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Topic: Mast cell

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	The Great Impostors - Mast Cell
		Mast Cell Tumours it is believed are one of the most commonly found skin tumours in the canine although it is thought to be very rare in cats.
		Mast Cell tumours are extremely difficult to treat successfully due to the variety of their appearance and biological behaviour.
		Mast Cell Tumours themselves are unique in there ability to form as multiple primary tumours at times, they are also unpredictable in their behaviour, because of this it is always advised to “grade” the tumour.
	www.bakalo.com /health/mast_cell.htm (920 words)

	Welcome to Mission MedVet
		Mast cell tumors, or MCTs, arise from mast cells, which are normal components of the body.
		Mast cells originate in the bone marrow and migrate to various locations throughout the body, especially in connective and vascular tissues.
		Mast cells in dogs normally contain histamine and heparin; these substances play a significant role in the inflammatory response to various disease processes, and in wound healing.
	www.missionmedvet.com /encyclopedia/mast_cell_tumor.htm (1693 words)

	Upstate Veterinary Specialists : Mast Cell Tumors (Site not responding. Last check: 2007-10-20)
		Mast cell tumors are the most common skin tumors of dogs and it is not known why certain dogs develop mast cell tumors and others do not.
		Mast cells are normal cells in the body that aid in incidences of inflammation/infection.
		Mast cell tumors are very responsive to radiation therapy, and most dogs (75 - 80%) are disease free 2 - 5 years after being treated with a combination of surgery and radiation therapy.
	www.upstatevetspecialists.com /mast_cell_tumors.php (1056 words)

	Mast cell - Wikipedia, the free encyclopedia
		Mast cells were first described by Paul Ehrlich in 1878 on the basis of their unique staining characteristics and large granules.
		Mast cells express a high-affinity receptor (FcεRI) for Immunoglobulin E (IgE), the least-abundant member of the antibodies.
		Mast cells are implicated in the pathology associated with the autoimmune disorders rheumatoid arthritis, bullous pemphigoid, and multiple sclerosis.
	en.wikipedia.org /wiki/Mast_cell (910 words)

	Mast Cell Tumors (Mastocytoma) in Dogs
		Mast cell tumors are among the most common tumors of dogs, accounting for approximately 20 percent of all skin tumors.
		The cause of mast cell tumors is unknown.
		Dogs that develop mast cell tumors often are older (usually 8 to 9 years of age), although they can occur in dogs of all ages.
	www.petplace.com /dogs/mast-cell-tumors-mastocytoma-in-dogs/page1.aspx (761 words)

	discussion of mast cell disease Reed
		Mast cell hyperplasias are poorly characterized but in part may represent a response of mast cells to the phenomena of cell mediated immunity.
		Infiltrates of mast cells are variably associated with eosinophils and in the face of a high component of eosinophils in cutaneous lesions, these relationships are often assumed to be a response to the degranulation of mast cells in response to trauma or stimulation.
		With a giemsa stain, the cells are sparsely arranged in the interstitium of the reticular dermis (Fig 26).
	www.xmission.com /~bweems/mastdiscussion.html (2039 words)

	Ferret Skin Tumor FAQ
		Mast cell tumors, although they are associated with a high rate of malignancy in the dog and cat, are generally benign in the ferret.
		Mast cell tumors are seen in a variety of species of animals including dogs, cats, cattle, horses, and man. Mast cell tumors go under a number of names, all meaning the same condition: mastocytoma, mastocytosis, mast cell sarcoma.
		Mast cells are a type of cell that are associated with the immune system and are found throughout the body in a variety of areas such as bone marrow, lymphoid organs, connective tissue and under the lining (mucosa) of the respiratory and gastrointestinal tract.
	www.ferretcentral.org /faq/med/mast.html (1589 words)

