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	Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis -- Reiss et al. 279 (2): 1281 -- ...
		Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis -- Reiss et al.
		lyase influences mammalian cell fate decisions, a recombinant
		Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
	www.jbc.org /cgi/content/abstract/279/2/1281 (949 words)

	Lyase - Wikipedia, the free encyclopedia
		In biochemistry, a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure.
		Lyases differ from other enzymes in that they only require one substrate for the reaction in one direction, but two substrates for the reverse reaction.
		Systematic names are formed as "substrate group lyase." Common names include decarboxylase, dehydratase, aldolase, etc. When the reverse reaction is more important, synthase may be used in the name.
	en.wikipedia.org /wiki/Lyase (224 words)

	Unbound MEDLINE \| An effective method for isolating alginate lyase-producing Bacillus sp. ATB-1015 strain and ...
		ATB-1015 strain and purification and characterization of the lyase.
		The extracellular alginate lyase was precipitated with ammonium sulphate from the culture broth, and purified by gel filtration and anion exchange chromatography.
		The lyase activity was completely inhibited by treatment with 1 mmol l-1 of EDTA and the decreased activity was almost completely recovered by the addition of 2 mmol l-1 of CaCl2.
	www.unboundmedicine.com /medline/ebm/record/9721637/abstract/An_effective_method_for_isolating_alginate_lyase_producing_Bacillus_sp_ATB_1015_strain_and_purification_and_characterization_of_the_lyase (269 words)

	3-hydroxy-3-methylglutaryl-CoA lyase deficiency - Wikipedia, the free encyclopedia
		3-hydroxy-3-methylglutaryl-CoA lyase deficiency also referred to as HMG-CoA lyase deficiency, is an uncommon inherited disorder in which the body cannot properly process the amino acid leucine.
		Additionally, the disorder prevents the body from making ketones, which are used for energy during fasting.
		Mutations in the HMGCL gene cause 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.
	en.wikipedia.org /wiki/3-hydroxy-3-methylglutaryl-CoA_lyase_deficiency (365 words)

	Adenosine Triphosphate Citrate Lyase Mediates Hypocitraturia in Rats -- Melnick et al. 98 (10): 2381 -- Journal of ...
		The purpose of the present study was to determine the role of ATP citrate lyase in renal citrate metabolism.
		ATP citrate lyase activity was measured using the hydroxamate assay (20).
		In the cytosol, ATP citrate lyase catalyzes the
	www.jci.org /cgi/content/full/98/10/2381 (3972 words)

	eMedicine - Argininosuccinate Lyase Deficiency : Article by Karl S Roth, MD (Site not responding. Last check: 2007-10-13)
		ASA lyase deficiency is an autosomal recessive genetic disorder.
		The gene for ASA lyase deficiency is located on chromosome 7 and has been mapped to the locus 7q11.2.
		Provide care for a patient with ASA lyase deficiency under the guidance of a biochemical geneticist/metabolic-disease specialist who is skilled in therapy of urea cycle diseases.
	www.emedicine.com /ped/topic2745.htm (2057 words)

	3-Hydroxy-3-Methylglutaryl-CoA (HMG) Lyase Deficiency
		Mutations in the HMG-CoA Lyase gene on chromosome 1 have been identified in a number of patients and prenatal diagnosis can be accomplished using DNA analysis.
		Acute symptoms of HMG-CoA Lyase Deficiency should be treated with IV glucose, bicarbonate for the metabolic acidosis and restriction of protein (Leucine).
		Because the diagnosis and therapy of HMG-CoA Lyase Deficiency is complex, the pediatrician is advised to manage the patient in close collaboration with a consulting pediatric metabolic disease specialist.
	www.pediatrix.com /body_screening_menu.cfm?id=1565 (651 words)

	Isocitrate Lyase Is Essential for Pathogenicity of the Fungus Leptosphaeria maculans to Canola (Brassica napus) -- ...
		Isocitrate Lyase Is Essential for Pathogenicity of the Fungus Leptosphaeria maculans to Canola (Brassica napus) -- Idnurm and Howlett 1 (5): 719 -- Eukaryotic Cell
		Regulation of the expression of the isocitrate lyase gene (acuD) of Aspergillus nidulans.
		Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
	ec.asm.org /cgi/content/full/1/5/719 (2896 words)

	Isocitrate Lyase Activity Is Required for Virulence of the Intracellular Pathogen Rhodococcus equi -- Wall et al. 73 ...
		Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis.
		Isocitrate lyase is essential for pathogenicity of the fungus Leptosphaeria maculans to canola (Brassica napus).
		Isocitrate lyase of the facultative intracellular pathogen Rhodococcus equi.
	iai.asm.org /cgi/content/full/73/10/6736 (3600 words)

	Overexpression of Sphingosine-1-Phosphate Lyase or Inhibition of Sphingosine Kinase in Dictyostelium discoideum Results ...
		The S-1-P lyase and sphingosine kinase enzymes shown in shaded boxes are the primary focus of this study.
		A full-length cDNA for the S-1-P lyase gene (sglA; accession
		Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm.
	ec.asm.org /cgi/content/full/3/3/795 (6102 words)

