Linda B. Buck - Factbites

Linda B. Buck - Factbites
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Topic: Linda B. Buck

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	MSN Encarta - Buck, <b>Lindab> B.
		Buck, <b>Lindab> B. Buck, <b>Lindab> B., born in 1947, American neuroscientist and cowinner of the 2004 Nobel Prize in medicine or physiology for discoveries that helped explain, at a molecular level, the processes involved in the sense of smell.
		Buck, in particular, has studied how the brain characterizes chemicals known as pheromones, which are associated with mating and other behaviors in a variety of animal species.
		After six years of false starts and failure, Buck and Axel succeeded in identifying a particular family of odor-sensing proteins â”the so-called âodorant receptors.â A receptor is a structure on the surface of a cell that allows it to admit or bind with outside substances.
	encarta.msn.com /encyclopedia_701703558/Buck_Linda_B.html

	<b>Lindab> B. Buck - Wikipedia, the free encyclopedia
		<b>Lindab> B. Buck, Ph.D., (born January 29, 1947) is an American biologist best known for her work on the olfactory system.
		Born in Seattle, Washington, Buck received her B.S. in psychology and microbiology in 1975 from the University of Washington, Seattle and her Ph.D. in immunology in 1980 from the University of Texas Southwestern Medical Center, Dallas.
		In their landmark paper published in 1991, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein-coupled receptors.
	en.wikipedia.org /wiki/Linda_B._Buck

	Harvard Medicine
		<b>Lindab> Buck, who since 2002 has been a full member at the Fred Hutchinson Cancer Research Center, joined the faculty of Harvard Medical School in 1991 as an assistant professor of neurobiology located in the Department of Neurobiology at the Quad.
		Buck essentially created the field of molecular mechanisms of olfactory sensory transduction in 1991, when she was a postdoctoral fellow in the laboratory of Richard Axel at Columbia, and she has been instrumental in its evolution thereafter.
		Perhaps the clearest assessment of Dr. Buck's impact is that it is impossible to imagine a course in neuroscience or a textbook of neuroscience that does not incorporate her work on olfactory receptor genes, their expression patterns, the corresponding innervation patterns of the primary sensory cells, and the odorant specificities of the receptor proteins.
	www.hms.harvard.edu /news/shatz_buck.html

	<b>Lindab> B. Buck, Ph.D.
		<b>Lindab> Buck studies exactly how odor molecules in the environment are detected by specialized receptors in the nose and then translated by the brain into specific smells.
		<b>Lindab> Buck's laboratory is studying how the olfactory system translates environmental chemicals into odor perceptions, instinctive behaviors, and emotional responses.
		Buck continues to be fascinated by the inner workings of the olfactory system, an enthusiasm she hopes to convey to the graduate students and postdoctoral fellows in her lab.
	www.geiscollection.com /research/investigators/buck_bio.html

	Buck elected to NAS
		<b>Lindab> Buck, affiliate professor of physiology and biophysics, is one of three UW faculty members elected to the National Academy of Sciences (NAS).
		Buck is the second member of the UW Department of Physiology and Biophysics to be elected to the NAS; professor Bertil Hille was elected in 1986.
		Buck, a neurobiologist, is an investigator for the Howard Hughes Medical Institute and is based at Basic Sciences Division of the Fred Hutchinson Cancer Research Center.
	depts.washington.edu /mednews/vol7/no18/buck.html

	The Seattle Times: Local News: Hutch scientist unlocked secret to sense of smell
		Curiosity and a propensity for becoming intrigued with thorny questions paid off for Dr. <b>Lindab> Buck, informed yesterday at 2:30 in the morning that she had won the Nobel Prize in physiology or medicine for her research on the sense of smell.
		Buck said her lab and Axel's lab, working independently, made a discovery: When information about a smell goes from receptors in the nose to the olfactory bulb in the brain, and then to the olfactory cortex in the brain, there is a different organization or "map" at each level.
		Buck, who recalled a period "filled with angst" in her 20s as she tried to figure out what to do with her life, said she feels extremely lucky to be a scientist.
	seattletimes.nwsource.com /html/localnews/2002054234_nobel05m.html

	Health Sciences/UW Medicine NCR
		Buck is extending her studies to explore the role of smell in emotions, appetites, and behaviors, such as eating, mating, and mothering.
		Buck later demonstrated that odors are recognized by specific combinations of receptors, much the way that a set of numbers forms a combination that unlocks a safe.
		Buck is the seventh woman to earn the Nobel Prize in physiology or medicine since its creation, and one of 34 female Laureates in any of the Nobel Prize fields.
	depts.washington.edu /hsnews/news/news2004/10_04_04.html

