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Topic: Lipidomics

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	Kansas Lipidomics Research Center
		Kansas lipid researchers have established the Kansas Lipidomics Research Center (KLRC) at Kansas State University with funding from Kansas NSF EPSCoR and KTEC.
		Lipidomics Research Center scientists include Ruth Welti, the Director of the KLRC and its Analytical Laboratory, Jyoti Shah, Susan Sun, and David Rintoul of Kansas State University, Rick Dobrowsky, and Steve LeVine of the University of Kansas, and Todd Williams, Director of the University of Kansas Mass Spectrometry Laboratory.
		Lipidomics is the branch of metabolomics in which non-water-soluble metabolites are studied.
	www.ksu.edu /lipid/lipidomics (219 words)

	Xianlin Han Abstract (Site not responding. Last check: 2007-11-06)
		Lipidomics is a rapidly expanding research field that uses analytical chemistry to investigate the biological function, significance, and sequelae of alterations in lipids and protein constituents mediating lipid metabolism, trafficking, or biological function in cells.
		By employing ESI intrasource separation techniques (i.e., shotgun lipidomics) that we have developed, individual molecular species of most major and many minor lipid classes can be fingerprinted and quantitated directly from biological lipid extracts without the need for chromatographic purification.
		The application of shotgun lipidomics to biomarker discovery in Alzheimer’s disease (AD) (i.e., the specific depletion of sulfatide mass content in brain tissues and cerebrospinal fluid at the earliest clinically recognizable stage of AD) will be presented.
	bigdaddy.scripps.edu /darlene/Asilomar/pages/abstracts/xhan.htm (170 words)

	Lipidomics - Wikipedia, the free encyclopedia
		Lipidomics is the large-scale study of non-water-soluble metabolites ( lipids).
		Key technologies used in lipidomics research include electrospray ionization mass spectrometry and liquid chromatography mass spectrometry.
		Lipidomics Core Facility at Medical University of South Carolina
	en.wikipedia.org /wiki/Lipidomics (74 words)

	New science at K-State attracts $4.2 million from National Science Foundation
		A subcontract of $1.2 million establishes the Kansas Lipidomics Research Center, one of a handful of centers for the study of lipids.
		Lipidomics is part of that larger area of study.
		Lipidomics researchers at K-State are working to identify lipids that regulate plant responses to pathogens and environmental stress and to identify plant genes involved in generating lipid regulators.
	www.eurekalert.org /pub_releases/2003-07/ksu-nsa070903.php (1812 words)

	Lipidomics
		Key technologies used in lipidomics research include mass spectrometry and gas chromatography-mass spectrometry.
		Kansas Lipidomics Research Center at Kansas State University, Manhattan
		Lipidomics Research Center Graz at University of Graz, Austria
	pedia.newsfilter.co.uk /wikipedia/l/li/lipidomics.html (193 words)

	Lipidomics Core Facility (Site not responding. Last check: 2007-11-06)
		The Lipidomics Core Facility builds on unique expertise at MUSC in sphingolipid biology, chemistry and analysis and their role in signal transduction and cell regulation.
		The Lipidomics Analytical Subcore performs qualitative (compound identification) and quantitative analysis at the basal levels as well as in response to chemotherapeutic agents.
		The Lipidomics Synthetic Subcore provides homogenic synthetic sphingolipids and their analogs for use in cellular, in vitro and in vivo studies in cancer research.
	hcc.musc.edu /research/shared_resources/lipidomics.cfm (409 words)

	Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics -- ...
		By employing shotgun lipidomics based on the separation of lipid classes in the electrospray ion source (intrasource separation) and 2D mass spectrometry (MS) techniques (Mass Spectrom.
		Herein, we extended shotgun lipidomics to the characterization and quantitation of cerebroside molecular species in biological samples.
		This method was demonstrated to have over a 1000-fold linear dynamic range in the low concentration region, and therefore, it should have a wide range of applications in studies on the cellular sphingolipid lipidome.
	www.jlr.org /cgi/content/short/D400022-JLR200v1 (347 words)

