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Topic: Lymphopenia

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	Arthritis Research & Therapy \| Full text \| Lymphopenia and autoimmune diseases
		In lymphopenia this balance is perturbed and the outgrowth of autoantigen-specific, proinflammatory T cells is facilitated by the depletion of the regulatory T-cell subset.
		As homeostatic expansion is tightly regulated by the available space in lymphoid organs [19], the authors conclude from their data that a depleted memory T-cell compartment fuels the generation of autoreactive effector cells in lymphopenic diabetogenic NOD mice.
		Lymphopenia, however, although frequently associated with autoimmune diseases, appears not to be sufficient for the development of human autoimmunity, which may require additional environmental and genetic factors to progress to clinical disease.
	arthritis-research.com /content/6/4/178 (2151 words)

	Lymphopenia - Wikipedia, the free encyclopedia
		Lymphopenia is the condition in which there exists an abnormally low number of lymphocytes in the blood.
		Lymphopenia can be caused by various types of chemotherapy, such as with cytotoxic agents or immunosuppresive drugs.
		Lymphopenia may be present as part of a pancytopenia, when the total number of blood cells are reduced.
	en.wikipedia.org /wiki/Lymphopenia (136 words)

	Lymphopenia -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-19)
		Lymphopenia is the condition in which there exists an abnormally low number of (An agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection) lymphocytes in the (The fluid (red in vertebrates) that is pumped by the heart) blood.
		Lymphopenia can be caused by various types of (The use of chemical agents to treat or control disease (or mental illness)) chemotherapy, such as with cytotoxic agents or immunosuppresive drugs.
		Lymphopenia may be present as part of a (An abnormal deficiency in all blood cells (red blood cells and white blood cells and platelets); usually associated with bone marrow tumor or with aplastic anemia) pancytopenia, when all the blood cells are of decreased number.
	www.absoluteastronomy.com /encyclopedia/l/ly/lymphopenia.htm (250 words)

	Lymphopenia (Site not responding. Last check: 2007-10-19)
		Lymphopenia and neutrophilia in SARS are related to the prevailing...
		Lymphopenia and abnormal lymphocyte subsets in the "BB" rat...
		Neonatal lethality and lymphopenia in mice with a homozygous...
	www.cougarhealth.com /health_topics/Lymphopenia.html (443 words)

	Clinical associations of lymphopenia in elderly persons admitted to acute medical and psychiatric wards. (Site not responding. Last check: 2007-10-19)
		Lymphopenia is a common finding in old people admitted to medical and psychiatric wards.
		Lymphopenia was associated with functional ability as measured by a lower Barthel score (p = 0.004), and cognitive impairment as measured by the Mini-Mental State Examination (p = 0.02).
		Lymphopenia may be a significant marker of vulnerability, and a larger study is required to elucidate the veracity and mechanisms of lymphopenia-associated debility.
	www.arclab.org /medlineupdates/abstract_9592690.html (233 words)

	Critical Care \| Full text \| Lymphopenia, hypoprolactinemia and lymphocyte depletion in pediatric multiple organ failure
		Lymphopenia is associated with secondary infection, multiple organ failure (MOF) and death in adults.
		Lymphocyte apoptosis occurs in pediatric patients with MOF and is associated with prolonged hypoprolactinemia and lymphopenia.
		Prolonged lymphopenia and SLD occur in pediatric MOF.
	ccforum.com /content/7/S2/P036 (407 words)

	The Leukogram - The Merck Veterinary Manual
		In cattle, in which lymphocytes predominate, the WBC count is variable depending on the degree of neutrophilia and lymphopenia.
		Lymphopenia is due to redistribution or lysis of lymphocytes.
		In the later stages of canine distemper with secondary bacterial infection, the total WBC count may be normal with neutrophilia, lymphopenia, and sometimes increased band neutrophils and toxic changes.
	www.merckvetmanual.com /mvm/htm/bc/10705.htm (884 words)

	Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. (Site not responding. Last check: 2007-10-19)
		Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.
		Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.There were no signs of inflammatory lesions in organs and tissues in F344.lyp/lyp rats examined at 120 days of age or older.
		Peripheral T cell lymphopenia (lyp) in the BioBreeding (BB) rat is linked to a frameshift mutation in Ian5, a member of the Immune Associated Nucleotide (Ian) gene family on rat chromosome 4.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/10201232.html (268 words)

	Emerging Infectious Diseases: Francisella tularensis peritonitis in stomach c... @ HighBeam Research (Site not responding. Last check: 2007-10-19)
		Our patient's peritonitis was likely related to metastatic stomach cancer that had breached the integrity of peritoneum and regional blood vessels and lymph nodes, leading to peritoneal spill of the organism (free or intra-macrophage ones).
		Because the patient was severely anemic, absolute lymphopenia developed from normal baseline (Figure).
		Lymphopenia is generally absent in tularemia, and this patient's response was likely a compromise for neutrophilia.
	www.highbeam.com /library/doc0.asp?DOCID=1G1:126239700&refid=ip_encyclopedia_hf (1939 words)

	Lymphopenia induced by acute bacterial infections in the elderly: a sign of age-related immune dysfunction of major ... (Site not responding. Last check: 2007-10-19)
		These studies were undertaken to investigate the effect of acute bacterial infections on the absolute number of peripheral blood lymphocytes (PBL) in an elderly population and to evaluate the prognostic significance of a decreased number of PBL in critically ill aged patients.
		The results show that a significant lymphopenia develops in elderly patients during the course of an acute bacterial infection whereas the same type of acute illness has no effect on the PBL count of younger subjects.
		The lymphopenia is not related to a particular localization of the infection nor to the type of bacterial pathogen.
	www.arclab.org /medlineupdates/abstract_4018589.html (193 words)

	Lymphopenia - WrongDiagnosis.com
		Lymphopenia: A decreased number of lymphocytes (white blood cells) in the blood which can be caused by many conditions.
		More detailed information about the symptoms, causes, and treatments of Lymphopenia is available below.
		Underlying medical conditions are other medical conditions that may possibly cause Lymphopenia.
	www.wrongdiagnosis.com /l/lymphopenia/intro.htm (631 words)

	Cancer Resources—Cancer News, Cancer Conferences, Cancer Causes, Cancer Prevention
		NEW YORK (Reuters Health) - In patients with glioma, long-term temozolomide therapy is commonly associated with prolonged, cumulative lymphopenia and a high incidence of infections, according to a report in the February 14 issue of Neurology.
		Overall, lymphopenia occurred in 52.9% of the patients, the authors report.
		Lymphopenia appear to be cumulative, as the rate increased from 25% in patients receiving no more than three cycles to 91% in patients receiving 10 or more cycles of chemotherapy.
	www.oncolink.com /resources/article.cfm?c=3&s=8&ss=23&Year=2006&Month=03&id=12923 (478 words)

	Relation between lymphopenia and bacteraemia in UK adults with medical emergencies -- Wyllie et al. 57 (9): 950 -- ...
		The odds of bacteraemia (number of patients with bacteraemia/number without bacteraemia) among the patients whose blood was cultured, stratified by neutrophil and lymphocyte counts.
		lymphopenia was found in 12% (63 of 530) of the patients with
		Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients.
	jcp.bmjjournals.com /cgi/content/full/57/9/950 (2425 words)

	Untitled Document (Site not responding. Last check: 2007-10-19)
		Neutropenia is the primary cause of leukopenia in animals with an N:L ratio greater than 1, and lymphopenia is a concomitant finding in animals with an N:L ratio less than 1.
		Neutropenia is more common in bacterial infections, and lymphopenia is common in viral infections.
		Severe bacterial and viral infections may cause leukopenia associated with both neutropenia and lymphopenia and decreased numbers of other leukocytes.
	www.vet.purdue.edu /depts/bms/nour/bms520/content/blood/leukocytes8.htm (82 words)

