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Macromolecule - Wikipedia, the free encyclopedia This usage is common in particular when the individual macromolecules involved aggregate or "assemble" spontaneously and rarely exist in isolation. Another common macromolecular property that does not characterize smaller molecules is the need for assistance in dissolving into solution. Many require salts or particular ions to dissolve in water. en.wikipedia.org /wiki/Macromolecule   (383 words)

Microgravity and Macromolecular Crystallography Macromolecular crystal growth is seen as an ideal experiment to make use of the reduced acceleration environment provided by an orbiting spacecraft. Macromolecular crystallography is a multidisciplinary science involving the crystallization of a macromolecule or complex of macromolecules, followed by X-ray or neutron diffraction to determine the three-dimensional structure. In macromolecular crystal growth it affects the vapor diffusion and liquid-liquid diffusion crystal growth methods but is generally masked by gravitational effects on the ground. pubs.acs.org /cgi-bin/jtextd?cgdefu/1/1/html/cg005511b.html   (8590 words)

Macromolecular Crystallography Macromolecular Crystallography is a technique used to study biological molecules such as proteins, viruses and nucleic acids (RNA and DNA) to a resolution higher than ~5 Å. The macromolecular structure can be determined by analysis of the intensities and positions of the diffraction spots. The Macromolecular Crystallography Group at the Stanford Synchrotron Radiation Laboratory operates and develops beamlines providing state of the art macromolecular crystallography facilities and support for visiting researchers. smb.slac.stanford.edu   (324 words)

Quality of Macromolecular Models The original data in macromolecular structure determination by single-crystal X-ray crystallography are the measured positions and intensities of reflections in the diffraction pattern produced by the macromolecular crystal. The original data in macromolecular structure determination by NMR are very high-resolution multidimensional NMR spectra collected so as to reveal correlations between atoms that lie within a few bonds of each other (J coupling) or within a short distance of each other through space (NOE coupling). The symmetry of functional macromolecular complexes in solution is sometimes important to understanding their functions, as in the binding of regulatory proteins having twofold rotational symmetry to palindromic DNA sequences. www.usm.maine.edu /~rhodes/ModQual/index.html   (7397 words)

International Union of Pure and Applied Chemistry The IUPAC Commission on Macromolecular Nomenclature is the leading nomenclature body in the polymer field. This Compendium is a compilation of the IUPAC recommendations on macromolecular nomenclature which provides definitions of terms relating to polymers and rules for naming polymers based on structure or source. An introduction to macromolecular nomenclature and bibliography of biopolymer-related nomenclature recommendations are also included. www.iupac.org /publications/books/author/metanomski.html   (394 words)

Macromolecular Crystallography Laboratory, NCI - Home Zbigniew Dauter, is involved in developing new methods for phasing macromolecular structures by anomalous scattering, particularly with signals from comparatively light atoms such as bromine. Jacek Lubkowski’s Macromolecular Assembly Structure and Cell Signaling Section is investigating structural basis of anti-viral and anti-bacterial activity of various proteins involved in intercellular signaling. Alexander Wlodawer, the Protein Structure Section has been investigating retroviral protease and integrase; lectins with antiviral activity; a variety of other proteases, ribonucleases, and kinases; and a number of cytokines and cytokine-receptor complexes. mcl1.ncifcrf.gov   (240 words)

Protein folding by the effects of macromolecular crowding -- Tokuriki et al. 13 (1): 125 -- Protein Science Effect of a concentrated "inert" macromolecular cosolute on the stability of a globular protein with respect to denaturation by heat and by chaotropes: A statistical-thermodynamic model. The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media. Zimmerman, S.B. and Minton, A.P. Macromolecular crowding: Biochemical, biophysical, and physiological consequences. www.proteinscience.org /cgi/content/full/13/1/125   (5228 words)

