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Topic: Major Basic Protein

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	PRG2 - proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
		Major basic protein (MBP) is a primary constituent of eosinophil granules.
		A principal constituent of eosinophil granules is the major basic protein (MBP).
		The eosinophil major basic protein (EMBP) is the predominant constituent of the crystalline core of the eosinophil primary granule.
	www.ihop-net.org /UniPub/iHOP/gi/91285.html (6382 words)

	Figures (Site not responding. Last check: 2007-10-10)
		Major basic protein density in bronchial biopsy specimens.
		Major basic protein (MBP) density in a bronchial biopsy specimen from a (A) subject in clinical remission of asthma and from a (B) healthy control.
		Ratio of major basic protein staining and subepithelium in bronchial biopsy specimens.
	www.medscape.com /content/2003/00/44/63/446396/446396_fig.html (117 words)

	Eosinophils, major basic protein, and polycationic peptides augment bovine airway myocyte Ca2+ mobilization -- Wylam et ...
		Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin.
		Identification by immunofluorescence of eosinophil granule major basic protein in lung tissue of patients with bronchial asthma.
		The effect of human eosinophil granule major basic protein on airway hyperresponsiveness in the rat in vivo.
	ajplung.physiology.org /cgi/content/full/274/6/L997 (4360 words)

	In Vivo Neutralization of Eosinophil-derived Major Basic Protein Inhibits Antigen-induced Bronchial Hyperreactivity in ...
		Kinetics of eosinophil accumulation and MBP release in the BAL fluid.
		administered MBP to increase the in vitro and in vivo contractile
		Gleich, G.J., D.A. Loegering, and J.E. Macdonald (1973) Identification of a major basic protein in guinea pig eosinophil granules.
	www.jci.org /cgi/content/full/97/4/1117 (4042 words)

	REVIEW ARTICLE Eosinophils
		MBP in the eosinophil granule is released into respiratory tissue of patients with severe asthma and that it is associated with tissue damage.
		In vitro, the eosinophil granule major basic protein (MBP) is toxic to the MBP-mediated damage to the respiratory epithelium consists of desquamation and frank destruction of ciliated cells
		Eosinophil cationic protein as a serological marker of disease activity in childhood bronchial asthma.
	www.ayubmed.edu.pk /JAMC/PAST/14-4/Waseem.htm (4829 words)

	[No title] (Site not responding. Last check: 2007-10-10)
		Deposition of MBP is common in the lungs of asthmatics, accompanying airway epithelial damage and the appearance of airway hyperresponsiveness (AHR).
		A DNA construct comprising an inactivated major basic protein gene, wherein the inactivation is due to disruption of a sequence in said gene such that expression of functional major basic protein is prevented.
		The cells of claim 13, wherein said cells are isolated from a mouse homozygous for an inactivated major basic protein gene, wherein said inactivation results in a mouse lacking major basic protein.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/34489.010510&ELEMENT_SET=DECL (4580 words)

	[No title]
		Eosinophil Cationic Protein (ECP) is a highly basic protein of ribonuclease-A family that is released from matrix of eosinophil granules.
		It was suggested that quantitation of 'eosinophil' cationic protein in serum might be useful in the study of eosinophil granulocyte turnover and function in vivo.
		Serum eosinophil cationic protein (ECP) as a mediator of inflammation in acute asthma, during resolution and during the monitoring of stable asthmatic patients treated with inhaled steroids according to a dose reduction schedule.
	www.ayubmed.edu.pk /JAMC/PAST/16-3/Badar.htm (4338 words)

	APStracts 5:0085C, 1998. (Site not responding. Last check: 2007-10-10)
		Eosinophil major basic protein increases membrane permeability in mammalian urinary bladder epithelium.
		The eosinophil granule protein major basic protein (MBP) is toxic to a wide variety of cell types, by a poorly understood mechanism.
		The magnitude of the MBP-induced conductance was a function of MBP concentration, and the rate of the initial increase in conductance was a function of the transepithelial voltage.
	www.uth.tmc.edu /apstracts/1998/cell/April/85C.html (263 words)

	Eosinophil Major Basic Protein Stimulates Neutrophil Superoxide Production by a Class IA Phosphoinositide 3-Kinase and ...
		MBP stimulated the release of 25 ± 2% of the total lysozyme content and 331 ± 86 pg of IL-8/ml in the absence of inhibitor.
		Protein kinase C- as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes: potential role in glucose transport.
		Protein kinase C (PKC) isoforms translocate to Triton-insoluble fractions in stimulated human neutrophils: correlation of conventional PKC with activation of NADPH oxidase.
	www.jimmunol.org /cgi/content/full/171/7/3734 (4611 words)

	Method for the treatment of bronchial asthma and like hypersensitivity diseases by administration of anionic polymers ...
		Filley, W.V., et al., "Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma", The Lancet, 2, 11-16, (1982).
		Frigas, E., "Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma", Mayo Clinic.
		Jacoby, D.B., et al., "Human Eosinophil major basic protein is in endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor", J. Clin.
	www.delphion.com /details?pn=US05827512__ (1077 words)