	Argininosuccinic Aciduria (ASA Lyase)/Citrullinemia (ASA Synthase)
		Argininosuccinate Lyase Deficiency causes a less dramatic increase of plasma Citrulline, but is no less clinically devastating.
		Argininosuccinate Lyase Deficiency patients have measurable levels of Argininosuccinic acid in plasma, which is not normally detected.
		Sodium benzoate is given to conjugate Glycine, a major amino acid that contributes ammonia to the urea cycle, forming hippurate, which is subsequently excreted in the urine.
	www.pediatrix.com /body_screening_menu.cfm?id=1719 (780 words)

	Lyase Website
		Lyase adopts the principle of working to clear objectives and then meeting them.
		Lyase develops marketing strategies for the sole purpose of business growth.
		Lyase employ lateral thinking to generate sales channels for companies of all sizes.
	www.bikeriders.co.uk (124 words)

	Expanded Newborn Screening Using Tandem Mass Spectromety
		HMG lyase deficiency is one type of organic acid disorder.
		Some people with HMG lyase deficiency never have symptoms and are only found to be affected after a brother or sister is diagnosed.
		HMG lyase deficiency is inherited in an autosomal recessive manner.
	www.newbornscreening.info /Parents/organicaciddisorders/HMGCoA.html (2400 words)

	Phenylalanine ammonia lyase activity and anthocyanin accumulation in the aleurone tissue (Site not responding. Last check: 2007-10-13)
		The phenylalanine ammonia lyase activity in the developing aleurone tissue of C C kernels was investigated in order to see whether there is any correlation between anthocyanin accumulation and phenylalanine ammonia lyase levels.
		Phenylalanine ammonia lyase was assayed (Zuker, 1965 and Saunders et al., 1975 with certain modifications) in acetone powder extracts of fresh aleurone tissue (25mM sodium borate buffer pH 8.8 with polyvinylpolypyrrolidone, mg/mg).
		It was also observed that phenylalanine ammonia lyase activity was localized primarily in aleurone (84%) compared to the endosperm (5%) and the embryo (11%) tissue.
	www.maizegdb.org /mnl/59/79jayaram.html (325 words)

	Polysaccharide Lyase: Molecular Cloning, Sequencing, and Overexpression of the Xanthan Lyase Gene of Bacillus sp. ...
		Polysaccharide Lyase: Molecular Cloning, Sequencing, and Overexpression of the Xanthan Lyase Gene of Bacillus sp.
		Nucleotide sequence of the xanthan lyase gene and its deduced amino acid sequence.
		Ahlgren, J. Purification and characterization of a pyruvated-mannose-specific xanthan lyase from heat-stable, salt-tolerant bacteria.
	aem.asm.org /cgi/content/full/67/2/713 (4501 words)

	Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum -- Li et al. 128 (18): ...
		Migration is impaired in S-1-P lyase null slugs.
		The wild-type Ax4 (A) and S-1-P lyase null (B) cells were grown axenically and harvested for the slug migration assay as described in the Materials and Methods.
		lyase is known to be a downstream component in the pathway of
	dev.biologists.org /cgi/content/full/128/18/3473 (6301 words)

	An unusual pectate lyase from a Bacillus sp. with high activity on pectin: cloning and characterization -- Soriano et ...
		An unusual pectate lyase from a Bacillus sp.
		The gene pelA encoding a pectate lyase from the strain Bacillus
		González-Candelas, L. and Kolattukudy, P. Isolation and analysis of a novel inducible pectate lyase gene from the phytopathogenic fungus Fusarium solani f.
	mic.sgmjournals.org /cgi/content/full/146/1/89 (3451 words)

	Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial ...
		Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro -- Longley et al.
		phosphate lyase activity intrinsic to the catalytic subunit.
		Many basic proteins such as histones and polyamines are able to perform dRP lyase activity with very low efficiency (32).
	www.pnas.org /cgi/content/full/95/21/12244 (3131 words)

	Spore Photoproduct Lyase from Bacillus subtilis Spores Is a Novel Iron-Sulfur DNA Repair Enzyme Which Shares Features ...
		SP lyase assays from crude spore extracts were performed by a modification of the protocol described for RNR by Ollagnier
		Assay of SP lyase activity with enzyme purified on nickel-NTA agarose was performed by a slight modification of the procedure
		Molecular cloning and characterization of the Bacillus subtilis spore photoproduct lyase (spl) gene, which is involved in repair of UV radiation-induced DNA damage during spore germination.
	jb.asm.org /cgi/content/full/180/18/4879 (5331 words)

	Improvision application center: Journal references
		Sphingosine-1-phosphate is irreversibly degraded by the highly conserved enzyme sphingosine-1-phosphate lyase.
		In this study, regulation of sphingosine-1-phosphate lyase gene expression was investigated in Caenorhabditis elegans, where lyase expression is spatially restricted to cells of the developing and adult gut and is essential for normal development.
		Additionally, we demonstrate that the human sphingosine-1-phosphate lyase gene is regulated by a GATA transcription factor.
	www.improvision.com /application_center/references/detail.php?id=145 (259 words)

