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Topic: Lipoic acid

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	Alpha-Lipoic Acid
		Lipoic acid shows evidence of being effective in the treatment of diabetic neuropathy and may be useful in treating some other aspects of diabetes.
		Lipoic acid is believed to work in this context, at least in part, through its antioxidant properties and its reported ability to increase cellular levels of glutathione that are typically depleted by the reactive oxygen species formation that characterizes ischemia-reperfusion.
		Claims that lipoic acid slows aging of the brain and is an anti-aging substance generally seem to be related to its potent antioxidant properties.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/alp_0159.shtml (2111 words)

	Lipoic acid - Wikipedia, the free encyclopedia
		Lipoate is a critical cofactor for aerobic metabolism, participating in transfer of acyl or methylamine groups in 2-Oxoacid dehydrogenase (2-OADH) and glycine cleavage complexes (GCV) respectively.
		Lipoate was first called pyruvate oxidation factor (POF) by Irwin C Gunsalus, the former chair of Biochemistry at the University of Illinois at Urbana-Champaign.
		Lipoic acid is a redox-active molecule (ΔE= -0.288) capable of thiol-disulfide exchange, giving it antioxidant activity.
	en.wikipedia.org /wiki/Lipoic_acid (1105 words)

	Alpha-Lipoic Acid
		Alpha-lipoic acid works together with other antioxidants such as vitamins C and E. It is important for growth, helps to prevent cell damage, and helps the body rid itself of harmful substances.
		There have been several case reports of use of alpha-lipoic acid in combination with silymarin (milk thistle) and selenium (a substance with liver-protecting and antioxidant properties) to help treat hepatitis C (a serious type of hepatitis contracted from blood and bodily fluids that does not have an adequate cure or treatment).
		Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.
	www.umm.edu /altmed/ConsSupplements/AlphaLipoicAcidcs.html (1232 words)

	OUR LIPOIC ACID
		Lipoic acid from Alpha Science is processed in such a way as to yield the active R- isomer only with a purity guaranteed to be higher than 99%.
		Lipoic acid and its reduced form, DHLA, appear in tissues in free form indicating that lipoic acid is activated metabolically to DHLA in vivo.
		Lipoic acid is taken up rapidly by the cell and reduced to DHLA, which in turn reduces cystine to cysteine and accelerates the biosynthesis of GSH (23).
	www.integranutrition.com /lipoic-acid-sheet.html (1209 words)

	Lipoic Acid, K5
		Treatment summary: Lipoic acid is a coenzyme present in the mitochondria of cells.
		Lipoic acid is special because it is the only antioxidant that is able to deactivate free radicals that are both fat-soluble and water-soluble.
		For example, lipoic acid protects the liver from damage caused by alcohol, shields the lungs from damage caused by smoke, and enhances glucose disposal in type II diabetes (and reduces associated neuropathy and cataracts).
	www.stanford.edu /group/hopes/treatmts/antiox/k5.html (534 words)

	Lipoic Acid
		Lipoic acid is also involved in alpha-ketoglutarate dehydrogenase, a key energy process in the Krebs' cycle.
		Lipoic acid protects against the effects of toxic metals in the liver, as long as it gets there first, and the amount of toxin is not overwhelming.
		Lipoic acid is also indicated for antioxidant or toxicity protection, including open-angle glaucoma, amanita mushroom poisoning, and diabetic neuropathy.
	www.nutrimart.com /Bulk/Description/lipoacid.htm (482 words)

	Lipoic Acid
		In 1974 Dr. Ivanov reported that Lipoic Acid reduced cholesterol in aortic tissue by 45 percent, raising oxygen uptake in the heart by 72 percent, 148 percent in the aorta and 128 percent in the liver.
		Lipoic Acid may be an important agent in that effort.
		I've found Lipoic Acid to be an exciting, unique metabolite that boosts and recharges energy levels, raises the body's defenses against a host of maladies and is protective against a collection of age related deteriorations.
	www.pipeline.com /~bakti/MuscleMaker/lipoic.html (5624 words)

	Alpha Lipoic Acid sale - diabetes - antioxidant : by Ray Sahelian, M.D. R-Lipoic
		Alpha lipoic acid, also known as lipoic acid is a powerful, natural antioxidant slowly becoming recognized as having some unique properties in the therapy and prevention of a broad range of diseases.
		Thus, 50 mg of R-Lipoic Acid is equivalent to 100 mg of synthetic lipoic acid.
		Intraperitoneal administration of lipoic acid to aged rats led to a duration-dependent reduction and elevation in lipofuscin and enzyme activity, respectively, in the cortex, cerebellum, striatum, hippocampus, and hypothalamus of the brain.
	www.raysahelian.com /lipoic.html (7885 words)

