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Topic: Low density lipoprotein

Related Topics

LDL

High density lipoprotein

Lipoprotein

Hypercholesterolemia

Very low density lipoprotein

Cholesterol

HDL cholesterol

Triglyceride

Atherosclerosis

Scandinavian Simvastatin Survival Study

Heart disease

Simvastatin

Statin

Harpist

American Heart Association

	Low density lipoprotein - Wikipedia, the free encyclopedia
		Low-density lipoprotein (LDL) refers to a class and range of lipoprotein particles, varying in their size and contents, which carry cholesterol in the blood and around the body, for use by cells.
		Because LDL transports cholesterol to the arteries, increased levels are associated with atherosclerosis, and thus myocardial infarctions, strokes and peripheral vascular disease.
		LDL is formed as VLDL lipoproteins, which lose triglyceride through the action of lipoprotein lipase (LPL), and become smaller and denser containing a higher proportion of cholesterol.
	en.wikipedia.org /wiki/Low_density_lipoprotein (1028 words)

	MedlinePlus Medical Encyclopedia: LDL
		LDL is a test that measures the amount of low-density lipoprotein (LDL) cholesterol in blood serum.
		The main function of LDL seems to be to carry cholesterol to various tissues throughout the body.
		LDL is sometimes referred to as "bad" cholesterol, because elevated levels of LDL correlate most directly with coronary heart disease.
	www.nlm.nih.gov /medlineplus/ency/article/003495.htm (830 words)

	Very low density lipoprotein - Wikipedia, the free encyclopedia
		It is assembled in the liver from cholesterol and apolipoproteins.
		It is converted in the bloodstream to low density lipoprotein (LDL).
		VLDL is prone to accelerate atherosclerosis, and is elevated in a number of diseases and metabolic states.
	en.wikipedia.org /wiki/Very_low_density_lipoprotein (82 words)

	Low density lipoprotein - Freepedia (Site not responding. Last check: 2007-10-19)
		Low-density lipoprotein (LDL) is a lipoprotein that carries cholesterol around the body, for use by various cells.
		Because LDL transports cholesterol to the arteries, increased levels are associated with atherosclerosis, and thus myocardial infarctions and strokes.
		LDL is formed as VLDL lipoproteins lose triglyceride, and become smaller and denser containing a higher proportion of cholesterol.
	en.freepedia.org /LDL.html (123 words)

	Low density lipoprotein - Unipedia
		Low-density lipoprotein (LDL) refers to a class and range of lipoprotein particles, varying somewhat in their size and contents, which carry cholesterol in the blood and around the body, for use by various cells.It is the final stage of VLDL (very low-density lipoprotein)witch is produced by the liver.
		LDL is formed as VLDL lipoproteins lose triglyceride through the action of lipoprotein lipase (LPL), and become smaller and denser containing a higher proportion of cholesterol.
		LDL particles actually vary in size and density, and studies have shown that a pattern that has more small dense LDL particles equates to a higher risk factor for Coronary Heart Disease (CHD) than does a pattern with more of the larger "fluffy" LDL particles.
	www.unipedia.info /LDL.html (812 words)

	LDL (low-density lipoprotein) cholesterol
		LDL (low-density lipoprotein) cholesterol is the “bad” cholesterol, which carries mostly fat and only a small amount of protein from the liver to other parts of the body.
		A high LDL cholesterol level is considered a risk factor for coronary artery disease because, under certain conditions, it can cause hardening of the arteries (atherosclerosis).
		An LDL cholesterol level of 100 to 129 mg/dL (2.6 to 3.35 mmol/L) is considered near optimal.
	my.webmd.com /hw/health_guide_atoz/stl158077.asp (223 words)

	Low-Density Lipoprotein Cholesterol (Direct)
		For the direct determination of LDL cholesterol in nonfasting patients or in patients whose fasting triglycerides are >400 mg/dL, where the estimation of LDL by calculation may not be possible or may lead to inaccuracies.
		LDL cholesterol measurement, in conjunction with other lipid measurements, has been shown to be useful in assessing the risk of coronary heart disease (CHD).
		Laboratory estimation of LDL cholesterol is most commonly determined by the use of formulas, such as the Friedewald formula.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sc033800.htm (339 words)

	LDL
		This is a test that measures the amount of low-density lipoprotein (LDL) cholesterol in serum.
		Since cholesterol is water insoluble, most cholesterol is carried in the blood by lipoproteins (large protein-like molecules, including chylomicrons, VLDL, LDL, and HDL).
		This is also true for high density lipoprotein (HDL) and very low density lipoprotein (VLDL).
	www.healthscout.com /ency/1/003495.html (648 words)

