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Topic: Schwannoma, malignant

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	Schwannoma, malignant (Site not responding. Last check: 2007-10-23)
		Malignant schwannoma is a tumor of the peripheral nervous system that arises in the nerve sheath.
		Synonyms are neurogenic sarcoma, neurofibrosarcoma and malignant peripheral nerve sheat tumor (MPNST).
		Malignant Triton tumor is a rare variant of MPNST with rhabdomyosarcoma cells and mesenchymal differenciation very frequent in NF1 patients.
	www.orpha.net /static/GB/schwannoma.html (212 words)

	Nikon MicroscopyU: Human Pathology Digital Image Gallery - Malignant Schwannoma
		Malignant schwannomas are rare and are classified among the soft tissue sarcomas, accounting for about ten percent of all such tumors diagnosed.
		The five-year survival rate associated with malignant schwannomas is low, primarily due to poor response of the tumors to available treatments and metastasis to the lungs and other areas of the body.
		Malignant Schwannoma at 20x Magnification - Malignant schwannomas can be difficult to diagnose, and are usually more than 5 centimeters in diameter by the time they are brought to the attention of a medical professional and identified.
	www.microscopyu.com /galleries/pathology/malignantschwannoma.html (353 words)

	s020403a - Spinal Cord Schwannoma
		Schwannomas should be considered in the differential diagnosis of intramedullary tumours when magnetic resonance images show a strongly enhancing mass with sharply delineated borders.
		The pathogenesis of the second and third malignancies may be attributed to the histologic pattern of HD with long-term survival and increased cumulative risk, non-alternating MOPP courses and continued supporting therapy and radiotherapy given to the involved fields.
		Abstract: Intradural extramedullary schwannomas are nerve sheath neoplasms that consist of focal proliferations of Schwann cells involving a spinal nerve.
	www.emory.edu /WHSCL/grady/amreport/litsrch01/s020403a.html (3910 words)

	Schwannoma (Site not responding. Last check: 2007-10-23)
		Schwannomas of the head and neck are uncommon tumors that arise from cranial, peripheral or autonomic nerves.
		Twenty-five schwannomas occurred in the scalp, face and external ear canal, 9 in the oral or nasal cavity and 18 in the neck.
		Cervical plexus schwannomas originated either in the peripheral nerves or in an unidentified area of the nervous system; seven tumors were found in the posterior triangle of the neck and two in the anterior triangle.
	www.thedoctorsdoctor.com /diseases/schwannoma.htm (5470 words)

	Bioline International Official Site (site up-dated regularly)
		In view of wheeze on clinical examination and the fact that he had malignant tumour earlier, a CT scan chest was done, which showed multiple, small, thin-walled cystic lesions with multiple tiny nodular lesions in the periphery of both lungs.
		The rarity of isolated limb involvement in Kaposi's sarcoma and the past history of malignant schwannoma of the same limb contributed to the absence of Kaposi's sarcoma as a diagnostic possibility in the work-up of the patient.
		Malignant melanoma was considered in the differential diagnosis because of the pigmented nodules, pigmentation in the ulcers and because the distribution of lesions looked like intransit metastases.
	www.bioline.org.br /request?is04028 (1027 words)

	NEUROGENIC INTRATHORACIC TUMORS
		As a rule the melanotic tumors of probable ganglion cell origin are highly malignant, in contrast with the benign behaviour of the melanotic schwannomas of nerve sheath origin [11].
		Malignant peripheral nerve sheath tumors (MPNST) are the malignant variants of schwannomas and neurofibromas.
		Malignant schwannoma is associated with a poor patient survival rate [19].
	www.thorax.org /journee2004/NEUROGENIC.htm (4035 words)

	Bui TD, et al. Pancreatic Schwannoma. A Case Report and Review of the Literature. JOP. J Pancreas (Online) 2004; ...
		Schwannomas usually occur in the extremities, but can also be found in the trunk, head and neck, retroperitoneum, mediastinum, pelvis and rectum [1].
		Malignant transformation is associated with von Recklinghausen’s disease in 8% of cases [1, 10].
		On histological analysis, schwannomas have two different patterns which are designated as Antoni A and B. Antoni A refers to areas that are highly cellular and composed of spindle cells arranged in a palisading fashion without mitotic figures, while Antoni B areas are typically hypocellular with degenerative changes (Figure 5) [6].
	www.joplink.net /prev/200411/14.html (1890 words)

