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Topic: Macrophage


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 NDI Terminology - macrophage   (Site not responding. Last check: 2007-11-05)
The morphology of macrophages varies among different tissues and between normal and pathologic states, and not all macrophages can be identified by morphology alone.
However, most macrophages are large cells with a round or indented nucleus, a well-developed Golgi apparatus, abundant endocytotic vacuoles, lysosomes, and phagolysosomes, and a plasma membrane covered with ruffles or microvilli.
Among the cells now recognized as macrophages are histiocytes, Kupffer cells, osteoclasts, microglial cells, synovial type A cells, interdigitating cells, and Langerhans cells (in normal tissues) and epithelioid cells and Langerhans-type and foreign-body-type multinucleated giant cells (in inflamed tissues).
www.ndif.org /Terms/macrophage.html   (154 words)

  
 Macrophage Encyclopedia Article @ XXXL.com
The attraction of wandering macrophages to a damaged site occurs through chemotaxis, triggered by a number of things, depending on circumstances; primarily, damaged cells and pathogens release chemical substances to which macrophages are attracted, mast cells and basophils release histamine and macrophages already at the site release cytokines to attract more of its kind.
When a macrophage ingests a pathogen, the pathogen becomes trapped in a food vacuole, which then fuses with a lysosome.
The presentation is done by integrating it into the cell membrane by displaying it attached to a MHC class II molecule, indicating to other white blood cells that the macrophage is not a pathogen, despite having antigens on its surface.
www.xxxl.com /encyclopedia/Macrophage   (343 words)

  
 Phagocytosis
This human macrophage, like its cousin the neutrophil, is a professional "phagocyte" or eating cell (phago = "eating", cyte = "cell").
The macrophage is using its internal cytoskeleton to envelop cells of the fungus Candida albicans.
To insure that the organisms not grow and divide within the macrophage, the white cell must kill the organisms by some means such as the OXIDATIVE BURST.
www.cellsalive.com /mac.htm   (118 words)

  
 Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance ...
Macrophages are the resident professional phagocytes in noninflamed
Sibille, Y., and Reynolds, H.Y. Macrophages and polymorphonuclear neutrophils in lung defense and injury.
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.
www.jci.org /cgi/content/full/115/2/359   (6342 words)

  
 Enhancement of Splenic-Macrophage Fc{gamma} Receptor Expression by Treatment with Estrogens -- Gomez et al. 8 (4): 806 ...
We further studied the effect of the treatment with estrogens on splenic macrophage Fc R cell surface expression.
Macrophage Fc receptor expression is altered by treatment with dopaminergic drugs.
Identification of glucocorticoid receptors in monocytes and macrophages.
cdli.asm.org /cgi/content/full/8/4/806   (2733 words)

  
 PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor ...
Macrophage colony-stimulating factor receptor (M-CSFR) expression is deficient in PAP BAL cells.
of exogenous GM-CSF to alveolar macrophages in vitro and in
Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis.
ajplung.physiology.org /cgi/content/full/285/5/L1132   (3031 words)

  
 Fetal Alcohol Exposure Impairs Alveolar Macrophage Function via Decreased Glutathione Availability -- GAUTHIER et al. ...   (Site not responding. Last check: 2007-11-05)
Fetal macrophage were isolated by bronchoalveolar lavage and cultured for 4 h.
Fetal macrophages were isolated on d 55 by bronchoalveolar lavage and cultured for 2 h.
Fetal macrophage were isolated by bronchoalveolar lavage and cultured with ± 200 µM GSH for 2 h.
www.pedresearch.org /cgi/content/full/57/1/76   (4417 words)

  
 Intracellular mechanisms responsible for exercise-induced suppression of macrophage antigen presentation -- Ceddia et ...
The macrophage AP protocol was adapted from published work (14, 15) and described in detail in our previous study (5).
Effects of macrophage fixation on the exhaustive exercise stress (Exh)-induced suppression of macrophage antigen presentation at suboptimal and optimal chicken ovalbumin (C-Ova) doses.
Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.
jap.physiology.org /cgi/content/full/88/2/804   (3791 words)