	Pregnancy-Associated Plasma Protein A and Its Endogenous Inhibitor, the Proform of Eosinophil Major Basic Protein ... (Site not responding. Last check: 2007-10-10)
		Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor.
		Quantification and characterization of pregnancy-associated complexes of angiotensinogen and the proform of eosinophil major basic protein in serum and amniotic fluid.
		Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction.
	circ.ahajournals.org /cgi/content/full/109/14/1724 (3126 words)

	Quantification and Characterization of Pregnancy-associated Complexes of Angiotensinogen and the Proform of Eosinophil ...
		Quantification and Characterization of Pregnancy-associated Complexes of Angiotensinogen and the Proform of Eosinophil Major Basic Protein in Serum and Amniotic Fluid -- Christiansen et al.
		MBP is generated by proteolytic cleavage of ProMBP (2)(3).
		Major basic protein as a predictor of preterm labor: a preliminary report.
	www.clinchem.org /cgi/content/full/46/8/1099 (4033 words)

	Ozone-induced hyperresponsiveness and blockade of M2 muscarinic receptors by eosinophil major basic protein -- Yost et ...
		Identification of a major basic protein in guinea pig eosinophil granules.
		Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M
		Antiserum to the major basic protein of guinea pig eosinophil granules.
	jap.physiology.org /cgi/content/full/87/4/1272 (3452 words)

	Muscarinic Receptors and Control of Airway Smooth Muscle -- FRYER and JACOBY 158 (5): 154 -- American Journal of ...
		Nerves are stained with an antibody to PGP 9.5, and eosinophils with an antibody to major basic protein.
		Major basic protein is an antagonist for the neuronal M
		Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.
	ajrccm.atsjournals.org /cgi/content/full/158/5/S2/S154 (3538 words)

	Major Basic Protein Monoclonal & Pro-MBP polyclonals antibodies from RDI Divison of Fitzgerald Industries Intl
		SPECIFICITY : CBL419 is specific for eosinophil major basic protein irrespective of the stages of eosinophil activation and can be regarded as a "pan-eosinophil" marker.
		This antibody will recognize the 23.8 kDa secreated pro-form of MBP (Pregnancy Associated MBP) found in the placenta and serum of pregnant women as well as the 13.8 kDa mature form of the protein which is found in the matrix of the eosinophil large specific granual.
		Purified MBP migrates at ~ 14kDa, and typical human samples range from 10-16kDa.ELISA development for MBP estimation.Optimal working dilutions must be determined by the end user.
	www.researchd.com /miscabs/cbl419.htm (721 words)

	Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: abundant ...
		MBP was ranked as the fourth most-increased transcript in human MCs when approximately 12 000 genes were examined.
		MBP has been thought to play a key role in allergic inflammation because this highly basic protein is deposited on the damaged
		Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma.
	www.bloodjournal.org /cgi/content/full/98/4/1127 (4556 words)

	Immunology and Uveitis Service \| Laboratory Research
		BMK-13 antibody recognizes major basic protein (MBP) of the eosinophils.
		Antibody binding to the eosinophils present in the biopsied, inflamed conjunctiva or sclera of the patients with Wegener’s granulomatosis was then visualized by using an alkaline phosphatase/anti alkaline phosphatase/fast red method, with negative controls consisting of specimens processed in an identical way, with the exception that the primary antibody was omitted.
		We hypotehsize that the presence of "activated" eosinophils in sclera or conjunctiva of patients with the limited or even the "very limited" form of Wegener’s granulomatosis is a sign that might be predictive of which patients will have their limited disease progress to the more generalized form.
	www.uveitis.org /medical/lab/laborato.html (429 words)

	NEJM -- Dermal deposition of eosinophil-granule major basic protein in atopic dermatitis. Comparison with onchocerciasis
		To determine whether eosinophil degranulation occurs in lesions of atopic dermatitis, we analyzed tissues by immunofluorescence for the presence of the eosinophil-granule major basic protein.
		The fibrillar pattern of major basic protein staining in atopic dermatitis was very similar to that seen in lichenified lesions of untreated onchocerciasis.
		These results suggest that eosinophils commonly release granule proteins in the dermis and that assessment of eosinophil involvement in disease cannot be based simply on numbers of eosinophils in tissue.
	content.nejm.org /cgi/content/short/313/5/282 (831 words)

	APStracts 5:0048L, 1998. (Site not responding. Last check: 2007-10-10)
		We assessed the direct effects of activated human eosinophil supernatant, major basic protein (MBP), and polycationic polypeptides on basal and agonist stimulated intracellular calcium concentrations ([Ca2+]i) in cultured bovine tracheal smooth muscle (TSM) cells.
		This elevated [Ca2+]i to polycationic proteins was manifest in epithelium-denuded bovine TSM strips as concentration -dependent increased basal tone.
		We conclude that activated eosinophil supernatant, MBP and other polycationic proteins have a direct effect on both basal and subsequent agonist-elicited Ca2+ mobilization in cultured TSM cells; TSM strips in vitro demonstrated respectively augmented and diminished responses to the contractile agonist, acetylcholine.
	www.uth.tmc.edu /apstracts/1998/lung/March/48L.html (302 words)

