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Topic: MAOIs

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	Erowid MAOI Vault
		MAOIs inhibit naturally occurring enzymes in the human body.
		This inhibition leads to increased levels of chemicals such as the neurotransmitters serotonin and dopamine.
		By slowing their metabolism, MAOIs also allow chemicals such as N,N-DMT, to become active when taken orally.
	www.erowid.org /chemicals/maois/maois.shtml (120 words)

	Monoamine oxidase inhibitors (MAOIs) - CNN.com
		Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant in use, dating back to the 1950s.
		Researchers believe MAOIs relieve depression by preventing the enzyme monoamine oxidase from metabolizing the neurotransmitters norepinephrine (nor-ep-ih-NEF-rin), serotonin (ser-oh-TOE-nin) and dopamine (DOE-puh-mene) in the brain.
		Here are the MAOIs that have been specifically approved by the Food and Drug Administration to treat depression, with their generic names followed by available brand names in parentheses:
	www.cnn.com /HEALTH/library/MH/00072.html (643 words)

	Monoamine oxidase inhibitors (MAOIs) for social anxiety disorder - Medications - Medical Encyclopedia - MSN Health ... (Site not responding. Last check: )
		However, MAOIs are still the treatment of choice in cases of anxiety or depression with unusual features, such as a heavy feeling in the arms and legs, sensitivity to rejection, and a reactive mood.
		MAOIs are often used as an alternative treatment for anxiety or depression that has not responded to other medications.
		MAOIs can cause death if they are combined with certain foods, taken with certain medications, or taken as an overdose.
	health.msn.com /encyclopedia/medications/articlepage.aspx?cp-documentid=100065378 (549 words)

	What are MAOIs?
		MAOIs, along with tricyclic anti-depressants, were the first to pharmacologically address depression.
		While MAOIs were hailed as great wonder drugs upon their discovery, scientists did not understand the connection between the absence of monoamine oxidase and tyramine.
		MAOIs cannot be combined with allergy medications, many pain medications, most decongestants, most sedatives, tricyclic antidepressants, and illegal drugs like crystal meth and cocaine.
	www.wisegeek.com /what-are-maois.htm (656 words)

	Monoamine oxidase inhibitors - detailed screen
		Monoamine oxidase inhibitors (MAOIs) are a group of medicines that are used in the treatment of depression and anxiety.
		MAOIs appear to work well in people with atypical depression (depression with features which are opposite to the usual symptoms of depression, such as increased sleep, increased appetite, and increased weight).
		MAOIs are not widely used, as they do not work as well as SSRIs or TCAs in most types of depression, and most of them need strict dietary restrictions.
	www.entheology.org /library/maoi/maoi2.htm (642 words)

	Depression Management
		The primary reasons for minimal MAOI use are the risk of hypertensive crisis (see Adverse effects), the potential for drug interactions (see Drug interactions) and the availability of safer antidepressant agents such as the SSRIs.
		Administration of an MAOI with meperidine and dextromethorphan have also produced a very similar syndrome that may be related to serotonin reuptake inhibition.
		Switching to an MAOI usually requires a period of 7-14 days, but can be months for an agent with a long half-live and active metabolite such as fluoxetine.
	www.continuingeducation.com /pharmacy/depressionmgmt/options.html (6559 words)

	Monoamine-oxidase inhibitors (Group PIM G025)
		MAOIs cause an increase in the concentration of norepinephrine, dopamine, and 5HT in the brain and other tissues accompanied by a variety of effects.
		MAOIs overdose or concurrent ingestion of thyramine-rich foods or medications which increase the availability of biogenic amines with MAOIs may cause a life-threatening serotonin syndrome resulting in severe cardiovascular and/or CNS reactions.
		Diagnosis of MAOIs poisoning is clinical and based on history of overdose and/or access to MAOI drugs and the presence of agitation, hypertension, sweating, hyperthermia and muscle tremor.
	www.intox.org /databank/documents/pharm/maoi/pimg025.htm (2258 words)

	MAOIs - Candidates (Site not responding. Last check: )
		MAOIs are often used on patients vulnerable to depression but who don't suffer from the classic symptoms of major depression.
		MAOIs are often used for those patients with atypical depression, those with extreme sensitivity to rejection, prone to overeating and oversleeping, and those with "overly" strong reactions to the environment.
		MAOIs can be of particular danger to those with serious heart problems, epilepsy, bronchitis, asthma, or high blood pressure.
	www.macalester.edu /~agerber/depression/maois_candidates.html (172 words)

	MAOI
		MAOIs, in their original form presented an unusual problem for the prescribing physician.
		MAOIs can be used to potentiate the effect of a number of hallucinogenic drugs, notably phenethylamines, tryptamines, DXM and several others.
		MAOIs may not be combined with other anti-depressants, most notably tricyclic antidepressants, as the combined use may result in hypertensive crisis.
	www.depressionanxietylinks.com /glossary/MAOI.htm (681 words)