  
 EMDS - European Macrophage and Dendritic Cell Society
The European Macrophage and Dendritic Cell Society (EMDS) has emerged from the activities of the former European Macrophage Study Group (EMSG), a loose association of scientists interested in basic and clinical aspects of monocytes, macrophages, dendritic cells and other myleoid cells in man and experimental animal models.
The annual macrophage conference originated from meetings in the Upper Rhine area organized by scientists from the universities and research centres of Strasbourg, Freiburg and Basel, but rapidly grew up to a European format.
At the end of year 2000, the members of the EMS decided to rename the society as European Macrophage and Dendritic Cell Society (EMDS) in order to better emphasize the two main streams of research within the Society.
www.macrophage.de   (159 words)

  
 Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations -- Morand et al. 41 (5): 558 -- ...
Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis.
Macrophage migration inhibitory factor (MIF) in rheumatoid arthritis: evidence for pro-inflammatory function and regulation by glucocorticoids.
Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis.
rheumatology.oxfordjournals.org /cgi/content/full/41/5/558   (2293 words)

  
 Aberrant Macrophage and Neutrophil Population Dynamics and Impaired Th1 Response to Listeria monocytogenes in ...
Effects of macrophage colony-stimulating factor on reduction of viable bacteria and survival of mice during Listeria monocytogenes infection: characteristics of monocyte subpopulations.
Elimination of resident macrophages from the livers and spleens of immune mice impairs acquired resistance against a secondary Listeria monocytogenes infection.
Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation.
iai.asm.org /cgi/content/full/69/3/1795   (6705 words)

  
 Macrophage heterogeneity in renal inflammation -- Erwig et al. 18 (10): 1962 -- Nephrology Dialysis Transplantation
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase.
Macrophages from inflamed but not normal glomeruli are unresponsive to anti-inflammatory cytokines.
Macrophages transfected with adenovirus to express IL-4 reduce inflammation in experimental glomerulonephritis.
ndt.oxfordjournals.org /cgi/content/full/18/10/1962   (1795 words)

  
 Obesity is associated with macrophage accumulation in adipose tissue -- Weisberg et al. 112 (12): 1796 -- Journal of ...
Macrophages in the liver and muscle of lean and obese mice.
Macrophages were rarely detected in areas surrounding the myofibrils (c and d).
Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin.
www.jci.org /cgi/content/full/112/12/1796   (7142 words)

  
 Expansive Arterial Remodeling Is Associated With Increased Neointimal Macrophage Foam Cell Content: The Murine Model of ...   (Site not responding. Last check: 2007-11-05)
Seven days post-ligation, macrophages are a prominent feature of the neointima in ApoE KO carotid arteries and are also detectable in the adventitia, whereas only sparse macrophages can be detected in WT carotid arteries.
The intimal area occupied by Mac-3–positive macrophages rapidly increases in the ligated carotid arteries of ApoE KO, whereas macrophages are rarely found in the WT ligated carotid arteries.
Macrophage infiltration in acute coronary syndromes: implications for plaque rupture.
circ.ahajournals.org /cgi/content/full/105/22/2686   (3729 words)

  
 MicroAngela - Macrophage
Macrophages are white blood cells that crawl around in the extracellular fluids of your body and gobble up microbes and other foreign material.
Parts of the cell surround the particle to be eaten, then the macrophage's membrane flows together and the particle ends up inside.
In this image, metal particles were eaten, and they are the fl spots inside the orange vacuoles.
www.pbrc.hawaii.edu /bemf/microangela/macroph.htm   (121 words)

  
 Macrophage Control of Herpes Simplex Virus Type 1 Replication in the Peripheral Nervous System -- Kodukula et al. 162 ...
Macrophage depletion dramatically reduces the mRNA for iNOS in the HSV-1-infected TG.
Because activated macrophages are present in the infected TG and produce cytokines that inhibit HSV-1 replication in vitro,
Macrophage depletion augments HSV-1 replication in the TG.
www.jimmunol.org /cgi/content/full/162/5/2895   (5635 words)

  
 Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced ...
Adherent peripheral blood monocyte-derived macrophages were cultured in the presence or absence of 1 µM DX for different times, as shown.
Macrophage cell lysates were assessed for expression of A, CrkL (36 kDa) and B, p130Cas (130 kDa) by SDS-PAGE and Western blotting.
Macrophage phagocytosis of aging neutrophils in inflammation: programmed cell death in the neutrophil leads to its recognition by macrophages.
www.jimmunol.org /cgi/content/full/167/2/976   (6282 words)

