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Topic: Lidocaine

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	eMedicine - Toxicity, Lidocaine : Article by Ruben Peralta
		Lidocaine is an amide local anesthetic and a less commonly used antiarrhythmic that exerts its effects on nerve axon sodium channels, preventing depolarization.
		Lidocaine toxicity occurs with unintended intravascular administration or with administration of an excessive dose.
		Lidocaine's main effects are due to decreased conductance of sodium channels, antiarrhythmic effect, sedation, and neural blockade.
	www.emedicine.com /med/topic1297.htm (2148 words)

	MedlinePlus Drug Information: Lidocaine Viscous
		Lidocaine viscous, a local anesthetic, is used to treat the pain of a sore or irritated mouth and throat often associated with cancer chemotherapy and certain medical procedures.
		Lidocaine viscous is not normally used for sore throats due to cold, flu, or infections such as strep throat.
		Lidocaine viscous usually is used as needed but not more frequently than every 3 hours, with a maximum of eight doses in 24 hours.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682701.html (548 words)

	CIGNA - lidocaine topical
		Lidocaine topical is used to relieve pain associated with sunburn; insect bites; poison ivy; poison oak; poison sumac; minor cuts; scratches; and burns; sores in the mouth; dental procedures; hemorrhoids; and shingles (herpes infection).
		Lidocaine topical is in the FDA pregnancy category B. This means that it is unlikely to be harmful to an unborn baby.
		Lidocaine oral cavity patches are applied to the gums by a dentist or a dental assistant before a dental procedure.
	www.cigna.com /healthinfo/d00683a1.html (1258 words)

	Lidocaine topical Information on Healthline
		Lidocaine topical is used to relieve pain associated with sunburn; insect bites; poison ivy; poison oak; poison sumac; minor cuts; scratches; and burns; sores in the mouth; dental procedures; hemorrhoids; and shingles (herpes infection).
		Lidocaine topical is in the FDA pregnancy category B. This means that it is unlikely to be harmful to an unborn baby.
		Lidocaine oral cavity patches are applied to the gums by a dentist or a dental assistant before a dental procedure.
	www.healthline.com /multumcontent/lidocaine-topical (943 words)

	S-Caine (Lidocaine and Tetracaine) clinical pharmacology - prescription drugs and medications at RxList
		Lidocaine is metabolized rapidly by the liver to a number of metabolites, including monoethylglycinexylidide (MEGX) and glycinexylidide (GX), both of which have pharmacologic activity similar to, but less potent than that of lidocaine.
		The major metabolic pathway of lidocaine, sequential N-deethylation to MEGX and GX, is primarily mediated by CYP1A2 with a minor role of CYP3A4.
		Lidocaine and its metabolites are excreted by the kidneys.
	www.rxlist.com /cgi/generic4/s-caine_cp.htm (844 words)

	CiteULike: Effects of lidocaine on shock-induced vulnerability.
		INTRODUCTION: Lidocaine is known to increase the defibrillation threshold (DFT) of monophasic shocks (MS) and have no effect on DFT of biphasic shocks (BS).
		Lidocaine caused reduction of the conduction velocity during pacing (0.58 +/- 0.08 m/s vs 0.44 +/- 0.05 m/s, P < 0.01), shock-induced break excitation (0.82 +/- 0.17 m/s vs 0.30 +/- 0.07 m/s, P < 0.01), and postshock reentry (0.34 +/- 0.07 m/s vs 0.19 +/- 0.08 m/s, P < 0.01).
		Reduction of conduction velocity by lidocaine resulted in increased dispersion of repolarization and led to upper limit of VP increase for both MS and BS.
	www.citeulike.org /user/brocktice/article/762132 (713 words)

	Requirements for Child-Resistant Packaging; Requirements for Products Containing Lidocaine or Dibucaine
		Lidocaine, a local anesthetic, was identified as a topical drug that presented a potential ingestion hazard to young children.
		Lidocaine is an ingredient in a wide variety of preparations used as anesthetics, general antiseptics, and burn remedies, and for skin care.
		Lidocaine formulations packaged in tubes (creams, ointments, and gels) and bottles (liquids and gels) comprise 7 and 8 percent of units in their respective topical anesthetic package categories.
	www.cpsc.gov /businfo/frnotices/fr95/95-17992.html (12797 words)

	National Headache Foundation: Lidocaine
		Lidocaine is an anesthetic agent, usually injected to produce numbness in a small area of skin.
		The supposed mechanism by which lidocaine works in clusters and migraines is by numbing the portion of the trigeminal nerve known as the sphenopalatine ganglion.
		The most effective use of lidocaine is for the patient who has severe migraines and where the more specific abortive medications take an hour or more to produce resolution of the migraines.
	www.headaches.org /consumer/topicsheets/lidocaine.html (286 words)

