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Topic: Lipoxin

In the News (Fri 27 Nov 09)

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	An oily, sustained counter-regulatory response to TB -- Karp and Cooper 115 (6): 1473 -- Journal of Clinical ...
		Lipoxins are potent antiinflammatory lipid mediators that restrain
		lipoxin analogs for the therapy of tissue inflammatory diseases.
		Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis.
	www.jci.org /cgi/content/full/115/6/1473 (1657 words)

	Product News and Information
		Analyses of the lipoxin analog's mechanism of action revealed a novel role for lipoxins in blocking the cellular cascade of dysfunctional immune responses that leads to inflammation in the mucosal lining of the gastrointestinal tract.
		Lipoxin - technically called lipoxin A4 - is a lipid mediator (fatty acid derived molecule) generated by the immune system as part of the response to antigens and inflammation by lipoxygenase-dependent arachidonic acid metabolism.
		Naturally occurring lipoxin A4 promotes the resolution of inflammation and modulates immune cell activity via potent agonist actions at lipoxin receptors on granulocytes, macrophages, dendritic cells, T lymphocytes, and epithelial cells.
	www.pharmacistelink.com /product/news/20041109berlex_news.html (1103 words)

	15-epi-lipoxin A4-mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation -- Paul-Clark et ...
		The role of nitric oxide in lipoxin A4-induced polymorphonuclear neutrophil-dependent cytotoxicity to human vascular endothelium in vitro.
		Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion.
		Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions.
	www.jem.org /cgi/content/full/200/1/69 (5018 words)

	LIPOXINSIN CHRONIC INFLAMMATION -- Kantarci and Van Dyke 14 (1): 4 -- Critical Reviews in Oral Biology & Medicine
		Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases.
		Lipoxin biosynthesis and its impact in inflammatory and vascular events.
		Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side.
	crobm.iadrjournals.org /cgi/content/full/14/1/4 (5165 words)

	An Aspirin-Triggered Lipoxin A4 Stable Analog Displays a Unique Topical Anti-Inflammatory Profile -- Schottelius et al. ...
		Lipoxins and 15-epi-lipoxins are counter-regulatory lipid mediators that
		of lipoxins that interfere with the activation and migration of
		Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils.
	www.jimmunol.org /cgi/content/full/169/12/7063 (4246 words)

	HUM-MOLGEN: Reduced Lipoxin Linked To Damaged Cystic Fibrosis Lungs
		Lipoxins are tiny lipids that 'switch off' the infection-fighting neutrophils that inadvertently damage the lung when releasing their toxic antimicrobials.
		Lipoxins convert the immune response from one dominated by neutrophils to one dominated by lymphocytes and macrophages, whose attacks are more focused and produce less collateral damage.
		When synthetic lipoxin was administered to these mice, they were able to decrease bacteria numbers faster and had reduced disease severity compared with control mice.
	hum-molgen.org /NewsGen/03-2004/msg36.html (393 words)

	USC College : News : Petasis
		The compounds, called lipoxin analogs, are now being eyed as candidates for drug development, having shown great promise in quelling disease-associated inflammation in animal studies of dermatitis, asthma, and kidney disease.
		Using the lipoxin analogs as tools, the team went on to reveal lipoxins worked as the immune system’s “traffic cops” to halt inflammation, among other key activities.
		Anti-inflammatory lipoxins, produced by neutrophils in the same biochemical cascade that initiates inflammation, signal other cells to retreat from an inflamed site and to begin the healing process.
	www.usc.edu /schools/college/news/petasis (1324 words)

	Modulation of Interferon-Induced Genes by Lipoxin Analogue in Anti-Glomerular Basement Membrane Nephritis -- Ohse et ...
		Lipoxin A4 is known to inhibit the expression of P-selectin
		Fiore S, Serhan CN: Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: Inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction.
		Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: Evidence for competition at a common receptor.
	jasn.asnjournals.org /cgi/content/full/15/4/919 (4216 words)

