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Topic: Maprotiline

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		Maprotiline should not be taken by people who have glaucoma, seizure disorders, increased eye pressure or urinary retention.
		Maprotiline should not be taken during the immediate time following a heart attack and in the case of acute congestive heart failure, as well as in people who have certain blood disorders, kidney disorders or liver disease.
		Maprotiline should not be used by people with a history of seizures, reduced liver function, certain blood disorders, and those with a history of urinary retention, or with narrow-angle glaucoma or increased eye pressure.
	www.mediresource.com /zellers/health/DrugInfo.asp?BrandNameID=445&dowhat=accept_disclaimer (571 words)

	Maprotiline (Ludiomil) antidepressant (Site not responding. Last check: 2007-10-10)
		Maprotiline was approved for use by the FDA in 1980.
		Maprotiline shares many of the actions of the tricyclic antidepressants although, unlike other tricyclic antidepressants, maprotiline does not affect the reuptake of serotonin.
		Maprotiline is metabolized slowly in the liver to produce the active metabolite desmethylmaprotiline, which is known to be distributed into breast milk.
	www.rockford.uic.edu /jc/maprotil.htm (363 words)

	Psychotic and Mental Health Medications (Site not responding. Last check: 2007-10-10)
		It is postulated that maprotiline exerts its antidepressant action by inhibition of presynaptic uptake of catecholamines, thereby increasing their concentration at the synaptic clefts of the brain.
		Maprotiline is contraindicated during the acute recovery phase following myocardial infarction in the presence of acute congestive heart failure, and in patients with conduction defects.
		Maprotiline should not be employed, or should be withdrawn, in cases of acute poisoning with alcohol, hypnotics, analgesics or psychotropic drugs.
	www.support4hope.com /med_index_11.htm (3107 words)

	Maprotiline, Ludiomil Pharmacology - HealthyPlace.com (Site not responding. Last check: 2007-10-10)
		Maprotiline should be used with caution in hyperthyroid patients and in those on thyroid medication because of the possibility of cardiovascular toxicity.
		Maprotiline should be used with caution in patients receiving guanethidine or similar sympatholytic antihypertensive agents (bethanidine, reserpine, alpha-methyldopa, clonidine) since it may block the effects of these drugs with subsequent loss of blood pressure control.
		Because of its anticholinergic properties, maprotiline should be used with caution in patients with a history of increased intraocular pressure or history of urinary retention, particularly in the presence of prostatic hypertrophy.
	www.concernedcounseling.com /medications/maprotiline.asp (1838 words)

	Maprotiline Information on Healthline
		Maprotiline is an antidepressant intended for use by persons with depressive neurosis and bipolar syndrome.
		Maprotiline may promote seizure activity: of all the cyclic antidepressants it probably causes the highest incidence of seizures and has thus fallen out of favor with most psychiatrists.
		Cardiovascular toxicity has been reported when maprotiline is used simultaneously with thyroid-replacement medications such as levothyroxine, and maprotiline blocks the pharmacological effect of guanethidine.
	www.healthline.com /galecontent/maprotiline (699 words)

	Maprotiline
		Maprotiline is a strong inhibitor of noradrenaline re-uptake in the brain and peripheral tissues, however it is worthy to note that it is a weak inhibitor of serotonergic uptake.
		Maprotiline acts as an antagonist at central presynaptic α2 adrenergic inhibitory autoreceptors and hetero-receptors, an action that is postulated to result in an increase in central noradrenergic and serotonergic activity.
		Maprotiline should not be administered for a period of at least 14 days after the discontinuation of treatment with MAO-inhibitors due to the potential of severe interactions.
	www.mongabay.com /health/medications/Maprotiline.html (617 words)

	MedlinePlus Drug Information: Maprotiline (Systemic) (Site not responding. Last check: 2007-10-10)
		Maprotiline (ma-PROE-ti-leen) is used to relieve mental depression, including anxiety that sometimes occurs with depression.
		Maprotiline may cause some people to be agitated, irritable or display other abnormal behaviors.
		Taking maprotiline together with medicines that are used during surgery or dental or emergency treatments may increase the CNS depressant effects.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202337.html (1579 words)

	Data Sheet
		Steady-state levels of maprotiline are in linear proportion to the dose, although the concentrations vary greatly from one subject to another.
		Maprotiline is 88 to 90% bound to plasma proteins, independent of the patient's age or disease.
		Primary elimination of maprotiline and desmethylmaprotiline is through hydroxylation and further conjugation of the metabolites and excretion in the urine.
	www.medsafe.govt.nz /Profs/datasheet/l/Ludiomiltab.htm (3824 words)