	Cranial Base Program \| Conditions Treated (Site not responding. Last check: 2007-10-23)
		A chordoma is a malignant tumor that arises from the embryonic remnants of the notochord (primitive fetal spinal cord).
		Malignant fibrous histiocytomas are most commonly found in the extremities but approximately 8% of lesions are found in the craniofacial region.
		Malignant schwannomas account for approximately 14% of all soft tissue sarcomas in the head and neck region.
	www.med.umich.edu /oto/cranialbase/conditions.htm (3647 words)

	Nasal Schwannoma
		The schwannomas arise from either the ophthalmic or the maxillary branches of the trigeminal nerve and both sympathetic fibers from the cephalic ganglion and/or parasympathetic fibers from the sphenopalatine ganglion are also found in the nasal mucosa.
		Malignant transformation of a nasal schwannoma is an exceedingly rare event; and in an extensive review of 430,00 cases of nonepithelial tumors of the nasal cavity and paranasal sinuses as well as the nasopharynx, Pearson found only four cases of malignant schwannoma.
		These malignant schwannomas typically occurred throughout the same age range as nasal schwannnomas, between the second and fifth decade and are usually more aggressive with invasion of surrounding tissue structures.
	www.bcm.edu /oto/grand/02_04_04.htm (2940 words)

	ENT Journal
		Malignant schwannoma is an aggressive tumor that carries a poor prognosis despite wide excision, chemotherapy, and radiotherapy.
		Malignant schwannoma of the parapharyngeal space is an uncommon finding; to our knowledge, only four cases have been described in the literature during the past 30 years, and only one of them involved a patient who had clinical evidence of neurofibromatosis type 1.
		In this article, we describe a new case of malignant schwannoma of the parapharyngeal space in a patient who had clinical evidence of neurofibromatosis type 1.
	www.entjournal.com /Past_Issues.htm?ID=1814 (273 words)

	World Journal of Surgical Oncology \| Full text \| Malignant schwannoma of the upper mediastinum originating from the ...
		Malignant schwannoma of the upper mediastinum originating from the vagus nerve is extremely rare.
		Malignant peripheral nerve sheath tumors (MPNST) including malignant schwannoma are the malignant variants of schwannomas and neurofibromas.
		Malignant schwannoma of the upper mediastinum arising from the vagus nerve is rare.
	www.wjso.com /content/3/1/65 (1422 words)

	Malignant
		In medicine, malignant is a clinical term that is used to describe a clinical course that progresses rapidly to death.
		Malignant transformation is a synonym for progression to malignancy.
		Although malignant transformation may occur because of changes within the cell, it can be induced by inorganic toxic substances such as cadmium or arsenite and organics such as tobacco-specific nitrosamines.
	www.mrsci.com /Medical-Terms/Malignant.php (554 words)

	eMedicine - Pathology: Sarcomas of the Head and Neck : Article by K Christopher McMains, MD
		Inflammatory or xanthomatous malignant fibrous histiocytoma is characterized by the proliferation of histiocytes, xanthomatous cells, and neutrophils, and it may be difficult to distinguish from an inflammatory disorder.
		Malignant schwannomas, also known as malignant peripheral nerve sheath tumors or neurofibrosarcomas, arise from peripheral or cranial nerves and account for 5-10% of all sarcomas.
		At gross examination, a malignant schwannoma appears as a fusiform or nodular mass that is firm or fleshy, and its origin may clearly be peripheral nerve tissue.
	www.emedicine.com /ent/topic675.htm (11785 words)

	Malignant
		Synovial sarcoma is a highly malignant soft tissue tumor that arises in the region of a joint, tendon, or bursae.
		Malignant fibrous histiocytoma is a malignant soft tissue tumor with foci of macrophage differentiation.
		Malignant soft tissue tumors of the hand (excluding skin) are exceedingly rare; however, maintain clinical awareness when evaluating a soft tissue mass in a hand.
	www.brts.pwp.blueyonder.co.uk /malignant.htm (4473 words)