	Mast Cell Tumors
		Mast cells are meant to participate in the war against parasites (as opposed to the war against bacterial or viral invaders).
		While the mast cell tumor does not spread to lung the way other tumors do, there are many lymph nodes in the chest and it is helpful to radiograph the chest to assess the size of these lymph nodes and thus help determine the extent of tumor spread.
		Mast cell tumors that originate in deeper tissues such as the liver or spleen carry a particularly grave prognosis.
	www.marvistavet.com /html/body_mast_cell_tumors.html (1818 words)

	Bath-Brunswick Veterinary Associates Article
		Mast cell tumors can be somewhat unpredictable in their behavior, relative to other types of tumors in dogs.
		Mast cell tumors affecting the limbs, head, or neck tend to correlate with a more favorable prognosis than those found on the trunk or groin.
		Radiation therapy is an option for dogs whose mast cells tumors are localized, but too large for a clean resection or in an area difficult to resect such as tissues of the facial region, or as follow-up therapy for tumors with dirty margins.
	www.bathbrunswickvet.com /library/cancer3.html?articleID=15 (1265 words)

	Mast Cell Tumor
		Mast cells originate in the bone marrow and migrate to various locations throughout the body, especially in connective and vascular tissues.
		Mast cells in dogs normally contain histamine and heparin; these substances play a significant role in the inflammatory response to various disease processes, and in wound healing.
		Mast cell tumors in the inguinal and perineal areas appear to be more aggressive than mast cell tumors at other locations.
	www.dermvet.com /mastcelltumor.htm (1700 words)

	Fall/Winter 1997 News > Topics in Oncology: Mast Cell Tumors (Site not responding. Last check: 2007-10-20)
		The classical mast cell tumor is a red, raised, firm dermal mass found on the trunk or perineum of dogs.
		The mast cell tumor, though, is called "the great mimic" for a reason: almost any mass in almost any form can potentially be a mast cell tumor.
		The mast cell tumor was initially treated with radiation therapy but without success; amputation was necessary to remove this tumor.
	www.southpaws.com /news/97-4-oncology-mastcell.html (347 words)

	Mast Cell Tumors - WSAVA 2004 Congress
		Mast cell tumors tend to metastasize to nodes, liver spleen and bone marrow...
		Mast cell tumors are classified as round cell tumors along with lymphosarcoma, histiocytomas and transmissible venereal tumors.
		Mast cell tumors in regional lymph nodes and bone marrow appear to be more resistant to the effects of radiotherapy than those confined to the skin.
	www.vin.com /proceedings/Proceedings.plx?CID=WSAVA2004&PID=8709&O=Generic (2256 words)

	Mast Cell Tumors
		Mast cell tumors are the second most common tumor of the skin in the ferret, and an excellent example how diseases of ferrets differ significantly from those of the dog and cat.
		Mast cell tumors increase in frequency with age in the ferret, and several mast cell tumors may be present at once on the skin of ferrets.
		Mast cell tumors in the ferret are invariably benign, and pose no significant health risk, other than that incurred with general anesthesia and surgery.
	www.afip.org /ferrets/Mast/mastcell.html (574 words)

	Team discovers 'missing link' in origins of allergy attacks
		Mast cells, a critical part of the immune system, develop from hematopoietic (blood) stem cells that originate in bone marrow and journey through the blood stream to complete their maturation in peripheral tissues such as the skin, gut and respiratory tract.
		Although the progenitor gives rise only to mast cells, it is different enough that it isn't detectable as a mast cell, which may explain a puzzling, but crucial, aspect of how mast cells respond to allergens.
		It may be that wherever mature mast cells reside, their progenitors are also present, but dormant until an allergen or other stimulus is detected, whereupon they finish differentiating and unleash the appropriate mediator from within.
	news-service.stanford.edu /news/2005/august10/med-mastcell-081005.html (781 words)