	<b>Lindab> Buck Perl Award
		<b>Lindab> Buck, a member of the basic sciences division at the Fred Hutchinson Cancer Research Center, is co-recipient of the third annual Perl/University of North Carolina Neuroscience Prize.
		Buck, who is also a UW affiliate professor of physiology and biophysics and investigator at the Howard Hughes Medical Institute (HHMI), and Richard Axel, professor at Columbia University and HHMI investigator, will receive the award for their discovery of the family of olfactory receptor proteins.
		Buck earlier discovered the genes containing the blueprints for olfactory receptors, work she began while a postdoctoral fellow in Axel's laboratory at Columbia.
	depts.washington.edu /mednews/vol7/no09/buck.html

	Researchers Sniff Out Secrets of Smell
		<b>Lindab> Buck discovered that sensors in the nose are like letters of the alphabet.
		Some years ago, <b>Lindab> Buck, now an associate professor of neurobiology at Harvard Medical School, discovered that mice have approximately 1,000 different sensors in their noses.
		Buck and her colleagues discovered that each receptor recognizes multiple odorants, and a single odorant can be recognized by multiple receptors.
	www.news.harvard.edu /gazette/1999/04.08/smell.html

	HHMI News: Search for Taste Receptors Yields Sweet Success
		<b>Lindab> Buck, an HHMI investigator at Harvard Medical School, and her colleagues Hiroaki Matsunami and Jean-Pierre Montmayeur published their findings in the April 6, 2000, issue of Nature.
		Buck and her colleagues narrowed their search for taste-related GPCRs to a region of a mouse chromosome that other scientists had found to be involved in the ability to taste a particular bitter substance.
		Among the many possible practical benefits, said Buck, might be the development of chemicals that block the bitter taste of medicines, which would considerably increase the likelihood that patients would maintain their drug regimens.
	www.practicingsafescience.org /news/buck2.html

	<b>Lindab> B. Buck - Wikipedia en espaÃ±ol
		<b>Lindab> B. Buck, mÃ©dico, (nacida el 19 de enero, 1947) es una cientÃfica estadounidense conocida por sus trabajos sobre sistema olfatorio.
	es.wikipedia.org /wiki/Linda_B._Buck

	<b>Lindab> B. Buck - Wikipedia
		<b>Lindab> Buck ist Teil der Arbeitsgruppe fÃ¼r medizinische Grundlagenforschung am Fred Hutchinson Cancer Research Center sowie Professorin fÃ¼r Physiologie und Biophysik am Howard Hughes Medical Institute (HHMI), zuvor hatte sie eine Professur an der Harvard Medical School inne.
		Die Forschung von <b>Lindab> Buck beschÃ¤ftigt sich mit der Frage, wie Reize an das Gehirn Ã¼bertragen werden.
		Durch unabhÃ¤ngige Studien konnten Axel und Buck nachweisen, dass jedes Neuron nur einen Rezeptortyp ansteuert und dass in der Riechschleimhaut die gleich aufgebauten Rezeptoren nach einem zufÃ¤lligen Muster verteilt sind, im Bulbus olfactorius jedoch alle in der gleichen Region wahrgenommen werden.
	de.wikipedia.org /wiki/Linda_B._Buck

	<b>Lindab> Lowery and her Buck
		<b>Lindab>, (who began hunting only 2 ½ years ago) brought her beautiful buck in at the end of the day on November 27th, 1998.
		<b>Lindab>'s "big bodied 6 pointer" turned out to be the best buck of the week!
		<b>Lindab> says, "I give them a name a say a prayer before pulling the trigger." Her first deer was Andy, second was Beatrice, third was Cecille, and the list went on.
	www.tomboy-womenoutdoors.com /stories/linda_lowery.html

	NIH Record-2-09-99--Buck To Give Director's Lecture
		Dr. <b>Lindab> Buck, recognized for her pioneering work on the molecular basis of odor perception, will present the NIH Director's Lecture on Wednesday, Feb. 17, at 3 p.m.
		Buck received B.S. degrees in microbiology and psychology from the University of Washington, a Ph.D. in immunology from the University of Texas Southwestern Medical Center in Dallas, and did postdoctoral research at Columbia University.
		Buck has also served as a member of both the programs advisory committee and the integrated planning and policy working group of the National Institute on Deafness and Other Communication Disorders.
	www.nih.gov /news/NIH-Record/02_09_99/story04.htm

