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Topic: Lipogenesis

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	Mechanisms of nutritional and hormonal regulation of lipogenesis
		Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting.
		Lipogenesis encompasses the processes of fatty acid synthesis and subsequent triglyceride synthesis, and takes place in both liver and adipose tissue (Figure 1).
		Lipogenesis entails a number of discrete steps, shown in the middle, which are controlled via allosteric interactions, by covalent modification and via changes in gene expression.
	www.nature.com /cgi-taf/DynaPage.taf?file=/embor/journal/v2/n4/full/embor440.html (0 words)

	Obese women convert carbohydrate to fat faster than lean women
		With the control diet, de novo lipogenesis was nearly twice the rate in the obese than in the lean subjects, regardless of the source of the carbohydrate.
		Although rates of de novo lipogenesis in the carbohydrate-enriched energy-balanced control diet were significantly greater in the obese than in the lean women, the absolute quantities of fat synthesized from carbohydrate via de novo lipogenesis during both phases of the study were relatively small.
		De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women.
	www.eurekalert.org /pub_releases/2001-11/ajoc-owc111601.php (519 words)

	Effect of Carbohydrate Overfeeding on Whole Body and Adipose Tissue Metabolism in Humans -- Minehira et al. 11 (9): ...
		lipogenesis in subcutaneous adipose tissue of healthy lean humans.
		de novo lipogenesis at the expense of glycogen synthesis.
		In contrast with hepatic de novo lipogenesis, the quantification
	www.obesityresearch.org /cgi/content/full/11/9/1096 (0 words)

	Guthormones Adipokines Neuropeptides and the cause of Obesity
		Lipogenesis which occurs in liver and adipose tissue involves fatty acid synthesis followed by triglyceride synthesis.
		Insulin is a strong inducer of lipogenesis through activation of lipogenic and glycolytic enzymes, as well as by facilitating glucose entry into the adipose tissues by recruiting glucose transporters to the plasma membrane.
		PUFA (polyunsaturated fatty acids) decrease lipogenesis by suppressing gene expression of fatty acid synthase, and stearoyl-Coa desaturase in the liver.
	www.adipocyte.co.uk /Lipogenesis.htm (599 words)

	Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat -- Lee et al. 279 (2): E425 -- AJP - Endocrinology ...
		The rate of lipogenesis relative to the influx of unlabeled fatty acid is given by the FNS to the fraction of unlabeled molecules
		The rate of lipogenesis relative to the influx of unlabeled fatty acid is given by the FNS of unlabeled molecules or FNS/(1
		Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes.
	ajpendo.physiology.org /cgi/content/full/279/2/E425 (5073 words)

	Myriceline — the patented herbal extract to prevent and remove cellulite.
		Lipogenesis is a process that is aimed at storing energy, in the form of TG, into the adipocyte.
		The later stimulates the translocation of transporter GLUT-4 from intracellular vesicles, where it is stored, to the cell membrane surface, thus increasing glucose intake (due to the lack of glycerol kinase into the adipocytes, glucose intake is essential for the synthesis of triglycerides).
		Inhibiting lipogenesis (decreasing the rate of fatty acid and triglyceride synthesis, consequently reducing the formation of new fat).
	www.ageless.co.za /myriceline.htm (2318 words)

	Nutrition Journal \| Full text \| Consumption of resistant starch decreases postprandial lipogenesis in white adipose ...
		Estimation of total lipogenesis and glycogenesis was conducted as previously described [4].
		Over the 2 h postprandial period, there was approximately a 30% reduction in the amount of lipogenesis, exclusively in white adipose tissue, in response to a RS diet relative to a DS diet.
		Decreased lipogenesis selectively in WAT and a reduction in adipocyte cell size in response to RS feeding have broad implications for the treatment and prevention of obesity.
	www.nutritionj.com /content/5/1/25 (0 words)

	Doctoral research pr Effects of increased lipogenesis on the behaviour of epithel ...
		Doctoral research pr Effects of increased lipogenesis on the behaviour of epithel...
		Effects of increased lipogenesis on the behaviour of epithelial tumour cells.
		In this project we study the role of increased lipogenesis in cancer cell biology and explore the underlying molecular mechanism.
	www.kuleuven.ac.be /research/researchdatabase/project/3M03/3M030174.htm (60 words)

