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Topic: Matrix metalloproteinase

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		Messenger ribonucleic acid expression for gelatinase A, gelatinase B, and tissue inhibitors of matrix metalloproteinase types 1 and 2 was studied with use of reverse transcriptase-polymerase chain reaction and localization of messenger ribonucleic acid was accomplished with use of in situ hybridization.
		Matrix metalloproteinase-2 was seen in membranes from nonlaboring women and in women with intraamniotic infection, whereas matrix metalloproteinase-9 was seen only in membranes from women with intraamniotic infection.
		Immunohistochemistry demonstrated the presence of tissue inhibitor of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-2 peptides in both amnion and chorion and in cells of the reticular layer of the matrix.
	www.perinatalresearch.com /pnr/abstracts/collagenolytic.html (370 words)

	Matrix metalloproteinase - Wikipedia, the free encyclopedia
		Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins.
		They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine in/activation.
		These enzymes display a broad ability to cleave extracellular matrix proteins but are unable to cleave the triple-helical fibrillar collagens.
	en.wikipedia.org /wiki/Matrix_metalloproteinase (1432 words)

	Arthritis Research & Therapy \| Full text \| Active synovial matrix metalloproteinase-2 is associated with ...
		Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients.
		Matrix metalloproteinase (MMP)-2, MMP-9, MMP-14 and tissue inhibitor of metalloproteinase (TIMP)-2 expression in synovial tissue.
		Several metalloproteinases that are capable of the proteolytic degradation of extracellular matrix are thought to play a major role in the dissolution of the bone and cartilage matrix, allowing the invasive cells to migrate into the stroma across cell boundaries.
	arthritis-research.com /content/2/2/145 (5737 words)

	Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves
		Recent studies suggest that abnormal matrix metalloproteinase activity may also be associated with the formation of atherosclerotic and nonatherosclerotic thoracic aortic aneurysms.
		The objective of this study was to compare the activities of matrix metalloproteinases and levels of their inhibitors in thoracic aneurysms of patients with bicuspid and tricuspid aortic valves.
		Methods: Endogenous and total activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 were measured in proximal nonatherosclerotic thoracic aortic aneurysms of 16 patients with bicuspid aortic valves and 12 patients with tricuspid aortic valves.
	www.columbia.edu /~cea8/Aneurysm_papers/June_2004.htm (1175 words)

	Matrix Metalloproteinase Inhibitors: Do They Have a Place in Anticancer Therapy?
		Matrix metalloproteinases (MMPs) are a family of enzymes involved in degradation of extracellular matrix.
		Matrix metallo-proteinases (MMPs) are a family of enzymes involved in degradation of extracellular matrix (gelatinases, collagenases) and are key for metastasis and angiogenesis (Figure 1).
		Matrix metalloproteinases (MMPs), which are secreted by both tumor and stromal cells, are involved in degradation of extracellular matrix.
	www.chelationtherapyonline.com /PreventCancer/p21.htm (11312 words)

	Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer
		The bioactivity of matrix metalloproteinases was studied in tissues from colorectal cancer patients by means of both quantitative gelatin zymography and a fluorometric activity assay.
		Broad-spectrum matrix metalloproteinase activity and both the active and latent forms of the gelatinases matrix metalloproteinase-2 and -9 were higher in tumour than in normal mucosa.
		Neither the active form of matrix metalloproteinase-9 nor broad-spectrum matrix metalloproteinase activity in tumour tissue did correlate with any of the clinicopathological parameters investigated.
	www.nature.com /bjc/journal/v86/n12/abs/6600366a.html (292 words)

	MMP2 - Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) - aka: CLG4A, CLG4 - Cancer ...
		Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma.
		Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis.
		S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme.
	www.cancerindex.org /geneweb/MMP2.htm (642 words)

	Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis -- Medina et al. 284 ...
		Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine.
		The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia-induced lung injury in newborn rats.
		The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis.
	ajpgi.physiology.org /cgi/content/full/284/1/G116 (3691 words)

	Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma ... (Site not responding. Last check: )
		Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophages of asthmatics.
		Sputum matrix metalloproteinase-9:tissue inhibitor of metalloproteinase-1 ratio in acute asthma.
		Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation.
	www.arabmedmag.com /issue-31-05-2005/pneumology/main03.htm (2571 words)

