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Topic: Maturity onset diabetes of the young

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	Nine Novel Mutations in Maturity-Onset Diabetes of the Young (MODY) Candidate Genes in 22 Spanish Families -- Barrio ... (Site not responding. Last check: 2007-09-11)
		subtype of MODY, and GCK/MODY2 mutations in 25% of pedigrees
		) mutations in maturity-onset diabetes of the young.
		in a Danish pedigree with maturity onset diabetes of the young.
	jcem.endojournals.org /cgi/content/full/87/6/2532 (4131 words)

	p990924d - Mature Onset Diabetes of the Young (MODY)
		Abstract: Maturity onset diabetes of the young is characterized by early onset diabetes inherited in an autosomal dominant pattern.
		ADM is a subtype of MODY that occurs in approximately 10% of African-Americans with youth onset diabetes.
		The majority of youth onset diabetes remains type 1; however, the frequency of type 2 diabetes is rising in obese children and adolescents and especially in obese minority youth.
	www.emory.edu /WHSCL/grady/amreport/litsrch99/p990924d.html (827 words)

	children with DIABETES - MODY
		MODY is often not recognised and people may be treated as Type 1 or Type 2 diabetes by their doctors.
		MODY was first described by Tattersall (U.K.) (1, 2) and Fajan (U.S.A.) (2) in 1974, after they had noticed a group of young people with diabetes who were treated without insulin 2 years or more after diagnosis.
		A Prevalent Amino Acid Polymorphism at Codon 98 (Ala98Val) of the Hepatocyte Nuclear Factor-1 Is Associated With Maturity-Onset Diabetes of the Young and Younger Age at Onset of Type 2 Diabetes in Asian Indians.
	www.childrenwithdiabetes.com /clinic/mody.htm (659 words)

	Maturity onset diabetes of the young definition - Medical Dictionary definitions of popular medical terms
		Maturity onset diabetes of the young: Diabetes mellitus that has early onset (usually before the age of 25), is non-insulin-dependent, and is inherited in an autosomal dominant manner.
		MODY is often considered a subtype of type 2 diabetes but it is unlike the usual type 2 diabetes in that insulin secretion, not the action of insulin, is impaired.
		MODY1 is caused by mutation in the hepatocyte nuclear factor-4-alpha gene (HNF4A) on chromosome 20.
	www.medterms.com /script/main/art.asp?articlekey=25030 (295 words)

	children with DIABETES - Diabetes Dictionary: M
		A form of diabetes characterised by early age of onset (usually less than 25 years of age), autosomal dominant inheritance (that is, it is inherited by 50% of a parent's children) with diabetes in at least 2 generations of the patient's family.
		MODY diabetes that can often be controlled with meal planning or diabetes pills, at least in the early stages of diabetes.
		It differs from type 2 diabetes in that patients have a defect in insulin secretion or glucose metabolism, and are not resistant to insulin.
	www.childrenwithdiabetes.com /dictionary/m.htm (1045 words)

	Maturity onset diabetes of the young - Wikipedia, the free encyclopedia
		MODY 1 is due to a loss-of-function mutation in the HNF4α gene on chromosome 20 that codes for transcription factor 14 (TCF14).
		MODY 3 is caused by mutations of the HNF1α gene, a homeobox gene on chromosome 12.
		MODY 4 arises from mutations of the IPF1 homeobox gene on chromosome 13.
	en.wikipedia.org /wiki/Maturity_onset_diabetes_of_the_young (2684 words)

	Familial Clustering of Type II Diabetes Mellitus (DM)
		The age-corrected relative risk of type II DM for the offspring of diabetic parents was found to be progressively increasing from a nonconsanguineous diabetic father (22%) or mother (26.5%), to non-consanguineous conjugal diabetic parents (27%) and to the offspring of consanguineous single or conjugal diabetic parents (37.5%).
		Maturity-onset diabetes of the young (MODY) was suspected in 10 probands (5%), and early-onset type II DM in the offspring of conjugal diabetic parents in 16 probands (9%).
		Diabetic nephropathy was diagnosed by measuring concentration of urinary albumin (mg/L) and creatinine (g/L) in 24-hour urine and calculating urinary albumin to creatinine ratio (mg/g), in the absence of urinary tract infection.
	www.kfshrc.edu.sa /annals/194/98-265.html (5404 words)

