
	Where results make sense

Topic: Ligand (biochemistry)

Related Topics

receptor biochemistry

List of biochemistry topics

clinical biochemistry

Protein biochemistry

substrate biochemistry

RAS Biochemistry Institute

biochemistry topics

steady state biochemistry

Sir William Dunn Professor of Biochemistry

In the News (Tue 8 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Ligand - Voyager, the free encyclopedia (Site not responding. Last check: 2007-10-10)
		In biology, a ligand is an extracellular substance that binds to receptors.
		The charge on the central atom called the oxidation number constrains the number of ligands that may be bonded because each type of ligand donates a characteristic number of electrons, and there is a requirement for overall neutrality.
		If the directly-bonded ligands (the "inner-sphere" ligands) do not balance the charge, this may be done by purely a ionic interaction with another set of counter ions (the "outer-sphere" ligands).
	www.voyager.in /Ligand (640 words)

	DBGET Database Document: LIGAND
		INTRODUCTION LIGAND, Database of Chemical Compounds and Reactions in Biological Pathways, is designed to provide the linkage between chemical and biological aspects of life in the light of enzymatic reactions.
		The ENZYME section is a collection of all known enzymatic reactions classified according to the nomenclature of the International Union of Biochemistry and Molecular Biology (IUBMB): International Union of Biochemistry and Molecular Biology, "Enzyme Nomenclature: Recommendations (1992) of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology", Academic Press, New York (1992).
		LIGAND is tightly coupled to the pathway database of the KEGG system (http://www.genome.ad.jp/kegg/), providing links to the gene catalogs of a number of organisms.
	www.genome.ad.jp /htbin/show_man?ligand (4218 words)

	The biochemistry of drugs
		In order for a ligand to bind, it must contain a specific combination of atoms that presents the correct size, shape, and charge composition in order to bind and interact with the receptor.
		In order for ligand and receptor to interact, there must be a driving force that compels the ligand to leave the water and bind to the receptor.
		Since the hydrophobic portions of the ligand and receptor prefer to be juxtaposed, the arrangement of hydrophobic surfaces provides yet another way that receptors can limit the binding of inappropriate targets.
	www.newdrugdesign.com /Rachel_Theory_02.html (970 words)

	University of Calgary: Calendar: Courses: Biochemistry
		Prerequisites: One of Chemistry 353 or 355; and Biochemistry 393.
		Prerequisites: Biochemistry 341 or 393; Chemistry 341 or 353 or 355; one of Mathematics 249, 251 or 261 and one of Mathematics 253, 263, 211 or 221; one of Physics 211 or 221, and 223.
		Prerequisites: One of Biochemistry 341 or 393 and Biochemistry 471 or Chemistry 371.
	www.ucalgary.ca /pubs/calendar/current/what/courses/BCEM.htm (1174 words)

	Biochemistry Chemistry Courses (Site not responding. Last check: 2007-10-10)
		The biochemistry curriculum offers a choice between a one-semester survey course of biochemistry, C483, or a two-semester sequence, C484-C485 that provides a more in-depth treatment of these topics.
		The other two undergraduate biochemistry courses offered, C487 and C481, are required for biochemistry majors, though other students who have met the pre-requisites will also find them interesting.
		C481 is a lecture course in biophysical chemistry, and C487 is a lab course in experimental biochemistry.
	chemlearn.chem.indiana.edu /advise/courses/BCM.htm (610 words)

	[No title] (Site not responding. Last check: 2007-10-10)
		For multivalency to occur, the ligands that are connected by a linker or linkers have to be presented to their ligand binding sites by the linker (s) in a specific manner in order to bring about the desired ligand-orienting result, and thus produce a multibinding event.
		The ligands are covalently attached to the linker or linkers using conventional chemical techniques providing for covalent linkage of the ligand to the linker or linkers.
		The relative orientation in which the ligand domains are displayed derives from the particular point or points of attachment of the ligands to the linker, and on the framework geometry.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=99/63929.991216&ELEMENT_SET=DECL (8326 words)