	Lipoic Acid
		A moderate correlation between the increase in blood alpha-lipoic acid concentration in patients with the liver diseases during the replacement therapy with alpha-lipoic acid drugs and a number of parameters of thrombelastogram was established.
		The features of the pharmacokinetics of preparations of alpha-lipoic acid (lipoic acid, thioctacide) as compared with their pharmacodynamic effects were studied in 125 patients with chronic diffuse diseases of the liver of viral and alcohol etiology.
		Enzymic synthesis of the iron-sulfur cluster of spinach ferredoxin.
	www.cfsn.com /lipoic.html (3256 words)

	LIPOIC ACID
		The anti-glycation capacity of lipoic acid combined with its capacity for hydrophobic binding enables lipoic acid to prevent glycosylation of albumin in the bloodstream.
		Lipoic acid is known to biochemists as being part of a prosthetic group (lipoamide) of the dihydrolipoamide acetyltransferase portion of the pyruvate dehydrogenase enzyme complex that converts pyruvate to Acetyl-CoA prior to entry into the citric acid cycle.
		Lipoic acid is also beneficial in reducing ischemic-reperfusion injury by direct action as well as by glutathione protection and xanthine oxidase inhibition [FREE RADICAL BIOLOGY and MEDICINE; Packer, L.; 19(2):227-250 (1995)].
	www.benbest.com /nutrceut/lipoic.html (859 words)

	R-Lipoic Acid from Advanced Orthomolecular Research: Introducing R(+) Lipoic Acid (Site not responding. Last check: 2007-09-10)
		If you're taking a conventional lipoic acid pill, then you need to know that the health-promoting, anti-aging benefits associated with this nutrient are only being delivered by half of your supplement.
		Lipoic acid is known as a powerful and versatile antioxidant.
		Lipoic acid is known for its ability to protect brain and nerve cells from free radicals and toxins.
	www.r-lipoic.com (1194 words)

	Alpha-Lipoic acid (Site not responding. Last check: 2007-09-10)
		Lipoic acid is an antioxidant found in certain foods, including red meat, spinach, broccoli, potatoes, yams, carrots, beets, and yeast (see Broccoli).
		Lipoic acid is an antioxidant that is promoted to protect the body against cancer and other diseases.
		In 1957, lipoic acid was isolated and characterized as a compound found in yeast extracts.
	www.alternativehealth.co.nz /cancer/vitamins/lipoicacid.htm (2731 words)

	Why Lipoic Acid Is Necessary (Site not responding. Last check: 2007-09-10)
		Although alpha-lipoic acid supplementation has been found to reduce measures of oxidative stress in animal models of diabetes, evidence that alpha-lipoic acid reduces oxidative stress in humans with diabetes is limited.
		The biosynthetic pathway for alpha-lipoic acid is not known, but it appears to be synthesized in the mitochondria from an 8-carbon fatty acid and elemental sulfur (5).
		Although alpha-lipoic acid is found in a wide variety of foods from plant and animal sources, quantitative information on the alpha-lipoic acid content of food is limited.
	www.youngagain.com /lipoic.html (2793 words)

	R-ALA (Alpha Lipoic Acid)
		R-Lipoic acid is the only form of lipoic acid that is proven to significantly increase your cellular and mitochondrial antioxidant activity for preventing mitochondrial decay.
		R-Lipoic acid is the only form of lipoic acid that is proven to improve memory, reduce brain damage, reverse cognitive dysfunction, and protect the brain from neuro degeneration associated with aging.
		R-Lipoic acid is the only form of lipoic acid that is been proven to significantly increase insulin sensitivity, enhance glucose transport, increase metabolic rate and reduce the gain in body fat from aging.
	zlabs.us /rala.html (3136 words)

	Le Magazine, February 2005 - Report: R-Dihydro-Lipoic Acid
		By 1988, alpha-lipoic acid had been revealed as a powerful biological antioxidant, exhibiting a potential to quench free radicals equal to that of coenzyme Q10 (CoQ10) and vitamins C and E. Researchers also discovered that alpha-lipoic acid is unique in being the only antioxidant known to work in both fat- and water-soluble tissues.
		To understand how alpha-lipoic acid and R-dihydro-lipoic acid work against various degenerative disorders, it is first necessary to understand how these compounds work in the bodyâ”specifically, how they interact chemically with other critical antioxidants such as glutathione and vitamins C and E to combat harmful reactive oxygen species.
		Alpha-lipoic acid has been shown to be particularly helpful for conditions arising from diabetes, and has been used in Europe for over 30 years for diabetic complications caused by overproduction of reactive oxygen species and nitrogen radicals.
	www.lef.org /magazine/mag2005/feb2005_report_lipoic_01.htm (2018 words)

	Alpha-Lipoic Acid
		Alpha-Lipoic Acid, also known as thioctic acid, is a natural anti-oxidant which has been used for years in Europe because of its ability to maintain or restore liver health.
		A second possible benefit of Alpha-Lipoic Acid would be its ability to raise glutathione (GSH) levels and to decrease concentrations of reactive oxidants.
		In one study of Alpha-Lipoic Acid the amount of iron in their blood was shown to decrease significantly.
	www.delano.com /ReferenceArticles/Alpha-Lipoic-Acid.html (554 words)