	New Drugs on the Horizon: Matrix Metalloproteinase Inhibitors -- Rothenberg et al. 17 (4): 237 -- Stem Cells
		Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat.
		Marimastat, a novel matrix metalloproteinase inhibitor in patients with advanced carcinoma of the pancreas.
		Phase I study of AG3340, a matrix metalloproteinase inhibitor, in combination with mitoxantrone/prednisone in patients having advanced prostate cancer.
	stemcells.alphamedpress.org /cgi/content/full/17/4/237 (2237 words)

	Effects of Matrix Metalloproteinase Inhibitors on Bone Resorption and Orthodontic Tooth Movement -- Holliday et al. 82 ...
		The marrow cultures were loaded onto the coated or uncoated dentin slices in the presence of the matrix metalloproteinase inhibitor 44463 or its ineffective stereo-isomer, 44201.
		Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones.
		Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.
	jdr.iadrjournals.org /cgi/content/full/82/9/687 (2756 words)

	Matrix metalloproteinase-28 transcript and protein are expressed in rhesus monkey placenta during early pregnancy -- Li ...
		Matrix metalloproteinase-28 transcript and protein are expressed in rhesus monkey placenta during early pregnancy -- Li et al.
		Matrix metalloproteinase-28 transcript and protein are expressed in rhesus monkey placenta during early pregnancy
		Wang, H., Li, Q., Shao, L. and Zhu, C. (2001) Expression of matrix metalloproteinase (MMP) -2, -9, -14 and tissue inhibitor of metalloproteinases (TIMP)-1, -2, -3 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy.
	molehr.oxfordjournals.org /cgi/content/full/9/4/205 (3717 words)

	Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation ...
		Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.
		Inhibition of matrix metalloproteinases by over-expression of tissue inhibitor of metalloproteinase-2 inhibits the growth of experimental hemangiomas.
		Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma.
	www.nature.com /labinvest/journal/v84/n1/full/3700003a.html (7562 words)

	Neurohormonal activation is associated with increased levels of plasma matrix metalloproteinase-2 in human heart ...
		Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion.
		Matrix metalloproteinase inhibition during the development of congestive heart failure: effects on left ventricular dimensions and function.
		Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
	eurheartj.oxfordjournals.org /cgi/content/full/26/5/481 (3207 words)

	Cyclic Changes in the Matrix Metalloproteinase System in the Ovary and Uterus -- Curry and Osteen 64 (5): 1285 -- ...
		Inhibitors of mammalian tissue collagenase and metalloproteinases suppress ovulation in the perfused rat ovary.
		Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period.
		Involvement of matrix metalloproteinases 2 and 9, tissue inhibitor of metalloproteinases and apoptosis in tissue remodelling in the sheep placenta.
	www.biolreprod.org /cgi/content/full/64/5/1285 (8127 words)

	Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during ...
		Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal -- Lockwood et al.
		Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal
		Birkedal-Hansen 1995 Proteolytic remodeling of the extracellular matrix.
	endo.endojournals.org /cgi/content/full/139/11/4607 (5219 words)

	Co-localization of matrix metalloproteinase-1 and mast cell tryptase in the human uterus -- Milne et al. 7 (6): 559 -- ...
		Hampton, A.L. and Salamonsen, L.A. (1994) Expression of messenger ribonucleic acid encoding matrix metalloproteinases and their tissue inhibitors is related to menstruation.
		(1996) Immunolocalization of the matrix metalloproteinases gelatinase B and stromelysin 1 in human endometrium throughout the menstrual cycle.
		(1998) Matrix metalloproteinase and matrix metalloproteinase inhibitor expression in endometrial stromal cells during progestin-initiated decidualization and menstruation-related progestin withdrawal.
	molehr.oxfordjournals.org /cgi/content/full/7/6/559 (3926 words)