	Canine Mast Cell Tumors
		Mast cells are cells that normally occur in the skin and other tissues, such as the intestines and respiratory tract.
		Mast cell tumors are commonly graded and staged, meaning classified as to how they are expected to behave.
		In determining the appropriate therapy for mast cell tumors and their wide variety of forms, it is important to remember that each animal needs to be evaluated and treated individually.
	www.peteducation.com /article.cfm?cls=2&cat=1638&articleid=461 (1273 words)

	Prostatitis, IC and Mast Cells
		The density of visible mast cells declined after 4 weeks in a pattern that corresponded with the increased percent of mast cells undergoing degranulation.
		While the correlation of the nerve mast cell axis with mast cell degranulation does not prove our hypothesis of mast cell mediated inflammatory mediator release in the development of nonbacterial prostatitis, it suggests that such a relationship is possible.
		Granulated bladder mast cells per mm2 of bladder tissue and urine histamine content were monitored as the cystitis developed over the next few days.
	www.chronicprostatitis.com /mastcells.html (1191 words)

	Mast Cells Contribute to Development of Asthma
		The number of mast cells in ASM was markedly greater in the group with asthma (median, 5.1 cells/mm2) than in the other two groups (median for both, 0 cells/mm2).
		In lung resection and postmortem studies, mast cells were the predominant type of inflammatory cell localized in the ASM in samples from patients with asthma.
		Brightling and his colleagues have concluded that the interaction between ASM and mast cells is a key element in the development of airway dysfunction in asthma.
	www.respiratoryreviews.com /sep02/rr_sep02_mastcells.html (638 words)

	Mast Cell Disease in Dogs and Cats: An Overview (Site not responding. Last check: 2007-10-20)
		Mast cell is present in the blood smear of a dog with cutaneous neoplasms.
		The diagnosis of mast cell leukemia is based upon a moderate to marked leukocytosis composed of a significant proportion of mast cells (3-74%) on the complete blood cell count as well as diffuse bone marrow infiltration with these cells (Figs.
		Moderate numbers of mast cells (similar to the cell illustrated here) were present in the stained blood smear of this dog with mast cell leukemia.
	www.vet.uga.edu /vpp/CLERK/Dahm/index.htm (1829 words)

	Mast Cell Tumors (Site not responding. Last check: 2007-10-20)
		Mast cells are normally activated in response to foreign proteins being ingested or injected into an animal.
		Mast cell tumors occur when these cells begin to reproduce abnormally, either in a single solitary mass, or as an infiltration of cancer cells into normal connective tissue, such as skin, muscle or fat.
		The ideal treatment of mast cell tumors is to remove them along with wide borders of normal appearing skin.
	www.nriah.com /oldsite/Treatment/Care_sheets/Mast_Cell_Tumors.htm (494 words)

	Mast Cell Disease
		Mast cells with bilobed or multilobed nuclei in a nodular lesion of a patient with urticaria pigmentosa.
		Although the nodular lesion with atypical mast cells did not appear to be cytologically malignant, the occurrence of atypical mast cells in a nodular lesion but not in a papular lesion might denote progression of the disease as suggested by the emergence of cells positive for p53.
		Because addition of interleukin-4 (IL-4) to mast cell cultures is reported to induce apoptosis, the hypothesis was considered that individuals carrying the gain-of-function polymorphism Q576R in the cytoplasmic domain of the alpha-subunit of the IL-4 receptor (IL-4R) might be relatively resistant to the gain-of-function mutation in c-kit.
	www.thedoctorsdoctor.com /diseases/mast_cell_disease.htm (11920 words)

	Pet Health Topics from the College of Veterinary Medicine, Washington State University (Site not responding. Last check: 2007-10-20)
		The behavior of mast cell tumors reflects their grade (a term used by pathologists and oncologists to describe such things as how-well differentiated a tumor is, how frequently it is dividing, how invasive to adjacent structures, and other criteria).
		Mast cell tumors have 3 grades, with grade I being the least aggressive and least likely to spread to other organs (metastasize), and grade III being highly aggressive tumors with a high likelihood of metastasis; most grade II tumors tend not to metastasize, although they can do so.
		For mast cell tumors that were not, or because of location, could not be completely removed, radiation therapy is often the best treatment for residual disease, although a more aggressive second surgery is possible for some dogs.
	www.vetmed.wsu.edu /ClientED/mastCell.asp (933 words)