	Subperiosteal Schwannoma Of The Ulna
		This is a report of a case of subperiosteal schwannoma arising from the surface of the ulna in a 28 years old lady.
		Schwannoma or neurilemmoma, is a benign tumour of nerve sheath origin with a very low incidence in bone.
		In this particular case, the schwannoma was on the surface of the ulna, eroding into the ulna causing scalloping of the outer cortex and extending into the surrounding soft tissues, without invading them.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijos/vol3n1/schwannoma.xml (907 words)

	Malignant Schwannoma of the Trigeminal Nerve -- Stone et al. 22 (3): 505 -- American Journal of Neuroradiology
		of a patient with malignant schwannoma of the trigeminal nerve.
		Malignant schwannomas of the cranial nerves are much less common.
		Malignant schwannoma arising in the intracranial trigeminal nerve: a report of an autopsy case and a review of the literature.
	www.ajnr.org /cgi/content/full/22/3/505 (1391 words)

	[No title]
		Schwannomas in general are slow growing and usually do no affect the nerve of origin.
		Malignant neurogenic tumors have been reported in the parapharyngeal space include malignant schwannoma, malignant paraganglioma, malignant neuroblastoma, or sympathicoblastoma.
		The schwannoma on the CT scan is in the post-styloid space and usually displaces the carotid artery anteromedially.
	www.utmb.edu /otoref/Grnds/Parapharyngeal-tumor-060322/Parapharyngeal-tumor-060322.doc (2467 words)

	Malignant nerve sheath tumor
		Malignant peripheral nerve tumors of the oral cavity: review of the literature and report of a case.
		Malignant peripheral nerve sheath tumor with divergent differentiation.
		Malignant peripheral nerve sheath tumors (malignant schwannoma) in children.
	www.maxillofacialcenter.com /BondBook/softtissue/mnst.html (1075 words)

	Malignant Peripheral Nerve Sheath Tumors (Site not responding. Last check: 2007-10-23)
		The malignant peripheral nerve sheath tumor (MPNST) is the malignant counterpart to benign soft tissue tumors such as neurofibromas and schwannomas.
		Malignant peripheral nerve sheath tumor with perineurial differentiation: 'malignant perineurioma'.
		Schwannomas consisted principally of S-100 protein-positive Schwann cells, whereas a few CD34-positive fibroblastic cells were present in Antoni B areas.
	www.thedoctorsdoctor.com /diseases/mpnst.htm (4327 words)

	Fisher
		In cellular schwannoma, the ultrastructure is that of well differentiated schwann cells but with less interdigitation than in regular schwannoma.
		Granular cell schwannoma is the suggested term for granular cell tumor (previously myoblastoma), because of its S100 positive immunophenotype, occasional neural connection, and occasional appearance in neurofibromatosis.
		Malignant perineurial cell tumor Some poorly differentiated (S100 negative) MPNST are found ultrastructurally to have features of perineurial cell differentiation.
	sup.ultrakohl.com /Newsletter/May1999/pages/neuro.html (1793 words)

	Soft Tissue Sarcomas - 2° paragraph
		However, malignant schwannoma is included as well, which has an ectodermic origin.
		Malignancy grade clearly distinguishes patients with different prognoses and natural histories, so that different histotypes with the same malignancy grade basically display the same clinical behaviour, while different malignancy grades may be consistent with one histotype.
		The former is founded on the histotype and the degree of tumor necrosis, while the latter is based on the degree of necrosis, the degree of morphological differentiation, and the mitotic index.
	telescan.nki.nl /start/chapt-01/chap1-2.html (933 words)

	Malignancy -- References & Resources on AN (Site not responding. Last check: 2007-10-23)
		A picture of tissue from a malignant schwannoma (vestibular schwannoma is another name for acoustic neuroma or AN) can be found at: http://www.tumorboard.com/cgi-bin/dsearch.cgi (type "schwannoma" under description, not under image name).
		While a malignant acoustic neuroma appears to be extremely rare, there are a small number of cases of malignancy reported after radiation.
		(The malignancies reported are not actually malignant acoustic neuromas, but secondary tumors of a different sort believed to have been caused by the radiation.) There are only a small number of such reports as best we can tell, and the link between radiation and malignancy is tenuous at this point.
	www.anseattle.org /refresmalignancy.html (1119 words)

