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Topic: Major histocompatibility complex


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In the News (Sat 17 Aug 19)

  
  Histocompatibility   (Site not responding. Last check: 2007-09-15)
The Major Histocompatibility Complex (MHC) is a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and "antigen presentation".
The MHC molecules control the immune response through recognition of "self" and "non-self" and, consequently, serve as targets in transplantation rejection.
The major histocompatibility complex is encoded by several genes located on human chromosome 6.
www.cehs.siu.edu /fix/medmicro/mhc.htm   (889 words)

  
 Major histocompatibility complex   (Site not responding. Last check: 2007-09-15)
The major histocompatibility complex ('''MHC''') is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles.
To disambiguate the usage, some of the biomedical literature uses Mhc to refer specifically to the HLA protein molecules and reserves MHC for the region of the genome that encodes for this molecule, however this convention is not consistently adhered to.
MHC gene families are found in essentially all vertebrates, though the gene composition and genomic arrangement varies widely.
major-histocompatibility-complex.kiwiki.homeip.net   (1268 words)

  
 Heredity - The evolutionary ecology of the major histocompatibility complex
Heredity - The evolutionary ecology of the major histocompatibility complex
The evolutionary ecology of the major histocompatibility complex
Similarly, in sockeye salmon (Oncorhynchus nerka), a deficit of homozygosity at the MHC class II 1 locus was observed in 13 of 31 populations (Miller et al, 2001).
www.nature.com /uidfinder/10.1038/sj.hdy.6800724   (10154 words)

  
 THE MAJOR HISTOCOMPATIBILITY COMPLEX
MHC class II molecules are constitutively expressed only by certain cells involved in immune responses, though they can be induced on a wider variety of cells.
All MHC loci are expressed co-dominantly, that is to say both the set of alleles inherited from one's father and the set inherited from one's mother are expressed on each cell.
Thus the biological role of MHC proteins is to bind small peptides and to "present" these at the cell surface for the inspection of T cell antigen receptors.
www-immuno.path.cam.ac.uk /~immuno/part1/lec07/lec7_97.html   (1619 words)

  
 MAJOR HISTOCOMPATIBILITY COMPLEX
MHC class II molecules comprise two non-identical peptides (alpha and beta) which are non-covalently associated and traverse the plasma membrane with the N terminus to the outside of the cell.
Thus, as for class I MHC, the genetic polymorphism determines the chemical structure of the groove and influences the specificity and affinity of peptide binding and T cell recognition.
MHC class I molecule is in dark blue, the associated beta 2 microglobulin in light blue.
pathmicro.med.sc.edu /bowers/mhc.htm   (2423 words)

  
 Major Histocompatibility Complex - multiple sclerosis encyclopaedia   (Site not responding. Last check: 2007-09-15)
The Major Histocompatibility Complex (MHC) is a group of genes that, in humans, code for a complex of cell surface proteins called the Human Leukocyte Antigen (HLA).
The MHC class I binds to a type of immune system cell called a killer (cytotoxic) T cell and "presents" the captured antigen to it.
MHC class III proteins are a diverse group of molecules that perform a variety of functions in the body.
home.btconnect.com /mult-sclerosis/majorhistocompatibilitycomplex.html   (538 words)

  
 Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression -- Harton and Ting 20 (17): ...
Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity.
MHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression.
Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.
mcb.asm.org /cgi/content/full/20/17/6185   (6905 words)

  
 Major Histocompatibility Complex [M.Tevfik Dorak]
Also important is the fact that the MHC is inherited en bloc as a haplotype with the exception of the rare recombinational events.
MHC class I and class II supertypes are biologically as functional as private specificities.
Molecular and biological interaction between major histocompatibility complex class I antigens and luteinizing hormone receptors or beta-adrenergic receptors triggers cellular response in mice.
dorakmt.tripod.com /mhc/mhc.html   (2721 words)

  
 Major Histocompatibility Complex Information on Healthline
This specialized type of immunity is usually needed to eliminate an infection and is dependent on the role of the proteins of the major histocompatibility complex.
The major players in acquired immunity are the antigen-presenting cells (APCs), B-cells, their secreted antibodies, and the T-cells.
Related to this role in disease immunity, MHC is also important in organ and tissue transplantation, as well as playing a role in susceptibility to certain diseases.
www.healthline.com /galecontent/major-histocompatibility-complex   (1011 words)