	Counting fats: new consortium to map cellular lipids
		Brown is leading one of six national “lipidomics” centers, the consortium sites that will sift through and identify all of the lipids in the cell.
		Phospholipids are the focus of Brown’s lipidomics center; they are especially important to cell signaling and account for a large portion of the cell’s lipid pool.
		Another aspect of lipidomics that excites Brown is the idea of using “lipid profiles” as a way to further refine the molecular understanding of disease.
	www.mc.vanderbilt.edu /reporter?ID=2889 (1373 words)

	Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a ...
		Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics -- Han and Gross 44 (6): 1071 -- Journal of Lipid Research
		Lipidomics is a rapidly expanding research field in which multiple
		of the lipidome in diabetic myocardium ( 20).
	www.jlr.org /cgi/content/full/44/6/1071?maxtoshow=&HITS=20&hits=20&RESULTFORMAT=&searchid=1090294003144_2491&stored_search=&FIRSTINDEX=0&tocsectionid=Thematic+Reviews*&displaysectionid=Thematic+Reviews&journalcode=jlr (4883 words)

	Charleston, SC Business Information - News Article
		And therein lies the interest shown by the National Institutes of Health to award Obeid and Hannun—and MUSC—a Center of Biological Research Excellence (COBRE) grant, a five-year renewable affirmation to explore the roles of lipids in cell growth, cell death, cell aging, inflammation and infectious diseases.
		The grant will allow the center to support the lipidomics research of junior faculty members as they are mentored by senior investigators and eventually "graduate" and themselves mentor new recruits to the program.
		Also within the center will be three research cores: The lipidomics core to measure and synthesize lipids, an animal pathobiology core to develop specific animal models of disease, and a protein science core to allow people to work on the proteins that work on the lipids.
	www.crda.org /news_article.shtml?id=227 (969 words)

	Lipid Signaling/Lipidomics Group
		University of Kansas, researchers from the Lipid Signaling/Lipidomics Group have established the
		Kansas Lipidomics Research Center at Kansas State University.
		Copyright 2005 @ Kansas Lipidomics Research Center, Kansas State University.
	www.ksu.edu /lipid (130 words)

	Network 'Life Science Bavaria'
		The LipoFIT® lipidomics and metabolomics platform which is used by LipoFIT Analytic GmbH offers new cutting-edge analytical methods for the diagnostic application of biomolecular NMR spectroscopy in medicine and food chemistry.
		The examination of the fat- and cholesterol-containing particle distribution in human blood sera is in close co-operation with the Medical Center at the University of Regensburg.
		Exclusive patent rights of the LipoFIT® lipidomics and metabolomics platform for the analysis of the complete lipoprotein distribution in human blood sera are in the ownership of LipoFIT Analytic GmbH.
	www.lifescience.de /portal/life_profile_detail,11358,,46629,detail.html (325 words)

	Boilerplate: Other Specialized Research Resources
		Examples of this are atomic force microscopy, which will interface with lipidomics, proteomics, viral vector and gene function facilities, and FRET-microscopy (Fluorescence Resonant Energy Transfer) for the screening of protein:protein interactions.
		Lipidomics Core Facility (Hollings Cancer Center; Biochemistry and Molecular Biology) (rev 12/03)
		The Lipidomics Core Facility provides expertise, analysis and synthetic molecular tools to examine the role of sphingolipids in cancer and other diseases and disorders.
	research.musc.edu /bp/osrr.html (5585 words)

	Brian Cummings (Site not responding. Last check: 2007-11-06)
		Brian Cumming's research uses a lipidomics approach to understand the role of fatty acid metabolizing in the regulation of cancer cell growth and death.
		Lipidomics aims at understanding how differences in lipids, and lipid metabolizing enzyme, can be used to kill cancer cells or protect normal cells.
		Specifically, Dr. Cummings' research aims at understanding the functional implications that a group of proteins call phospholipase A2s have on the ability of normal and cancer cells to grow and die.
	www.biomed.uga.edu /mem_cummings_brian.htm (258 words)