	Thoracoscopic Excision of a Malignant Schwannoma of the Intrathoracic Vagus Nerve -- Singer 59 (6): 1586 -- The Annals ... (Site not responding. Last check: 2007-10-23)
		Thoracoscopic Excision of a Malignant Schwannoma of the Intrathoracic Vagus Nerve -- Singer 59 (6): 1586 -- The Annals of Thoracic Surgery
		Thoracoscopic Excision of a Malignant Schwannoma of the Intrathoracic Vagus Nerve
		Malignant schwannomas of the intrathoracic vagus nerve are rare
	ats.ctsnetjournals.org /cgi/content/abstract/59/6/1586 (104 words)

	Childhood Soft Tissue Sarcoma Treatment - National Cancer Institute
		Childhood soft tissue sarcoma is a disease in which cancer (malignant) cells begin growing in soft tissue in the body.
		The chance of recovery (prognosis) and choice of treatment depend on the type, location, and stage of the tumor and the age, size, stage of development, and general health of the patient.
		A malignant (cancerous) tumor of smooth muscle cells that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.
	www.cancer.gov /cancertopics/pdq/treatment/child-soft-tissue-sarcoma/Patient/page1/print (1508 words)

	Point Mutation of neu Oncogene in Animal Peripheral Nerve Sheath Tumors -- Stoica et al. 38 (6): 679 -- Veterinary ...
		Histology of this tumor illustrates a classical pattern of a schwannoma charaterized by cell nuclei forming a typical hypercellular palisading pattern (Antoni A) and hypocellular areas (Antoni B).
		Schwannoma cell nuclei are arranged in a typical palisading pattern.
		Williamson LH, Farell RL: Intracranial schwannoma in a horse.
	www.vetpathology.org /cgi/content/full/38/6/679 (3229 words)

	Final Diagnosis -- Case 112
		Malignant peripheral nerve sheath tumours (MPNST) are uncommon primary malignant tumours of peripheral nerves.
		Of several reported examples of malignant schwannomas in the sinonasal region, the case of Fernandez et al.
		The malignant counterpart to the neurofibroma and schwannoma is rare outside the setting of neurofibromatosis type I with two important exceptions reemphasized by the present example: MPNST involving the head and neck are less commonly associated with NF-1, MES are less commonly associated with NF-1.
	path.upmc.edu /cases/case112/dx.html (1093 words)

	rop9-98
		Hajdu SI: Cellular schwannoma: a clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients [Letter].
		Woodruff JM: Cellular schwannoma and its necessary distinction from malignant peripheral nerve sheath tumors and sarcomas.
		Hasegawa SL, et al: Schwannomas of the sinonasal tract and nasopharynx.
	www.afip.org /Departments/OMaxPath2/rop9-98.html (392 words)

	Final Diagnosis -- Case 406
		Since not all the tumors in this group are clearly schwannian in origin, malignant peripheral nerve sheath tumor (MPNST) is currently preferred term for the neoplasm previously known as malignant schwannoma, neurogenic sarcoma, and neurofibrosarcoma (1).
		Additional hint for the diagnosis of malignancy in a neurofibromas-like tumor is the presence of focal densely cellular regions and necrosis (Figures 3 and 4).
		Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor.
	path.upmc.edu /cases/case406/dx.html (698 words)

	UCLA NEUROSURGERY \| Peripheral Nerve Diseases & Disorders (Site not responding. Last check: 2007-10-23)
		These are malignant tumors that arise from the sheaths that surround peripheral nerves.
		This classification of tumors includes tumors that were previously called malignant schwannoma, malignant neurofibroma, nerve sheath fibrosarcoma, and neurofibrosarcoma.
		Previous radiation of benign and malignant conditions has been implicated in the genesis of 10% of MNSTs.
	neurosurgery.ucla.edu /Diagnoses/PeripheralNerve/PeripheralNerveDis_9.html (235 words)

	Ethylnitrosourea-induced Development of Malignant Schwannomas in the Rat: Two Distinct Loci on Chromosome 10 Involved ... (Site not responding. Last check: 2007-10-23)
		Fourteen BDIX rats developed malignant schwannomas, two rats exhibited other types of tumors, and five rats (marked with stars) were killed without disease when neurological symptoms were wrongly assumed.
		Animals with symptoms caused by tumors other than schwannomas or other diseases were counted as "censored observations"; their survival times are marked with ticks.
		A, LOH on chromosome 10 in EtNU-induced rat schwannomas.
	cancerres.aacrjournals.org /cgi/content/full/59/5/1109 (4387 words)

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