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Topic: Leukocyte

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In the News (Sun 17 Feb 19)

  Neurological Research: Nitric oxide synthase inhibitor augments post-ischemic leukocyte adhesion in the cerebral ...   (Site not responding. Last check: 2007-10-06)
The number of leukocytes adhering to the endothelium for longer than 3 sec was determined during ischemia (5 min and 60 min) and during reperfusion (5 min and 60 min).
Leukocytes may contribute to secondary brain injury, particularly during reperfusion, and become involved in cellular actions that determine the development of the initial ischemic event into an irreversible infarct.
Leukocyte adhesion to the venular endothelium was measured during partial forebrain ischemia and reperfusion, with and without NOS inhibition, and in a third group in which pial venous flow velocity was restricted in order to prevent post-ischemic hyperemia.
www.findarticles.com /p/articles/mi_qa3909/is_199906/ai_n8859416   (1310 words)

 Draft Guidance for Industry: Pre-Storage Leukocyte Reduction of Whole Blood and Blood Components Intended for ...
At present, leukocyte reduction is not considered appropriate for the prevention of transfusion-associated graft-versus-host disease (TA-GVHD) owing to the availability of irradiation as the definitive and preferred method against this serious adverse transfusion outcome [15].
Leukocyte reduction filters are typically component-specific; a filter intended for one component type should not be used with other component types [16].
Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions.
www.fda.gov /cber/gdlns/preleuk.htm   (5976 words)

 Biocenter - Research Groups - Leukocyte adhesion - molecular mechanisms
Leukocyte adhesion is of pivotal importance in leukocyte physiology.
If leukocytes cannot adhere to other leukocytes or various target cells, B lymphocytes cannot synthesize immunoglobulins, T and natural killer cells are not cytotoxic, and neutrophils show no phagocytosis or chemotaxis.
Several leukocyte adhesion molecules have been described among the most important of which are the leukocyte-specific §2-integrins, the intercellular adhesion molecules (ICAM) and the carbohydrate-binding selectins.
www.biocenter.helsinki.fi /groups/GAHMBERG/GAHMBERG_old.HTML   (461 words)

The most effective way to remove leukocytes is the use of specially designed filters (up to 99% WBC removal).
Leukocyte reduction has been proposed as a way to achieve this (2).
CMV transmission can be prevented either by administration of components from seronegative donors or by vigorous leukocyte reduction of blood components from random donors.
www.geocities.com /swvaguy/newsletter/leukocytereduction/leukoreducedblood.htm   (363 words)

 The Functional Paradox of CD43 in Leukocyte Recruitment: A Study Using CD43-deficient Mice -- Woodman et al. 188 (11): ...   (Site not responding. Last check: 2007-10-06)
of adhesion molecules; selectins are responsible for leukocyte
Leukocyte rolling is dependent upon activation-regulated selectins (E and P) on the endothelium (1).
The percentage of adherent leukocytes that emigrated in response to PAF is shown.
www.jem.org /cgi/content/full/188/11/2181   (3589 words)

 Leukocyte Activation and Flow Behavior in Rat Skeletal Muscle in Sepsis -- PIPER et al. 157 (1): 129 -- American ...
In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion.
and anti-CD11b) that inhibit leukocyte adhesion to postcapillary
Leukocyte adhesion to venular endothelium is shear-rate dependent (21).
ajrccm.atsjournals.org /cgi/content/full/157/1/129   (3498 words)

 Current Research: Leukocyte-endothelial adhesion   (Site not responding. Last check: 2007-10-06)
Although a passive leukocyte resembles a sphere in shape, its surface membrane is ruffled.
In the viscoelastic case, a transition from a spherical shape to a tear-drop shape typical for rolling leukocytes in vivo is observed.
We have also analyzed the effect of bond lifetime on leukocyte adhesion: if the receptor-ligand bonds live in a stressed state for a sufficiently long time, the leukocyte membrane can be extended and disrupted under high shear.
www.duke.edu /~damir/texts/current/cell/leukocyte_adhesion.html   (868 words)

As more studies on leukocyte reduction are conducted, the Red Cross is moving toward universal leukocyte reduction as evidence mounts that leukocyte reduction is a prudent choice for quality patient care.
Blood can undergo leukocyte reduction at the bedside at the time of transfusion ("poststorage bedside filtration"), in the hospital blood bank during component preparation ("poststorage laboratory filtration"), or as part of the manufacturing process ("prestorage leukocyte reduction").
This filtration may occur shortly after blood is collected at the blood center, known as prestorage leukocyte reduction; at the hospital after the blood has been delivered, known as in-lab post-storage leukocyte reduction; or at the patient’s bedside, known as bedside leukocyte reduction.
chapters.redcross.org /ca/socal/physician/products.html   (1580 words)