	NDEP \| Diabetes in Children and Adolescents Fact Sheet (Site not responding. Last check: 2007-09-11)
		Diabetes is a chronic disease in which the body does not make or properly use insulin, a hormone that is needed to convert glucose and other food into energy.
		Maturity-onset diabetes of the young (MODY) is a rare form of diabetes in children that is caused by a single gene defect that results in faulty insulin secretion.
		MODY is thought to account for 2 to 5 percent of all cases of diabetes and often goes unrecognized.
	ndep.nih.gov /diabetes/youth/youth_FS.htm (6323 words)

	eMedicine - Diabetes Mellitus, Type 2 : Article Excerpt by: William L Isley, MD
		Background: Type 2 diabetes mellitus is a group of disorders characterized by hyperglycemia and associated with microvascular (ie, retinal, renal, possibly neuropathic), macrovascular (ie, coronary, peripheral vascular), and neuropathic (ie, autonomic, peripheral) complications.
		The genetics of type 2 diabetes are complex and not completely understood, but presumably this disease is related to multiple genes (with the exception of maturity-onset diabetes of the young [MODY]).
		MODY is associated with autosomal dominant inheritance and is characterized by onset in at least 1 family member younger than 25 years, correction of fasting hyperglycemia without insulin for at least 2 years, and absence of ketosis.
	www.emedicine.com /med/byname/diabetes-mellitus-type-2.htm (666 words)

	Genetic testing for maturity onset diabetes of the young in childhood hyperglycaemia -- Matyka et al. 78 (6): 552 -- ...
		Maturity onset diabetes of the young is an important diagnosis to consider in a child with incidental hyperglycaemia.
		Maturity onset diabetes of the young is an uncommon condition first identified by Tattersall in 1974.
		Mutations in the hepatocyte nuclear factor 1 alpha gene are a common cause of maturity-onset diabetes of the young in the United Kingdom.
	adc.bmjjournals.com /cgi/content/full/78/6/552 (1458 words)

	NIDDM is a heterogeneous disorder composed of subtypes with spectrum of variable inheritance (Site not responding. Last check: 2007-09-11)
		Among the monogenic forms, maturity onset diabetes of young (MODY) is a disorder of beta cell dysfunction characterised by an early age of onset and an autosomal dominant inheritance.
		MODY pedigrees show a phenomenon of anticipation, i.e., a progressive reduction in the age of diagnosis in succeeding generations, probably because of increasing awareness leading to earlier testing.
		MODY can be easily distinguished from type 2 diabetes by a prominent family history in three or more generations, a young age at presentation, absence of obesity, and by the absence of the metabolic syndrome (diabetes, insulin resistance, hypertension, hypertriglyceridaemia).
	www.indegene.com /End/FeatArt/indEndFeatArt16.html (3035 words)

	Half of Clinically Defined Maturity-Onset Diabetes of the Young Patients in Denmark Do Not Have Mutations in HNF4A, ...
		of diabetes (34, 35, 39), and the MODY probands from the Czech
		gene in maturity-onset diabetes of the young (MODY1).
		gene in a Danish pedigree with maturity-onset diabetes of the young.
	jcem.endojournals.org /cgi/content/full/90/8/4607 (4995 words)

	Diabetes
		Diabetes should be properly referred to as diabetes mellitus, in distinction from diabetes insipidus.
		Two additional groups of children with diabetic ketoacidosis but without cerebral edema were also identified: 181 randomly selected children and 174 children matched to those in the cerebral-edema group with respect to age at presentation, onset of diabetes (established vs. newly diagnosed disease), initial serum glucose concentration, and initial venous pH.
		Diabetic retinopathy was present in 10% of early diabetes, 69% of late diabetes, but not in isolated thick basement membrane.
	www.thedoctorsdoctor.com /diseases/diabetes.html (10513 words)

