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Topic: Lymphoblast

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	Cell culture medium - Patent 4038139
		In a method for culturing lymphoblast cells of the type involving culturing cells in an aqueous nutrient medium containing animal serum the improvement which comprises using swine serum in combination with a surfactant to inhibit the precipitation of serum protein.
		Human lymphoblast cells may be grown through successive subcultures using a conventional cell culture medium in which the serum component consists of swine serum.
		MICH strain human lymphoblasts cells age grown in shake flask cultures in conventional media to which are added 10% foetal calf serum, swine, lamb, chicken, newborn calf or horse serum, each of these sera being commerical preparations.
	www.freepatentsonline.com /4038139.html (1647 words)

	Signal transduction of somatostatin in human B lymphoblasts -- Rosskopf et al. 284 (1): C179 -- AJP - Cell Physiology
		Lymphoblast RNA was prepared and reverse transcribed using Superscript reverse transcriptase as described (44).
		B lymphoblasts were stimulated for 2 min with 100 nM SST, 100 nM platelet-activating factor (PAF), or for 15 min with 250 nM of the phorbol ester TPA or remained nonstimulated (control).
		Inhibition by somatostatin of the proliferation of T-lymphocytes and Molt-4 lymphoblasts.
	ajpcell.physiology.org /cgi/content/full/284/1/C179 (6211 words)

	Acute Lymphoblastic Leukemia (ALL)
		Acute lymphoblastic leukemia (ALL), also referred to as acute lymphocytic leukemia or acute lymphoid leukemia, is a type of cancer that starts in the inner part of the bones (bone marrow), but often moves quickly into the blood.
		These lymphoblast white blood cells should turn into lymphocytes (mature white blood cells that help to protect the body from infections), but they do not.
		Too many lymphoblast cells grow in the marrow, which decreases the growth of red blood cells, other white blood cells and platelets.
	www.fhcrc.org /research/diseases/all (767 words)

	CCR: FAQ about Lymphoblastoid Cell Culture
		Lymphoblastoid cell lines obtained from the Coriell Cell Repositories were established by Epstein-Barr Virus transformation of peripheral blood mononuclear cells using phytohemagluttinin as a mitogen.
		Lymphoblast cultures are shipped in T25 tissue culture flasks that have been filled to capacity with carbon dioxide-equilibrated medium to provide sufficient nutrients for extended transport times.
		Lymphoblast cultures should be counted the next day and either split if sufficient growth has occurred or the medium volume decreased to yield a cell density of 200,000 - 500,000 viable cells/ml.
	ccr.coriell.org /ccr/faq/lymph.html (739 words)

	Growth factor-like action of lysophosphatidic acid on human B lymphoblasts -- Rosskopf et al. 274 (6): C1573 -- AJP - ...
		S binding to digitonin-permeabilized B lymphoblasts was assayed as described previously (36).
		B lymphoblasts were stimulated with 100 nM LPA (lanes 5 and 6) or 100 nM PAF (lanes 3 and 4) or remained nonstimulated (Control, lanes 1 and 2).
		In B lymphoblasts the MAP kinase cascade is activated in response to PAF stimulation or cross-linking of membrane IgM (11,
	ajpcell.physiology.org /cgi/content/full/274/6/C1573 (5662 words)

	The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro ...
		Lymphoblasts and normal spleen T cells were incubated with 50
		Each point represents the mean increase over diluent control-injected sites in four animals and is shown on the abscissa at the average age of the lesion during the 3 h the labeled cells were circulating in the animal.
		Control sites were 67 ± 4 and 55 ± 5 for the lymphoblasts, and 20.4 ± 2.5 and 18.6 ± 2.3 for spleen T cells in the 1.5 and 5 h lesions, respectively.
	www.jleukbio.org /cgi/content/full/74/5/791 (5913 words)

	im0616
		Lymphoblasts from most donors will be in an optimal state for use in the IL-12 bioassay protocols after this incubation, but in general the optimal length of the incubation should be determined empirically (see Critical Parameters).
		In the authors2' experience, bioassays based on the ability of IL-12 to induce proliferation of activated T lymphoblasts are technically the simplest, yet yield reproducible, quantitative results.
		Although the simple lymphoblast proliferation assay described in Alternate Protocol 1 suffers from a lack of specificity, the antibody-capture bioassay described in Basic Protocol 1 overcomes this problem by measuring lymphoblast proliferation in response to IL-12 specifically bound to an immobilized anti-IL-12 monoclonal antibody.
	www.does.org /masterli/im0616.htm (6726 words)

	Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia ...
		(A) Lymphoblast cell lines were exposed to UV radiation, cultured for 30 minutes, and subjected to immunoprecipitation with anti-JNK.
		(B) Control and FA-A lymphoblasts were incubated in the presence of MMC for the indicated times and analyzed for the activity of JNK as assessed by phosphorylation of the GST-ATF2 substrate (top panel).
		Transduction of EBV-transformed FA lymphoblasts with the corresponding
	www.bloodjournal.org /cgi/content/full/103/1/128 (3791 words)

	IFN-{gamma} Stimulates the Expression of a Novel Secretoglobin That Regulates Chemotactic Cell Migration and Invasion ...
		Cell lysates from lymphoblasts were immunoprecipitated with IIS Ab and resolved by SDS-PAGE under reducing conditions, and immunoblots were prepared using IIS Ab.
		Note that the preadsorption of the antiserum with the synthetic oligopeptide, used as the Ag for generating IIS Ab, failed to recognize the IIS protein band.
		The effect of IIS antisense S-oligonucleotide treatment of lymphoblasts on cellular migration and invasion.
	www.jimmunol.org /cgi/content/full/172/7/4245 (5519 words)

	Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic ...
		The median lymphoblast glutathione level in samples from patients at relapse was 6.85 nmol/mg protein (range, 1.49-16.5).
		Critical study of prognostic factors in childhood acute lymphoblastic leukaemia: differences in outcome are poorly explained by the most significant prognostic variables.
		Relationship of pretreatment lymphoblast proliferative activity and prognosis in 97 children with acute lymphoblastic leukaemia.
	www.bloodjournal.org /cgi/content/full/97/2/393 (4751 words)

	Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients -- Hashem et al. 32 (21): 6334 -- ...
		Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients -- Hashem et al.
		Lymphoblast cell line 428 was treated with 500 and 700 µg/ml
		Lymphoblast cell line 428 and 313-1-15 were treated with 0.1
	nar.oxfordjournals.org /cgi/content/full/32/21/6334 (7296 words)

	Lymphocyte Development (Site not responding. Last check: 2007-10-19)
		Lymphocytes split off to their own line of stem cells quite early in development, thus the lymphocytes are considered a separate line from the entire collection of myeloid cells (erythrocytes, monocytes, neutrophils, eosinophils, basophils).
		The first cell that is morphologically recognizable as being distinct to the lymphoid line is the lymphoblast.
		Lymphoblasts can divide 2-3 times to form prolymphocytes.
	www.som.tulane.edu /classware/pathology/Krause/Blood/LP.html (175 words)

	Roles of {alpha}4 integrins/VCAM-1 and LFA-1/ICAM-1 in the binding and transendothelial migration of T lymphocytes and ...
		Lymphoblasts were generated using 300 ng/ml BsAb for 72 h, and enriched by density gradient centrifugation and FACS sorting.
		LN cells (A) and lymphoblasts (B) were analysed for size, subset composition and integrin expression by flow cytometry.
		The adhesion of T lymphocytes (open symbols) and T lymphoblasts (closed symbols) to cultured HEC (A and B) or immobilized VCAM-1 (C and D) was measured in the presence of antibodies to
	intimm.oxfordjournals.org /cgi/content/full/12/3/241 (5676 words)

	Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes -- Hershfield et al. ...
		Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes -- Hershfield et al.
		The adenosine kinase-deficient mutant was still as sensitive as its parent to growth inhibition caused by adenosine deaminase was inhibited.
		Thus, the toxicity of adenine and adenosine to human lymphoblasts is not mediated by nucleotides to which they may be converted.
	www.sciencemag.org /cgi/content/abstract/197/4310/1284 (308 words)

	Friedreich's Ataxia, No Changes in Mitochondrial Labile Iron in Human Lymphoblasts and Fibroblasts: A DECREASE IN ...
		RPA (29), is not affected in human FRDA fibroblasts and lymphoblasts.
		Lymphoblast and fibroblast cell lines from four Friedreich's ataxia patients and four age- and sex-matched controls were loaded with the mitochondrial iron indicator RPA (0.2 µ
		Fibroblasts (A) and lymphoblasts (B) from an FRDA patient and an age- and sex-matched control, respectively, were washed twice with the respective medium containing 50 µ
	www.jbc.org /cgi/content/full/280/8/6701 (5750 words)