	Scientist at Fred Hutch wins Nobel
		<b>Lindab> Buck listens as Mark Groudine, the head of her division, explains how he learned, and passed along, the news she had won the Nobel Prize.
		Buck and Axel mapped how the signal travels from individual receptors on millions of nerve cells in the nose to various regions of the brain, allowing people to tell the difference between the smell of fresh-cut grass, say, and that of putrefying garbage.
		Buck and Axel discovered the more than 350 genes that encode as many olfactory receptors, which in turn is what gives humans the ability to discriminate between up to 100,000 odors.
	seattlepi.nwsource.com /local/193773_nobel05.html

	Olfaction - Wikipedia, the free encyclopedia
		As discovered by <b>Lindab> B. Buck and Richard Axel, mammals generally have about 1000 genes for odor receptors.
		In vertebrates smells are sensed by the olfactory epithelium located in the nose and processed by the olfactory system.
	en.wikipedia.org /wiki/Olfaction

	Spotlight: How we smell
		Buck and Axel showed that each olfactory receptor cell expresses a single odorant receptor protein and so there has to be as many types of olfactory receptor cell as there are odorant receptors.
		Axel and Buck discovered on explanation for our olfactory prowess - a large gene family, comprised of some 1,000 different genes that give rise to an equivalent number of olfactory receptor types and published their seminal paper in 1991.
		However, most odours are not produced by single molecules but by a combination of different chemicals, so that "odorant pattern", a mosaic of smell rather than colour is sensed.
	www.psigate.ac.uk /spotlight/issue19b/medicine.html

	Neuroscience for Kids -Smelly Research Equals Nobel Prize
		<b>Lindab> Buck is the 11th woman to receive a Nobel Prize in sciences in the 103 years the prizes have been awarded.
		<b>Lindab> Buck, PhD, a professor at the Fred Hutchinson Cancer Research Center (Seattle, WA) each received a wake-up call on October 4, 2004.
		Buck is expanding her research on odorant receptors to other types of receptors, such as those involved in bitter tastes, sweet tastes and pheromones.
	faculty.washington.edu /chudler/nobel04.html

	Harvard Gazette: Radcliffe conference looks at biological systems
		Conference topics included a detailed explanation of the sense of smell from <b>Lindab> Buck, associate director of the Division of Basic Sciences at the Fred Hutchinson Cancer Research Center and affiliate professor at the University of Washington.
		Buck, who, with Richard Axel, won the Nobel Prize in Physiology or Medicine last year, provided a broad overview of her work on the sense of smell.
		Buck said the sense of smell is critically important in nature.
	www.news.harvard.edu /gazette/2005/05.12/11-biodesign.html

	Science Outreach Program
		<b>Lindab> Buck, and Richard Axel, are HHMI Investigators, members of the National Academy of Sciences, and shared the 2003 Perl/University of North Carolina Neuroscience Prize for their 1991 discovery of the family of olfactory receptor proteins.
		In an article on the Howard Hughes Medical Institute web site, Dr. <b>Lindab> Buck describes her lab's discovery of a precise sensory map in the olfactory cortex.
		Leslie Vosshall begins her presentation of the Buck and Axel paper with an introduction to the sense of smell.
	www.rockefeller.edu /outreach/buck.php

	EMF News: Nobel Prize Awarded to <b>Lindab> Buck
		<b>Lindab> B. Buck of the Fred Hutchinson Cancer Research Center will share the 2004 Nobel Prize in Medicine with Richard Axel of the Howard Hughes Medical Institute.
		Buck is in her final year as an Ellison Medical Foundation Senior Scholar in Aging and has been doing research to screen large chemical libraries for compounds that extend lifespan in C.
		Their independent work on the basic biology of the sense of smell led to identification of genes responsible for specific odor receptor proteins and the pathways of olfactory messages between the nose and the brain.
	www.ellisonfoundation.org /news_detail.jsp?id=67

	<b>Lindab> Buck
		Following graduate training at UT Southwestern, she joined Nobel Prize co-recipient Richard Axel's lab at Columbia University for postdoctoral work and later became Professor of Neurobiology at Harvard Medical School.
	www.washington.edu /research/atuw/buck.html

	Profile
		Buck LB,The molecular architecture of odor and pheromone sensing in mammals.
		Berghard A, Buck LB,Sensory transduction in vomeronasal neurons: evidence for G alpha o, G alpha i2, and adenylyl cyclase II as major components of a pheromone signaling cascade.
		Weber DA, Buck LB, Delohery TM, Agostino N, Pernis B,Class II MHC molecules are spontaneously internalized in acidic endosomes by activated B cells.
	myprofile.cos.com /lbuck