  
 Macrophage definition - Medical Dictionary definitions of popular medical terms   (Site not responding. Last check: 2007-11-05)
Macrophage: A type of white blood that ingests (takes in) foreign material.
Macrophages are key players in the immune response to foreign invaders such as infectious microorganisms.
Macrophages help destroy bacteria, protozoa, and tumor cells.
www.medterms.com /script/main/art.asp?articlekey=4238   (210 words)

  
 Transient Induction of Cyclin T1 during Human Macrophage Differentiation Regulates Human Immunodeficiency Virus Type 1 ...
latent infection in macrophages and that opportunistic infection
Isolated monocytes were cultured under conditions to induce macrophage differentiation or differentiation to immature DC (iDC) or mature DC (mDC) as described in Materials and Methods.
Macrophages as a source of HIV during opportunistic infections.
jvi.asm.org /cgi/content/full/76/21/10579   (6384 words)

  
 V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate.
We recently described a primary isolate (89.6) which is highly macrophage tropic and yet differs from other macrophage-tropic strains studied in that it is cytopathic in T cells.
This suggests either that macrophage tropism is defined by structural determinants resulting from complex interactions among multiple env regions rather than V3 sequence-specific requirements or that there are multiple mechanisms by which different strains may establish productive macrophage infection.
In addition, because the HXB V3 loop supports productive macrophage infection in the background of 89.6, phenotypic characterization of V3 sequences should be considered specific to the viral context in which they are placed.
www.aegis.com /aidsline/1995/may/M9550414.html   (522 words)

  
 Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons ...
Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons -- Forgie et al.
Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons
macrophage motility and chemotaxis (Skeel and Leonard, 1994
dev.biologists.org /cgi/content/full/130/5/995   (5276 words)

  
 Life and Death in a Macrophage: Role of the Glyoxylate Cycle in Virulence -- Lorenz and Fink 1 (5): 657 -- Eukaryotic ...
by cultured macrophages in the presence of serum.
The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages.
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
ec.asm.org /cgi/content/full/1/5/657   (3384 words)

  
 Macrophage fusion: the making of osteoclasts and giant cells -- Vignery 202 (3): 337 -- The Journal of Experimental ...
Macrophages are present in all tissues and can fuse with other
essential for the survival of the fused macrophages (11).
A similar scenario may occur during the formation of giant cells in which macrophages respond to interleukin-4 by inducing the expression of DC-STAMP, which then facilitates fusion.
www.jem.org /cgi/content/full/202/3/337   (2706 words)

  
 Expression of Macrophage Migration Inhibitory Factor Transcript and Protein by First-Trimester Human Trophoblasts -- ...
Macrophages are the main target of MIF [3, 36].
A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens.
Cutting age: role of macrophage migration inhibitory factor in inhibiting NK cell activity and preserving immune privilege.
www.biolreprod.org /cgi/content/full/60/6/1299   (3452 words)

  
 Primary T-Cell and Activated Macrophage Response Associated with Tumor Protection Using Peptide/Poly-N-Acetyl ...
Increase in Relative Macrophage Population and Level of Activation in the Spleens of Vaccinated Mice.
we depleted the peritoneal and splenic macrophage populations.
The effect of macrophage depletion on primary antitumor response.
clincancerres.aacrjournals.org /cgi/content/full/5/5/1173   (6224 words)

  
 Crystallization of Free Cholesterol in Model Macrophage Foam Cells -- Kellner-Weibel et al. 19 (8): 1891 -- ...
B, A cholesterol needle that appears in the center of the field of view has been colonized by multiple macrophages, which have become attached to and spread over the surface of the crystal.
Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma.
Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death.
atvb.ahajournals.org /cgi/content/full/19/8/1891   (4896 words)

  
 {beta}1 and {beta}2 Integrins Mediate Adhesion during Macrophage Fusion and Multinucleated Foreign Body Giant Cell ...
Macrophage fusion was induced with IL-4 using a modification
Expression of integrins on monocytes or monocyte-derived macrophages.
McNally AK, Anderson JM: Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity.
ajp.amjpathol.org /cgi/content/full/160/2/621   (4601 words)

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