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Topic: Lymphoma in animals

    Note: these results are not from the primary (high quality) database.

Intracranial Lymphomas in Simian Retrovirus-Positive Macaca fascicularis -- Paramastri et al. 39 (3): 399 -- Veterinary Pathology Guzman RE, Kerlin RL, Zimmerman TE: Histologic lesions in cynomolgus monkeys ( Macaca fascicularis) naturally infected with simian retrovirus type D: comparison of seropositive, virus-positive, and uninfected animals. Habis A, Baskin GB, Murphey-Corb M, Levy LS: Simian AIDS associated lymphoma in rhesus and cynomolgus monkeys recapitulates the primary pathobiological features of AIDS-associated non-Hodgkin's lymphoma. Monkey No. 2 presented with moderate to severe ptosis and swelling www.vetpathology.org /cgi/content/full/39/3/399

Laboratory Primate Newsletter, Volume 24, Number 3 Malignant lymphoma occured in six Macaca arctoides from a colony of 83 animals during a 30-month period. Since 6 of these animals were born in the colony, a means of transmission was sought and it was determined that multiple use of a syringe to administer intravenous anesthesia was the probable means of cross transmission. Malignant lymphoma in a colony of Macaca arctoides. www.brown.edu /Research/Primate/lpn24-3.html

Barium and Compounds (CASRN 7440-39-3), IRIS, Environmental Protection Agency The incidences of lymphoma leukemia and lung tumors in the male (7/37 and 4/37, respectively) and female (5/21 and 3/21) mice exposed to barium were not significantly different from the incidences in the control mice (males: 3/38 for lymphoma leukemia and 5/38 for lung tumors; females: 3/47 and 9/47, respectively). In this study, fibrous pneumonia and necrosis of the mucous membrane of the large bronchi was observed 9 mo after animals received an intratracheal dose of 50 mg barium carbonate (35 mg barium). In males, longevity (defined as the mean life span of the last surviving 5 animals of each sex in each treatment group) was significantly (p=0.025) reduced at 815 days for barium-treated males as compared with 920 days for the controls. www.epa.gov /iris/subst/0010.htm

Studies Find No Evidence That Simian Virus 40 Is Related To Human Cancer Simian Virus 40 Found In Human Lymphoma Samples (March 18, 2002) -- Evidence of simian virus 40 (SV40) infection found in 42 percent of non-Hodgkin lymphoma samples could shed new light on the genesis of these blood cancers that have become more common over the past... This has been a significant public health concern, as SV40 has been shown to cause cancer in experimental animals. No Role For Simian Virus 40 In Human Pleural Mesotheliomas (September 27, 2004) -- A study, published in the September 25 issue of Lancet, calls into question the proposed link between SV40 and pleural mesothelioma and provides a possible explanation for the discrepancies in the... www.sciencedaily.com /releases/2004/08/040825092736.htm

ASPCA Poison List Because poisoning often results in the secondary poisoning of non-target animals, toxic substances to control rodents should be used only as a last resort, and then with great precaution. The herbicide 2,4-D, a component in Agent Orange used by many lawn treatment companies, is associated with canine malignant lymphoma, a cancer. The majority of poisonings related to these chemicals are due to improper use, especially when many different types of insecticides are used at the same time. www.jeanesholistics.com /poisonlist.html   (721 words)

Thomas Hodgkin - Wikipedia, the free encyclopedia In 1823, Hodgkin qualified for his M.D. at Edinburgh with a thesis on the physiological mechanisms of absorption in animals. Hodgkin described the disease that bears his name (Hodgkin's lymphoma) in 1832, in a paper titled On Some Morbid Appearances of the Absorbent Glands and Spleen. He is now best known for the first account of Hodgkin's disease, a form of lymphoma and blood disease, in 1832. en.wikipedia.org /wiki/Thomas_Hodgkin   (721 words)

Dorlands Medical Dictionary A wide variety of animals, including opossums, skunks, raccoons, foxes, pigs, and dogs, shed the infective organisms in the urine, and human infection is due to direct contact with the urine or tissue of such animals or to contact with contaminated water, soil, or vegetation. The lesion is usually benign but may be associated with non-Hodgkin lymphoma. interrogans are believed to be capable of causing any of the clinical syndromes, which vary from a mild carrier state to a fatal disease. www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_l_07zPzhtm   (3957 words)