	Linus Pauling Institute at Oregon State University
		Alpha-lipoic acid (LA), also known as thioctic acid, is a naturally occurring compound that is synthesized in small amounts by humans.
		Alpna-lipoic acid (LA), also known as thioctic acid, is a naturally occurring compound that is synthesized in small amounts by plants and animals, including humans (1, 2).
		LA is synthesized de novo from an 8-carbon fatty acid (octanoic acid) in mitochondria, where protein-bound LA functions as an enzyme cofactor.
	lpi.oregonstate.edu /infocenter/othernuts/la (3868 words)

	Alpha Lipoic Acid - Enhance Energy & Cell Protection - Alpha Lipoic Acid (Site not responding. Last check: 2007-09-10)
		Alpha Lipoic Acid supports the citric acid cycle, otherwise known as the Krebs cycle, the most fundamental energy producing action in the human body.
		Alpha Lipoic Acid supports production of ATP (the body's cellular energy) by acting as a catalyst in producing acetyl-coenzyme A. Secondly, Alpha Lipoic Acid's role as an antioxidant is important.
		Alpha Lipoic Acid is one of the most important, yet least known nutrients in the antioxidant family.
	www.immunesupport.com /alpha_lipoic_acid.htm (184 words)

	ALPHA LIPOIC ACID (ALA)
		Acting as a potent antioxidant, DHLA was found to protect rat pancreatic islet cells from destruction by reactive oxygen species.10 In vitro, lipoic acid was found to stimulate glucose uptake by muscle cells in a manner similar to insulin.
		Moreover, a decrease in the activity of plasma glutathione peroxidase observed in the glucose-fed rats was prevented by lipoic acid treatment.
		In this prospective, open and non-randomized study, the effect of alpha-lipoic acid on the progression of endothelial cell damage and the course of diabetic nephropathy, as assessed by measurement of plasma thrombomodulin and urinary albumin concentration (UAC), was evaluated in 84 patients with diabetes mellitus over 18 months.
	www.chiro.org /nutrition/Alpha_Lipoic_Acid.shtml (1899 words)

	Alpha Lipoic Acid Guaranteed Potent & Pure! (Site not responding. Last check: 2007-09-10)
		Primarily because of these advantages and its usefulness as a broad-spectrum cellular protector, alpha lipoic acid is emerging as the premier anti-aging antioxidant.
		As we age, mitochondrial function is impaired, and this impairment is theorized to cause the adverse effects of aging.
		Alpha lipoic acid is a powerful antioxidant on its own and works closely with vitamin C, E and other antioxidants, "recycling" them and making them much more available.
	www.vaxa.com /Alpha_Lipoic_Acid.cfm (536 words)

	Amazon.com: Natrol Alpha Lipoic Acid, 300 mg (50 Capsules): Health & Personal Care (Site not responding. Last check: 2007-09-10)
		Natrol's Alpha Lipoic Acid (ALA) is a powerful antioxidant that helps protect the body from oxidative damage related to aging and exercise.
		Most studies have used intravenous alpha lipoic acid, but oral supplementation has nonetheless proved partially helpful in treating at least one form of diabetic neuropathy (using 800 mg per day).
		Alpha Lipoic Acid (ALA) is a powerful antioxidant that helps protect the body from oxidative damage related to aging and exercise.
	www.amazon.com /Natrol-Alpha-Lipoic-Acid-Capsules/dp/B0000DANC2 (889 words)

	Alpha Lipoic Acid
		Alpha-lipoic acid is a coenzyme that assists in the conversion of pyruvate to acetyl-coA.
		Alpha Lipoic Acid is prescribed in Germany for adult onset of diabetes.
		We are one of the largest manufacturers of Alpha Lipoic Acid and Acetyl L Carnitine in the United States and manufacture under the Colorado Nutrition Brand.
	www.virtuvites.com /colorado/alpha_lipoic_acid.htm (501 words)

	Alpha Lipoic Acid (ALA) - Alpha Lipoic Acid products on discount!
		Alpha Lipoic Acid, manufactered in Europe, is a disulfide molecule (containing two thiol groups).
		Alpha Lipoic Acid 50 mg, with Vitamins C and E, dietary supplement.
		The Metabolic antioxidant, oxidation Alpha Lipoic Acid has been the subject of hundreds of studies f...
	www.nutrovita.com /store/Alpha-Lipoic-Acid.htm (281 words)

	Alpha Lipoic Acid 100 mg - Powerful Antioxidants
		History and use of Alpha Lipoic Acid (100 mg):
		Alpha Lipoic Acid (ALA) is valuable because it not only neutralizes free radicals, but it also "recycles" Vitamin E and Vitamin C. It can restore the antioxidant properties of these vitamins after they have neutralized free radicals.
		Because ALA is soluble in both water and fat in can move into all parts of cells to deactivate free radicals.
	www.vitastore.biz /products/AlphaLipoic100.html (303 words)

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