	Lidocaine Patch Information on Healthline
		As lidocaine causes a temporary numbness or loss of sensation when injected in the tissues, it is used as a local anesthetic and in the treatment of pain.
		Additionally, the lidocaine patch is sometimes used in the treatment of some chronic forms of nerve pain such as the pain associated with fibromyalgia.
		When it is applied to the skin, lidocaine is released into the epidermal and dermal layers of the skin, reducing pain at the site of the dysfunctional nerves damaged by the prior herpes zoster infection.
	www.healthline.com /galecontent/lidocaine-patch (740 words)

	S-Caine (Lidocaine and Tetracaine) drug warnings and precautions - prescription drugs and medications at RxList
		In the in vitro chromosome aberration assay, tetracaine was negative in the absence of metabolic activation, and equivocal in the presence of metabolic activation.
		In humans, the use of lidocaine for labor conduction analgesia has not been associated with an increased incidence of adverse fetal effects either during delivery or during the neonatal period.
		Based on these data and the low concentrations of lidocaine and tetracaine found in the plasma after topical administration of S-Caine in recommended doses, the small amount of these primary compounds and their metabolites that would be ingested orally by a suckling infant is unlikely to cause adverse effects (see CLINICAL PHARMACOLOGY, Pharmacokinetics).
	www.rxlist.com /cgi/generic4/s-caine_wcp.htm (1226 words)

	Lidocaine Ointment facts and comparsions at Drugs.com
		Lidocaine Ointment may cause drowsiness, dizziness, or blurred vision.
		Store Lidocaine Ointment at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container.
		Lidocaine Ointment is to be used only by the patient for whom it is prescribed.
	www.drugs.com /cdi/lidocaine_ointment.html (1118 words)

	LIDOCAINE - TOPICAL (Lidamantle, Xylocaine) side effects, medical uses, and drug interactions.
		Lidocaine may also be used to relieve irritation and inflammation in the mouth and throat.
		PRECAUTIONS: Before using lidocaine, tell your doctor or pharmacist if you are allergic to it; or to other amide type anesthetics; or if you have any other allergies.
		Before using this medicine, consult your doctor or pharmacist if you have: bacterial infection in the area where lidocaine is to be used, damaged mucous membranes (e.g., nose, mouth, anal area).
	www.medicinenet.com /lidocaine-topical/article.htm (587 words)

	Safety Issues With Adding Lidocaine to IV Potassium Infustions (Excerpt)
		Following hospital policy, the physician then prescribed 25 mg of lidocaine to be added to each subsequent bag of potassium chloride to reduce vein discomfort.
		Adding to the confusion, lidocaine is available in a variety of different formulations (e.g., with and without preservatives or epinephrine, in 1% and 2% concentrations).
		Lim et al.(1) found the use of lidocaine effective in a group of 28 patients when it was given as a 3 mL bolus prior to infusion of 20 mEq of KCl in 100 mL of 5% dextrose.
	www.ismp.org /MSAarticles/Safety.htm (820 words)

	Topical anesthetic lidocaine gel
		The biological half-life of lidocaine is 1.5 hrs; its plasma clearance averages 1 lt/min and is dependent on liver blood flow.
		(lidocaine 4%) is indicated for the temporary relief of pain and itching.
		Systemic adverse effects of lidocaine are similar in nature to those observed with other amide type local anesthetics including CNS excitation and/or depression (light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest).
	topicaine.net /f/package_insert.htm (1416 words)

	Lidocaine Nasal Drops Relieve Migraine
		Overall, there were 94 headaches in the lidocaine group and 104 in the placebo group.
		According to treatment logs kept by the patients, lidocaine users experienced relief within 5 minutes during 31% of treatment attempts, a rate found in only 6.7% of placebo users.
		The 15-minute response rate was 35% in the lidocaine group and 7.7% in the placebo group.
	www.personalmd.com /news/a1998062614.shtml (462 words)

	Lidocaine : Epilepsy.com/Professionals
		In animals, lidocaine produces epileptiform activity that is limited to the amygdala and hippocampus.
		Lidocaine doses that are commonly used for local anesthesia can cause CNS toxicity if they are inadvertently administered intravenously.
		Lidocaine is injected intravenously to provide local anesthesia (intravenous regional anesthesia or Bier blocks).
	professionals.epilepsy.com /page/local_lidocaine.html (630 words)

	Lidocaine (Topical) - MayoClinic.com
		When lidocaine is applied to the skin, it produces pain relief by blocking the signals at the nerve endings in the skin.
		Lidocaine topical systems are used to relieve pain and discomfort associated with herpes zoster virus infection of the skin (shingles).
		However, lidocaine has not been shown to cause birth defects or other problems in animal studies.
	www.mayoclinic.com /health/drug-information/DR500058 (1181 words)