	SNOTE \| A \| Ancillary studies to evaluate pathogenesis, genetic factors, proteomics, metabolomics, lipidomics, imaging ...
		Ancillary studies to evaluate pathogenesis, genetic factors, proteomics, metabolomics, lipidomics, imaging studies and determinates of progression and severity of NASH, NAFLD or crytogenic cirrhosis.
		Ancillary studies to evaluate the natural history, pathogenesis, genetic factors, proteomics, metabolomics, lipidomics, imaging studies, and determinants of progression and severity of nonalcoholic fatty liver disease present a variety of opportunities for CRADAs.
		(4) Develop serum/plasma proteomic, metabolomic, and lipidomic expression arrays that are diagnostic of fatty liver disease or NASH or cryptogenic cirrhosis and that would provide staging and grading of the degree of cell injury, steatosis and fibrosis in the liver as well as insights into the pathogenesis of this disease.
	www.fbodaily.com /archive/2005/04-April/01-Apr-2005/FBO-00778467.htm (1448 words)

	[No title] (Site not responding. Last check: 2007-11-06)
		Das Gründerprojekt Lipidomics Heidelberg hat ein hochempfindliches Verfahren zur Erstellung von Lipidprofilen entwickelt.
		Lipidomics Heidelberg forscht in Zusammenarbeit mit dem Universitätsklinikum Heidelberg an der Identifizierung weiterer medizinisch-diagnostischer Marker und entwickelt das Verfahren für den Einsatz im High Troughput Screening weiter.
		Die von Lipidomics entwickelten Messtechniken ermöglichen die Identifizierung von einzelnen Lipidklassen, ohne dass eine Vortrennung erforderlich ist.
	www.gruenderverbund.info /website/gruender/gruendungen/lipidomics (196 words)

	Faculty Profile: Youping Deng (Site not responding. Last check: 2007-11-06)
		My current and future research is focused on developing new tools for high throughput data analysis, comparative genomics, designing biology databases, and studying new targeting molecules and their cellular signal transduction pathways for fighting cancer and diabetes.
		In the 21st century, biology has become the land of the “-omics” including genomics, transcriptomics, proteomics, lipidomics, metabolomics, etc. Each of these “-omics” generates a huge amount of high throughput data.
		The online lipidomics information management system is to systematically track, disseminate and mine lipidomics experimental data.
	www.biology.usm.edu /Faculty_Profile_Youping_Deng.htm (687 words)

	International Cannabinoid Research Society \| 2004 Symposium Satellite
		Targeted Lipidomics: Lipid signaling molecules, endogenous lipid modulators (endolipids) and drugs of abuse.
		June 22, 2004, 8:00 AM to 5:00 PM Workshop Organization: This is a one day workshop and is intended as a brainstorming session to discuss the emerging technologies, especially the impact of "lipidomics" and new lipid signaling molecules, on drug abuse research.
		metabolites (the "lipidome") in complex tissue extracts are needed.
	www.cannabinoidsociety.org /SYMPOSIUM.2004/2004.SYMP.SATELLITE.html (453 words)

	Lipidomics - free-definition (Site not responding. Last check: 2007-11-06)
		Kansas Lipidomics Research Center ( http://www.ksu.edu/lipid/lipidomics) at Kansas State University, Manhattan
		Lipidomics Research Center Graz ( http://lipidomics.uni-graz.at) at University of Graz, Austria
		Lipidomics Core Facility ( http://hcc.musc.edu/research/shared_resources/lipidomics.cfm) at Medical University of South Carolina
	www.free-definition.com /Lipidomics.html (232 words)

	WP3 Applications of Lipidomics
		This workshop with the preliminary title "Diseases related to the lipidome" (roughly 35-45 participants) will be organized in Hungary by Pam Fredman (P6), Gerd Utermann (P14), and Balázs Sarkadi (P11) as the local organizer.
		Potentially, this workshop will be organized as a satellite to the 2006 ICBL meeting in Pécs, Hungary, in which case the number of participants may be higher.
		Whereas the scientists attending the general meeting will be exposed to industry at the poster sessions and during a special session, industry has specific interests in Metabolomics and Lipidomics that are better discussed in a dedicated setting.
	www.bijvoet-center.nl /elife/proposal/workplan/workpackage-descriptions/wp3 (715 words)

	WP2 Lipidomics Expertise Platform
		The results of the workshop will be translated into a paper critically evaluating technology development and the role of lipidomics expertise platforms.
		The main objective is to bundle the European efforts and resources into a strong network that will allow themselves and others outside the forefront technology labs to profit from the combined expertise, both via the platform website and via future training possibilities after the end of the project that the platform needs to realize.
		With his great contacts in both the medical world and industry, Gerd Schmitz is in an optimal position to define the most promising technology for developing Lipidomics as a field in itself and as a routine for the clinical laboratory.
	www.bijvoet-center.nl /elife/proposal/workplan/workpackage-descriptions/wp2 (691 words)