	List of Publications
		Borisov V.B. Osborne J.P., Arutjunjan A.M., Gennis R.B., Konstantinov A.A. Reaction of cytochrome bd oxidase from E.coli with the ligands.
		Bonding of heme d iron to an endogenous protein ligand at the sixth axial position upon reduction is proposed and several possible mechanisms of such a process are considered.
		The results are consistent with the proposal that hemes b-595 and d form a diheme oxygen-reducing center with a binding capacity for a single exogenous ligand molecule that partitions between the hemes d and b-595 in accordance with their intrinsic affinities for the ligand.
	www.genebee.msu.su /EAprize/example.htm (3923 words)

	The Hydrogenase Cytochrome b Heme Ligands of Azotobacter vinelandii Are Required for Full H2 Oxidation Capability -- ...
		ligand (45), which is essential for activity (16).
		Transmembrane topology and axial ligands to hemes in the cytochrome b subunit of Bacillus subtilis succinate:menaquinone reductase.
		Identification of histidine 105 in the B1 subunit of soluble guanylate cyclase as the heme proximal ligand.
	jb.asm.org /cgi/content/full/182/12/3429 (4614 words)

	BCH5425 Molecular Biology and Biotechnology (Site not responding. Last check: 2007-10-10)
		The ligand is typically, a small molecule, and it diffuses throughout the environment until it binds to a specific receptor
		Since the ligand is unaffected by the membrane te ligand concentration on the side with no receptor is equal to the free ligand concentration [L] everywhere in the sample (i.e.
		The ligand concentration will be equal to the free ligand concentration [L] plus the ligand present in the receptor complex [RL] (in other words, there should be a higher concentration of ligand on the side with the receptor if the receptor has affinity for the ligand)
	wine1.sb.fsu.edu /BCH4053l/lecture09/lecture09.htm (1447 words)

	Biochemistry at UConn
		The Graduate Program in Biochemistry furnishes students with an extensive education which will allow for the understanding of the structure and function of biological macromolecules.
		MCB 204/301 (undergraduate or graduate biochemistry) or equivalent.
		Students with insufficient background in biochemistry are encouraged to take MCB 301 (or its equivalent without a lab as MCB 396) during their first semester.
	www.mcb.uconn.edu /research/biochem/biochem.html (1420 words)

	Category:Biochemistry - Wikipedia, the free encyclopedia
		Biochemists study the elements, compounds and chemical reactions that are controlled by enzymes and take place in all living organisms.
		The main article for this category is Biochemistry.
		There are 10 subcategories shown below (more may be shown on subsequent pages).
	en.wikipedia.org /wiki/Category:Biochemistry (104 words)

	[No title]
		Fluorescence and NMR experiments were used to characterize the energetic, structural and kinetic properties of fatty acid binding to this variant, and the results were compared and contr asted with wild-type I-FABP and a single-site mutant, R106T.
		T his rate-limiting process was interpreted as a conformational change involving the helical region that allows the ligand access to the internal cavity.
		The rat intestinal fatty acid binding protein is an almost all beta-sheet protein that encloses a large interior cavity into which the fatty acid ligand binds.
	www.biochem.wustl.edu /cflab/ifabpabstracts.html (1024 words)

	[No title]
		Fluorescence and NMR experiments were used to characterize the energetic, structural and kinetic properties of fatty acid binding to this variant, and the results were compared and contrasted with wild-type I-FABP and a single-site mutant, R106T.
		In contrast, 13C-filtered NOESY spectra of [16-13C]-palmitate bound to D17-SG indicated that the fatty acid-protein interactions at the methyl end of the binding cavity were disrupted.
		This rate-limiting process was interpreted as a conformational change involving the helical region that allows the ligand access to the internal cavity.
	www.biochem.wustl.edu /~frieden/ifabpabstracts.html (1005 words)

	Dr. Vasanthi Jayaraman
		These investigations provide a detailed understanding of the agonist controlled function of the glutamate receptors and hence aid in the rational design of drugs targeting this group of important proteins that are involved in diverse neuropathologies, such as epilepsy and ischemia.
		Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy.
		Is the isolated ligand binding domain a good model of the domain in the native receptor?
	www.uth.tmc.edu /bmb/faculty/Jayaraman/jayaraman.html (336 words)