  
 Structure and Function of the major histocompatibility complex (MHC) proteins.
The MHC Class II proteins (found only on B lymphocytes, macrophages, and other cells that present antigens to T cells), which primarily present peptides which have been digested from external sources, are needed for T-cell communication with B-cells and macrophages.
The MHC proteins, and several closely associated with them in the carrying out of their functions, are coded for by loci that are close together within the Human Genome.
Major Histocompatibility Complex proteins and their associated molecules are fundamental in the process of antigen presentation.
www.cryst.bbk.ac.uk /pps97/assignments/projects/coadwell/MHCSTFU1.HTM   (609 words)

  
 HON Allergy Glossary Major Histocompatibility Complex (MHC)
A cluster of genes on chromosome 6 in humans, encoding cell surface molecules that are polymorphic and that code for antigens which lead to rapid graft rejection between members of a single species which differ at these loci.
A molecule encoded to genes of the MHC which participates in antigen presentation to cytotoxic T (CD8+) cells.
A molecule encoded by genes of the MHC which participates in antigen presentation to helper T (CD4+) cells.
www.hon.ch /Library/Theme/Allergy/Glossary/mhc.html   (153 words)

  
 Major histocompatibility complex - Wikipedia, the free encyclopedia
Part of the proteins encoded by the MHC are the proteins on the outer part of body cells that are (effectively) unique to that person.
The MHC class I encodes heterodimeric peptide binding proteins, as well as antigen processing molecules such as TAP and Tapasin.
Schematic representation of MHC class II MHC Class II molecules are found only on a few specialized cell types, including macrophages, dendritic cells, activated T cells, and B cells, all of which are professional antigen-presenting cells (APCs).
en.wikipedia.org /wiki/Major_histocompatibility_complex   (2178 words)

  
 Sequence and gene map of a human major histocompatibility complex
A paper authored by members of the MHC sequencing consortium is scheduled for the Oct. 28 issue of the journal Nature.
The MHC controls many activities of the immune cells, including the transplantation rejection process and the killing of virus-infected cells by specific killer T lymphocytes.
In addition to being critical in the marrow transplant process, the MHC has a large number and variety of disease associations, and thus the scope of this advance would have the potential for a broad impact on human health.
www.fhcrc.org /about/ne/news/1999/10/27/mhc.htm   (388 words)

  
 Major Histocompatibility Complex Proteins
Class I and class II MHC proteins (also referred to as MHC molecules) are critical to the function of the immune system.
Class II MHC proteins, encoded in the region of the chromosome for HLA-D, differ from Class I molecules in their presentation of peptides in the binding groove by allowing access to the ends of the peptide.
Class I MHC molecules present to killer T Cells, whereas Class II MHC molecules present to helper T Cells, and are found only on immune system cells.
www.iscid.org /encyclopedia/Major_Histocompatibility_Complex_Proteins   (179 words)

  
 Transcriptional regulation of major histocompatibility complex class I gene by insulin and IGF-I in FRTL-5 thyroid ...
Transcriptional regulation of major histocompatibility complex class I gene by insulin and IGF-I in FRTL-5 thyroid cells -- Giuliani et al.
Transcriptional regulation of major histocompatibility complex class I gene by insulin and IGF-I in FRTL-5 thyroid cells
MHC class I gene expression and that its action is similar to
joe.endocrinology-journals.org /cgi/content/abstract/189/3/605   (329 words)

  
 Major histocompatibility complex (MHC)
If you have a better definition for Major histocompatibility complex (MHC) than the one presented here, please let us know by making use of the suggest a term option.
This definition of Major histocompatibility complex (MHC) may be disputed by other professionals.
Our attempt is to provide easy definitions on Major histocompatibility complex (MHC) and any other medical topic for the public at large.
www.medicalglossary.net /Major_histocompatibility_complex_(MHC).htm   (717 words)

  
 Sus scrofa - Class I pig major histocompatibility complex
Recent success in overcoming the hyperacute rejection phase of porcine tissues in non-concordant xenotransplantation experiments support their possible use for human transplantation even though formidable obstacles remain.
Among the antigenic determinants present in porcine cells, molecules of the major histocompatibility complex (MHC) play a pivotal role.
Further manipulation of the swine MHC requires the sequence of the corresponding chromosomal fragment.
www.genoscope.cns.fr /externe/English/Projets/Projet_AA/AA.html   (108 words)

  
 IMGT Databases at the EBI
IMGT, the international ImMunoGeneTics project, is a collection of high-quality integrated databases specialising in Immunoglobulins, T cell receptors and the Major Histocompatibility Complex (MHC) of all vertebrate species.
The IMGT project was established in 1989 by the Université Montpellier II and the CNRS (Montpellier, France) and works in close collaboration with the EBI.
IMGT/HLA is a database for sequences of the human MHC, referred to as HLA.
www.ebi.ac.uk /imgt   (163 words)

