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Topic: Leydig cell

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	Non-Germ Cell Tumors of the Testis - Tumors of the Testis
		Approximately 5-6% of all testis tumors are non-germ cell tumors of the testis.
		Leydig cell tumors are the most common non-germ cell tumors of the testis and account for 1-3% of all testicular tumors.
		Reinke crystals are fusiform-shaped cytoplasmic inclusions that are pathognomonic for Leydig cells.
	www.health.am /cr/testis-non-germ-cell-tumors (577 words)

	Endotext.com - Endocrinology Of Male Reproduction, Testicular Cancer Pathogenesis, Diagnosis and Endocrine Aspects
		Leydig cells are located in the interstitial compartment of the testis and are involved in the development of secondary male characteristics and maintenance of spermatogenesis.
		However, Leydig cell hyperplasia is distinct from tumors that are usually solitary, and the role of the LH receptor and G protein mutations in the tumorigenesis may be limited to few cases (105, 107).
		Leydig cell tumors are always benign in children and can be treated with surgical enucleation when the tumor is encapsulated (97), whereas in adults malignant tumors have been found in 10-15 % of patients, and inguinal orchidectomy remains the treatment of choice (110).
	www.endotext.org /male/male13/male13.htm (5779 words)

	Population Council \| News Release \| Stem Leydig Cells Discovered
		To do this, scientists must find cells that: (1) are self-renewing; (2) can differentiate into the target cell in a Petri dish; and (3) can colonize a tissue in a live animal that is devoid of the target cell and transform themselves into that target cell.
		Leydig cells progress through three stages of development, from progenitor, to immature, and ultimately to fully differentiated adult Leydig cell.
		Theoretically, these stem cells could be removed from hypogonadal boys and men, grown in a Petri dish, and then transplanted back into the same people as a treatment for their male-hormone deficiency.
	www.popcouncil.org /mediacenter/newsreleases/LeydigStemCell.html (802 words)

	Leydig cell - definition from Biology-Online.org
		Leydig cells, also known as interstitial cells of Leydig, are found adjacent to the seminiferous tubules in the testes.
		Leydig cells can synthesize testosterone and are often closely related to nerves.
		Leydig cells have round vesicular nuclei and a granular eosinophilic cytoplasm.
	www.biology-online.org /dictionary/Leydig_cell (216 words)

	Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad -- Brennan et al. 17 ...
		Proliferation and migration of mesenchymal cells in response to
		receptor on cells of the mesonephros and interstitial
		was in the gonad or in the migrating mesonephric cells.
	www.genesdev.org /cgi/content/full/17/6/800 (6180 words)

	Leydig Cell Tumors of the Testis
		Leydig cell tumor in a patient with gynecomastia.
		Leydig cell tumors of the testis are uncommon, and bilateral lesions are extremely rare.
		We report a case of bilateral Leydig cell tumor of the testis treated with radical orchiectomy and contralateral subtotal orchiectomy with the intent of preservation of hormonal function and fertility.
	www.thedoctorsdoctor.com /diseases/testis_leydigcelltumor.htm (2514 words)

	Reproductive Biology and Endocrinology \| Full text \| Stimulation of TM3 Leydig cell proliferation via GABAAreceptors: A ...
		Although fetal Leydig cells represent a differentiated cell population, there is evidence for a moderate increase in the number of these cells during the first two weeks of postnatal development [31,39].
		Among these cells are likely connective tissue cells and endothelial cells [59-61], but also fetal Leydig cells and mesenchymal precursors of adult Leydig cells, as judged by their typical location and morphology.
		The number of fetal Leydig cells increases moderately in rodents during the first two weeks of postnatal development [31,39] and it is possible that GABA may mediate this effect.
	www.rbej.com /content/2/1/13 (5736 words)

	eMedicine - Leydig Cell Tumors : Article Excerpt by: Scott Rutchik, MD
		Background: Leydig cell tumors are rare tumors of the male gonadal interstitium, although they are the most common type of interstitial testis tumor.
		Leydig cell tumors are frequently hormonally active, leading to feminizing or virilizing syndromes (see Image 1).
		Because of its androgenizing effects, a Leydig cell tumor must always be considered in the differential diagnosis of precocious puberty in boys.
	www.emedicine.com /med/byname/leydig-cell-tumors.htm (313 words)

	Testicular Leydig's Cell Hyperplasia: MR Imaging and Sonographic Findings -- Carucci et al. 180 (2): 501 -- American ...
		A nodular aggregate of hyperplastic Leydig's cells is identified in lower half of image.
		Adult patients with Leydig's cell hyperplasia are usually asymptomatic [2].
		Leydig cell tumor and metachronous Leydig cell hyperplasia: a case associated with gynecomastia and elevated urinary estrogens.
	www.ajronline.org /cgi/content/full/180/2/501 (1126 words)