	DACC Drug Monographs
		MAOIs should not be used in combination with dextromethorphan or with CNS depressants (eg, alcohol and certain narcotics such as meperidine).
		MAOIs are generally reserved for second-line therapy because of their side effects, low therapeutic index and potential to cause life-threatening hypertensive reactions.
		MAOIs are effective treatment of depression and have a role in the therapy of comorbid anxiety and depression, atypical depression, panic disorder and bulimia.
	daccx.bsd.uchicago.edu /drug/bulletins/n0697.html (5997 words)

	MONOAMINE OXIDASE INHIBITORS (MAOIs) FOR DEPRESSION
		Monoamine oxidase inhibitors (MAOIs), which were some of the first antidepressants to be developed, may be helpful for people with so-called ‘atypical’ depression, where a person’s mood may brighten up with positive events but there may be other symptoms such as oversleeping, sensitivity to rejection, and intense fatigue.
		The reason why this is necessary is because MAOIs react with an amino acid known as tyramine, which is found in many popular foods and alcoholic beverages, including chocolate, banana skins, broad bean pods, matured cheeses and red wine.
		There is a newer MAOI available called moclobemide (Aurorix) which does not appear to be subject to as many of the dietary restrictions as the other MAOIs.
	www.mydr.com.au /default.asp?article=2849 (764 words)

	Carilion - MAOIs for childhood and adolescent depression
		Monoamine oxidase inhibitors (MAOIs) are very rarely given to children or adolescents and usually are not the first medications given to treat their depression.
		Moclobemide—a reversible MAOI not available in the United States— is the only MAOI with some evidence to support its use in the treatment of childhood depression.
		MAOIs must be discontinued gradually to reduce the chance of withdrawal symptoms.
	www.carilion.com /kbase/htm/ty61/20/ty6120-sec.htm (301 words)

	MAOIs - Monoamine oxidase inhibitors (MAOI)
		MAOI is an acronym for Monoamine Oxidase Inhibitor.
		MAOIs are generally used in patients who have not responded to other treatments.
		MAOIs are liable to produce dangerous reactions with other drugs and some food; therefore they are not recommended as first-line antidepressant drugs.
	www.depression-guide.com /maoi.htm (722 words)

	Monoamine oxidase inhibitors (MAOIs) for panic disorder - [Medication] - Quest Diagnostics Patient Health Library (Site not responding. Last check: )
		Monoamine oxidase inhibitors (MAOIs) help balance certain chemicals in the brain (neurotransmitters) to relieve symptoms of anxiety associated with panic disorder.
		Although MAOIs are as effective as other antidepressants for treating panic disorder, other antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants are generally tried first because they have less serious side effects.
		MAOIs are not recommended for children, teens, or nursing or pregnant women.
	www.questdiagnostics.com /kbase/topic/detail/drug/zu1082/detail.htm (423 words)

	MAOIs - side effects (Site not responding. Last check: )
		MAOIs alone do not have very substantial effects apart from lowering blood pressure, increasing the likelihood of episodes of dizziness or fainting such as standing up quickly from a period of rest.
		First generation MAOIs blocked both forms, but newer MAOIs have been developed to selectively block MAO-A, with minimal affects on MAO-B. These drugs are much safer, as patients do not have to be as careful with their diet.
		Since a severe headache or chest pain during MAOI therapy is the primary warning sign of a serious spike in blood pressure, anyone who normally gets severe headaches might overlook an important warning sign.
	www.macalester.edu /~agerber/depression/maois_side_effects.html (467 words)

	NAMI-NYS
		Monoamine Oxidase Inhibitors (MAOIs), such as phenelzine (Nardil) and tranylcypromine (Parnate), are mainly prescribed for patients with “atypical” depression or who do not respond well to other medications.
		MAOIs are also used to treat other disorders including anxiety disorders.
		MAOIs can also cause severe interactions with certain foods, beverages and other drugs, leading to a severe headache and a life-threatening rise in blood pressure.
	www.naminys.org /tricyclics.htm (361 words)

	Monoamine oxidase inhibitors (MAOIs) - MayoClinic.com
		MAOIs are a type of antidepressant that can relieve the symptoms of depression, such as sadness and irritability.
		Here are the MAOIs that have been specifically approved by the Food and Drug Administration to treat depression, with their generic or chemical names followed by available brand names in parentheses:
		If you take MAOIs, you'll face dietary restrictions that require you to limit consumption of foods that contain a high level of tyramine, such as many cheeses, pickled foods, chocolates, certain meats, beer, wine, and alcohol-free or reduced-alcohol beer and wine.
	www.mayoclinic.com /health/maois/MH00072 (638 words)

	Patient Education Reports - UMMC (Site not responding. Last check: )
		MAOI inhibitors are the most effective antidepressants for atypical depression, but have some severe side effects and restrictive dietary rules.
		Newer MAOIs, such as moclobemide (Aurorix, Manerix), target only one form of the MAOI enzyme, and it may be effective without the significant side effects of the older MAOIs for patients with dysthymia.
		MAOIs may also cause birth defects and should not be taken by pregnant women.
	www.umm.edu /patiented/doc08drugs.html (4225 words)