	3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency - Genetics Home Reference
		3-hydroxy-3-methylglutaryl-coenzyme A (CoA) lyase deficiency (also referred to as HMG-CoA lyase deficiency) is an uncommon inherited disorder in which the body cannot properly process a particular amino acid (a building block of proteins).
		Mutations in the HMGCL gene cause 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency.
		Most often, the parents of an individual with an autosomal recessive disorder are carriers of one copy of the altered gene but do not show signs and symptoms of the disorder.
	ghr.nlm.nih.gov /condition=3hydroxy3methylglutarylcoalyasedeficiency (714 words)

	[No title]
		A number of enzymes, belonging to the lyase class, for which fumarate is a substrate, have been shown to share a short conserved sequence around a methionine which is probably involved in the catalytic activity of this type of enzymes [1, 2].
		P04424 (ARLY_HUMAN): Arginosuccinase, EC:4.3.2.1 (argininosuccinate lyase), which catalyzes the formation of arginine and fumarate from argininosuccinate, the last step in the biosynthesis of arginine.
		P25739 (PUR8_ECOLI): Adenylosuccinase, EC:4.3.2.2 (adenylosuccinate lyase) [4], which catalyzes the eighth step in the de novo biosynthesis of purines, the formation of 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide and fumarate from 1-(5- phosphoribosyl)-4-(N-succino-carboxamide).
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000362 (643 words)

	Effects of Hyaluronan Lyase, Hyaluronidase, and Chondroitin ABC Lyase on Mammalian Vitreous Gel -- Bishop et al. 40 ...
		Effects of Hyaluronan Lyase, Hyaluronidase, and Chondroitin ABC Lyase on Mammalian Vitreous Gel -- Bishop et al.
		The void volume HA concentration was calculated from the integrated refractive index of material that eluted before 11 ml (shaded area); 11 ml was chosen because it was determined from the shape of the elution profile that all the material in the void volume had eluted from the column at this volume.
		The same vitreous extract as (A) but with subsequent overnight digestion at 37°C with 2.5 U/ml Streptomyces HA lyase before chromatography (B); as a result of this additional digestion the refractive index peak was completely abolished from the void volume, thus demonstrating that only HA contributed to this peak.
	www.iovs.org /cgi/content/full/40/10/2173 (3413 words)

	Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, ...
		Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket -- van der Kemp et al.
		The AP lyase activity of wild-type hOgg1 and the mutants was
		Girard,P.M., Guibourt,N. and Boiteux,S. (1997) The Ogg1 protein of Saccharomyces cerevisiae: a 7,8-dihydro-8-oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity.
	nar.oxfordjournals.org /cgi/content/full/32/2/570 (5148 words)

	References - phenylalanine and lyase - HORT640 - Metabolic Plant Physiology - Department of Horticulture and Landscape ...
		Mase K, Sato K, Nakano Y, Nishikubo N, Tsuboi Y, Zhou J, Kitano H, Katayama Y 2005 The ectopic expression of phenylalanine ammonia lyase with ectopic accumulation of polysaccharide-linked hydroxycinnamoyl esters in internode parenchyma of rice mutant Fukei 71.
		Newman MA, von Roepenack-Lahaye E, Parr A, Daniels MJ, Dow JM 2001 Induction of hydroxycinnamoyl-tyramine conjugates in pepper by Xanthomonas campestris, a plant defense response activated by hrp gene-dependent and hrp gene-independent mechanisms.
		Schmidt K, Heberle B, Kurrasch J, Nehls R, Stahl DJ 2004 Suppression of phenylalanine ammonia lyase expression in sugar beet by the fungal pathogen Cercospora beticola is mediated at the core promoter of the gene.
	www.hort.purdue.edu /rhodcv/hort640c/referen/pal.htm (5494 words)

	Argininosuccinate Lyase - Biochemical Analysis
		Physiologically, argininosuccinate lyase catalyzes the conversion of argininosuccinic acid into arginine and fumarate.
		The deficiency of argininosuccinate lyase causes argininosuccinic aciduria.
		This assay measures the ability of the enzyme to catalyze the reverse reaction, i.e.
	www.bcm.edu /geneticlabs/tests/biochem/argininosuccinatelyase.html (196 words)

	Cloning and characterization of two ripening-related strawberry (Fragariaxananassa cv. Chandler) pectate lyase genes -- ...
		lyase genes from higher plants was isolated and characterized.
		Alfano JR, Ham JH, Collmer A. Use of Tn5tac1 to clone a pel gene encoding a highly alkaline asparagine-rich pectate lyase isozyme from an Erwinia chrysanthemi EC16 mutant with deletions affecting the major pectate lyase isoenzymes.
		Isolation and characterization of a tobacco gene with homology to pectate lyase which is specifically expressed during microsporogenesis.
	jxb.oxfordjournals.org /cgi/content/full/54/383/633 (5852 words)

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