	Identification of a Major Cyclic AMP-Dependent Protein Kinase A Phosphorylation Site within the Cytoplasmic Tail of the ...
		The low-density lipoprotein (LDL) receptor-related protein (LRP) is a multiligand endocytic receptor that belongs to the LDL
		Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
		Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts.
	mcb.asm.org /cgi/content/full/21/4/1185 (6463 words)

	LDL: Low-Density Lipoprotein
		An LDL test measures the level of low-density lipoprotein, or LDL, in the blood.
		The LDL test is usually done as part of a lipid profile test that also includes total cholesterol, HDL test, and triglycerides.
		An LDL test may be used to evaluate a person's risk for various conditions.
	www.3-rx.com /ldl/default.php (425 words)

	Analysis of Expression of Genes Involved in Apolipoprotein E-Based Lipoprotein Metabolism in Pregnant Mice Deficient in ...
		Analysis of Expression of Genes Involved in Apolipoprotein E-Based Lipoprotein Metabolism in Pregnant Mice Deficient in the Receptor-Associated Protein, the Low Density Lipoprotein Receptor, or Apolipoprotein E -- Umans et al.
		lipoprotein receptor (VLDLR) [6], apoER2 [7], LR8B [8], and
		Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor related protein/alpha-2-macroglobulin receptor in vitro.
	www.biolreprod.org /cgi/content/full/61/5/1216 (6349 words)

	Antioxidant Supplementation Effects on Low-Density Lipoprotein Oxidation for Individuals with Type 2 Diabetes Mellitus ...
		The susceptibility of LDL to in vitro oxidation was assessed
		LDL, 10 to 50 µg/mL, were incubated for two hours with cells; DiI was extracted, measured by spectrofluorometry and reported as µg LDL protein/mg cell protein.
		of LDL increases the susceptibility to oxidation [9,52].
	www.jacn.org /cgi/content/full/18/5/451 (4603 words)

	LDL (low-density lipoprotein) definition - Cholesterol: health and medical information about high cholesterol and heart ...
		LDL (low-density lipoprotein): A molecule that is a combination of lipid (fat) and protein.
		Lipoproteins are the form in which lipids are transported in the blood.
		Low-density lipoprotein (LDL) transports cholesterol from the liver to the tissues of the body.
	www.medterms.com /script/main/art.asp?articlekey=6232 (199 words)

	Diabetic Life - Adding Fiber May Help Diabetics
		Researchers found that fiber supplements lower levels of "bad" low-density lipoprotein (LDL) cholesterol and increase levels of "good" high-density lipoprotein (HDL) cholesterol in people with this type of diabetes.
		Their total blood cholesterol, triglycerides, LDL, and HDL were measured at the start of the study and again after 90 days.
		LDL decreased from 129 mg/dL to 92 mg/dL (28.7 percent).
	www.diabeticlife.org /ms/news/525369/main.html (472 words)

	Enhanced Macrophage Resistance to Pseudomonas Exotoxin A Is Correlated with Decreased Expression of the Low-Density ...
		Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is a hepatic receptor for tissue-type plasminogen activator.
		Evidence that the newly cloned low density lipoprotein receptor-related protein (LRP) is the alpha 2-macroglobulin receptor.
		Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.
	iai.asm.org /cgi/content/full/67/11/5827 (4395 words)

	Lipids Online Slides: hdl, high-density lipoprotein cholesterol (Site not responding. Last check: 2007-10-19)
		Because these patients frequently have low high-density lipoprotein cholesterol (HDL-C), LDL-C should be used instead of total cholesterol, as recommended in the NCEP guidelines.
		In the Lipoprotein and Coronary Atherosclerosis Study (LCAS), fluvastatin significantly reduced coronary artery disease progression among patients with low high-density lipoprotein cholesterol (HDL-C), as measured by decreases in minimum lumen diameter (MLD): 0.065 mm versus 0.274 mm with placebo (P = 0.0004).
		In the Lipoprotein and Coronary Atherosclerosis Study (LCAS), the probability of event-free survival was significantly improved with fluvastatin among patients with low high-density lipoprotein cholesterol (HDL-C) levels (P = 0.002; left panel).
	www.lipidsonline.org /slides/slide01.cfm?q=hdl&dpg=204 (958 words)

	Regulation of Rac1 activation by the low density lipoprotein receptor-related protein -- Ma et al. 159 (6): 1061 -- The ...
		Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (LRP-1) associates with the adaptor protein SHC in Src-transformed cells.
		Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.
		The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.
	www.jcb.org /cgi/content/full/159/6/1061 (6766 words)

	Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related ...
		Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates the cellular internalization and degradation of thrombospondin: a process facilitated by cell-surface proteoglycans.
		Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.
		The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans.
	www.bloodjournal.org /cgi/content/full/96/10/3459 (5721 words)

	InterPro: IPR002172 Low density lipoprotein-receptor, class A (Site not responding. Last check: 2007-10-19)
		Low density lipoprotein (LDL) is the major cholesterol-carrying lipoprotein of plasma.
		Some entries could be mapped to very low level (specific) GO terms, while entries describing wider families or common domains were mapped to higher level terms or could not be mapped at all.
		Many of the PTM sites have low specificity and the number of proteins recognised by the sequence signatures cannot be displayed.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR002172 (2999 words)

	Very-Low-Density Lipoprotein Receptor Fragment Shed from HeLa Cells Inhibits Human Rhinovirus Infection -- Marlovits et ...
		Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.
		An antibody fragment from a phage display library competes for ligand binding to the low density lipoprotein receptor family and inhibits rhinovirus infection.
		Expression of very low density lipoprotein receptor in the vascular wall: analysis of human tissues by in situ hybridization and immunohistochemistry.
	jvi.asm.org /cgi/content/full/72/12/10246 (4546 words)

	Stable Incorporation of a Lipophilic Daunorubicin Prodrug into Apolipoprotein E-Exposing Liposomes Induces Uptake of ...
		The low disposition of LAD in the extrahepatic tissues,
		Clearance of LAD-loaded apoE liposomes in LDL receptor-deficient and wild-type mice.
		Brown MS and Goldstein JL (1975) Regulation of the activity of the low density lipoprotein receptor in human fibroblasts.
	www.jpet.org /cgi/content/full/289/1/1 (4979 words)

	Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis -- Shaul 547 (1): 21 -- The Journal ...
		The impact of lipoproteins on eNOS localization in caveolae is examined, and the existence of an eNOS signalling module in caveolae is considered.
		It is anticipated that issues of eNOS modulation by lipoproteins will continue to warrant strong consideration both in our efforts to understand the role of cholesterol in the initiation of atherogenesis, and our attempts to take preventative and therapeutic advantage of these mechanisms to modify the development of hypercholesterolaemia-induced vascular disease.
		Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation.
	jp.physoc.org /cgi/content/full/547/1/21 (6507 words)

	Increased levels of autoantibodies against copper-oxidized low density lipoprotein, malondialdehyde-modified low ...
		Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest1989;84:1086–95.
		Autoantibodies against oxidized low density lipoproteins (oxLDL): characterization of antibody isotype, subclass, affinity and effect on the macrophage uptake of oxLDL.
		Low density lipoprotein of synovial fluid in inflammatory joint disease is mildly oxidized.
	rheumatology.oupjournals.org /cgi/content/full/41/9/988 (2970 words)

	Oxidized Low-Density Lipoprotein Activates Migration and Degranulation of Human Granulocytes -- Sedgwick et al. 29 (6): ...
		LDL in the absence or presence of unlabeled 50 µg/ml LDL,
		LDL was oxidized by exposure to natural light and air over time.
		Induction of murine macrophage growth by oxidized low-density lipoprotein is mediated by granulocyte macrophage colony-stimulating factor.
	ajrcmb.atsjournals.org /cgi/content/full/29/6/702 (4129 words)

	Atkins Nutritionals: The Science Behind Atkins: Research Summaries: Cholesterol: Low-Density Lipoprotein Subclass ... (Site not responding. Last check: 2007-10-19)
		Low-density lipoprotein (LDL) subclass pattern B is characterized by small, dense LDL particles, and associated with increased levels of triglycerides and lower levels of high-density lipoprotein cholesterol (HDL-C).
		Pattern B is associated with increased risk of heart disease compared to individuals with high levels of larger, buoyant LDL (pattern A), which is associated with lower risk of heart disease.
		The authors suggest that genetic and environmental factors may influence LDL subclass (pattern A versus pattern B) distributions and thus contribute substantially to an individual’s response to a low- fat diet.
	atkins.com /Archive/2002/1/11-63225.html (542 words)

	Expression of adhesion molecules by Lp(a): a potential novel mechanism for its atherogenicity -- Allen et al. 12 (15): ...
		The LDL receptor antibody IgGC7 was purchased from Amersham
		The effect of regulating the expression of the LDL receptor on VCAM-1 and E-selectin surface expression on HCAEC induced by 100 µg/ml of Lp(a).
		Tam, S. P., Brissette, L., Ramharack, R., and Deeley, R. (1991) Differences between the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor in human hepatoma cells and fibroblasts reside primarily at the translational and posttranslational levels.
	www.fasebj.org /cgi/content/full/12/15/1765 (5771 words)

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