Macromolecular Resources - Welcome The Macromolecular Resource Facility is a provider of high quality Biotechnology Products and Services. Macromolecular Resources supports the education, research and public missions of Colorado State University. Macromolecular Resources is a part of the Colorado State University community. mmr.bmb.colostate.edu   (149 words)

Macromolecular Crystallography Proposal Submittal Beam time for macromolecular crystallography projects is obtained by submitting an SSRL Macromolecular Crystallography Proposal. Users are invited to submit new proposals for Macromolecular Crystallography before December 1, 2003 for beam time eligibility beginning in March 2004. Due to the oversubscription on macromolecular crystallography lines, not all beam time requests can be met in a given scheduling period. www-ssrl.slac.stanford.edu /users/user_admin/px_proposal_guide.html   (3116 words)

Macromolecular Chemical Nomenclature IUPAC Commission on Macromolecular Nomenclature, "Kobunshi Meimeiho" (translation of "Compendium of Macromolecular Nomenclature"), Committee of Macromolecular Nomenclature, Society of Polymer Science, Japan, McGraw-Hill, Tokyo, 1993 (in Japanese). IUPAC Commission on Macromolecular Nomenclature, "Kompendium Nomenklatury Makromolekularnej", Komisja Nomenklatury, Polskie Towarzystwo Chemiczne, Warszawa, 1995 (in Polish). IUPAC Comissão de Nomenclatura Macromolecular, "Compêndio de Nomenclatura Macromolecular", Comitê Brasileiro para Assuntos de Química junto à IUPAC, E-papers Serviços Editoriais Ltda, Rio de Janeiro, Brasil, 2002 (in Portuguese) www.chem.qmul.ac.uk /iupac/bibliog/macro.html   (1492 words)

Neutron Macromolecular Crystallography   (Site not responding. Last check: 2007-10-23) The Conference will focus on the role of hydrogen atoms in biological structure and function and will highlight the contributions that next generation neutron macromolecular crystallography instruments can make in defining accurate hydrogen atom positions, protonation states and hydration states in biological macromolecules. The Macromolecular Neutron Diffractometer (MaNDi) proposed for SNS will provide 10 to 100 times performance gains when compared to current neutron facilities and a beam line has been allocated for structural biology research. The major objective of the July 12-13th meeting is to raise awareness and support for MaNDi in the structural biology community and to identify the most important problems that neutron macromolecular crystallography can uniquely address. www.hwi.buffalo.edu /ACA/meetingspg_list/MacCrystalMeeting.html   (156 words)

Macromolecular Motions We were amongst the first groups to study macromolecular motions statistically, on a large-scale. In particular, we have set up a publicly accessible Database of Macromolecular Motions and coupled it with simulation tools to interpolate between structural conformations; the database also has associated tools to predict likely motions based on simple models, such as normal modes and localized hinges connecting rigid domains. These allowed us to classify motions based on the interdigitating packing at internal interfaces: motions are identified as shear or hinge, based on whether or not a well-packed interface is maintained between the dynamic elements throughout the motion. papers.gersteinlab.org /papers/subject/motions   (395 words)

NIH-CSR Biological Chemistry and Macromolecular Biophysics IRG [BCMB] Applications that emphasize application of imaging agents to macromolecular structure or function may be assigned for review by MSF-C (or -A or- B as appropriate). With Macromolecular Structure and Function A, B, and C [MSFA, MSFB, and MSFC]: The SBCA and SBCB study sections have shared interests with MSFA, MSFB, and MSFC in development and analysis of inhibitors of macromolecular interactions (protein-protein, protein-nucleic acid, etc.). With Macromolecular Structure and Function C [MSFC]: Investigations of soluble domains of membrane-bound proteins (including receptors) may be reviewed by MSFC if the primary emphasis is on their extra-membrane function. cms.csr.nih.gov /PeerReviewMeetings/CSRIRGDescription/BCMBIRG/BCMBIRGAll.htm   (4419 words)