	Aberrant Hepatic Expression of PPAR{gamma}2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin ...
		Hepatic TG mass and de novo lipogenesis are increased in apoB/BATless mice.
		SREBP1-c and LXR in the increased lipogenesis observed in apoB/BATless
		SREBP-1c, in the regulation of hepatic lipogenesis (8).
	www.jbc.org /cgi/content/full/281/49/37603 (0 words)

	Increased Lipogenesis in Human Tumors
		The present thesis forms an integral part of the efforts to understand the molecular mechanisms and the biological and clinical significance of increased lipogenesis in tumor cells.
		In part I, it is explored whether the PI3-kinase/Akt pathway, a signal transduction cascade which is frequently dysregulated and constitutively activated in cancer cells, may contribute to increased lipogenesis.
		In part II, the authors have tried to gain more insight into the functional significance of tumor-associated lipogenesis by unraveling the nature and fate of newly synthesized lipids in cancer cells.
	www.coronetbooks.com /books/i/incr438x.htm (0 words)

	Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity -- Diraison ...
		The fractional contributions of cholesterol synthesis and hepatic lipogenesis to plasma free cholesterol and to plasma TG pools, respectively, were calculated from the deuterium enrichments
		Hepatic lipogenesis and cholesterol synthesis in the control group (C, n = 10) and in obese subjects before (OB, n = 8) and during (OBr, n = 4) caloric restriction.
		The increase in hepatic lipogenesis agrees with previous reports (13).
	ajpendo.physiology.org /cgi/content/full/282/1/E46 (4731 words)

	Inhibition of lipogenesis (Site not responding. Last check: )
		Lipogenesis in mammals is inhibited by benzofurancarboxylic acids substituted on the aromatic ring by one of certain moieties, and the 2,3-dihydro counterparts thereof.
		The data obtained from the tests are set out in Table 1,as the percent inhibition of lipogenesis compared to the results obtained in the control tests wherein only the test compound was omitted.
		However, in general, satisfactory results are obtained when the acids are administered in a dosage of from about 1 to about 400 milligrams per kilogram of the animal's body weight.
	www.sacnewsmonthly.com /invent/filter/inhibition_lipogenesis.html (2998 words)

	Nutrition & Metabolism \| Full text \| Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen ...
		Dietary medium-chain triglycerides (MCT) inhibit body fat mass growth in both animals and human [1-10] Early studies suggest that this effect might be caused by rapid absorption of MCT-derived MCFA and their β-oxidation in the liver, which reduces the circulating fatty acids available to the adipocytes [11].
		This is correlated with inhibition of lipogenesis and reduction of lipogenic gene expression.
		Compared to the pharmaceutical inhibitors of lipogenesis [68,69], the effects of octanoate can be considered as moderate and yet might be more desirable for physiological regulation of body fat mass without adversely affecting normal fat tissue functions.
	www.nutritionandmetabolism.com /content/3/1/30 (5165 words)

	Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans -- Diraison et al. 44 ...
		the ACC isoform implicated in lipogenesis, and sterol-regulatory
		Parks, E. Dietary carbohydrate's effect on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations.
		Hepatic lipogenesis and cholesterol synthesis in hyperthyroid patients.
	www.jlr.org /cgi/content/full/44/4/846 (4927 words)

	Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes -- Kamel et al. 89 (9): 4601 -- Journal of Clinical ...
		Glucose incorporation into lipids in the absence (basal lipogenesis), presence of maximum effective concentration of insulin with basal lipogenesis subtracted (insulin-induced lipogenesis), and total lipogenesis (basal + insulin-induced lipogenesis) are shown.
		B, Concentration of insulin resulting in EC of lipogenesis in adipocytes from 10 infants, 10 children, and nine adults.
		Glucose incorporation into lipids in the absence (basal lipogenesis), presence of maximum effective concentration of insulin (insulin-induced lipogenesis), and total lipogenesis (basal + insulin-induced lipogenesis) are shown.
	jcem.endojournals.org /cgi/content/full/89/9/4601 (3956 words)