	SARS Reference \| Clinical Presentation and Diagnosis
		Progressive lymphopenia was found in the peripheral blood of 153/157 (98 %) patients with SARS, reaching its lowest point in the second week.
		Lymphopenia was also shown in hemato-lymphoid organs at postmortem examination.
		In total, 32% of patients required intensive care at a mean of 11.0 days after onset of symptoms, among whom 79% had to be intubated at a mean of 12.9 days.
	sarsreference.com /sarsref/diag.htm (4392 words)

	The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats.
		The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats.
		The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats.This confirmed a lyp gene dose-dependent segregation of the IFN gamma high phenotype.
		We conclude that the quantitative ratio of cytokine producing thymocytes is associated with the lyp genotype.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/1169381.html (244 words)

	IngentaConnect B lymphopenia in uraemia is related to an accelerated in vitro ap... (Site not responding. Last check: 2007-10-19)
		IngentaConnect B lymphopenia in uraemia is related to an accelerated in vitro ap...
		This effect was more pronounced in B lymphocytes and a significant correlation between the B lymphopenia and the percentage of apoptotic B cells after 48 h of culture without stimulus was observed.
		Our data indicate that B lymphopenia in CRF may be partially attributed to an increased susceptibility to cell death by apoptosis that is associated with a decreased expression of Bcl-2.
	api.ingentaconnect.com /content/oup/ndt/2000/00000015/00000004/art00502 (322 words)

	Best Practice Medicine- Professional Reference - Leukopenia (Site not responding. Last check: 2007-10-19)
		Recall that neutropenia with or without lymphopenia occurs in approximately 8% of asymptomatic HIV carriers, and in as many as 70% to 75% of adults with AIDS.
		The mortality rate in infected neutropenic patients is in the 5% range, even in studies using monotherapy [23].
		The prognosis of lymphopenia is variable depending on five determinants: the pathophysiology of the underlying disease, its duration, the type of lymphocyte affected, status of the nodal tissues, and the degree to which the cellular or humoral immunity is involved.
	merck.micromedex.com /index.asp?page=bpm_brief&article_id=BPM01HE04 (1500 words)

	TSRI - News and Publications
		Now, the study by Theofilopoulos and his colleagues suggests the anti-tumor effect of immunotherapy could be increased if it were coupled with an injection of fresh T cells after chemotherapy or irradiation.
		However, the body responds to lymphopenia via a "homeostatic" mechanism that induces proliferation in the T cells and other lymphocytes that survive the chemotherapy or irradiation.
		What Theofilopoulos and his colleagues found was that if these T cells see the cancer antigen when they proliferate, they will have a marked bias towards the cancer antigen, seek out cancer cells, and kill them.
	www.scripps.edu /news/press/071502.html (805 words)

	The Scripps Research Institute - Scientfic Report 2005
		Thus, the perplexing association of lymphopenia with autoimmunity might be explained on the basis of compensatory self-mediated homeostatic proliferation of T cells.
		Similarly, in animals with a genetic predisposition to autoimmunity (autoimmune background), which have a higher frequency of potentially autoreactive T cells, the rare occurrence of homeostatic proliferation might not lead to autoimmunity because the frequency of the autoreactive cells remains low and other requirements are absent.
		By contrast, in animals with a genetic predisposition to autoimmunity in which lymphopenia occurs recurrently or chronically, proliferation and selection of autoreactive T cells together with other factors such as adequate antigen presentation and costimulation might lead to autoimmunity.
	www.scripps.edu /news/sr/sr2005/imm05theo.html (1938 words)