	Lipidomics Encyclopedia Article, History, Biography @ Local Color Art (Site not responding. Last check: 2007-11-06)
		Lipidomics Encyclopedia Article, History, Biography @ Local Color Art
		Find the Best Sites For lipidomics With Starware - Starware search is an excellent resource for quality sites on lipidomics and much more!
		Find lipidomics - Your relevant result is a click away!
	www.karr.net /search/encyclopedia/Lipidomics (246 words)

	Outlook: Lipidomics Research
		In a matter of minutes, shotgun lipidomics can quantify and identify nearly all of the hundreds of lipids in a complex biological sample, even those present in minute amounts.
		“ With shotgun lipidomics we can compare the lipid profile of various tissues during the healthy state to that of the disease state with amazing accuracy,” says Richard W. Gross, MD, PhD, the division’s director and a professor of medicine, chemistry and of molecular biology and pharmacology.
		But the heart of shotgun lipidomics is a set of chemical techniques that ensure each lipid will appear on the instrument’s screen in a unique and predictable location, and this is where innovative thinking was needed.
	outlook.wustl.edu /spring2005/lipids.html (1318 words)

	NIDA - Publications - NIDA Notes - Vol. 19, No. 5 - Research News
		At the Washington conference, Dr. Edward Dennis of the University of California-San Diego provided an overview of lipid researchers' major investigative resource—a collaboration of more than 30 researchers at 18 universities known as the Lipid Metabolites and Pathways Strategy (MAPS) Consortium, funded by the National Institute of General Medical Sciences.
		"We plan to generate 'road maps' that will define how all the lipid components of a cell move through the complex lipidomic network, from biosynthesis to removal, including their important roles as secondary messengers," he explained.
		Lipid MAPS is divided into focus areas that concentrate on major groupings of lipids, informatics, cell biology, lipid detection and quantitation, and lipid synthesis.
	www.nida.nih.gov /NIDA_notes/NNvol19N5/NIDA.html (661 words)

	AfCS-Nature Signaling Gateway - about us - AfCS - AfCS laboratories
		The primary goal of the Alliance for Cellular Signaling (AfCS) Lipidomics Laboratory is to achieve comprehensive analysis of membrane lipid composition in response to cell surface receptor stimulation.
		Changes are identified in cellular glycerophospholipid (GPL) composition as a consequence of activating signaling pathways in the macrophage model cell line RAW 264.7.
		Begin the outlined perturbation studies for the larger ligand screen list (initially piloted for the FXM ligands), including the use of small molecule inhibitors and siRNAs to disrupt targeted nodes in the signaling pathways of interest.
	www.signaling-gateway.org /aboutus/LipidLab.html (597 words)

	UniversitätsSpital Zürich - IKC - Lipidomics
		The critical point in studying the in-vivo metabolism and the clinical impact of the different lipids is the need of one or several analytical methods, which enable the sensitive, specific determination of the different lipid classes in their unaltered state.
		The title, which has recently been given to the theme of studying lipids in their natural environment, is lipidomics.
		As yet only cholesterol and its distribution in different lipoproteins as well as triglycerides have been used as diagnostic and prognostic markers.
	www.ikc.usz.ch /german/LehreUndForschung/Research/Lipidomics (277 words)

	postdoctoral positions in Lipidomics and Proteomics
		Proteomics candidate will focus on the comparative analysis of orthologous protein complexes isolated from phylogenetically distant organisms, including organisms with yet unsequenced genomes, by mass spectrometry and bioinformatics.
		Lipidomics candidate will participate in molecular characterization of endogenous lipids by a new method of multiple precursor ion scanning on a quadrupole time-of-flight mass spectrometer.
		The "shotgun lipidomics" approach will be applied to study lipid rafts within an interdisciplinary SFB/TR program "Membrane Microdomains in Human Diseases".
	www.cyber-spy.com /jobs-groups/182-292.bionet.jobs.offered.html (369 words)

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