	GRANULOSA CELL TUMOR OF THE OVARY
		The granulosa cells are cuboidal to polygonal cells that are arranged in cords, sheets or strands.
		The theca cells are spindle cells and are arranged in sheets.
		In the poorly-differentiated tumors, disorderly arranged epithelial cells are scattered in a sarcomatous stroma.
	www.bioscience.org /atlases/tumpath/freprod/ovary/9/micro.htm (298 words)

	Effect of beta-blockers on the production of Testosterone by rat’s Leydig cells
		Background: The Leydig cell is the source of the male sex steroids, or androgens, which are essential for the maintenance of the male phenotype, the male gonads, and spermatogenesis.
		In the absence of LH in vivo, there is a rapid decline in Testosterone secretion by the Leydig cell and a gradual regression of the Leydig cells with loss of cytoplasmic volume and the intracellular structures associated with steroidogenesis, although Leydig cell numbers are marginally affected.
		The effects of gonadotrophin-releasing hormone-immunization and recombinant follicle-stimulating hormone on Leydig cell and macrophage populations of the adult rat testis.
	www.ayubmed.edu.pk /JAMC/PAST/16-4/UmarKhan.htm (1734 words)

	Sertoli-Leydig Cell Tumor of the Ovary
		Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases.
		Ovarian Sertoli cell tumors are rare, and their morphologic spectrum, behavior, and factors influencing the latter are not clearly established.
		The cells usually had pale to occasionally densely eosinophilic cytoplasm, but 6 tumors were composed of cells with prominent foamy cytoplasm, falling in the category of "lipid-rich" Sertoli cell tumor, and one had cells with clear non-foamy cytoplasm.
	www.thedoctorsdoctor.com /diseases/ovary_sertolileydig.htm (3618 words)

	Sertoli-Leydig cell tumor
		The Sertoli cells, which are located in the male gonads (the testes), provide nourishment to the sperm cells.
		The Leydig cells secrete the male sex hormone testosterone.
		Arrhenoblastomas are a type of ovary tumor whose cells (Sertoli-Leydig cells) produce and secrete a male sex hormone, causing virilization (male physical characteristics such as facial hair and deep voice) in women.
	www.mercydesmoines.org /ADAM/Encyclopedia/ency/001172.asp (199 words)

	eMedicine - Leydig Cell Tumors : Article by Scott Rutchik, MD
		Leydig cell tumors are diagnosed based on histopathology.
		Leydig cell tumor endocrine function is independent of the hypothalamus-pituitary-gonadal hormonal axis and should demonstrate no response to either adrenocorticotropic hormone stimulation or dexamethasone suppression testing.
		Abdominal and chest CT scanning or radiography is reserved for patients who have a malignant Leydig cell tumor, although procession to CT imaging upon diagnosis of a testis mass prior to orchiectomy is not uncommon.
	www.emedicine.com /med/topic1294.htm (1662 words)

	Dr. Koop - Leydig cell tumor
		A leydig cell tumor is a tumor of the testicle consisting of masses of abnormal interstitial cells that may secrete testosterone.
		This is an uncommon tumor in prepubertal children, but may be the cause of early puberty.
		In contrast with germ cell tumors of the testicles, there does not seem to be an association with cryptorchidism (undescended testes).
	www.drkoop.com /ency/93/000409.html (322 words)

	Leydig Cell Apoptosis after the Administration of Ethane Dimethanesulfonate to the Adult Male Rat Is a Fas-Mediated ...
		Leydig Cell Apoptosis after the Administration of Ethane Dimethanesulfonate to the Adult Male Rat Is a Fas-Mediated Process -- Taylor et al.
		Leydig Cell Apoptosis after the Administration of Ethane Dimethanesulfonate to the Adult Male Rat Is a Fas-Mediated Process
		Leydig cells undergo apoptosis in response to the cytotoxin
	endo.endojournals.org /cgi/content/full/140/8/3797 (4410 words)

	Long-term suppression of Leydig cell steroidogenesis prevents Leydig cell aging -- Chen and Zirkin 96 (26): 14877 -- ...
		Leydig cells were collected from testes of each of the treated and control rats and then pooled from groups of 2-3 rats.
		C, Control rats of 3 and 13 months of age received empty implants for 8 months; the implants were removed; and 2 months later, when the rats were 13 (young) and 23 (aged) months of age, respectively, Leydig cells were isolated and assessed for their ability to produce testosterone.
		Leydig cells from the 23-month-old control rats produced significantly less testosterone than cells from the 13-month-old controls.
	www.pnas.org /cgi/content/full/96/26/14877 (3018 words)

	Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances -- Akingbemi et al. 101 ...
		cells, was measured by RIA in aliquots of the spent media after incubation of Leydig cells for 3 h.
		Increased proliferative activity in Leydig cells is therefore due to induction of cell cycle proteins by DEHP treatment.
		Leydig cells to a greater extent in humans than in the rat.
	www.pnas.org /cgi/content/full/101/3/775 (4172 words)

