MedlinePlus Drug Information: Levamisole (Systemic)(Site not responding. Last check: 2007-10-13)
Levamisole ( lee-VAM-i-sole) is used with another cancer medicine (fluorouracil) to help make it work better against cancer of the colon.
Although there is no specific information comparing use of levamisole in the elderly with use in other age groups, this medicine has been used in elderly patients and is not expected to cause different side effects or problems in older people than it does in younger adults.
Levamisole may cause a temporary loss of hair in some people.
Levamisole hydrochloride occurs as a white to pale cream colored, odorĀless or nearly odorless, crystalline powder.
Levamisole is less effective against the immature forms of these parasites and is generally ineffective in cattle (but not sheep) against arrested larval forms.
Levamisole is primarily metabolized with less than 6% excreted unchanged in the urine.
Levamisole is used in human medicine as an anthelminthic in a single dose form at 2.5 mg/kg.
Levamisole- dependent leuco agglutinations were present in the patient's serum in high titre (1/512) during the acute phase.
Levamisole was further evaluated for effects on development in studies in which it was administered to rats and rabbits during all or part of gestation.
Levamisole induces increased cyclic guanosine monophosphate levels in the immunocytes, and possesses antioxidant properties which may be linked to its immunomodulating functions.
Further, levamisole presents indirect thymomimetic activity which is mediated by a serum factor that does not depend on the presence of a functioning thymus.
Skin tests were below normal in 16 out 22 of the levamisole group, and in 12 out of 19 of the placebo group; at the end of the trial they were still below normal in 13 out of 22 patients of the first group and in 14 out of 19 of the second.
Currently, Levamisole HCL is used in humans for diseases related to imbalances in the regulation of immune responses or deficiencies of the immune system, including autoimmune diseases, chronic and recurrent diseases, chronic infections and cancer.
Levamisole affects the neurotransmitters and paralyzes the worm (spastic paralysis).
Injectable Levamisole phosphate 13.5% is equivalent to 136.5 mg of Levamisole Hydrochloride.
Biologictherapy.Org: About Biologic Therapy: Levamisole(Site not responding. Last check: 2007-10-13)
Levamisole is a drug that was previously used for eliminating intestinal parasites in animals.
Levamisole can stimulate a normal and a depressed immune system, and is often classified as both an immunoregulator and immunostimulant.
A combination of 5-FU and levamisole is used in stage TNM 3 or Duke's C over a duration of 1 year postoperatively and is combined with radiation therapy for Duke's stage B2 and TNM stage 4.
Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest that CaM kinase and tyrosine kinase regulate sensitivity to levamisole -- Trailovic et al.
on the peak response to levamisole or acetylcholine.
CN: 422708) on levamisole and acetylcholine responses ( Fig.
Conclusion: According to both twelve years of clinical research evidence and the knowledge and expertise of the manufacturer's pharmacologist: Levamisole is the broad spectrum parasiticide of choice in Didelphid opossums, for ascarids, whipworms, hookworms, strongyles, strongyloids, lungworms, etc.
Levamisole and the Lower Urinary Tract in Opossums
The usual (deworming) dose of Levamisole (13.65% or 136.5 mg/ml) for opossums is 0.02 ml/lb (2.75mg/lb).
www.opossum.org /levamisole.htm (1631 words)
Levamisole Hydrochloride(Site not responding. Last check: 2007-10-13)
Levamisole enhances the effectiveness of fluorouracil, a drug used to treat cancer of the colon.
Levamisole is not expected to cause different side effects or problems in older persons than it does in younger patients.
When alcohol is consumed with the combination of levamisole and fluorouracil, severe nausea and vomiting may result.
Levamisole (Systemic) - MayoClinic.com(Site not responding. Last check: 2007-10-13)
Levamisole (lee-VAM-i-sole) is used with another cancer medicine (fluorouracil) to help make it work better against cancer of the colon.
It is not known whether levamisole passes into the breast milk in humans, although it passes into cows' milk.
Although there is no specific information comparing use of levamisole in the elderly with use in other age groups, this medicine has been used in elderly patients and is not expected to cause different side effects or problems in older people than it does in younger adults.
Polish Journal of Pharmacology(Site not responding. Last check: 2007-10-13)
Levamisole, known for a long time as an antiparasitic drug due to its immunomodulating properties, has been used in the therapy of immune disorders.
The action of levamisole depends on the dose and the manner of administration, and it seems interesting to establish whether similar dependencies exist for the membrane enzymes of lymphocytes.
An apparent deactivation of ecto-ATPase of lymphocytes T was observed when high doses of levamisole were administered four times.
www.if-pan.krakow.pl /pjp/983_6.htm (161 words)
Levamisole Asbestos(Site not responding. Last check: 2007-10-13)
of alp kansas mesothelioma and its inhibitor levamisole l on androgen metabolism in oral periosteal...
ER, Fisher B: A clinical trial to assess the relative efficacy of 5-FU + leucovorin, 5-FU + Levamisole, and 5-FU + Leucovorin + Levamisole in patients with dukes B and C carcinoma of the colon...
Constantin levallorphan levallorphan tartrate levamisole levan levan fructotransferase levana...
Levamisole has not been studied in pregnant women.
It is not known whether levamisole passes into the breast milk in humans, although it passes into cows' milk.
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of levamisole in children with use in other age groups.
Levamisole is used to treat malignant melanoma (a type of skin cancer), and in combination with fluorouracil it is used to teat a particular type of colon cancer.
When levamisole is used in combination with fluorouracil for the treatment of colon cancer, it should be started no sooner than one week, but no later than five weeks, after bowel surgery (as soon as medication can be tolerated).
Levamisole often causes nausea, but it is important that you keep taking the medication unless your doctor instructs you otherwise.
Levamisole and 5-fluorouracil have now become the standard chemotherapeutic regimen for patients with Stage III colon carcinoma.
A case of multifocal inflammatory leukoencephalopathy secondary to levamisole alone or combination of levamisole and 5-fluorouracil is reported.
In patients receiving 5-FU and levamisole who develop focal neurologic symptoms with an abnormal MRI scan, the diagnosis of CNS metastasis should not be made without a thorough diagnostic evaluation.