 ABC Blood Bulletin: Leukocyte Reduction of Blood Components   (Site not responding. Last check: 2007-10-06)
Leukocytes (WBC) are present in varying concentrations in all cellular blood components, including modified whole blood, red blood cells, platelets prepared from units of whole blood, and platelets collected by apheresis.
In patients experiencing this rare complication of transfusion, acute respiratory distress syndrome is attributable to a reaction between leukoagglutinating or HLA specific antibodies in the donor's plasma and the patient's leukocytes, resulting in complement mediated leukocyte aggregation and pulmonary leukostasis.
Leukocyte reduction does not prevent antibody mediated transfusion reactions such as hemolytic or hypersensitivity reactions not involving donor leukocytes.
www.lifeblood.org /news/abc_v01_n02.htm   (1325 words)

 eMedicine - Leukocyte Adhesion Deficiency : Article by Ann O'Neill Shigeoka, MD†   (Site not responding. Last check: 2007-10-06)
Several variant leukocyte adhesion disorders have also been reported, including the following: CD18 can be expressed but nonfunctional because of mutations that affect clustering or conformation, and E selectin can be expressed but rapidly cleaved from the cell surface so that it is only present in soluble form in the serum.
Rolling is a reversible process, partly because L selectin on leukocytes is shed from the cell surface and P selectin is internalized in endothelial cells.
These leukocyte adhesion disorders are unlikely to be confused with hyperimmunoglobulin E syndrome or chronic granulomatous disease because the clinical response to infection resembles neutropenia, but the CBC count shows dramatic neutrophilia.
www.emedicine.com /ped/topic1302.htm   (3920 words)

 Differential Contribution of Various Adhesion Molecules to Leukocyte Kinetics in Pulmonary Microvessels of ...
Significance of Adhesion Molecules for Leukocyte Kinetics in Arterioles and Venules
Rolling leukocyte frequency in venules of hyperoxia-exposed lungs was significantly increased and exceeded that in arterioles
Significance of Adhesion Molecules for Leukocyte Kinetics in Capillaries
ajrccm.atsjournals.org /cgi/content/full/157/2/599   (5982 words)

 APStracts 7:0072H, 2000.   (Site not responding. Last check: 2007-10-06)
To investigate the direct effect of leukocyte adherence to microvessel walls on microvessel permeability, we developed a method to measure changes in hydraulic conductivity (Lp) before and after leukocyte adhesion in individually perfused venular microvessels in frog mesentery.
Application of ketotifen, a mast cell stabilizer, and desferrioxamine mesylate, an iron-chelating reagent, attenuated the increase in Lp induced by leukocyte adhesion, suggesting the involvement of oxidants and the activation of mast cells in leukocyte adhesion-induced permeability increase.
Furthermore, with the use of a silver staining in vivo technique, the locations of the adherent leukocytes on the microvessel wall were identified quantitatively in intact microvessels.
www.uth.tmc.edu /apstracts/2000/heart/February/72h.html   (330 words)

 Critical Role of the {alpha}4 Integrin/VCAM-1 Pathway in Cerebral Leukocyte Trafficking in Lupus-Prone MRL/faslpr Mice ...
Leukocyte rolling data (A) are shown for animals before Ab treatment, after treatment with anti-VCAM-1, and after subsequent treatment with anti-P-selectin (mean ± SEM of n = 6 mice).
Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice.
Leukocyte rolling in venules of striated muscle and skin is mediated by P-selectin, not by L-selectin.
www.jimmunol.org /cgi/content/full/170/1/520   (4674 words)

 Lipopolysaccharide-Induced Leukocyte Rolling and Adhesion in the Rat Mesenteric Microcirculation: Regulation by ...
leukocyte phenotype observed with LPS superfusion of the mesentery.
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.
Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule.
www.jimmunol.org /cgi/content/full/161/12/6861   (7558 words)

 Leukocyte activation does not mediate myocardial leukocyte retention during endotoxemia in rabbits -- Goddard et al. ...
Leukocyte activation does not mediate myocardial leukocyte retention during endotoxemia in rabbits -- Goddard et al.
Leukocyte activation does not mediate myocardial leukocyte retention during endotoxemia in rabbits
Our goal was to determine whether coronary leukocyte retention after endotoxin infusion was due primarily to leukocyte activation.
ajpheart.physiology.org /cgi/content/abstract/275/5/H1548   (263 words)

 Leukocyte Accumulation and Hemodynamic Changes in the Cerebral Microcirculation During Early Reperfusion After Stroke ...
Leukocytes and platelets are readily distinguished from one
to be associated with leukocyte adherence to the platelets or endothelium.
Leukocyte involvement in cerebral ischemia and reperfusion injury.
stroke.ahajournals.org /cgi/content/full/31/5/1153   (5070 words)

 human leukocyte antigen --  Encyclopædia Britannica
More results on "human leukocyte antigen" when you join.
Leukocytes are found within tissues, where they fight infections, and in circulation.
Each individual's cells have a spectrum of genetically determined cell surface protein antigens, the major histocompatibility complex (MHC) antigens, or human leukocyte antigens as they are...
www.britannica.com /eb/article-9002535?tocId=9002535   (788 words)

 leukocyte on Encyclopedia.com   (Site not responding. Last check: 2007-10-06)
Tumor necrosis factor-[alpha] in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic...
FDA Clears Pall's New Leukocyte Reduction Filter For Improved Blood Processing Efficiency.
Soy isoflavones prevent the ovarian hormone deficiency-associated rise in leukocytes in rats.
www.encyclopedia.com /html/X/X-leukocyt.asp   (320 words)