	Failure of normal adult Leydig cell development in androgen-receptor-deficient mice -- O'Shaughnessy et al. 115 (17): ...
		Leydig cell number during development in normal mice and in AR-null animals.
		The fetal Leydig cell population is responsible for masculinisation
		Russo, J. and de Rosas, J. Differentiation of the Leydig cell of the mouse testis during the fetal period—an ultrastructural study.
	jcs.biologists.org /cgi/content/full/115/17/3491 (4200 words)

	Leydig Cell Hypoplasia: Absent Luteinizing Hormone Receptor Cell Surface Expression Caused by a Novel Homozygous ...
		Leydig Cell Hypoplasia: Absent Luteinizing Hormone Receptor Cell Surface Expression Caused by a Novel Homozygous Mutation in the Extracellular Domain -- Richter-Unruh et al.
		Leydig Cell Hypoplasia: Absent Luteinizing Hormone Receptor Cell Surface Expression Caused by a Novel Homozygous Mutation in the Extracellular Domain
		Leydig cell hypoplasia is a rare autosomal recessive condition
	jcem.endojournals.org /cgi/content/abstract/89/10/5161 (376 words)

	OVARIAN CANCER: Diagnosis and Treatment
		Eventually these cells grow into a mass and this is termed a 'tumor'.
		Granulosa cell tumors, which are most common in postmenopausal women, may cause vaginal bleeding and an elevated level of the tumor marker inhibin in the blood.
		Sertoli-Leydig cell tumors are rare; the average age of patients diagnosed with these tumors is 25, and only 10% of patients are over 50.
	ovariancancer.jhmi.edu /stromal.cfm (539 words)

	Sertoli-Leydig cell tumour - Wikipedia, the free encyclopedia
		Sertoli-Leydig cell tumours are part of the sex cord-stromal tumour group of ovarian neoplasms.
		The average age of patients with Sertoli-Leydig tumours is 25, and one-third present with virilization.
		The most typical is composed of tubules lined by Sertoli cells and interstitial clusters of Leydig cells.
	en.wikipedia.org /wiki/Sertoli-Leydig_cell_tumour (125 words)

	Malignant Leydig Cell Adenoma of the Testicle
		Less common lesions in a man of this age are germ cell tumors (seminoma, embryonal cell carcinoma, teratoma, choriocarcinoma, and yolk sac tumor) and stromal cell tumors (Leydig cell tumor and Sertoli cell tumor).
		Leydig (interstitial) cell tumors are uncommon, accounting for 1-3% of all testicular neoplasms, and occur predominantly in men between the ages of 20 and 50 years.
		Only 10-15% of Leydig cell tumors are malignant, as in this case.
	brighamrad.harvard.edu /Cases/bwh/hcache/224/full.html (548 words)

	The actions of calcitonin on the TM3 Leydig cell line and on rat Leydig cell-enriched cultures -- Nakhla et al. 10 (4): ...
		The actions of calcitonin on the TM3 Leydig cell line and on rat Leydig cell-enriched cultures -- Nakhla et al.
		The actions of calcitonin on the TM3 Leydig cell line and on rat Leydig cell-enriched cultures
		that these cells may be one of the many sites affected by this peptide.
	www.andrologyjournal.org /cgi/content/abstract/10/4/311 (422 words)

	Leydig cell - Wikipedia, the free encyclopedia
		They release the class of hormones called androgens (C19 steroids).
		LH increases cholesterol desmolase activity, leading to testosterone secretion by Leydig cells.
		FSH (Follicle Stimulating Hormone) increases the response of Leydig cells to LH (Luteinizing Hormone) by up regulation.
	en.wikipedia.org /wiki/Leydig_cell (247 words)

	Prolonged Histamine Deficiency in Histidine Decarboxylase Gene Knockout Mice Affects Leydig Cell Function -- Mondillo ...
		Prolonged Histamine Deficiency in Histidine Decarboxylase Gene Knockout Mice Affects Leydig Cell Function -- Mondillo et al.
		Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary; and the
		To evaluate the dependency of Leydig cells on histamine
	www.andrologyjournal.org /cgi/content/abstract/28/1/86 (312 words)

	Leydig Cell Tumors of the Testis: Gray Scale and Color Doppler Sonographic Appearance -- Maizlin et al. 23 (7): 959 -- ...
		Leydig Cell Tumors of the Testis: Gray Scale and Color Doppler Sonographic Appearance -- Maizlin et al.
		appearance of 10 proven Leydig cell tumors in 9 patients aged
		In 1 testis, 2 discrete Leydig cell tumors
	www.jultrasoundmed.org /cgi/content/abstract/23/7/959 (321 words)

	AllRefer Health - Leydig Cell Tumor (Testicular Tumor, Tumor - Leydig Cell)
		AllRefer Health - Leydig Cell Tumor (Testicular Tumor, Tumor - Leydig Cell)
		You are here : AllRefer.com > Health > Diseases and Conditions > Leydig Cell Tumor
		Alternate Names : Testicular Tumor, Tumor - Leydig Cell
	health.allrefer.com /health/leydig-cell-tumor-info.html (337 words)

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