	Regulation of phospholipase D activity - Patent 6864288
		The methods include, administration of an effective anti-PLD amount of a lipoxin analog described infra, such that a disease or condition associated with initiated by PLD generation of superoxide or degranulation activity, is modulated.
		A "lipoxin analog" shall mean a compound which has an "active region" that functions like the active region of a "natural lipoxin", but which has a "metabolic transformation region" that differs from natural lipoxin.
		Lipoxin analogs include compounds which are structurally similar to a natural lipoxin, compounds which share the same receptor recognition site, compounds which share the same or similar lipoxin metabolic transformation region as lipoxin, and compounds which are art-recognized as being analogs of lipoxin.
	www.freepatentsonline.com /6864288.html (12439 words)

	Physical exercise increases urinary excretion of lipoxin A4 and related compounds -- Gangemi et al. 94 (6): 2237 -- ...
		Lipoxins (LX) are lipoxygenase-derived eicosanoids with potent anti-inflammatory activities and vascular bed-dependent vasodilatory
		Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis.
		Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages.
	jap.physiology.org /cgi/content/full/94/6/2237 (2300 words)

	[No title] (Site not responding. Last check: 2007-11-02)
		"The lipoxin analog is another step in our development program to broaden the therapeutic options for Crohn's patients." The laboratory findings appear in this week's edition of the Proceedings of the National Academy of Sciences.
		Evolving research suggests that the primary defect in Crohn's disease may be a breakdown in the layers of mucosal barrier protecting the gastrointestinal tract.
		In the research conducted by Berlex and its scientific collaborators on the colitis model of Crohn's disease, the company's oral lipoxin analog strongly attenuated mucosal markers of inflammation and also dramatically reduced the induction of IL-2, TNF-alpha and interferon gamma observed in the mucosa.
	www.berlex.com /html/press/articles/11092004.html (1207 words)

	Articles \| Center of Flow Cytometry and FACS
		The purpose of the study was to transfect LRLP gene into human lung fibroblasts and investigate the mechanism of its enhancing antagonistic effect of Lipoxin A(4) on human lung fibroblasts proliferation induced by connective tissue growth factor.
		Cultured HLF and HLF/LRLP were stimulated for 24 h with CTGF (1 microg/ml) in the presence and absence of pretreatment of Lipoxin A(4) (10.0 nmol/L) for 30 min.
		Pretreatment with 10 nm Lipoxin A(4) inhibited the proliferation of HLF and HLF/LRLP.
	cytometry.cz /en/articles/388-[transfection-of-lipoxin-a4-receptor-l... (1942 words)

	New studies demonstrate efficacy of novel Lipoxin analog in laboratory models of Crohn's disease (Site not responding. Last check: 2007-11-02)
		Berlex announced today that new laboratory results demonstrate that its modified version of the naturally occurring lipoxin molecule exerts potent anti-inflammatory and immunomodulatory effects in Crohn's disease in vivo models and may provide a promising new oral treatment.
		Improvements in colitis symptoms -- weight loss, colon injury and mucosal inflammation -- for the oral lipoxin analog were similar to published findings for injectible anti-cytokine therapies and equal to oral prednisolone in a head-to-head pre-clinical comparison.
		The lipoxin analog both prevented and treated colitis -- suggesting potential use in induction of remission and/or maintenance therapy in Crohn's disease.
	www.news-medical.net /?id=6208 (564 words)

	hospitalpharma.com \| Feature \| Lipoxin A4 (LXA4) mimics shown reduce inflammation by inhibiting the p38-MAPK ...
		In contrast to the leukotrienes (LTs) and the prostaglandins, the lipoxins (LXs) are involved in the regulation and resolution of inflammation and are anti-inflammatory.
		The paper “A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils”(J Immunol.
		Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo.
	www.hospitalpharma.com /Features/feature.asp?ROW_ID=453 (1164 words)

	Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with ...
		Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity -- Maddox et al.
		Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation: Stimulation of Macrophage Phagocytosis of Apoptotic Neutrophils In Vivo
		Lipoxins and Aspirin-triggered Lipoxins Inhibit Neutrophil Recruitment and Vascular Permeability
	www.fasebj.org /cgi/content/abstract/12/6/487 (591 words)

	International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors -- Brink et al. 55 (1): ...
		The leukotrienes and lipoxins are biologically active metabolites derived from arachidonic acid.
		The leukotrienes and lipoxins are lipid mediators derived from arachidonic acid, which is released from cell membrane phospholipids by the action of phospholipase A
		The lipoxin receptor (ALX) is also included in the chemoattractant receptor class along with formyl peptide receptors (FPL).
	pharmrev.aspetjournals.org /cgi/content/full/55/1/195 (5260 words)

	Resolution of Inflammation: A New Paradigm for the Pathogenesis of Periodontal Diseases -- Van Dyke and Serhan 82 (2): ...
		Lipoxins are generated through transcellular biosynthetic routes through the action of two lipoxygenases on the same arachidonic acid molecule to act as endogenous stop signals in inflammation.
		Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation.
		Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis.
	jdr.iadrjournals.org /cgi/content/full/82/2/82 (5417 words)

	doc 59 (Site not responding. Last check: 2007-11-02)
		Conformational analysis of lipoxin A, lipoxin B and their trans-isomers.
		Brasseur R, Deleers M, Ruysschaert JM, Samuelsson B, Serhan CN Lipoxin A and lipoxin B (LXA and LXB) are formed from the oxygenation of arachidonic acid by interactions between the 5- and 15-lipoxygenases of human leukocytes.
		Both lipoxin A and lipoxin B can form globular conformations, while their all-trans isomers form rigid extended structures.
	www.fsagx.ac.be /bp/abstracts/a59.htm (227 words)

	Lipoxins: endogenous regulators of inflammation -- McMahon and Godson 286 (2): 189 -- AJP - Renal Physiology
		Lipoxins: endogenous regulators of inflammation -- McMahon and Godson 286 (2): 189 -- AJP - Renal Physiology
		Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analogue.
		Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution.
	ajprenal.physiology.org /cgi/content/full/286/2/F189 (6295 words)

	Imbalance Between Lipoxin A4 and Leukotriene B4 in Chronic Mastitis-Affected Cows -- Boutet et al. 86 (11): 3430 -- ...
		Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins.
		Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: A role for cyclooxygenase-2 and lipoxins in periodontal disease.
		Serhan, C. Lipoxin biosynthesis and its impact in inflammatory and vascular events.
	jds.fass.org /cgi/content/full/86/11/3430 (3150 words)

	ScienceDaily: Scientists View 'Dark Side' Of The Body (Site not responding. Last check: 2007-11-02)
		The compounds, called lipoxin analogs, are now being eyed as candidates for drug development, having shown great promise in quelling disease-associated inflammation in animal studies of dermatitis, asthma, kidney disease and now gum disease and cystic fibrosis.
		Adding a fluorine atom to his best prospect, he came up with what he was after a potent lipoxin analog that lasts for hours.
		Their findings suggest that lipoxin analogs may prove helpful as a therapy for gum disease, the primary cause of adult tooth loss.
	www.sciencedaily.com /releases/2004/09/040903093522.htm (2043 words)

	Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis -- Souza et al. ...
		Gastric damage induced by aspirin (50 mg/kg po) in rats with iodoacetamide-induced gastritis and normal rats and the effects of preexposure to a lipoxin receptor antagonist [N-tert-butoxycarbonylmethionine-leucine-phenylalanine (BOC; 10 µM)].
		Leukocyte adherence 60 min after ASA (50 mg/kg) in normal rats and rats with gastritis, and the effects of preexposure to the lipoxin A
		Each bar represents the mean ± SE for at least 4 rats, and the data shown are for the final time period in the experiment.
	ajpgi.physiology.org /cgi/content/full/285/1/G54 (4517 words)

	Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo -- Clish et ...
		Lipoxin A4 and Aspirin-Triggered 15-epi-Lipoxin A4 Inhibit Human Neutrophil Migration: Comparisons Between Synthetic 15 Epimers in Chemotaxis and Transmigration with Microvessel Endothelial Cells and Epithelial Cells
		Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes
		Lipoxins Induce Actin Reorganization in Monocytes and Macrophages But Not in Neutrophils : Differential Involvement of Rho GTPases
	www.pnas.org /cgi/content/abstract/96/14/8247 (1616 words)

	Pathogen-induced Chemokine Secretion from Model Intestinal Epithelium is Inhibited by Lipoxin A4 Analogs -- Gewirtz et ...
		(a) Structure of lipoxins and lipoxin analogs used in these experiments, shown as carboxylic acids, although analogs were synthesized and used as methyl esters.
		Lipoxin A4 inhibits phosphoinositide hydrolysis in human neutrophils.
		Takano, N.A. Petasis, V.V. Fokin, and C.N. Serhan (1997) Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor.
	www.jci.org /cgi/content/full/101/9/1860 (5287 words)

	Aspirin Triggers Previously Undescribed Bioactive Eicosanoids by Human Endothelial Cell-Leukocyte Interactions -- ... (Site not responding. Last check: 2007-11-02)
		Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1alpha -initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine-Chemokine Axis
		Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon gamma and Inhibits Tumor Necrosis Factor alpha -induced IL-8 Release
		Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor
	intl.pnas.org /cgi/content/abstract/92/21/9475 (2436 words)

	Lipoxins Are Potential Endogenous Antiinflammatory Mediators in Asthma -- Bonnans et al. 165 (11): 1531 -- American ...
		Lipoxins Are Potential Endogenous Antiinflammatory Mediators in Asthma -- Bonnans et al.
		Correspondence and requests for reprints should be addressed to Dr. Pascal Chanez, Hôpital Arnaud de Villeneuve, 371 Av du Doyen Gaston Giraud, 34295 Montpellier, Cedex 5, France.
		Lipoxin A4 Stimulates a Cytosolic Ca2+ Increase in Human Bronchial Epithelium
	ajrccm.atsjournals.org /cgi/content/abstract/165/11/1531 (520 words)

	Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon gamma ...
		Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon gamma and Inhibits Tumor Necrosis Factor alpha -induced IL-8 Release -- Gronert et al.
		Lipoxin A4 and Aspirin-Triggered 15-Epi-Lipoxin A4 Antagonize TNF-{alpha}-Stimulated Neutrophil-Enterocyte Interactions In Vitro and Attenuate TNF-{alpha}-Induced Chemokine Release and Colonocyte Apoptosis in Human Intestinal Mucosa Ex Vivo
		Lipoxin A4 Antagonizes the Mitogenic Effects of Leukotriene D4 in Human Renal Mesangial Cells.
	www.jem.org /cgi/content/abstract/187/8/1285 (1607 words)

	Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity ...
		Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis -- Gewirtz et al.
		Lipoxin A4 Regulates Bronchial Epithelial Cell Responses to Acid Injury
		Lipoxin A4 Modifies Platelet-Derived Growth Factor-Induced Profibrotic Gene Expression in Human Renal Mesangial Cells
	www.jimmunol.org /cgi/content/abstract/168/10/5260 (863 words)

	Gastritis Increases Resistance to Aspirin-Induced Mucosal Injury via COX-2-Mediated Lipoxin Synthesis -- Souza et al., ...
		Gastritis Increases Resistance to Aspirin-Induced Mucosal Injury via COX-2-Mediated Lipoxin Synthesis -- Souza et al., 10.1152/ajpgi.00525.2002 -- AJP - Gastrointestinal and Liver Physiology
		and of a lipoxin receptor antagonist were assessed.
		elicited greater lipoxin synthesis in the inflamed than in the
	ajpgi.physiology.org /cgi/content/short/00525.2002v1 (355 words)

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