tumor.
		Leucovorin calcium rescue is indicated after high-dose methotrexate therapy in osteosarcoma.
	www.pharmcast.com /WarningLetters/Yr2002/November2002/Xanodyne1102.htm (1870 words)

	Leucovorin
		Leucovorin works differently depending on whether it is used with methotrexate (MTX) or fluorouracil (5-FU).
		Methotrexate: Leucovorin is given to "rescue" the gastrointestinal lining and bone marrow cells from MTX toxicity.
		Leucovorin is used with either methotrexate (MTX) for the treatment of ectopic pregnancy or fluorouracil (5-FU) for colon or breast cancer.
	www.webmd.com /cancer/Leucovorin-4309 (368 words)

	Leucovorin
		Leucovorin is a compound similar to Folic acid, which is a vital Vitamin.
		Intravenous form of Leucovorin is used when an immediate effect is needed and in cases of severe Methotrexate toxicity.
		Leucovorin enhances the binding of 5-FU to this enzyme and as a result prolongs the life span of 5-FU, resulting in a greater anti cancer effect.
	www.tirgan.com /leucvrn.htm (308 words)

	Leucovorin and Leucovorin Side Effects - Chemotherapy Drugs
		Leucovorin is a compound similar to folic acid, which is a necessary vitamin.
		Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate.
		Leucovorin is not a chemotherapy drug itself, however it is used in addition to these chemotherapy drugs to enhance anti cancer effects (with fluorouracil) or to help prevent or lessen side effects (with methotrexate).
	www.chemocare.com /BIO/leucovorin.asp (867 words)

	leucovorin drug information, leucovorin side effects
		Leucovorin (loo-koe-VOR-in) is used as an antidote to the harmful effects of methotrexate (a cancer...
		Leucovorin is used to reduce the side effects of large doses of medications such as methotrexate (Rheumatrex...
		Leucovorin (loo-koe-VOR-in) is used as an antidote to the...
	www.drugs.com /sch/leucovorin (490 words)

	Cancer Treatment Information—Chemotherapy, Radiation Oncology, and Surgery \| OncoLink
		In this case, leucovorin is used to enhance the effects of the fluorouracil, i.e.
		Leucovorin is also given with a chemotherapy agent called methotrexate, but in this case it is given to "rescue" normal, healthy cells from the damage caused by the methotrexate.
		Leucovorin is given every 6 hours until the blood level of methotrexate is at an acceptable level (this level varies by protocol).
	www.oncolink.com /treatment/article.cfm?c=2&s=10&id=318 (307 words)

	Leucovorin (folinic acid) : Cancerbackup
		Leucovorin is not a chemotherapy drug but is often given as part of chemotherapy treatment.
		Leucovorin is a vitamin that is often given with 5FU chemotherapy to treat cancers of the colon, rectum and other parts of the digestive system.
		Leucovorin has been shown to increase the effectiveness of the chemotherapy drug 5FU.
	www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Leucovorin (346 words)

	Leucovorin Drug Information
		Breast-feeding-It is not known whether leucovorin passes into the breast milk.
		Kidney disease-Levels of methotrexate may be increased because of its slower removal from the body, so the dose of leucovorin may not be enough to block the unwanted effects of methotrexate
		Nausea and vomiting-Not enough leucovorin may be absorbed into the body to block the unwanted effects of methotrexate
	www.drugs.com /cons/Leucovorin.html (1341 words)

	Leucovorin, Eastern Carolina
		Leucovorin is used either with methotrexate for the treatment of ectopic pregnancy or with fluorouracil (5-FU) for advanced colon cancer.
		Leucovorin works differently, depending on which medication it is used with.
		Methotrexate: Leucovorin is given to "rescue" the gastrointestinal lining and bone marrow cells from methotrexate toxicity.
	www.uhseast.com /171708.cfm (202 words)

	Leucovorin Calcium on MediResource TM - Health Simplified (Site not responding. Last check: 2007-10-14)
		Leucovorin is a medication that acts the same way in the body as folic acid.
		Leucovorin is used to reduce the folic-acid-lowering side effects of methotrexate, because it is not affected by methotrexate in the same way as folic acid is. It can also be used as a "rescue" in the case of inadvertent overdosages of folic acid blockers.
		To prevent methotrexate side effects or to treat overdose, leucovorin can either be given as intravenous (into the vein) or intramuscular (into the muscle) injection, or be taken by mouth in tablet form (if there is no nausea and vomiting).
	www.mediresource.com /e/health/drug_detail.asp?brand_name_id=1427&dowhat=accept_disclaimer (833 words)