	Diabetes: Thymectomy and radiation-induced type 1 diabete... @ HighBeam Research (Site not responding. Last check: 2007-10-19)
		Crosses were validated by verifying the linkage of lymphopenia with the appropriate markers on chromosome 4 (2).
		Both spontaneous diabetes in BBDP rats and the diabetic syndrome induced in PVG.[RT1.sup.u] rats by adult thymectomy and multiple, low doses of TX-R are also associated with T-lymphopenia, and, in both cases, it has been demonstrated that the lymphopenia plays a central role in disease pathogenesis (25,26).
		Furthermore, it has been shown that a lack of regulatory T-cells is one of the pathogenic mechanisms of the T-lymphopenia in both BBDP and PVG.[RT1.sup.u] rats (25,26).
	www.highbeam.com /library/doc0.asp?DOCID=1G1:92520040&refid=ip_encyclopedia_hf (5407 words)

	Medical Dictionary: Lymphopenia - WrongDiagnosis.com
		Lymphopenia (medical condition): A decreased number of lymphocytes (white blood cells) in the blood which can be caused by many conditions
		Lymphopenia: An abnormally small number of lymphocytes in the circulating blood.
		Lymphopenia : decrease in the proportion of lymphocytes in the blood.
	www.wrongdiagnosis.com /medical/lymphopenia.htm (267 words)

	Arthritis Research & Therapy \| Full text \| Interleukin-7 deficiency in rheumatoid arthritis: consequences for ...
		Peripheral blood T-cell lymphopenia is long-lasting in patients with rheumatoid arthritis (RA) receiving lymphodepleting therapies, such as monoclonal antibodies [1-3] or high-dose cyclophosphamide with autologous stem cell rescue (autologous stem cell transplantation) [4,5].
		T-cell lymphopenia in RA patients as long as 7 years after a single course of CAMPATH-1H monoclonal antibody treatment [25] and up to 36 months after autologous stem cell transplantation [26].
		IL-7 is produced in response to lymphopenia [7] and stimulates proliferation of both naïve and memory human T-cells.
	arthritis-research.com /content/7/1/R80 (6434 words)

	Human Disease from Influenza A (H5N1), Thailand, 2004 \| CDC EID
		Later in the course of the disease, organ failure or dysfunction was commonly observed, including respiratory failure in 9 (75%) patients, cardiac failure in 5 (42%), and renal dysfunction in 4 (33%).
		The history of direct contact with sick and dying poultry, young age of many patients, pneumonia and lymphopenia, and progression to ARDS in spite of broad-spectrum antimicrobial treatment indicate that specific laboratory testing for H5 influenza should be sought.
		Although the initial chest radiographs would not immediately identify these cases as unusual, deaths in children and younger adults from hospitalized, radiographically confirmed pneumonia typically range from 1% to 10% and from 1%–5% among patients with radiographically confirmed pneumonia in rural Thailand (18–20).
	www.cdc.gov /ncidod/eid/vol11no02/04-1061.htm (4677 words)

	Untitled Document (Site not responding. Last check: 2007-10-19)
		Lymphopenia the reduction in lymphocyte number and is due to several factors:
		Corticosteroid -induced lympholsis in blood and lymphoid tissues, and increased shift of lymphocytes from blood to tissues.
		It results from the loss of lymphocytes in the lymph drained from the body.
	www.vet.purdue.edu /bms/nour/bms520/content/blood/agranulocytes4.htm (128 words)

	eMedicine - Severe Combined Immunodeficiency : Article Excerpt by Elizabeth A Secord
		ADA deficiency: Lymphopenia occurs from the death of T and B cells secondary to the accumulation of toxic metabolites in the purine salvage pathway.
		PNP deficiency: Lymphopenia occurs from the death of T cells secondary to the accumulation of toxic metabolites in the purine salvage pathway.
		Reticular dysgenesis: Lymphopenia occurs from the absence of myeloid cells in the bone marrow.
	www.emedicine.com /med/byname/severe-combined-immunodeficiency.htm (1097 words)

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