	Dissertations from Karolinska Institutet - Published by Karolinska Institutet Karolinska Institutet - ki.se
		Lipolysis and lipogenesis were studied in isolated adipocytes from humans and rats of various ages.
		However, I rate of basal lipogenesis was approximately three times higher in infants and children than adults, while insulin stimulated lipogenesis was two times higher in infants than in children and adults.
		The high rate of lipogenesis early in life is probably important factor for age-dependent expansion of the adipose tissue.
	diss.kib.ki.se /1999/91-628-3485-1 (410 words)

	Porcine leptin inhibits lipogenesis in porcine adipocytes -- Ramsay 81 (12): 3008 -- Journal of Animal Science
		Porcine leptin inhibits lipogenesis in porcine adipocytes -- Ramsay 81 (12): 3008 -- Journal of Animal Science
		of lipogenesis to this metabolic shift is unknown.
		Mersmann, H. The effect of insulin on porcine adipose tissue lipogenesis.
	jas.fass.org /cgi/content/full/81/12/3008 (5157 words)

	Dr. Uyeda , Dr. Kosaku Uyeda, Dr. Kosaku Uyeda (Site not responding. Last check: )
		The research aim of this laboratory is to elucidate biochemical mechanisms for regulation of carbohydrate metabolism and lipogenesis.
		We have recently purified and identified from liver a transcription factor which responds to high glucose by specifically binding to the carbohydrate responsive element of the liver pyruvate kinase gene and activates transcription.
		We are currently in search of a specific protein phosphatase(s) which catalyze the dephosphorylation reactions as well as glucose signaling compounds which turn on the protein phosphatases using a variety of techniques.
	www.utsouthwestern.edu /findfac/research/0,2357,17512,00.html (580 words)

	Thyroxine 5'-Deiodination Mediates Norepinephrine-Induced Lipogenesis in Dispersed Brown Adipocytes -- Bianco et al. ...
		NE dose-response curve of lipogenesis and ME and ACC activities of isolated brown adipocytes incubated for 12 h: effects of thyroid hormones.
		NE dose-response curve of lipogenesis and ME and ACC activities of isolated brown adipocytes incubated for 48 h: effects of thyroid hormones.
		Freake HC, Schwartz HL, Oppenheimer JH 1989 The regulation of lipogenesis by thyroid hormone and its contribution to thermogenesis.
	endo.endojournals.org /cgi/content/full/139/2/571 (5387 words)

	CiteULike: Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, ... (Site not responding. Last check: )
		CiteULike: Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets.
		Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets.
		Until recently, the importance of hepatic de novo lipogenesis (DNL) in contributing to hypertriglyceridemia was difficult to assess because of methodologic limitations.
	www.citeulike.org /user/kmcolo/article/1019989 (565 words)

	Hints of Western Medicine from Chinese Medicine -- Okuda 228 (10): 1250 -- Experimental Biology and Medicine
		Insulin is known to stimulate lipogenesis from glucose and inhibit
		Effect of adenosine on insulin-induced lipogenesis in rat fat cells.
		Effect of the fraction at tube No.40 on epinephrine-induced lipolysis and lipogenesis from glucose in fat cells.
	www.ebmonline.org /cgi/content/full/228/10/1250 (0 words)

	De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women -- McDevitt et al. 74 ...
		De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women -- McDevitt et al.
		for which de novo lipogenesis was greater in the obese subjects.
		De novo lipogenesis was 2- to 3-fold higher after overfeeding
	www.ajcn.org /cgi/content/abstract/74/6/737?ck=nck (0 words)

	Stimulation of cholesterol synthesis and hepatic lipogenesis in patients with severe malabsorption -- Cachefo et al. 44 ...
		Stimulation of cholesterol synthesis and hepatic lipogenesis in patients with severe malabsorption -- Cachefo et al.
		Fractional values for cholesterol synthesis (A) and hepatic lipogenesis (B) in control subjects (C) and in patients with severe intestinal malabsorption receiving (NP) or weaned (W) of parenteral nutrition.
		have a stimulation of cholesterol synthesis and hepatic lipogenesis.
	www.jlr.org /cgi/content/full/44/7/1349 (3396 words)