	Medical Dictionary: Acute lymphoblastic leukemia - WrongDiagnosis.com
		A quickly progressing disease in which too many immature white blood cells (called lymphoblasts) are found in the blood and bone marrow.
		Acute lymphoblastic leukemia: Leukemia with an acute onset, characterized by the presence of lymphoblasts or Burkitt cells in the bone marrow and the peripheral blood.
		It includes the precursor B lymphoblastic leukemia, precursor T lymphoblastic leukemia, and Burkitt's leukemia.
	www.wrongdiagnosis.com /medical/acute_lymphoblastic_leukemia.htm (413 words)

	The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 ...
		The recovered membrane protein fraction (P) was quantified by laser scanning densitometry and 100% was set as the amount that was imported into wild-type mitochondria from one of three separate experiments.
		A lymphoblast cell line derived from a new MTS family is defective in mitochondrial import
		Lymphoblast cell lines derived from an MTS patient with a Q34X mutation in DDP1 lack the DDP1–TIMM13 complex and show import defects.
	hmg.oxfordjournals.org /cgi/content/full/13/18/2101 (5912 words)

	NADPH Oxidase Activity in Preeclampsia With Immortalized Lymphoblasts Used as Models -- Lee et al. 41 (4): 925 -- ... (Site not responding. Last check: 2007-10-19)
		Lymphoblast NADPH oxidase protein abundance was analyzed with
		EBV lymphoblast chemiluminescence response was significantly enhanced in both preeclamptic groups compared with respective controls (F statistic, 10.922; P<0.002).
		D, Box-and-whisker plots of lymphoblast PMA-stimulated rhodamine-123 fluorescence in groups defined for B. Lymphoblast ROS response was significantly enhanced in both preeclamptic groups compared with respective controls (F statistic, 27.55; P<0.001).
	hyper.ahajournals.org /cgi/content/full/41/4/925 (3283 words)

	Clinical Trial: Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios
		We propose to collect genomic DNA and lymphoblast cell lines of a total of 150 DSM-IV schizophrenic patients and their first degree relatives including parents (parent-offspring trios) and non-affected siblings in three years.
		Specific Aims We propose to collect genomic DNA and lymphoblast cell lines of a total of 150 families with the probands fulfilling the criteria of DSM-IV schizophrenia in three years.
		Cell-line set-up All blood samples newly collected will have the lymphocyte transformed into lymphoblastic cell for preservation of cell-line which will be deposited into the cell bank of NHRI as the proposal requested.
	clinicaltrials.gov /ct/show/NCT00155506 (4155 words)

	Short description of cell lines. Species: mouse (Site not responding. Last check: 2007-10-19)
		Subclone 707 DK 4.8 (lymphoblast, leukemia, Friend) - ECACC
		Subclone 707 TG1 (lymphoblast, leukemia, Friend) - ECACC
		Subclone 707 TG2 (lymphoblast, leukemia, Friend) - ECACC
	www.biotech.ist.unige.it /cldb/spe21.html (216 words)

	Aberrant Splicing in the PKD2 Gene as a Cause of Polycystic Kidney Disease -- REYNOLDS et al. 10 (11): 2342 -- Journal ...
		The level of PKD2 expression in patient lymphoblast lines is reduced relative to wild type (w.t.).
		Note that with both YCC2 and YCB9, the level of normal polycystin-2 expression is reduced in PKD2 lymphoblasts compared with wild type, whereas type 1 ADPKD patient-derived lymphoblasts have polycystin-2 expression comparable with wild type.
		identified in the lymphoblast membrane fraction was indeed polycystin-2.
	jasn.asnjournals.org /cgi/content/full/10/11/2342 (5737 words)

	Lymphoblast: Exploring the Microscopic World Coursing Through Your Veins
		Lymphoblast: Exploring the Microscopic World Coursing Through Your Veins
		Lymphoblasts are 12-20 µm in diameter with a round to oval nucleus, sometimes eccentric in location.
		The nucleus to cytoplasm ratio is about 4:1 and the periphery of both the nucleus and the cell may be irregular in outline.
	www.wadsworth.org /chemheme/heme/microscope/lymphoblast.htm (107 words)