	Lidocaine Doses - Liposuction.com
		This is attributed to the decrease in cardiac output, and the consequent decrease in hepatic perfusion associated with advancing age.
		A lidocaine dose that would be safe under normal circumstances might be toxic as a result of unanticipated drug interactions.
		As a general rule, drugs that potentially interfere with lidocaine metabolism should be discontinued one to two weeks before using tumescent liposuction when relatively large dosages of lidocaine are anticipated.
	www.liposuction.com /pharmacology/lido_doses.php (381 words)

	lidocaine topical - [Medication]
		Symptoms of a lidocaine topical overdose may include dizziness, drowsiness, confusion, nervousness, ringing in the ears, blurred or double vision, sensation of heat or cold, numbness, twitching, seizures, unconsciousness, decreased breathing, and heart attack.
		Although lidocaine topical is unlikely to affect medicines taken by mouth, talk to your doctor before using lidocaine topical if you are taking digoxin (Lanoxin) or any medicine to control irregular heartbeats.
		Lidocaine topical is available with a prescription and over-the-counter under several brand and generic names.
	www.peacehealth.org /kbase/multum/d00683a1.htm (1195 words)

	CBBS: Can We Use Lidocaine for Numbing a Donor Phlebotomy Site Without a Physician's Prescription?
		As you may recall, a member wrote that lidocaine was being used to numb the phlebotomy site of whole blood and apheresis platelet donors, in order to alleviate the pain and anxiety of the big bore donor needle.
		Furthermore, putting aside the issue of safety, potency, and purity of a lidocaine assisted donation, the member comments that the need for a physician order for lidocaine could probably be met in much the same way as his institution approaches the collection of "double" red cells and plasma.
		According to this medical director, if a donor wants to have lidocaine to numb the pain of the big needle insertion, but is being drawn by an unlicensed member of the collection staff, a licensed staff member needs to be called over to inject the lidocaine and then let the phlebotomist finish the procedure.
	www.cbbsweb.org /enf/2001/lidocaine.html (1428 words)

	Lidocaine
		Are the doses given to an elderly person, someone over the age of 65, the same as a typical adult, what are the therapeutic doses, does need to be mixed with another medication if given to an older patient.
		Should Lidocaine be given to someone with a low blood pressure and high pulse rate.
		Lidocaine is used both as a local anaesthetic and as a drug to stabilize
	www.medhelp.org /forums/neuro/archive/4098.html (402 words)

	EMS House of DeFrance
		Metabolic clearance of lidocaine may be decreased in patients taking beta-adrenergic blockers or in patients with liver dysfunction.
		Apnea induced witll succinylcholine may be prolonged with large doses of lidocaine.
		Cardiac depression may occur if lidocaine is given concomitantly with IV phenytoin.
	www.kpemsc.org /pharm/lidoc.html (221 words)

	LIDODERM® (Lidocaine Patch 5%) - Targets the Lingering Pain After the Shingles
		If you still have pain more than one month after having shingles, you may be suffering from a condition known as Post-Herpetic Neuralgia (PHN), also referred to as post-shingles pain.
		(Lidocaine Patch 5%) is the only patch approved by the FDA to relieve post-shingles pain.*
		You should not use this product if you are sensitive to local anesthetics such as lidocaine, or to any of the other ingredients in LIDODERM
	www.lidoderm.com (619 words)

	[No title]
		Study results suggest that injections of the local anesthetic lidocaine, both into the ear and intravenously, may help the problem in most patients.
		The cause of tinnitus is unknown, but it is thought to be due to disorders affecting tiny "hair" cells in the inner ear, or affecting the nerve pathways between the inner ear and the brain.
		I would not recommend lidocaine as there are some concerns about its carcinogenicity and many people do not tolerate it.
	www.mercola.com /2000/may/28/lidocaine_tinnitus.htm (367 words)

	MedlinePlus Drug Information: Lidocaine Transdermal
		Lidocaine patches are used to relieve the pain of post-herpetic neuralgia (the burning, stabbing pains, or aches that may last for months or years after a shingles infection).
		Lidocaine is in a class of medications called local anesthetics.
		Lidocaine comes as a patch to apply to the skin.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a603026.html (905 words)

	Lidocaine hydrochloride injection
		Lidocaine hydrochloride is used to treat disturbances in the heart's rhythm.
		The pumping action of the heart is controlled by electrical impulses that are under the control of the nervous system.
		Lidocaine hydrochloride acts by decreasing the sensitivity of heart muscle to electrical impulses.
	www.netdoctor.co.uk /medicines/100001501.html (649 words)

	lidocaine (Site not responding. Last check: )
		Metabolic clearance of lidocaine may be decreased in patients taking beta adrenergic blockers in patients with decreased cardiac output or liver dysfunction.
		Apnea induced with succinycholine may be prolonged with large doses of lidocaine.
		Decrease infusion dose in the elderly and those with liver or renal dysfunction.
	www.templejc.edu /dept/ems/drugs/lidocaine.html (232 words)

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