	Increased lipogenesis in isolated hepatocytes from cold-acclimated ducklings -- Bedu et al. 283 (5): 1245 -- AJP - ...
		Activity of key enzyme of lipogenesis was measured in liver homogenates from TN and CA ducklings (Fig.
		Lipogenesis was measured by the in vitro incorporation of [1-
		Stimulation of S14 mRNA and lipogenesis in brown fat by hypothyroidism, cold exposure, and cafeteria feeding: evidence supporting a general role for S14 in lipogenesis and lipogenesis in the maintenance of thermogenesis.
	ajpregu.physiology.org /cgi/content/full/283/5/R1245 (5482 words)

	National Dairy Council - Weight Control: An Emerging Beneficial Role for Dairy
		On the other hand, suppression of 1,25-dihydroxyvitamin D with high calcium diets is thought to reduce intracellular calcium in fat cells, thereby decreasing lipogenesis and increasing lipolysis, resulting in an anti- obesity effect (19,22).
		When these mice were fed a low calcium, high fat, high sucrose diet for six weeks, adipocyte lipogenesis increased, lipolysis decreased, and gain in body weight and adipose tissue accelerated (19).
		In contrast, the high calcium diet markedly inhibited lipogenesis, increased lipolysis, and suppressed fat accretion and weight gain (19).
	www.nationaldairycouncil.org /NationalDairyCouncil/Health/Digest/dcd73-4Page3.htm (1732 words)

	I LOUVEAU and F GONDRET: Hormonal regulation of lipogenesis in porcine adipocytes (Journal of Endocrinology)
		The present study aimed to determine whether the regulation of lipogenesis by GH and/or insulin in porcine adipocytes also involved SREBP-1.
		The increase was maximal at 1.7 and 17 nM in subcutaneous and perirenal adipocytes respectively, suggesting inter-depot differences in the regulation of lipogenesis by insulin.
		Taken together, these data indicate that the regulation of lipogenesis by insulin and GH appears to not involve change in SREBP-1 mRNA level in porcine adipocytes.
	journals.endocrinology.org /joe/181/joe1810271.htm (0 words)

	Effects of cortisol and progesterone on insulin binding and lipogenesis in adipocytes from normal and diabetic rats -- ...
		Effects of cortisol and progesterone on insulin binding and lipogenesis in adipocytes from normal and diabetic rats -- Mendes et al.
		Effects of cortisol and progesterone on insulin binding and lipogenesis in adipocytes from normal and diabetic rats
		Cortisol implants in normal and diabetic rats reduced body weight, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in isolated adipocytes, whilst insulin sensitivity was unchanged.
	joe.endocrinology-journals.org /cgi/content/abstract/106/2/225 (280 words)

	Organic Vanadium Chelators Potentiate Vanadium-Evoked Glucose Metabolism In Vitro and In Vivo: Establishing Criteria ...
		activated lipogenesis to the extent of 4, 5, 16, 30, and 47% of
		B and C, lipogenesis was performed with control adipocytes and 100 µM concentrations of the ligands.
		Figure 2A shows activation of lipogenesis in vanadium-enriched adipocytes exposed to 10 µM concentration of various ligands.
	molpharm.aspetjournals.org /cgi/content/full/58/4/738 (4505 words)

	Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men -- Timlin et al. 54 (9): 2694 ...
		stimulation of lipogenesis was not apparent (6, 8, 9).
		Commerford SR, Pagliassotti MJ, Melby CL, Wei Y, Hill JO: Inherent capacity for lipogenesis or dietary fat retention is not increased in obesity-prone rats.
		Cohn JS, Johnson EJ, Millar JS, Cohn SD, Milne RW, Marcel YL, Russell RM, Schafer EJ: Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters.
	diabetes.diabetesjournals.org /cgi/content/full/54/9/2694 (4909 words)

	Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes -- Kamel et al. 89 (9): 4601 -- Journal of Clinical ...
		Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes -- Kamel et al.
		Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes
		lipogenesis, and insulin sensitivity were two times higher in
	jcem.endojournals.org /cgi/content/abstract/89/9/4601 (328 words)

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