	Melissa Calhoun
		Calhoun MW, Lemieux LJ, Garcia-Horsman JA, Thomas JW, Alben JO, Gennis RB (1995) The highly conserved methionine of subunit I of the heme-copper oxidases is not at the heme-copper dinuclear center: mutagenesis of M110 in subunit I of cytochrome bo3-type ubiquinol oxidase from Escherichia coli.
		Calhoun MW, Lemieux LJ, Thomas JW, Hill JJ, Goswitz VC, Alben JO, Gennis RB Spectroscopic characterization of mutants supports the assignment of histidine-419 as the axial ligand of heme o in the binuclear center of the cytochrome bo ubiquinol oxidase from Escherichia coli.
		Calhoun MW, Thomas JW, Hill JJ, Hosler JP, Shapleigh JP, Tecklenburg MM, Ferguson-Miller S, Babcock GT, Alben JO, Gennis RB (1993) Identity of the axial ligand of the high-spin heme in cytochrome oxidase: spectroscopic characterization of mutants in the bo-type oxidase of Escherichia coli and the aa3-type oxidase of Rhodobacter sphaeroides.
	www.outfitters.com /~melissa/mwcresume.html (823 words)

	Current Biochemistry Faculty - Ronald Somerville
		The resulting liganded species has high affinity for several operator targets, many of which lie within promoters specific for genes related to the biosynthesis of tryptophan.
		Using wild-type and mutant TrpR proteins, we are analyzing the physicochemical parameters that govern monomer-dimer equilibrium, ligand binding and operator recognition.
		A third pattern of regulatory response is seen for the tyrP promoter, which is repressed when tyrosine is the ligand and induced when phenylalanine is supplied.
	www.biochem.purdue.edu /faculty/somerville.html (635 words)

	Molecular Models for Biochemistry at CMU
		They are intended to complement standard biochemistry texts where more explanation is provided, but where interactive 3-D images of the molecules are not available.
		Biochemistry I: (03-231) Fall Term, 2002 and (03-232) Spring Term, 2002.
		The CMU RasMol Tutorial is an on-line version of the tutorial written by Dr. David Hackney for use in our biochemistry courses.
	www.bio.cmu.edu /courses/biochemmols (865 words)

	Study of Protein-Ligand Binding by Fluorescence -- Möller and Denicola 30 (5): 309 -- Biochemistry and Molecular ... (Site not responding. Last check: 2007-10-10)
		Study of Protein-Ligand Binding by Fluorescence -- Möller and Denicola 30 (5): 309 -- Biochemistry and Molecular Biology Education
		be applied to the study of ligand binding to proteins.
		Copyright © 2002 by the International Union of Biochemistry and Molecular Biology.
	www.bambed.org /cgi/content/abstract/30/5/309 (192 words)

	Faculty
		In collaboration with Dr. Pei, we are using NMR and combinatorial libraries to characterize the structure and ligand specificity of FHA domains from different proteins.
		Yongkiettrakul S, Byeon IJ, Tsai MD. (2004) "The ligand specificity of yeast Rad53 FHA domains at the +3 position is determined by nonconserved residues." Biochemistry 43(13), 3862-9.
		Dunlap, C.A., Tsai, M-.D. (2002) "Use of 2-aminopurine and tryptophan fluorescence as probes in kinetic analyses of DNA polymerase beta." Biochemistry 41, 11226-35.
	www.biosci.ohio-state.edu /~biochem/faculty/Tsai.html (1434 words)

	Ligand: Employment Opportunities (Site not responding. Last check: 2007-10-10)
		This position will support all research and development programs with test article administration and sample collection, and a range of in vitro activities, including exploratory metabolism using sub-cellular tissue fractions and cell lines and processing of samples for bio-analytical testing.
		M.S. (or equivalent) in biology, pharmacology, biochemistry, pharmaceutical sciences or related field along with 5+ years' of related work experience in the pharmaceutical industry (or) a Ph.D. and 0-2 years' related experience.
		Please indicate the reference number of the position you are interested in and submit your resume to jobs@ligand.com.
	www.ligand.com /employment/jobs_list.cfm?kc=17 (335 words)