  
 InterPro: IPR003006 Immunoglobulin/major histocompatibility complex   (Site not responding. Last check: 2007-09-15)
P01891 HLA class I histocompatibility antigen, A-68 alpha chain precursor (MHC class I antigen A*68) (Aw-68) (A-28)
P03989 HLA class I histocompatibility antigen, B-27 alpha chain precursor (MHC class I antigen B*27)
Li L. Bouvier M. Structures of HLA-A*1101 complexed with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle, secondary anchor residue.
www.ebi.ac.uk /interpro/IEntry?ac=IPR003006   (3027 words)

  
 The Molecular Perspective: Major Histocompatibility Complex -- Goodsell 10 (1): 80 -- The Oncologist
The Molecular Perspective: Major Histocompatibility Complex -- Goodsell 10 (1): 80 -- The Oncologist
MHC class I, shown on the left, is used my most of our cells to display their own peptides.
In the illustration, a peptide from influenza virus (bright red) is bound to the MHC on the surface of a special antigen-presenting cell.
theoncologist.alphamedpress.org /cgi/content/full/10/1/80   (796 words)

  
 Major histocompatibility complex, class I, A, Homo sapiens - UniGene Hs.181244
Major histocompatibility complex, class I, A, Homo sapiens - UniGene Hs.181244
Major histocompatibility complex, class I, A (HLA-A) Comparison of sequences in UniGene with proteins supported by a complete genome.
Human mRNA for HLA-A11E, a MHC class I molecule (major histocompatibility complex)
www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=181244   (2050 words)

  
 DigitalCommons@University of Nebraska - Lincoln | Interference with major histocompatibility complex class I pathway by ...
All three viruses down-regulate cell surface expression of major histocompatibility complex (MHC) class I molecules, in vitro.
The objectives of this study were to extend these findings to further characterize mechanisms of class I down-regulation by these viruses, and to identify the vial proteins responsible.
BHV-1 protein(s) responsible for TAP inhibition could be immunoprecipitated with the bovine TAP complex from infected cells.
digitalcommons.unl.edu /dissertations/AAI3147132   (393 words)

  
 Major histocompatibility complex, class I, B, Homo sapiens - UniGene Hs.77961
Major histocompatibility complex, class I, B, Homo sapiens - UniGene Hs.77961
Major histocompatibility complex, class I, B (HLA-B) Comparison of sequences in UniGene with proteins supported by a complete genome.
Homo sapiens major histocompatibility complex, class I, B (HLA-B), mRNA
www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=77961   (4332 words)

  
 Major histocompatibility complex - Wikipedia, the free encyclopedia
MHC I (1hsa) vs MHC II (1dlh) (more details...
About half have known immunological functions (see human leukocyte antigen).
In particular, virus infected and cancerous cells have a tendency to display unusual, nonself antigens on their surface.
en.wikipedia.org /wiki/MHC_II   (2179 words)

  
 Immunoglobulin E-independent Major Histocompatibility Complex-restricted T Cell Peptide Epitope-induced Late Asthmatic ...   (Site not responding. Last check: 2007-09-15)
Immunoglobulin E-independent Major Histocompatibility Complex-restricted T Cell Peptide Epitope-induced Late Asthmatic Reactions
In this study, we have demonstrated that peptides derived from a major allergen elicited an LAR in a proportion of sensitized
Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d 1.
www.jem.org /cgi/content/full/189/12/1885   (5577 words)

  
 Major histocompatibility complex
A cluster of genes located on chromosome 6 concerned with antigen production and critical to the success of transplantation.
The MHC includes the human leukocyte antigen (HLA) genes.
Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice.
www.affordablerx.com /healthcare/Major+histocompatibility+complex   (234 words)

  
 Amazon.com: Molecular Evolution of the Major Histocompatibility Complex (NATO Advanced Science Institute S.): Books: J. ...   (Site not responding. Last check: 2007-09-15)
Amazon.com: Molecular Evolution of the Major Histocompatibility Complex (NATO Advanced Science Institute S.): Books: J. Klein,D. Klein
This item is not eligible for Amazon Prime, but over a million other items are.
Molecular Evolution of the Major Histocompatibility Complex (NATO Advanced Science Institute S.) (Hardcover)
www.amazon.com /Molecular-evolution-major-histocompatibility-complex/dp/3540546081   (420 words)

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