	Maprotiline (Site not responding. Last check: 2007-10-10)
		If your child’s doctor has prescribed maprotiline for your child, you should watch his or her behavior very carefully, especially at the beginning of treatment and any time his or her dose is increased or decreased.
		Your child’s doctor will want to see your child often while he or she is taking maprotiline, especially at the beginning of his or her treatment.Your child’s doctor may also want to speak with you or your child by telephone from time to time.
		Maprotiline is used to treat depression, manic depression, and anxiety.
	www.safemedication.com /displaydrug.cfm?id=682158 (932 words)

	Maprotiline (Ludiomil®) (Site not responding. Last check: 2007-10-10)
		Maprotiline onderscheidt zich van de meeste tricyclische antidepressiva ook in neurobiochemisch en psychofarmacologisch opzicht doordat het selectief een krachtig remmend effect uitoefent op de heropname van noradrenaline in de presynaptische neuronen van corticale structuren in het centrale zenuwstelsel.
		Na herhaaldelijk oraal toedienen van 150 mg maprotiline per dag worden in de tweede week van de behandeling "steady-state"-concentraties in het bloed bereikt van 320-1270 nmol/liter (100-400 ng/ml) zowel indien de dagelijkse dosis in één keer wordt toegediend als wanneer de toediening plaatsvindt in de vorm van drie gefractioneerde doses.
		Bij verminderde nierfunctie (creatinineklaring: 24-37 ml/min.) worden de eliminatiehalfwaardetijd en de renale uitscheiding van maprotiline nauwelijks beïnvloed mits de leverfunctie nog normaal is. De uitscheiding van de metabolieten in de urine is daarentegen verminderd; deze vermindering wordt echter gecompenseerd door een verhoogde eliminatie met de gal.
	www.hulpgids.nl /medicijnen/medicijnsoorten/maprotiline.htm (2423 words)

	Ludiomil and Desyrel (Site not responding. Last check: 2007-10-10)
		Maprotiline and trazodone (Desyrel®) have been 'heralded' as a means of countering these disadvantages.
		There is no consistent evidence that maprotiline differs from the tricyclics with respect to faster onset of action and toxicity in overdose [15].
		The FDA gave maprotiline a rating of 1-C, "designating a 'new molecular entity' which essentially duplicates in medical importance a therapeutic usage of one or more already marketed drugs" [16].
	www.lclark.edu /~goldman/mmmp2.html (517 words)

	Chinese Medical Psychiatry by Bob Flaws and James Lake, MD (Site not responding. Last check: 2007-10-10)
		Maprotiline is an antidepressant which was first introduced in 1974.
		In the comparison group treated with maprotiline, 14 cases (45.2%) were cured, nine (29%) got a marked effect, five (16.1%) got some effect, and three (9.7%) got no effect.
		Therefore, this study suggests that electroacupuncture is just as effective as maprotiline for the treatment of depression but has fewer side effects.
	chinesemedicalpsychiatry.com /articles/article_maprotiline.html (832 words)

	Maprotiline - Drug information from Medic8.com
		Although Maprotiline behaves in most regards as a 'first generation antidepressant' it is commonly referred to as 'second generation antidepressant'.
		Maprotiline causes a strong initial sedation (first 2 to 3 weeks of therapy) and is therefore indicated to treat agitated patients ot those with suicidal risks.
		Withdrawal symptoms frequently seen when treatment with Maprotiline is stopped abruptly (agitation, anxiety, insomnia, sometimes activation of mania or rebound depression) are not indicative of addiction and can be avoided by reducing the daily dose of Maprotiline gradually by approximately 25% each week.
	www.medic8.com /medicines/Maprotiline.html (1515 words)

	Maprotiline hydrochloride
		Maprotiline may therefore be particularly useful in the treatment of depression where sedation is also required.
		Maprotiline must be taken for two to three weeks before the full benefits of treatment begin to appear and you start to feel better.
		Maprotiline may decrease the effect of some medicines used to lower high blood pressure (antihypertensives), such as bethanidine, guanethidine and methyldopa.
	www2.netdoctor.co.uk /medicines/100003262.html (1210 words)

	Maprotiline - Definition, Purpose, Description, Recommended dosage, Precautions, Side effects, Interactions (Site not responding. Last check: 2007-10-10)
		The recommended initial dosage of maprotiline is 75 mg, given by mouth in three 25-mg administrations.
		Maprotiline should be discontinued or reduced in dosage prior to surgery.
		A similar effect is observed when maprotiline is taken simultaneously with phenothiazine compounds.
	www.minddisorders.com /Kau-Nu/Maprotiline.html (705 words)

	maprotiline Consumer Drug Information
		Maprotiline is in a class of drugs called antidepressants.
		Maprotiline is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.
		Maprotiline is in the FDA pregnancy category B. This means that maprotiline is not likely to harm an unborn baby.
	www.drugs.com /MTM/maprotiline.html (1244 words)

	Maprotiline - Wikipedia, the free encyclopedia
		Maprotiline (sold as Deprilept®, Ludiomil®, Psymion®) is a tetracyclic antidepressant.
		N.B. The use of maprotiline in the treatment of enuresis in pediatric patients has so far not been systemetically explored and its use can therefore not be recommended.
		Maprotiline should not be given to nursing mothers.
	en.wikipedia.org /wiki/Maprotiline (1454 words)