	Mast Cell Tumors in Dogs - Rainbows Bridge
		Mast cell tumors can be somewhat unpredictable in their behavior, relative to other types of tumors in dogs.
		Mast cell tumors affecting the limbs, head, or neck tend to correlate with a more favorable prognosis than those found on the trunk or groin.
		Radiation therapy is an option for dogs whose mast cells tumors are localized, but too large for a clean resection or in an area difficult to resect such as tissues of the facial region, or as follow-up therapy for tumors with dirty margins.
	rainbowsbridge.com /New_Beginnings/pets_in_need/pets_with_cancer/Mast_Cell_Tumors_Dogs.htm (1300 words)

	Mast Cell Tumors - VeterinaryPartner.com - a VIN company!
		While the mast cell tumor does not spread to lungs the way other tumors do, there are many lymph nodes in the chest and it is helpful to radiograph the chest to assess the size of these lymph nodes and thus help determine the extent of tumor spread.
		The mast cell tumor situation is slightly different for cats though most of the same concepts hold true (so if you skipped the canine section to read the feline information it would be best to go back and read the canine section at this point).
		Mast cell tumors classically affect older cats; in one study the average age was 10 years.
	www.veterinarypartner.com /Content.plx?P=A&S=0&C=0&A=1600 (2400 words)

	Canine Cancer Mast Cell (Site not responding. Last check: 2007-10-20)
		I like to refer to mast cell tumors as cancer and “tricksters” because they can’t be trusted to behave according to their classification.
		The objective of this study is to determine the efficacy and tolerability of a novel, oral, investigational protein kinase inhibitor for the treatment of dogs with recurrent mast cell tumors.
		The objective of this study was to investigate the effects of alpha-linolenic acid (18:3n-3) and linoleic acid (18:2n-6) on the fatty acid composition and the activity and release of mast cell mediators in the canine mastocytoma cell line C2.
	www.caninecancerawareness.org /CanineCancerMastCell.html (1649 words)

	Mast Cell Neoplasms
		Mast cells are considered to be derived from the myelomonocytic precursors in the bone marrow.
		Most cats with mast cell tumors are middle-aged or older (median 10 years old; range 2 to 18 years old), there is apparently no sex predilection, and, according to one report, most are FeLV negative.
		As opposed to the dog, in which most mast cell tumors are cutaneous/subcutaneous, feline mast cell tumors occur in two main forms: visceral and cutaneous.
	maxshouse.com /Oncology/mast_cell_neoplasms.htm (738 words)

	MAST CELL TUMORS (Site not responding. Last check: 2007-10-20)
		Mast cell tumors are commonly seen on the skin surface of ferrets.
		In other species mast cell tumors can be aggressive and metastasize widely throughout the body, but in ferrets they generally run a benign course, remaining as skin surface nodules.
		Mast cell tumors appear as red skin nodules which are devoid of hair, slightly raised and can be up to ½ inch in diameter (see image).
	www.ferretnews.org /mastcell.html (335 words)

	Mast Cell Tumors (Site not responding. Last check: 2007-10-20)
		Mast cell tumors are some of the most common skin tumors seen in dogs.
		Mast cell tumors can display a wide range of behavior, from being relatively benign and easily treated with conservative surgery, to being very malignant with a high potential for both local regrowth and spread.
		Mast cell tumors are commonly treated with different combinations of surgery, radiotherapy, and chemotherapy.
	vmthpub.vetmed.wisc.edu /sa_services/med/oncology/Mast.htm (121 words)

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