Online Pharmacy, Tramadol, Paxil, antibiotics, amoxicillin, zithromax, Rx Online, pharmaceuticals, DHEA, prescription medications, prescription drugs. Tumor lysis syndrome (TLS) and renal failure remain significant causes of morbidity and mortality in children with newly diagnosed Burkitt's lymphoma and high white blood cell count acute lymphocytic leukemia (ALL) despite conventional management with aggressive hydration, alkalinization, allopurinol, and the slow introduction of chemotherapy. We evaluated the prospective use of continuous veno-venous hemofiltration (CVVH), in addition to conventional management to prevent renal failure from tumor lysis, in three children with advanced abdominal Burkitt's lymphoma and in two children with high white blood cell count T-cell ALL who were at very high risk based on LDH and urine output. At the end of reperfusion, there was a significant drop in sodium excretion by the right (intact circulation) kidney of the treated animals. www.hairmillion.com /rx-online-info/allopurinol-online-rx/allopurinol-online-rx.589.html   (990 words)

Cancer Control and Population Sciences: Current Research In this animal model system, we will assess the usefulness of lymphokine administration on the survival rates of mice injected with either the fibrosarcoma or the T cell lymphoma, and we will also measure in vitro cytotoxic responses of lymphoctyes/macrophages recovered from treated and control animals. The T cell lymphoma may be of particular value in demonstrating not only the potential usefulness but also the possible limitations of lymphokine therapy since a tumor of lymphoid origin may respond to lymphocyte products and to immunosurveillance differently than a tumor of non-lymphoid origin. The lymphokines, Inteleukin-2, (T cell growth factor), gamma interferon and beta interferon are potent regulators of the immune response as shown by their capacity to enhance cytotoxic T cell, natural killer cell and macrophage tumoricidal responses in vitro. dccps.nci.nih.gov /grants/abstract.asp?ApplID=3171306   (312 words)

Handbook of Carcinogenicity Potency and Genotoxicity Databases: Review by John S. Wassom The genotoxicity data consists of six in vitro tests conducted by the National Toxicology Program, i.e., L5178Y mouse lymphoma cell assay, chromosome aberrations and sister chromatid exchange tests in Chinese hamster ovary cells, Drosophila melanogaster sex-linked recessive lethal tests, and the Salmonella mammalian microsome assay. The editors and publisher are commended on expending the resources (time and money) to make this volume available as it represents a multi-year effort devoted to the documentation of test results for chemicals evaluated for carcinogenicity in animals and genotoxic activity in a series of short-term bioassays. CRC Press) have achieved with this book is to compress into a single source a wealth of data/information on chemical agents evaluated for carcinogenicity (1298) and genotoxicity (1525). potency.berkeley.edu /wassom.html   (312 words)

7/13/04, Research Roundup - Almanac, Vol. 51, No. 1 By comparing a portion of the MYH16 gene sequence in humans to that in five other animals-quantifying the so-called molecular clock-the researchers calculated that the inactivating mutation appeared in a hominid ancestor about 2.4 million years ago, after the lineages leading to humans and chimpanzees diverged. Funding for the study, was provided through research grants from the AFCRI, Cancer Research Institute (CRI), and the Leukemia and Lymphoma Society of America. To determine whether the mutation was a rare form of an active gene and not a mistake introduced by the technical nature of the investigation, the team tested DNA samples from geographically disparate human populations. www.upenn.edu /almanac/volumes/v51/n01/research.html   (312 words)

Waltham - OSU Symposium Neoplasia of the nictitating membrane is uncommon in small animals.  Adenoma/adenocarcinoma of the gland of the nictitating membrane, melanoma, fibrosarcoma, and lymphoma have been reported in dogs and cats. Figure 3.  Two dermoids of the lower eyelid are present in this 5-month-old Shetland Sheepdog.  Surgical excision and a blepharoplastic procedure were necessary to correct the defect. for replacement include suturing the gland to: 1) adjacent sclera; 2) extraocular muscle tendon; 3) ventral endorbita of the orbital rim.  The best technique to use in instances where the gland has recently prolapsed or has not been surgically replaced previously is the conjunctival imbrication (“Pocket”) technique. www.vin.com /VINDBPub/SearchPB/Proceedings/PR05000/PR00520.htm   (312 words)

Bovine Leukemia Virus Bovine leukemia virus (BLV) is an exogenous type C retrovirus that is associated with the development of malignant lymphoma in cattle. A strong relationship between polymorphism of the BoLA (bovine lympocyte antigen) - exon 2 of DRB3 revealed the presence of amino acids ER (glu-arg) at putative antigen binding residues 70 and 71 only in BoLA haplotypes associated with resistance to PL, while VDTY (val-asp-thr-val) sequence was frequently seen in PL animals. The prevalence of proviral bovine leukemia virus in peripheral blood mononuclear cells at two subclinical stages of infection. cagst.animal.uiuc.edu /blv   (582 words)

