
	Where results make sense

Topic: Lipoprotein lipase

Related Topics

Lipoprotein

LDL

Cholesterol

Nobel Prize in Physiology or Medicine

In the News (Wed 9 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Dimeric lipoprotein lipase is bound to triglyceride-rich plasma lipoproteins.
		To analyze the distribution pattern of lipoprotein lipase dimers among lipoprotein classes, a specific ELISA was used and gel filtration was performed in pre- and postheparin plasma from five subjects with triglyceride ranging from 69 to 522 mg/dl.
		In conclusion in pre- and postheparin samples most of the lipoprotein lipase dimers are associated with very low density lipoproteins when ex vivo lipolytic activity is inhibited, which supports the hypothesis that, in vivo, lipoprotein lipase may affect the receptor-mediated removal of these particles.
		Moreover, it suggests that the association between lipoprotein lipase and cholesterol-rich lipoproteins might be an ex vivo phenomenon due to lack of inhibition of lipolytic activity.
	www.medscape.com /medline/abstract?pmid=8978491 (348 words)

	Lipase - Wikipedia, the free encyclopedia
		A lipase is a water-soluble enzyme that catalyzes the hydrolysis of ester bonds in water–insoluble, lipid substrates.
		Lipases are ubiquitous throughout living organisms, and genes encoding lipases are even present in certain viruses.
		Lipoprotein lipase deficiency is caused by mutations in the gene encoding lipoprotein lipase [1].
	en.wikipedia.org /wiki/Lipase (647 words)

	LPL - lipoprotein lipase
		Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner.
		Lipoprotein lipase compensates for the defective function of apo E variants in vitro by interacting with proteoglycans and lipoprotein receptors.
		It is a multifunctional receptor responsible for binding and internalization of lipoproteins enriched with apoliprotein E, lipoprotein lipase, protease-alpha 2 macroglobulin complexes and plasminogen activator-inhibitor complexes.
	www.ihop-net.org /UniPub/iHOP/gg/89878.html (6462 words)

	Familial Lipoprotein Lipase Deficiency
		In familial LPL deficiency, clearance of chylomicrons from the plasma is impaired, causing triglycerides to accumulate in plasma and the plasma to have a milky ("lactescent" or "lipemic") appearance.
		The absence of lipoprotein lipase enzyme activity in postheparin plasma is diagnostic of familial LPL deficiency.
		Lipoprotein lipase is a glycoprotein that is synthesized in adipose tissue and cardiac and skeletal muscle, but not in the postpartum liver.
	www.geneclinics.org /profiles/lpl/details.html (4024 words)

	Human protein: P06858 - Lipoprotein lipase precursor (EC ) (LPL). EMBL Bioinformatic Harvester
		The lipoprotein lipase-encoding human gene: sequence from intron-6 to intron-9 and presence in intron-7 of a 40-million-year-old Alu sequence.
		Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and non-insulin- dependent diabetes.
		A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries.
	harvester.embl.de /harvester/P068/P06858.htm (2994 words)

	GENETIC DISORDERS - Familial Lipoprotein Lipase Deficiency
		Familial lipoprotein lipase deficiency is an inherited condition that disrupts the normal breakdown of fats in the body.
		The protein made by the LPL gene, lipoprotein lipase, is an enzyme that helps break down fat-carrying molecules (lipoproteins).
		As lipoproteins are broken down, they release fats the body uses for energy or puts into storage.
	www.medic8.com /genetics/familial-lipoprotein-lipase-deficiency.htm (366 words)

	Nutritional regulation of binding sites for lipoprotein lipase in rat heart -- Ruge et al. 278 (2): 211 -- AJP - ...
		Lipoprotein lipase mass and activity in plasma and their increase after heparin are separate parameters with different relations to plasma lipoproteins.
		Lipoprotein lipase in human plasma is mainly inactive and associated with cholesterol-rich lipoproteins.
		Hepatic and extrahepatic uptake of intravenously injected lipoprotein lipase.
	ajpendo.physiology.org /cgi/content/full/278/2/E211 (4860 words)

	Familial lipoprotein lipase deficiency Information on Healthline
		Familial lipoprotein lipase deficiency is a group of rare genetic disorders characterized by deficient activity of an
		(lipoprotein lipase) that breaks down fat molecules, causing the accumulation of large quantities of fat (lipoproteins) in the blood.
		The chylomicrons are not broken down properly because of the deficiency of the lipoprotein lipase enzyme.
	www.healthline.com /adamcontent/familial-lipoprotein-lipase-deficiency (575 words)

	Human lipoprotein lipase complementary DNA sequence -- Wion et al. 235 (4796): 1638 -- Science (Site not responding. Last check: 2007-10-28)
		Lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins.
		cld and lec23 are disparate mutations that affect maturation of lipoprotein lipase in the endoplasmic reticulum.
		A Mutation in the Lipoprotein Lipase Gene Is the Molecular Basis of Chylomicronemia in a Colony of Domestic Cats.
	www.sciencemag.org /cgi/content/abstract/235/4796/1638 (1467 words)