	Center News - 10/7/04 - <b>Lindab> Buck ‘surprised, overjoyed’ to win 2004 Nobel Prize
		Buck and Axel, independent of each other, discovered that pheromones are detected by two other families of G-protein coupled receptors localized to a different part of the nasal lining.
		“<b>Lindab>’s work is of fundamental importance to the understanding of the mechanisms that control the relay of sensory signals from the receptor to the central nervous system,” he said.
		Groudine also noted that the understanding of odor and taste perception, a field in which Buck also has made major contributions, could ultimately provide relief for patients undergoing chemotherapy who are unable to take bitter medications or whose sense of taste and smell are impaired by the potent drugs.
	www.fhcrc.org /pubs/center_news/2004/oct7/sart1.html?&

	Seattle, New York Researchers to Receive Neuroscience Prize -- MEDICA Portal
		<b>Lindab> Buck is a member of the basic sciences division at the Fred Hutchinson Cancer Research Center in Seattle and affiliate professor at the University of Washington.
		<b>Lindab> Buck and Richard Axel co-recipients of the third annual Perl-UNC Neuroscience Prize.
		Axel and Buck in recognition of their discovery of the family of olfactory receptor proteins.
	www.medica.de /cipp/md_medica/custom/pub/content,lang,2/ticket,g_a_s_t/oid,9189

	Blogger: Email Post to a Friend
		Any way, I thought of <b>Lindab> Buck this morning while writing news when the reports came out of Stockholm that the Nobel Prize for medicine had been awarded.
		I have no idea what <b>Lindab> Buck looked like then, much less now.
		She's ten years my senior and although <b>Lindab> under the stairs did seem a bit more practiced than I was in areas of ardor, I'm certain she wasn't a 23 year old seventh grader who went on to win one of the most prestigious prizes in science.
	www.blogger.com /email-post.g?blogID=5070612&postID=109693306678409198

	Tech Notes - New York SCC
		<b>Lindab> Buck moved on to Harvard and the Howard Hughes Medical Center and has made numerous contributions to the field, such as the proof of the combinatory nature of the reception process.
		Buck, <b>Lindab> and Axel, Richard, A Novel Multigene Family May Encode Odorant Receptors: A Molecular Basis for Odor Recognition, Cell, Vol.
		Richard Axel and <b>Lindab> Buck revolutionized the study of olfaction by finding the odor receptor gene family2.
	www.nyscc.org /news/archive/tech1004.htm

	USATODAY.com - Pair probing mystery of smell split Nobel Prize
		Richard Axel, 58, of the Howard Hughes Medical Institute at Columbia University in New York and <b>Lindab> Buck, 57, of the Fred Hutchinson Cancer Research Center in Seattle, split the $1.36 million prize for their "pioneering" solution to the neurochemical riddle of how people discern individual odors.
		In their subsequent, separate research, Buck and Axel showed how the nasal cells are organized and how the brain weaves individual signals from these cells into patterns that we recognize as distinct odors.
		Buck compared the system to the alphabet, in which 26 letters can combine to form countless words.
	www.usatoday.com /news/nation/2004-10-04-nobel-prize_x.htm?POE=NEWISVA

	People's Daily Online -- <b>Lindab> B. Buck, the only female Nobel laureate
		American scientist and Nobel Prize laureate <b>Lindab> B. Buck poses in front of the statue of Alfred Bernhard Nobel at Karolinska Institute in Stockholm, capital of Sweden, Dec. 7, 2004.
		American scientist and Nobel Prize laureate <b>Lindab> B. Buck smells flowers to explain her work at a news conference at Karolinska Institute in Stockholm, capital of Sweden, Dec. 7, 2004.
		American scientist and Nobel Prize laureate <b>Lindab> B. Buck attends a news conference at Karolinska Institute in Stockholm, capital of Sweden, Dec. 7, 2004.
	english.peopledaily.com.cn /200412/10/print20041210_166839.html

	The Gairdner Foundation Awards
		<b>Lindab> Buck is a Fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences.
		<b>Lindab> Buck received her undergraduate degree from the University of Washington, Seattle, and her Ph.D. degree from the University of Texas Southwestern Medical Center at Dallas.
		<b>Lindab> Buck's honors include the Lewis S. Rosenstiel Award for distinguished work in basic medical research, the Louis Vuitton–Moet Hennessy Science for Art Prize, the R. Wright Award in olfactory research, the Unilever Science Award.
	www.gairdner.org /03winner.html

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