	Maturity Onset Diabetes of the Young 5 -- 140 (7): I-42 -- Annals of Internal Medicine
		Maturity Onset Diabetes of the Young 5 -- 140 (7): I-42 -- Annals of Internal Medicine
		Maturity-onset diabetes of the young (MODY) is caused by a genetic
		Maturity-onset diabetes of the young 5 is an uncommon disease
	www.annals.org /cgi/content/full/140/7/I-42 (461 words)

	Onset definition - Medical Dictionary definitions of popular medical terms
		Onset: In medicine, the first appearance of the signs or symptoms of an illness as, for example, the onset of rheumatoid arthritis.
		For example, in the case of diabetes, there is juvenile-onset diabetes, adult-onset diabetes, and maturity onset diabetes of the young.
		Diseases may also be characterized by their speed of onset (and quickness of course) as acute (sudden), subacute (midway between sudden and gradual) or chronic (gradual).
	www.medterms.com /script/main/art.asp?articlekey=31474 (245 words)

	Diabetes Monitor - maturity onset diabetes of the young
		Diabetes Monitor - maturity onset diabetes of the young
		MODY is a group of diabetes disorders that affects about 2% of people with diabetes.
		The first MODY gene was found in 1992 (5), and there are now six known genes in which defects will cause MODY(4).
	www.diabetesmonitor.com /mody.htm (671 words)

	The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required ... (Site not responding. Last check: 2007-09-11)
		The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism -- Stoffel and Duncan 94 (24): 13209 -- Proceedings of the National Academy of Sciences
		diabetes mellitus (maturity-onset diabetes of the young; gene
		Diabetes, October 1, 2005; 54(10): 3035 - 3039.
	www.pnas.org /cgi/content/full/94/24/13209 (4426 words)

	NEJM -- Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young
		NEJM -- Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young
		McKinney, J., Cao, H., Behme, M. T., Mahon, J. L., Hegele, R. Maturity-Onset Diabetes of the Young (MODY) Mutation in Type 2 Diabetes and Latent Autoimmune Diabetes of the Adult.
		Hagenfeldt-Johansson, K. A., Herrera, P. L., Wang, H., Gjinovci, A., Ishihara, H., Wollheim, C. {beta}-Cell-Targeted Expression of a Dominant-Negative Hepatocyte Nuclear Factor-1{alpha} Induces a Maturity-Onset Diabetes of the Young (MODY)3-Like Phenotype in Transgenic Mice.
	content.nejm.org /cgi/content/extract/345/13/971 (2661 words)

	Maturity Onset Diabetes of the Young (MODY)
		Maturity-Onset Diabetes of the Young - Information for Patients and Professionals
		Predictive Testing in Maturity Onset Diabetes of the Young
		The diagnosis and management of monogenic diabetes in children (ISPAD Guidelines)
	www.projects.ex.ac.uk /diabetesgenes/mody/index.htm (39 words)

	GPI Odyssey: Maturity-Onset Diabetes of the Young (MODY) References (Site not responding. Last check: 2007-09-11)
		GPI Odyssey: Maturity-Onset Diabetes of the Young (MODY) References
		Bell, G. I.; Xiang, K.; Newman, M. V.; Wu, S.; Wright, L. G.; Fajans, S. S.; Spielman, R. S.; Cox, N. Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.
		Vaxillaire, M.; Boccio, V.; Philipi, A.; Vigouroux, C.; Terwilliger, J.; Passa, P.; Beckmann, J. S.; Velho, G.; Lathrop, G. M.; Froguel, P. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q.
	www.csu.edu.au /learning/ncgr/gpi/odyssey/diabetes/mody.html (199 words)

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