	Adipose Tissue
		Triglycerides made up of long chain fatty acids, in the form of chylomicrons (from intestinal absorption) or lipoproteins (from hepatic synthesis), are hydrolyzed to glycerol and free fatty acids by an enzyme called lipoprotein lipase (LPL).
		Lipoprotein lipase is synthesized in adipocytes and secreted into adjacent endothelial cells.
		However, lipoprotein lipase has been found to be increased in obesity, and this enzyme can increase the storage of triglycerides in adipose tissue.
	www.sportsci.org /encyc/adipose/adipose.html (3305 words)

	Dorlands Medical Dictionary
		(lip”o-, li”po-pro´tēn) any of the lipid-protein complexes in which lipids are transported in the blood; lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesteryl esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins; the four principal classes are high-density, low-density, and very-low-density lipoproteins and chylomicrons.
		It is formed in the circulation when very-low-density lipoproteins are degraded first to intermediate-density lipoproteins and then to LDL by the gain and loss of specific apolipoproteins and the loss of most of their triglycerides.
		Synthesized by the liver, they contain primarily triglycerides in their lipid cores, with some cholesteryl esters; as their triglycerides are cleaved by endothelial lipoprotein lipase and transferred to extrahepatic tissues, the VLDL particles lose most of their apolipoprotein C and become intermediate-density lipoproteins.
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_l_12zPzhtm (2787 words)

	André Bensadoun - Recent Publications
		Gershenwald JE, Bensadoun A and Saluja A (1985) Monoclonal antibodies to avian lipoprotein lipase.
		Bensadoun A and Daggy BP (1987) Role of lipoprotein lipase and hepatic lipase in the genesis of plasma lipoproteins.
		Berryman DE and Bensadoun A (1995) Heparan sulfate proteoglycans are primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in chinese hamster ovary cells.
	www.vet.cornell.edu /public/Research/Physio/Bensadoun/pub.htm (1560 words)

	The Lipoprotein Lipase HindIII Polymorphism: Association with Total Cholesterol and LDL-Cholesterol, but not with HDL ...
		Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis.
		Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS).
		Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities.
	www.clinchem.org /cgi/content/full/45/7/963 (2887 words)

	Hepatic Lipase, Lipoprotein Metabolism, and Atherogenesis -- Santamarina-Fojo et al. 24 (10): 1750 -- Arteriosclerosis, ...
		Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high-density lipoproteins.
		Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase.
		Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice.
	atvb.ahajournals.org /cgi/content/full/24/10/1750 (3742 words)

	Extreme Performance Consultants
		Lipoprotein lipase activity in skeletal muscle is related to insulin insensitivity.
		Evidence for a role of insulin in the regulation of abdominal adipose tissue lipoprotein lipase response to training in obese women.
		Effect of acute vigorous exercise on lipoprotein lipase activity of adipose tissue and skeletal muscle in physically active men.
	www.epc-odx.com /obesity (2019 words)

	NEJM -- Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases
		Lipoprotein lipase is an important regulator of lipid and lipoprotein metabolism.
		In the future, however, it may be possible to stimulate or inhibit the activity of lipoprotein lipase in specific tissues and to alter metabolic processes so as to improve the quality and length of life in patients with metabolic diseases such as hypertriglyceridemia, HDL2 deficiency, and obesity.
		Knutson, V. The Release of Lipoprotein Lipase from 3T3-L1 Adipocytes Is Regulated by Microvessel Endothelial Cells in an Insulin-Dependent Manner.
	content.nejm.org /cgi/content/abstract/320/16/1060 (2957 words)

	A Common Substitution (Asn291Ser) in Lipoprotein Lipase Is Associated with Increased Risk of Ischemic Heart Disease -- ...
		Lipoprotein lipase degrades triglycerides in plasma and as a byproduct produces HDL particles.
		Kastelein, and M.R. Hayden (1995) A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis.
		Ser human lipoprotein lipase is associated with reduced catalytic activity and does not influence binding to heparin.
	www.jci.org /cgi/content/full/99/7/1606 (4774 words)

	Mechanisms of Decreased Lipoprotein Lipase Activity in Adipocytes of Starved Rats Depend on Duration of Starvation -- ... (Site not responding. Last check: 2007-10-28)
		Lipoprotein lipase (LPL) synthesis in adipocytes of fed rats and rats starved for 1 or 3 d.
		Effect of insulin on lipoprotein lipase (LPL) synthesis in adipocytes of rats that were fed or starved for 1 d..
		of lipoprotein lipase synthesis by refeeding, insulin and dexamethasone.
	www.nutrition.org /cgi/content/full/128/6/940 (5295 words)

