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| | NTP: Luminol |
 | | The reaction of luminol with oxygen species generated by cells produces an excited intermediate that emits light (chemiluminescence) as it relaxes to a stable state (for reviews see Briheim et al., 1984; Kahl et al., 1987; Radi et al., 1993; Lundqvist and Dahlgren, 1996). |
 | | Luminol chemiluminescence occurs in aqueous solution with hydrogen peroxide and a supplemental oxidant such as ferricyanide, hypochlorite, persulfate, or the hydroxyl radical generated from hydrogen peroxide, and a metal derivative such as hemin. |
 | | Results from some studies indicate that luminol chemiluminescence in in vitro mammalian systems requires the presence of the enzyme myeloperoxidase (Dahlgren and Stendahl, 1983) and Fe (Klinger et al., 1996) to proceed, and is greatly enhanced in the presence of bicarbonate (Puget and Michelson, 1976; Radi et al., 1993). |
| ntp-server.niehs.nih.gov /index.cfm?objectid=6F5FCA5F-F1F6-975E-7303709FEC33A9BB (506 words) |
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