Chemical Fact Sheets -- Methyl Tert-butyl Ether (MTBE) Cancer: When exposed to high levels of MTBE over a long period of time, some laboratory animals developed kidney tumors, testicular tumors, lymphoma and leukemia. MTBE is a gasoline additive with a very strong odor. If levels of MTBE are very high in your water, you may need to avoid washing, bathing or using the water for other purposes. www.dhfs.state.wi.us /eh/chemfs/fs/MTBE.htm   (800 words)

Viral Survivor: Science News Online, Aug. 3, 2002 Epstein-Barr virus appears to cause at least two malignancies common in specific locations: Burkitt's lymphoma, a B cell cancer frequently found in Africa, and nasopharyngeal carcinoma, a tumor in the back of the throat that's the most common cancer among men in many parts of Asia. Resolving such questions is a challenge, he points out, because the virus doesn't infect mice or other laboratory animals in which investigators can easily test their theories. Studies have also linked the virus to other lymphomas in people with a weakened immune system and gastric carcinoma—a cancer of the lining of the stomach. www.sciencenews.org /20020803/bob10.asp   (2282 words)

Combination Therapy Drives Cancer Into Remission A two-drug combination therapy, published in tomorrow's issue of the journal Nature, led to the complete remission of a mouse model of B-cell lymphoma in all of the treated animals. Therefore, the combination therapy outlined by the new study is a promising general strategy for treating many cancers that are refractory to current therapies. Personalized cancer therapy, still in its infancy, involves profiling the genetic lesions within a patient's tumor cells at the level of DNA or protein and using the resulting profile to select the best drug or drug combination for treatment. www.sciencedaily.com /releases/2004/03/040318073757.htm   (1154 words)

Microbiology and Immunology The LTR is precisely conserved among independent cases of multicentric lymphoma, myeloproliferative disease and anemia in animals from the cohort. The 21-bp triplication was previously shown to act as a transcriptional enhancer preferentially in hematopoietic cells and to confer a replicative advantage. The objective of the present study was to examine the molecular mechanism by which the 21-bp triplication exerts its influence and the selective advantage responsible for its precise conservation. www.mcl.tulane.edu /microbiology/levyabs.htm   (1375 words)

Blog of Death: David Bale Bale, 62, died on Dec. 30 from brain lymphoma. Bale used his piloting skills to provide air rescue and food supplies to needy communities in Africa. This began an empathy with animals that would never end. www.blogofdeath.com /archives/000638.html   (1399 words)

G(D2) oligosaccharide: Target for cytotoxic T-lymphocyte (CTL) (Meeting abstract). Disialo-ganglioside G(D2) is expressed at high levels among human tumors (neuroblastomas, SCLC, melanomas, sarcomas, brain tumors) and a small group of murine lymphomas. Immunization of C57Bl/6 mice with irradiated EL4 cells stimulated a specific CTL response and protected these animals from engraftment of EL4 lymphoma. CTL activity was completely inhibited by GD2-oligosaccharide specific monoclonal antibodies and their F(ab')2 fragments, but not by a large panel of IgG3 myelomas or antibodies against GD3 or GM2. www.aegis.com /aidsline/1996/apr/M9640027.html   (484 words)

PUPD and Diabetes Insipidus - WSAVA 2002 Primary intracranial tumors causing DI in dogs and cats include craniopharyngioma, pituitary chromophobe adenoma, and pituitary chromophobe adenocarcinoma and metastatic tumors include metastatic mammary carcinoma, lymphoma, malignant melanoma, and pancreatic carcinoma. Plasma AVP concentrations are normal or increased in animals with this disorder. Central diabetes insipidus (CDI) is a polyuric syndrome that results from a lack of sufficient arginine vasopressin (AVP) to concentrate the urine for water conservation. www.vin.com /proceedings/Proceedings.plx?CID=WSAVA2002&PID=2556   (1513 words)

Duesberg on AIDS- The AIDS Dilemma Chemically distinct drugs cause distinct AIDS-defining diseases; for example, nitrite inhalants cause Kaposi's sarcoma, cocaine causes weight loss, and AZT causes immunodeficiency, lymphoma, muscle atrophy, and dementia. Likewise, the AIDS literature, the drug manufacturers, and non-scientific reports confirm that anti-HIV drugs cause AIDS and other diseases in humans and animals. AIDS-defining diseases of HIV-free patients are called by their old names. www.duesberg.com /papers/pddrgenetica.html   (665 words)

Lactate dehydrogenase - Wikipedia, the free encyclopedia Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It is used to follow-up cancer (especially lymphoma) patients, as cancer cells have a high rate of turnover, with destroyed cells leading to an elevated LDH activity. In medicine, LDH is often used as a marker of tissue breakdown. en.wikipedia.org /wiki/LDH   (446 words)