	CancerNetwork:
		Impaired methotrexate elimination or inadvertent overdosage: Begin leucovorin rescue as soon a possible after inadvertent overdosage and within 24 h of methotrexate administration when there is delayed excretion.
		If significant clinical toxicity is seen, extend leucovorin rescue for an additional 24 h (total 14 doses over 94 h) in subsequent courses of therapy.
		Leucovorin has no effect on nonhematologic toxicities of methotrexate such as nephrotoxicity resulting from drug and/or metabolite precipitation in kidneys.
	www.cancernetwork.com /drugs/leucovorin.htm (1143 words)

	Data Sheet
		Leucovorin Calcium Injection USP is indicated following high dose methotrexate therapy to reduce toxicity (leucovorin rescue).
		Leucovorin Calcium Injection USP has been reported to be incompatible with droperidol injection and foscarnet injection.
		Leucovorin Calcium Injection USP may be administered by the intramuscular or intravenous route.
	www.medsafe.govt.nz /Profs/Datasheet/discontinued/leucovorincalciuminj.htm (1292 words)

	Clinical Trial: Leucovorin for the Treatment of 5 q Minus Syndrome (Site not responding. Last check: 2007-10-14)
		The 5 q minus syndrome is a condition that occurs due to a missing segment of chromosome 5 in the normal genetic make-up of the cells responsible for forming blood cells.
		Leucovorin is an active form of the vitamin folic acid that does not require the missing genes to activate it.
		The objective of this protocol is to determine whether leucovorin treatment can normalize hematopoietic cell growth and differentiation in patients with 5q- syndrome which may lack the gene for dihydrofolate reductase enzyme.
	clinicaltrials.gov /ct/show/NCT00004997 (501 words)

	ADVENTRX: Products: Cancer: Cofactor
		As CoFactor is the active metabolite of leucovorin, CoFactor circumvents the chemical pathway that is required by leucovorin.
		Leucovorin (a non-"one carbon-donating" folate) has been used as the standard combination therapy as a modulator of 5-FU for cancer treatment.
		However, leucovorin is inactive directly and must undergo several metabolic transformations to MTHF to be effective.
	www.adventrx.com /products/antic_cofactor.htm (918 words)

	leucovorin - Ask.com Web Search
		Leucovorin is frequently used in conjunction with Methotrexate and 5-FU.
		Leucovorin is not a Chemotherapeutic drug itself, however it is an...
		Folinic acid (INN) or leucovorin (USAN), generally administered as calcium folinate (or leucovorin calcium), is an adjuvant used in cancer...
	www.ask.com /web?q=leucovorin (266 words)

	Trimetrexate With Leucovorin: Decisions That Save Lives, Decisions That Kill
		The dose of trimetrexate required to treat pneumocystis is potentially lethal; but an antidote, leucovorin, can be used to rescue human cells.
		Their abstract concludes "that the combination of trimetrexate and leucovorin is safe and effective for the initial treatment of pneumocystis pneumonia in patients with AIDS and for the treatment of patients with intolerance or lack of response to standard therapies".
		Second, it is not a drug to be used lightly, as it was potentially lethal unless leucovorin was also administered.
	www.aids.org /atn/a-052-02.html (1081 words)

	Leucovorin (Site not responding. Last check: 2007-10-14)
		Leucovorin decreases the toxic effects of some chemotherapy drugs on your bone marrow.
		Leucovorin is taken by mouth with or without food.
		Store leucovorin tablets at room temperature, away from heat, moisture, and light.
	www.hci.utah.edu /patientdocs/hci/drugs/leucovorin.htm (275 words)

	ACS :: New Treatments Improve Outlook for Colorectal Cancer
		Oxaliplatin, which was approved by the US Food and Drug Administration in August, 2002, has shown even more promise when given along with 5-FU and leucovorin.
		This time, the 5-FU and leucovorin were given by injection over a few minutes.
		The drug bevacizumab (Avastin), for instance, appears to help patients with advanced colorectal cancer respond better to treatment and live longer, when it is given in combination with 5-FU and leucovorin.
	www.cancer.org /docroot/NWS/content/NWS_1_1x_New_Treatments_Improve_Outlook_for_Colorectal_Cancer.asp (878 words)

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