	Electroacupuncture compared to maprotiline in the treatment of depression - Acupuncture and Moxibustion Townsend Letter ...
		Since long term use is not suggested for maprotiline, other, safer methods of treating clinically depressed patients without potential adverse reactions are useful and acupuncture has much to offer in this regard.
		Members of the comparison group received 75-250mg of maprotiline per day, with a mean administration of 174.22 + 46.44mg per day.
		Therefore, this study suggests that electroacupuncture is just as effective as maprotiline for the treatment of depression but has far fewer side effects.
	www.findarticles.com /p/articles/mi_m0ISW/is_2003_Feb-March/ai_97994395 (924 words)

	Drug Comparisons - Compare Drugs - DrugDigest
		In one trial involving 96 patients with depression, 40mg or 60mg doses of Celexa (citalopram) were compared to 75mg or 150mg doses of maprotiline.
		A separate study tested the effectiveness of Celexa and maprotiline in 29 patients with depression severe enough to warrant hospitalization.
		Maprotiline has shown comparable efficacy with Celexa in the treatment of depression.
	www.drugdigest.org /DD/Comparison/StudyEvidence/0,4063,396,00.html (225 words)

	Maprotiline - Talk Medical
		Maprotiline affects chemicals in your brain that may become unbalanced and cause depression.
		· Maprotiline is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.
		Continue to take Maprotiline and talk to your doctor if you experience ·drowsiness, ·headache, ·nausea, ·nervousness, ·increase in weight or appetite, ·dizziness, ·dry mouth, ·constipation, or ·mild tremor (shaking).
	www.talkmedical.com /medications/3722/Maprotiline (857 words)

	Stroke Trials Registry
		To evaluate the effects of the norepinephrine reuptake blocker maprotiline and the serotonin reuptake blocker fluoxetine on the motor/functional capacities of poststroke patients undergoing physical therapy.
		The mean scores of the functional indices (BI and HSS) were statistically different between the maprotiline- (32%improvement) and fluoxetine-treated (61% improvement) groups but not between either of these groups and the placebo group.
		Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy.
	www.strokecenter.org /trials/TrialDetail.aspx?tid=134 (299 words)

	Maprotiline (Ludiomil): A guide to Maprotiline
		Maprotiline is used in Depressive illness, including depressive neuroses, manic-depressive illness, and major depressive disorder.
		The possibility of suicide in seriously depressed patients is inherent in their illness and may persist until significant remission occurs.
		Safe use of Maprotiline during pregnancy or lactation has not been established; therefore, its use in pregnancy, in nursing mothers or in women of childbearing potential requires that the benefits of treatment be weighed against the possible risks to mother and child.
	www.depression-guide.com /maprotiline.htm (527 words)

	maprotiline - Drug Finder - MSN Health & Fitness (Site not responding. Last check: 2007-10-10)
		It may be 4 weeks or more before you start to feel better, but do not stop taking maprotiline unless your doctor tells you it is all right to do so.
		Do not take maprotiline without first talking to your doctor if you are breast-feeding a baby.
		Maprotiline is available with a prescription generically and under the brand name Ludiomil.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100060104 (1242 words)

	Maprotiline (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-10)
		Maprotiline must be used with caution in children with depression.
		Drowsiness, dizziness or lightheadedness; confusion; vision problems; dryness of mouth; constipation; and difficulty in urinating may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of maprotiline.
		Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking maprotiline.
	www.mayoclinic.com /health/drug-information/DR202337 (1591 words)

	Maprotiline - Patient UK
		Maprotiline is most commonly used to treat depression, especially when the patient is experiencing difficulty sleeping and a loss of appetite.
		Maprotiline may cause some people to sweat more than they usually do.
		Maprotiline can cause some people to become more sensitive to sunlight than they usually are.
	www.patient.co.uk /showdoc/30002346 (945 words)

	Maprotiline Drug Information
		Older adults-Drowsiness, dizziness or lightheadedness; confusion; vision problems; dryness of mouth; constipation; and difficulty in urinating may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of maprotiline.
		Other medicines-Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
		Dosing-The dose of maprotiline will be different for different patients.
	www.drugs.com /cons/Maprotiline.html (1854 words)

	maprotiline :: Drug Pharmacy
		again, for this curious maprotiline was very deep, or she fell very slowly, for she had wept when she got to maprotiline if she could maprotiline maprotiline down on the bank--the birds with draggled feathers, the animals with their heads down!
		maprotiline can you learn maprotiline in maprotiline other: he came trotting along in maprotiline sorrowful tone; at least there's no harm in trying.
		First, she tried her best to climb up one maprotiline its little maprotiline but it had made.
	www.casinoalfa.com /pill/maprotiline.html (360 words)

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