Palladium (EHC 226, 2002) In this study, it remained unclear whether reactivity to palladium(II) chloride in animals sensitized with nickel sulfate was due to cross-reactivity or to the induction of sensitivity by the repeated treatments. Mice given palladium(II) chloride (5 mg Pd /litre) in drinking-water from weaning until natural death developed malignant tumours, mainly lymphoma-leukaemia types and adenocarcinoma of the lung, at a statistically significant rate, but concomitant with an increased longevity in males, which may explain at least in part the increased tumour rate. An EC value of palladium(II) chloride for inhibition of DNA synthesis in vitro with mouse fibroblasts was 300 µmol/litre (32 mg Pd /litre). www.inchem.org /documents/ehc/ehc/ehc226.htm   (446 words)

Histone methyltransferases in tumor suppression Abnormal diet causes one third of cancer deaths in the US, and how it happens remains one of the important problems of cancer research. cancer, tumor, cells, RIZ1, genes, tumor suppressor, members, human cancers, RIZ, histone methyltransferases, Huang, animals, common, lymph node, lymphoma. Histone methyltransferases in tumor suppression Abnormal diet causes one third of cancer deaths in the US, and how it happens remains one of the important problems of cancer research. Two products are normally produced from a PR-domain family member which differ by the presence or absence of the PR domain; the PR-plus product is disrupted or underexpressed whereas the PR-minus product is present or overexpressed in cancer cells. www.clickerado.com /y/yin-yang/cancer.htm   (446 words)

TeacherSource . Recommended Books . Health & Fitness PBS For Lynn, the world is a glittering place until she is diagnosed with lymphoma, then it is Katie’s turn to look for the beauty, for her sister’s sake and for the rest her family’s. Mosquitoes are the deadliest animals in the world. In thirty-five years, Hawk won 12 skateboarding World Championships and invented more than 80 tricks,like the Madonna, the saran wrap, and his final fantastic 900 in the 1999 X Games. www.pbs.org /teachersource/recommended/health_fitness/bk_6-8.shtm   (446 words)

Agent Orange, Operation Ranch Hand : Vietnam War Herbicides After a scientific report in 1969 concluded that one of the primary chemicals used in Agent Orange could cause birth defects in laboratory animals, use of the herbicide was suspended. Those diseases are soft tissue sarcoma, non-Hodgkin's lymphoma, and Hodgkin's disease, as well as skin diseases chloracne and porphyria cutanea tarda (PCT). The committee's report specifically focuses on Agent Orange and other herbicides used in Vietnam, some of which contained dioxin, and unintended byproduct of the manufacturing process. www.landscaper.net /agent.htm   (2145 words)

Agent Orange, Operation Ranch Hand : Vietnam War Herbicides After a scientific report in 1969 concluded that one of the primary chemicals used in Agent Orange could cause birth defects in laboratory animals, use of the herbicide was suspended. Those diseases are soft tissue sarcoma, non-Hodgkin's lymphoma, and Hodgkin's disease, as well as skin diseases chloracne and porphyria cutanea tarda (PCT). The committee's report specifically focuses on Agent Orange and other herbicides used in Vietnam, some of which contained dioxin, and unintended byproduct of the manufacturing process. www.landscaper.net /agent.htm   (2145 words)

Agent Orange, Operation Ranch Hand : Vietnam War Herbicides After a scientific report in 1969 concluded that one of the primary chemicals used in Agent Orange could cause birth defects in laboratory animals, use of the herbicide was suspended. Those diseases are soft tissue sarcoma, non-Hodgkin's lymphoma, and Hodgkin's disease, as well as skin diseases chloracne and porphyria cutanea tarda (PCT). Below is a map of the provinces of the Central Highlands showing the total volume sprayed of the three major herbicides used in the war; Agents Orange, Blue and White. www.landscaper.net /agent.htm   (2145 words)

Development of Alternatives to Animal Use for Safety Testing and Hazard Assessment Much of this research was undertaken in vitro (in glass) in cells or tissues taken from animals or human beings. These include the Ames-Salmonella and mouse lymphoma assays for bacterial and mammalian mutations and the Chinese Hamster Ovary cell assay for chromosomal aberrations. Human cell and tissue culture in particular were regarded as highly promising methodologies which might prove quite useful, once preliminary research was able to identify certain biological endpoints which could be used to predict toxicity. www.solutions-site.org /artman/publish/article_67.shtml   (6860 words)

Veterinary Pathology A case of multicentric lymphoma with a mixed cell population of large to small round cells with the same nuclear features in a pig was studied immunohistochemically. This case as TCRBCL containing two types of heavy chains with light chain restriction (IgM- and IgG-) appears to be the first of its kind reported in the English literature for either pigs or domestic animals. The PRRSV was isolated in cell culture from 11 of the pigs. www.afip.org /acvp/Vet_Pathol/oldvetpathol/35-2.htm   (6860 words)

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