	Hyperinsulinism/Hyperammonemia Syndrome in Children with Regulatory Mutations in the Inhibitory Guanosine ...
		of lymphoblast GDH from patients with mutations in exons 6 and
		Lymphoblast GDH allosteric responses to ATP in HI/HA patients
		Relationship between plasma ammonium and lymphoblast GDH sensitivity to GTP inhibition in HI/HA patients.
	jcem.endojournals.org /cgi/content/full/86/4/1782 (3798 words)

	Slide 139
		Slide 139 was taken from a case of acute lymphoblastic anemia (ALL).
		The arrowed cell is a lymphoblast (code: 03).
		Because of the difficulties in distinguishing lymphoblasts from other types of blasts and without additional cytochemical stains or cell surface marker evidence, blast cell, not classified (code: 01) is an appropriate response for this challenge.
	www.wadsworth.org /chemheme/heme/cytoheme/ans139.htm (139 words)

	Definition of lymphoblast - NCI Dictionary of Cancer Terms
		Definition of lymphoblast - NCI Dictionary of Cancer Terms
		A lymphocyte that has gotten larger after being stimulated by an antigen.
		Lymphoblast also refers to an immature cell that can develop into a mature lymphocyte.
	www.nci.nih.gov /Templates/db_alpha.aspx?CdrID=302475 (60 words)

	{alpha}4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white ...
		T lymphoblasts are captured without rolling in the spinal cord white matter microvasculature.
		Six hours after infusion of T lymphoblasts, the Cell Tracker Orange–labeled T cell blasts (red fluorescence) could be localized outside the spinal cord microvasculature (green fluorescence) within the spinal cord parenchyma of control animals.
		Superimposed fluorescence is shown, which demonstrates one T cell blast attached within the venule (yellow fluorescence) and one T cell blast within the spinal cord parenchyma (red fluorescence).
	www.jci.org /cgi/content/full/108/4/557 (5910 words)

	International AIDS Society
		Methods: The anti-HIV activity of combinations of TFV and FTC against wild-type and mutant virus (K56R and M184V) was studied in the human leukemic lymphoblast cell line MT2.
		The anabolism of TFV and FTC, either alone or in combination, was studied over 24 hours in the human leukemic CEM lymphoblast cell line.
		Intracellular levels of the phosphorylated forms of each NRTI were evaluated by transient ion-pairing HPLC coupled to positive ion electrospray tandem mass spectrometry (LC/MS/MS).
	www.iasociety.org /abstract/show.asp?abstract_id=2176793 (372 words)

	Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent ...
		(C) T lymphoblasts were allowed to transmigrate across an activated HUVEC monolayer, and then cells were fixed, permeabilized, and stained with the anti–VCAM-1 mAb P8B1 (a–c, red), the anti-ICAM-1 mAb Hu5/3 (d–f, red), or the anti-ezrin pAb 90/3 (c and f, green).
		Representative confocal horizontal images showing an apical section of endothelium with adhered lymphoblasts on top (a and d) and a basal section with transmigrated lymphoblasts beneath the endothelium (b and e) are presented.
		Representative orthogonal sections corresponding to the white line in panel a or panel d are shown in panels c and f, respectively.
	www.jcb.org /cgi/content/full/157/7/1233 (7369 words)

	Discovery Health :: Diseases & Conditions :: acute lymphoblastic leukemia
		Discovery Health :: Diseases and Conditions :: acute lymphoblastic leukemia
		Samples of blood and bone marrow cells taken during a biopsy are examined for a buildup of immature cells, called lymphoblasts, and abnormal lymph cells.
		Afterward, other tests are done to evaluate the extent of the disease, such as:
	health.discovery.com /encyclopedias/illnesses.html?article=2119 (586 words)

	Partners Research Cores\| CHGR Tissue Culture Resource
		This facility provides processing of human blood samples for DNA, plasma and buffy coat storage and for initiation of lymphoblast cell lines in furtherance of the CHGR mission to promote the use of genetic strategies in basic and clinical research.
		The facility is located in the Center for Human Genetic Research, 5th floor of the Richard B. Simches Research Center, 185 Cambridge Street, Boston.
		Inquiries should be addressed to Mary Anne Anderson at (617) 724-2355 or by email at manderson4@ partners.org.
	www.partners.org /researchcores/resources/CHGR_tissue_culture_MGH.html (90 words)

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