	Zymographic Analyses and Measurement of Matrix Metalloproteinase-2 and -9 in Nipple Aspirate Fluids -- Mannello and ...
		Zymographic Analyses and Measurement of Matrix Metalloproteinase-2 and -9 in Nipple Aspirate Fluids
		Mannello F. Circulating 92-kDa matrix metalloproteinase (MMP-9) activity is enhanced in the euglobin plasma fraction of head and neck squamous cell carcinoma [Letter].
		Modified proenzymes as artificial substrates for proteolytic enzymes: a colorimetric assay of bacterial collagenase and matrix metalloproteinase activity using modified pro-urokinase.
	www.clinchem.org /cgi/content/full/49/9/1546 (2446 words)

	Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the ...
		Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP -- Reinhardt et al.
		Captopril inhibits the 72 kDa and 92 kDa matrix metalloproteinases.
		Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer.
	heart.bmjjournals.com /cgi/content/full/88/5/525 (3382 words)

	Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 and -2 in Type 2 Diabetes: Effect of 1 year's ...
		Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 and -2 in Type 2 Diabetes: Effect of 1 year's cardiovascular risk reduction therapy -- Tayebjee et al.
		Lim H, Tayebjee M, MacFadyen R, Lip GY: Tissue inhibitor of matrix metalloproteinase-1 is a marker of left ventricular diastolic dysfunction in diabetic heart disease (Abstract).
		McLennan S, Kelly D, Cox A, Cao Z, Lyons J, et al: Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases.
	care.diabetesjournals.org /cgi/content/full/27/8/2049 (1300 words)

	EMD - Calbiochem: Matrix Metalloproteinases (MMPs)
		Matrix Metalloproteinases (MMPs) are a family of zinc metalloendopeptidases secreted by cells, and are responsible for much of the turnover of matrix components.
		The MT-MMPs (Membrane Type Matrix Metalloproteinases) are localized to the cell surface.
		TIMP-3 is localized in the extracellular matrix (ECM), and TIMP-4 is localized mostly in vascular tissue.
	www.emdbiosciences.com /html/cbc/matrix_metalloproteinase_MMP.htm (1221 words)

	Development of a Solid-Phase Assay for Analysis of Matrix Metalloproteinase Activity -- Lauer-Fields et al. 15 (4): 305 ...
		Analysis of matrix metalloproteinase activity using triple-helical substrates incorporating fluorogenic l- or d-amino acids.
		Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability.
		Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3.
	jbt.highwire.org /cgi/content/full/15/4/305 (4186 words)

	Human protein: IPI00019242 * 75807 Da * MMP15 Matrix metalloproteinase-15 precursor - Bioinformatic Harvester @ KIT
		Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).
		Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.
		Membrane-type matrix metalloproteinases 1 and 2 exhibit broad- spectrum proteolytic capacities comparable to many matrix metalloproteinases.
	harvester.fzk.de /harvester/human/IPI00019/IPI00019242.htm (858 words)

	Matrix Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase mRNA Levels Are Specifically Altered in Torn ...
		Matrix Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase mRNA Levels Are Specifically Altered in Torn Rotator Cuff Tendons -- Lo et al.
		Matrix Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase mRNA Levels Are Specifically Altered in Torn Rotator Cuff Tendons
		and tissue inhibitors of metalloproteinase are altered in torn
	ajsm.highwire.org /cgi/content/abstract/32/5/1223 (394 words)

	Matrix Metalloproteinase-9 and Tensile Strength of Fetal Membranes in Uncomplicated Labor -- UCHIDE et al. 95 (6): 851 ...
		Matrix Metalloproteinase-9 and Tensile Strength of Fetal Membranes in Uncomplicated Labor -- UCHIDE et al.
		Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases-1 levels in amniotic fluids from pregnancies complicated by premature rupture of membranes.
		A role for matrix metalloproteinase-9 in spontaneous rupture of the fetal membranes.
	www.greenjournal.org /cgi/content/full/95/6/851 (2425 words)

	SciMedWeb® - MATRIX METALLOPROTEINASE-1 (MMP1)
		The tissue inhibitors of metalloproteinases, or TIMPs are major inhibitors of MMPs.
		Inhibitors of matrix metalloproteases were able to attenuate the migration of MDA-MB-231 cells through bone marrow fibroblast monolayers, suggesting a role for these enzymes in the migration of breast cancer cells through bone marrow adherent layers.
		Borden P. and Heller R.A. (1997) Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases.
	www.geocities.com /m.lacroix/marqueurs/mmp1.htm (2662 words)

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