 ► Leukocyte esterase
This is a test that measures leukocyte esterase activity in urine.
To obtain a clean-catch sample, men or boys should wipe clean the head of the penis.
Leukocyte esterase is a screening test used to detect an enzyme that suggests the presence of leukocytes (white blood cells), and probably a urinary tract infection.
www.umm.edu /ency/article/003584.htm   (397 words)

 HON Allergy Glossary White Blood Cell
Leukocytes or white blood cells (WBC) are cells in the blood that are involved in defending the body against infective organisms and foreign substances.
If the number of leukocytes is abnormally low (a condition known as leukopenia), infection is more likely to occur and it is more difficult for the body to get rid of the infection.
Measures the number of white blood cells in a microliter of blood.
www.hon.ch /Library/Theme/Allergy/Glossary/wbc.html   (236 words)

 Direct evidence of leukocyte adhesion in arterioles by angiotensin II -- Álvarez et al. 104 (2): 402 -- Blood
Four hours later, responses of leukocyte rolling flux (A), leukocyte rolling velocity (B), leukocyte adhesion (C), and leukocyte emigration (D) were quantified.
Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo.
Angiotensin II-induced leukocyte adhesion on human coronary endothelial cells is mediated by E-selectin.
www.bloodjournal.org /cgi/content/full/104/2/402   (5209 words)

 Laboratory of Leukocyte Biology   (Site not responding. Last check: 2007-10-06)
Principal Investigators in the Laboratory of Leukocyte Biology are: Francis W.
Staff Scientists in the Laboratory of Leukocyte Biology are: Maria C. Birchenall-Roberts, Ph.
In addition, emphasis is placed on characterizing the cellular and viral elements responsible for productive retroviral infection in leukocytes and the elements necessary for establishing, maintaining and overcoming latent infection in cells.
rex.nci.nih.gov /RESEARCH/basic/llb/llbpage.htm   (289 words)

 Leukocyte Depletion of Blood Cardioplegia Attenuates Reperfusion Injury -- Schmidt et al. 62 (6): 1691 -- The Annals of ...
Leukocyte Depletion of Blood Cardioplegia Attenuates Reperfusion Injury -- Schmidt et al.
Leukocyte depletion was examined in a canine model
Leukocyte filtration improves brain protection after a prolonged period of hypothermic circulatory arrest: A study in a chronic porcine model
ats.ctsnetjournals.org /cgi/content/abstract/62/6/1691   (438 words)

 Fujimi, et al., Activated Polymorphonuclear Leukocytes Enhance Production Of Leukocyte Microparticles With Increased ...   (Site not responding. Last check: 2007-10-06)
The objective of this study is to evaluate the production of leukocyte microparticles and the expression of adhesion molecules on their surface in patients with sepsis.
The production of leukocyte microparticles, the expression of CD11b on microparticles, and the oxidative activity in PMNLs were measured by flow cytometry in the presence or absence of formylmethionyl-leucyl-phenylalanine (FMLP).
Activated leukocyte microparticles may play a novel role in the pathogenesis of endothelial activation and leukocyte-endothelium interaction in sepsis.
www.aast.org /01abstracts/01absOral_012.html   (345 words)

 Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon -- Riaz et al., ...
The aims of the present study were to determine the effects and mechanisms of angiotensin II (Ang II) on leukocyte-endothelium interactions and the role of Ang II in a novel model of ischemia/reperfusion (I/R) in the mouse colon.
Ang II dose-dependently increased leukocyte rolling and adhesion in colonic venules.
Importantly, Ang II-induced leukocyte rolling was completely inhibited by immunoneutralization of P-selectin, and leukocyte adhesion was abolished in lymphocyte function antigen-1 (LFA-1)-deficient mice.
www.fasebj.org /cgi/content/abstract/03-0502fjev1   (332 words)

 Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration -- Shaw ...
Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.
JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.
Tumor necrosis factor-alpha-induced leukocyte adhesion and microvessel permeability.
www.jem.org /cgi/content/full/200/12/1571   (5390 words)

 Incremental Value of the Leukocyte Differential and the Rapid Creatine Kinase-MB Isoenzyme for the Early Diagnosis of ...
Incremental Value of the Leukocyte Differential and the Rapid Creatine Kinase-MB Isoenzyme for the Early Diagnosis of Myocardial Infarction
this may limit leukocyte destruction of the myocardium [29,30,31,32].
Comparison of four leukocyte differential methods with the National Committee for Clinical Laboratory Standards (NCCLS) reference method.
www.annals.org /cgi/content/full/122/5/335   (4409 words)

 Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier -- Xu et al. 72 (6): 1133 -- Journal of ...
Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier -- Xu et al.
in leukocyte trafficking in vivo at the blood-retinal barrier
of in vitro C-AM-labeled leukocytes with anti-CD44 monoclonal
www.jleukbio.org /cgi/content/abstract/72/6/1133   (460 words)

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