	Welcome - Department of Chemistry & Biochemistry, University of Texas at Austin
		The Department of Chemistry and Biochemistry at the University of Texas at Austin offers unsurpassed opportunities for world-class research across a broad range of chemical and biochemical fields.
		Scientists at The University of Texas at Austin have developed a quick and simple way to investigate the sugar coating that surrounds bacteria and plays a role in infection and immunity.
		The Department of Chemistry and Biochemistry, at the University of Texas at Austin is seeking an individual to play an essential role in our undergraduate program.
	www.cm.utexas.edu (205 words)

	Structural studies of globins, Q-Z
		H nuclear magnetic resonance determination of hydrogen bonding of the E10 (66) Arg sidechain to the bound ligand in Aplysia cyanomet myoglobin.
		The significance of haem for the structure of the haemoglobin molecule.
		Yamamoto, Y. and La Mar, G.N. H NMR study of dynamics and thermodynamics of heme rotational disorder in native and reconstituted hemoglobin A. Biochemistry 25, 5288-5297.
	metallo.scripps.edu /promise/GLOBINS_REF_QZ.html (4868 words)

	MEDICAL BIOCHEMISTRY
		The aim of this group is to help the residents in medical biochemistry program to peruse there speciality, open discussions, distribute teaching duties, materials and programs.
		One of the great appeals of a career in Medical Biochemistry is that it offers the opportunity to teach at many levels.
		Medical Biochemistry has a special appeal to those who enjoy solving disease-related problems, using technologies based upon fundamental sciences ranging from biophysics to molecular genetics, and including tools from the more traditional disciplines of biochemistry and physiology.
	groups.msn.com /MEDICALBIOCHEMISTRY (203 words)

	Wiley::Ligand-Receptor Energetics: A Guide for the Perplexed
		Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena.
		This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors.
		This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.
	www.wiley.com /WileyCDA/WileyTitle/productCd-0471176265,descCd-description.html (289 words)

	The Chemistry of Macrocyclic Ligand Complexes - Cambridge University Press (Site not responding. Last check: 2007-10-10)
		The study of macrocyclic chemistry represents a major area of activity which impinges on a range of other areas in both chemistry and biochemistry.
		The topics discussed also provide a suitable basis for a senior undergraduate or graduate course in macrocyclic chemistry and inorganic complexes.
		What is different about macrocyclic ligand complexes?; 2.
	www.cambridge.org /catalogue/catalogue.asp?ISBN=052125261X (276 words)

	APStracts 10:0086H, 2003. (Site not responding. Last check: 2007-10-10)
		Recently, we have shown that a widely used antagonist of the human bradykinin B2 receptor (B2R), HOEl4O, acts as a full agonist of the chicken ornithokinin receptor (BoR).
		Ligand efficacy of synthetic ligand HOE140 decreased in the order BoR > CKR- 2 > CKR-1 > B2R, whereas the efficacy of the endogenous kinin ligand was unchanged.
		Enhanced HOE140 efficacy was not due to a structural change in the ligand binding site or to an enhanced receptor expression level.
	www.uth.tmc.edu /apstracts/2003/heart/February/86h.html (226 words)

	Biochemistry molecular and cell biology (Site not responding. Last check: 2007-10-10)
		Introductory general biochemistry is taught in a number of different formats for a large number of students.
		It includes enzymology, and the specific biochemistry of the different types of tissues of an organism.
		The QD class for Biochemistry emphasizes the physical chemistry aspect of biochemistry**: atomic composition, structure (steriochemistry), energy changes, and the phenomena of atoms and compounds associated with biochemical substances.
	www.mann.cornell.edu /collections/policies/bioc.html (2091 words)

Try your search on: Qwika (all wikis)