	What foods you should avoid on MAOIs
		Monoamine oxidase is found in the gastrointestinal tract and inactivates tyramine; when drugs prevent the catabolism of exogenous tyramine, this amino acid is absorbed and displaces norepinephrine from sympathetic nerve ending and epinephrine from the adrenal glands.
		Approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction.
		Ayd (1986) reported that the freshness of the food is a key issue with MAOIs and that as long as foods are purchased from reputable shops and stored properly, the danger of a hypertensive crisis is minimal.
	deoxy.org /maoidiet.htm (1673 words)

	[No title]
		MAOIs are as effective as any other antidepressant, but you must avoid certain foods and drugs (see below).
		Because of this inconvenience, MAOIs are prescribed relatively infrequently.
		Because MAOIs have a stimulant effect, you may become depressed, anxious, agitated, sleepless or drowsy when you stop taking them, just as you would as if you stopped taking a stimulant drug.
	www.intelihealth.com /IH/ihtPrint/WSENF000/8596/35229/363036.html?d=dmtContent&hide=t&k=basePrint (469 words)

	Drugscope - DrugSearch (Site not responding. Last check: )
		Monoamine oxydase inhibitors or MAOIs are antidepressants used to treat conditions like depression, insomnia (inability to sleep), panic disorders and anxiety.
		This in turn increases the levels of 'feel-good' neurotransmitters (brain chemicals) such as serotonin, norepinephrine and dopamine, by preventing their breakdown in the brain.
		MAOIs can be dangerous if taken with certain foods and drugs.
	www.drugscope.org.uk /druginfo/drugsearch/ds_results.asp?file=\wip\11\1\1\maois.htm (294 words)

	Kelompok Maois Bergabung di Parlemen - KOMPAS CYBER MEDIA
		Kelompok Maois memperoleh 83 kursi dari 330 kursi di parlemen sementara.
		Kelompok Maois mewakili kelompok masyarakat terpinggirkan, seperti kelompok kasta rendah dalam masyarakat mayoritas Hindu di Nepal.
		Para pengamat mengatakan, kesepakatan itu menunjukkan Maois memang bermaksud memasuki arus besar politik.
	www.kompas.com /ver1/Internasional/0701/16/043650.htm (538 words)

	Brain Explorer - Focus on Brain Disorders - Depression - Treatment (Site not responding. Last check: )
		MAOIs are believed, by some clinicians, to be the most potent agent in the treatment of depression and anxiety, with phenelzine as the drug most frequently prescribed for many of these disorders (Bakish et al., 1998).
		MAOIs are seen as second-line therapies and many physicians are alarmed by the potential risks associated with the interaction with the amino acid tyramine and feel that the dietary restrictions this imposes are impractical.
		The newer MAOI moclobemide (Manerix, Aurorix), in contrast to the older MAOIs (eg phenelzine (Nardil), isocarboxazid (Marplan) and tranylcypromine (Parnate)), binds reversibly to the MAOA enzyme and therefore has a shorter duration of action which improves safety and reduces the washout time required before the initiation of a different antidepressant.
	www.brainexplorer.org /depression/Depression_Treatment.shtml (2141 words)

	Understanding Antidepressant Medications
		Because of these drug and food interactions, MAOIs may not be taken with many other types of medicines, and some foods that are high in tyramine, dopamine, or tryptophan must be avoided as well.
		MAOIs are rarely the first antidepressant drug prescribed, but they are an option when initial treatments do not work or are not tolerated.
		MAOIs are not a good choice for elderly or debilitated individuals.
	www.emedicinehealth.com /understanding_antidepressant_medications/page5_em.htm (764 words)

	NetDoctor.co.uk - Depression - Treating
		Monoamine oxidase inhibitors (MAOIs) are one of the oldest classes of antidepressants and are typically used when other antidepressants have not been effective.
		MAOIs should not be used in pregnancy and must not be given at the same time as other antidepressants as this can result in severe adverse effects.
		MAOIs must not be taken at the same time as foods containing high levels of tyramine, e.g.
	community.netdoktor.com /ccs/uk/depression/coping/treating/article.jsp?articleIdent=uk.depression.coping.treating.uk_depression_article_2049 (398 words)

	Monoamine oxidase inhibitors (MAOIs) for depression - MSN Health & Fitness - Depression (Site not responding. Last check: )
		These medications balance certain brain chemicals called neurotransmitters by reducing the amount of monoamine oxidase, the substance that breaks down the neurotransmitters.
		MAOIs usually are not the first medications given for depression because they have serious side effects when combined with certain foods and/or medications.
		Current research suggests that monoamine oxidase inhibitors may be less effective than other antidepressants (such as tricyclics) in treating severe depression but may be more effective than other antidepressants in those who have depression with uncommon symptoms such as sleeping and eating too much and being overly sensitive to rejection.
	health.msn.com /centers/depression/articlepage.aspx?cp-documentid=100069404 (538 words)

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