NIH-CSR Macromolecular Structure and Function Study Sections [MSFA, MSFB, MSFC] (BCMBIRG) The Macromolecular Structure and Function [MSF] Study Sections review applications that focus on the biochemistry and biophysics of sequence-structure-function relationships in proteins, nucleic acids, carbohydrates, their complexes, and interactions with small molecules. Metallobiochemical applications, in a broad sense, including such topics as metals in biology, chemical reactions and mechanisms, imaging agents, and molecular design, may be clustered in MSFA. In addition, glycobiology applications may be clustered in MSFB, and protein-protein and macromolecular assembly interactions may be clustered in MSFC. cms.csr.nih.gov /PeerReviewMeetings/CSRIRGDescription/BCMBIRG/MSFA.htm   (764 words)

[No title] Lubricating compositions characterised by the base-material being a macromolecular compound [4] Lubricating compositions characterised by the thickener being a macromolecular compound [4] Lubricating compositions characterised by the additive being a mixture of a macromolecular compound, a non-macromolecular compound and a compound of unknown or incompletely defined constitution, each of these compounds being essential [4] www.wipo.int /ibis/ipc7beta6/main.php?rnd=222403061&entry=C10M13300   (1073 words)

Wiley-VCH - Macromolecular Bioscience Macromolecular Bioscience focuses on the interdisciplinary field at the intersection of macromolecular and biological sciences, providing an efficient cross-fertilization of disciplines. The journal combines all aspects of biomaterials from basic research to applications, from chemistry to physics and from biotechnology to medicine. The aim of the journal is to cover research topics in the field of biopolymers, biocomposites, biomaterials, macromolecular membranes, polymers from renewable resources, synthetic biodegradable polymers, biodegradation, biocatalysis, biofunctions of macromolecules, and biomimetics. www.wiley-vch.de /publish/en/journals/alphabeticIndex/2127   (144 words)

Wiley::Macromolecular Chemistry and Physics   (Site not responding. Last check: 2007-10-23) Macromolecular Chemistry and Physics was the first journal to concentrate exclusively on macromolecular science. Outstanding macromolecular science research is presented in the form of strictly peer-reviewed Full Papers. From 2005 on, Macromolecular Chemistry and Physics is published twice a month. ca.wiley.com /WileyCDA/WileyTitle/productCd-2261.html   (227 words)

2006 GRC on Macromolecular Organization & Cell Function Thus, the conference places a major emphasis on interpretation of biochemical and structural data in the light of known intracellular conditions including the spatial distribution of proteins and metabolites. The approaches typically discussed at this meeting include studies on macromolecular assemblies, non-invasive imaging, cellular topology of second messenger signaling pathways, and the global analysis of cellular proteins and metabolites. Theoretical modeling, including the development and testing of mechanisms for handling large amounts of bioinformatics data, is a major emphasis of the conference based on the recognition that complex interactions are difficult to study without computational tools. www.grc.uri.edu /programs/2006/macromol.htm   (654 words)

Macromolecular Chemistry I Close cooperation is maintained with the departments of Physical Chemistry and Experimental Physics at the University of Bayreuth as well as with foreign universities and industry. The research spectrum of Macromolecular Chemistry I is broadened by the activities of Prof. As far as education, Macromolecular Chemistry I is represented in the courses of study Chemistry, Polymer- and Colloidal Chemistry, Material Sciences and since the winter semester 2004/2005 has been represented in the elite graduate program Macromolecular Science in the Elitenetzwerk Bayern. www.uni-bayreuth.de /content/mci/index.php?lang=en   (171 words)

Macromolecular X-Ray Crystallography   (Site not responding. Last check: 2007-10-23) The Macromolecular X-ray Core Facility is available for use by individuals at the medical school trained in X-ray crystallography. The director of the facility is Dr. Elias Lolis, and the facility is managed by Mr. Consultations or collaborations on macromolecular crystallization, X-ray characterization of crystals, processing and quality analysis of data, structure determination, molecular modeling, molecular docking and structure visualization, and analysis are also available. cellserv.med.yale.edu /imaging/xray   (320 words)