	BLAST Search Results
		Mus musculus lipase, endothelial (Lipg), mRNA 454 e-126 gbAF118768.1AF118768 Mus musculus endothelial lipase mRNA...
		Homo sapiens lipase, hepatic (LIPC), mRNA 392 e-107 gbBC021841.1BC021841 Mus musculus, lipase, hepatic, clone...
		Mus musculus lipase, hepatic (Lipc), mRNA 380 e-103 embX58426.1MMHTL Mouse mRNA for hepatic triglyceride lipase 380 e-103 gbM16235.1RATHLP Rat hepatic lipase mRNA 377 e-102 refNM_012597.1
	www.chickest.udel.edu /orthochick/c226.html (1865 words)

	Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and ...
		Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids -- Park et al.
		A new method for the measurement of lipoprotein lipase in postheparin plasma using sodium dodecyl sulfate for the inactivation of hepatic triglyceride lipase.
		Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins.
	www.ajcn.org /cgi/content/full/80/1/45 (4339 words)

	Lipoprotein Lipase Mutations, Plasma Lipids and Lipoproteins, and Risk of Ischemic Heart Disease : A Meta-Analysis -- ...
		Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation.
		The Asp9Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis.
		Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden.
	circ.ahajournals.org /cgi/content/full/99/22/2901 (4800 words)

	Familial lipoprotein lipase deficiency - Genetics Home Reference
		The condition is characterized by inflammation of the pancreas (pancreatitis), abdominal pain, enlargement of the liver and spleen (hepatosplenomegaly) and small yellow skin lesions called eruptive xanthomas.
		Mutations in the LPL gene cause familial lipoprotein lipase deficiency.
		You might also find information on treatment of familial lipoprotein lipase deficiency in Educational resources and Patient support.
	ghr.nlm.nih.gov /condition=familiallipoproteinlipasedeficiency (596 words)

	MedlinePlus Medical Encyclopedia: Familial lipoprotein lipase deficiency
		Familial lipoprotein lipase deficiency is a group of rare genetic disorders in which a person lacks a protein needed to break down fat molecules.
		Familial lipoprotein lipase deficiency is usually caused by a defective gene.
		This test looks for lipoprotein lipase activity in your blood.
	www.nlm.nih.gov /medlineplus/ency/article/000408.htm (550 words)

	Lipoprotein Lipase Enhances the Binding of Chylomicrons to Low Density Lipoprotein Receptor-Related Protein -- ...
		Chylomicron catabolism is known to be initiated by the enzyme lipoprotein lipase (triacylglycero-protein acylhydrolase, EC 3.1.1.34).
		Bovine and human lipoprotein lipases were able to increase the specific binding of the chylomicrons by up to 30-fold.
		Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
	www.pnas.org /cgi/content/abstract/88/19/8342 (2952 words)

	CIGNA - Familial Lipoprotein Lipase Deficiency
		Familial lipoprotein lipase deficiency is caused by a mutation in the LPL gene leading to very low or absent activity of the lipoprotein lipase enzyme.
		Familial hepatic lipase deficiency is a rare autosomal recessive genetic disorder characterized by elevated levels of triglycerides and early-onset coronary artery disease.
		Familial lipoprotein lipase deficiency, apo CII deficiency and hepatic lipase deficiency.
	www.cigna.com /healthinfo/nord474.html (1481 words)

	Secondary hyperparathyroidism downregulates lipoprotein lipase expression in chronic renal failure -- Vaziri et al. 273 ...
		Increase in lipoprotein lipase during clofibrate treatment of hypertriglyceridemia in patients on hemodialysis.
		Gene expression of lipoprotein lipase in experimental nephrosis.
		Human lipoprotein lipase relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodies.
	ajprenal.physiology.org /cgi/content/full/273/6/F925 (3006 words)

	Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat -- ...
		Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat -- Benavides et al.
		Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat
		Changes in adipose tissue and heart lipoprotein lipase activities and in serum glucose, insulin and corticosterone concentrations in rats adapted to a daily meal.
	ajpregu.physiology.org /cgi/content/full/275/3/R811 (3686 words)

	Acute Dyslipoproteinemia Induced by Interleukin-2: Lecithin:Cholesteryl Acyltransferase, Lipoprotein Lipase, and ...
		Acute Dyslipoproteinemia Induced by Interleukin-2: Lecithin:Cholesteryl Acyltransferase, Lipoprotein Lipase, and Hepatic Lipase Deficiencies
		lipoprotein lipase (LPL), hepatic lipase (HL), and lecithin:cholesteryl
		1988 Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein.
	jcem.endojournals.org /cgi/content/full/82/5/1572 (5100 words)

	Lipids Online Slides: lipoprotein lipase, high-density lipoprotein
		In the process of cholesterol transport, apo Bâ“containing VLDL particles are released to the circulation from the liver, and through metabolism by endothelial lipoprotein lipases (LPL) and hepatic lipases (HL), are catabolized into LDL particles.
		Role of Hepatic Lipase and Lipoprotein Lipase in HDL Metabolism
		The enzyme lipoprotein lipase (LPL), bound to the surface of the capillary endothelium (especially in muscle and adipose tissue), hydrolyzes TG in CMs and in VLDLs.
	www.lipidsonline.org /slides/slide01.cfm?q=lipoprotein+lipase (1342 words)

Try your search on: Qwika (all wikis)