	Chronic sinus infection thought to be tissue issue, Mayo Clinic scientists show it's snot
		The team found that in chronic sinus infection patients, activated white blood cells (eosinophils) cluster in the nasal and sinus mucus and scatter a toxic protein (major basic protein) onto the nasal and sinus membrane.
		While major basic protein was not distributed in the nasal and sinus tissue, the level of this protein in the mucus of chronic sinus infection patients far exceeded that needed to damage the nasal and sinus membranes and make them more susceptible to infections such as chronic sinus infection.
		Through various forms of laboratory examination of the tissue and attached mucus, the investigators observed an abundance of major basic protein throughout the nasal and sinus mucus in all 22 specimens, but not in the tissue.
	www.eurekalert.org /pub_releases/2005-07/mc-csi072805.php (659 words)

	Non-specific cellular defence (Site not responding. Last check: 2007-10-10)
		They increase greatly in many types of parasitic infection and defence against the larvae of parasitic worms and unicellular organisms seems to be one of their primary functions.
		The granules of eosinophils contain a substance called MBP (major basic protein) which is toxic to many parasitic larvae.
		Oxygen dependent mechanisms basically result from the respiratory burst associated with the act of phagocytosis.
	www.jdaross.mcmail.com /nonspecific_cellular_defence.htm (687 words)

	Eosinophil Major Basic Protein-1 Does Not Contribute to Allergen-Induced Airway Pathologies in Mouse Models of Asthma ...
		The identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2.
		Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates.
		The effect of human eosinophil granule major basic protein on airway responsiveness in the rat in vivo: a comparison with polycations.
	www.jimmunol.org /cgi/content/full/165/10/5509 (6233 words)

	The Faculty and their Research: Thomas
		Much of the pro-inflammatory activity of eosinophils is attributed to the release of major basic protein (MBP) and other cationic proteins present in eosinophil granules.
		Work from this laboratory has established that MBP activates neutrophils and other inflammatory cells, resulting in the release of numerous pro-inflammatory mediators.
		A primary research goal of the laboratory is elucidation of the mechanism(s) for inflammatory cell activation by MBP at the level of the intracellular signaling events and at the level of MBP recognition by the cells.
	www.rushu.rush.edu /immun/faculty/thomas.html (216 words)

	Pulmonary Infiltrates after Cytokine Therapy for Stem Cell Transplantation . Massive Deposition of Eosinophil Major ...
		Intense perivascular extracellular MBP staining pattern is indicated by the arrow.
		MBP is a known endothelial toxin in vitro (30, 31), it has
		Cytotoxic properties of the eosinophil major basic protein.
	ajrccm.atsjournals.org /cgi/content/full/160/4/1361 (2617 words)

	Method for the treatment of eosinophil-associated conditions with anionic polymers (US5498410)
		W. Filley et al., "Identification by Immunofluorescence of Eosinophil Granule Major Basic Protein in Lung Tissues of Patients with Bronchial Asthma", Lancet, 2, 11-16 (1982).
		E. Frigas et al., "Elevated Levels of the Eosinophil Granule Major Basic Protein in the Sputum of Patients with Bronchial Asthma", Mayo Clinic, Proc., 56, 345-353 (1981).
		G. Gleich et al., "Identification of a Major Basic Protein in Guinea Pig Eosinophil Granules", J. Exp. Med., 137, 1459-1471 (1973).
	www.delphion.com /details?pn=US05498410__ (1125 words)

	Complex of Pregnancy-associated Plasma Protein-A and the Proform of Eosinophil Major Basic Protein. DISULFIDE STRUCTURE ...
		Complex of Pregnancy-associated Plasma Protein-A and the Proform of Eosinophil Major Basic Protein.
		Pregnancy-associated plasma protein-A (PAPP-A) is a metzincin superfamily metalloproteinase responsible for cleavage of insulin-like
		Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module
	www.jbc.org /cgi/content/abstract/278/4/2106 (612 words)

	Design Arguments for the Existence of God [Internet Encyclopedia of Philosophy]
		The scriptures of each of the major classically theistic religions contain language that suggests that there is evidence of divine design in the world.
		Like the functions of a watch or a mousetrap, a cilium cannot perform its function unless its microtubules, nexin linkers, and motor proteins are all arranged and structured in precisely the manner in which they are structured; remove any component from the system and it cannot perform its function.
		Meyer concludes: "given the complexity of proteins, it is extremely unlikely that a random search through all the possible amino acid sequences could generate even a single relatively short functional protein in the time available since the beginning of the universe (let alone the time available on the early earth)" (Meyer 2002, 75).
	www.iep.utm.edu /d/design.htm (8076 words)

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