Design, Synthesis, and Characterization of Macromolecular Materials Macromolecular synthetic capabilities for the design and synthesis of complex macromolecular architectures This research area addresses the grand challenge of designing and controlling the nanoscale organization of macromolecular materials in order to achieve novel functionalities. Techniques and expertise will be developed to assist users in the characterization of novel macromolecular architectures in solution, on surfaces, and in the bulk by a variety of methods that include light scattering, small angle X-ray and neutron scattering, NMR, spectroscopic methods, electron microscopy (SEM and TEM), and AFM. www.cnms.ornl.gov /research/design.shtm   (258 words)

Macromolecular Nomenclature Note No. 14 In the "Macromolecular Nomenclature Notes" published in the previous issues of Polymer Preprints,(1) we reported progressively on the recommendations of the Commission on Macromolecular Nomenclature of the International Union of Pure and Applied Chemistry (IUPAC), ranging from source-based nomenclature for homopolymers and copolymers to structure-based nomenclature for regular and irregular single-strand and double strand polymers. It is of interest to note that the proposal for naming such non-linear macromolecules and assemblies was submitted to this Nomenclature Committee by one of the authors (LHS) many years ago. In the interest of international cooperation and standardization of macromolecular nomenclature, it was decided to submit the proposal to the IUPAC Commission. www.polyacs.org /nomcl/mnn14.html   (870 words)

Macromolecular Resources - DNA Sequencing - Shipping Information   (Site not responding. Last check: 2007-10-23) Emails with attached electropherograms are fairly large and may not be accommodated by some email providers. Typical turn around times are 1 - 2 days upon delivery of the template, add an extra day for template preparations done by Macromolecular Resources. Delays may be experienced on high volume days and if there is incorrect or missing information on the order form. macromolecular.colostate.edu /dna.shipping.html   (358 words)

Macromolecular Crystallographic Information (mmCIF) Tutorial The macromolecular Crystallographic Information File (mmCIF) provides a way of describing in detail the features of a macromolecular structure and the X-ray diffraction experiment that was used to derive that structure. Format - This is the most difficult aspect of the transition for a macromolecular crystallographer since the format of data represented by an mmCIF is significantly different from the PDB format. At present there is no formal provision for associating data contained in two blocks as would be desirable in the case of, for example, a native structure and a mutant. www.sdsc.edu /pb/cif/tutorial_mm.html   (2615 words)

Oxford University Press: Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Joachim Frank In the past ten years there has been a tremendous surge in applications of cryo-electron microscopy in the study of macromolecular assemblies, in especially those in single-particle form. Although the path toward atomic resolution is much more tedious than in electron crystallography of two-dimensional crystals, realization of such resolution for entirely asymmetrical molecules is now in close reach. In Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State, Joachim Frank describes the mathematical principles and working methods of single-particle reconstruction--a method designed to retrieve structural information from electron micrographs showing many "copies" of molecules trapped in ice in random orientations. www.oup.com /us/catalog/general/subject/Physics/AtomicMolecularOpticalphysics/~~/c2Y9YWxsJnNzPWF1dGhvciZzZD1hc2MmcGY9NTAmdmlldz11c2EmcHI9MTAmYm9va0NvdmVycz1udWxsJmNpPTAxOTUxODIxODk=   (328 words)

IPC 7 English version C10M 145/00-C10M 177/00 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds [4] Lubricating compositions characterised by the additive being a macromolecular compound containing atoms of elements not provided for in groups C10M 143/00 to C10M 153/00 [4] Lubricating compositions characterised by the additive being a mixture of two or more macromolecular compounds covered by more than one of the main groups C10M 143/00 to C10M 155/00, each of these compounds being essential [4] www.wipo.int /classifications/fulltext/new_ipc/ipc7/ec10m03.htm   (903 words)

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