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Topic: Memory T cells


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In the News (Wed 15 Feb 12)

  
  Investigators and Program Directors
Of interest is the observation that aging is associated with an enhanced level of memory T cells, suggesting that the qualitative T cell response differs in the elderly.
Further, differences in the proportion of memory to naive T cells may be responsible for immune dysfunction and autoimmunity associated with the aging process.
Lee, W.T., Pradmanabhan, J. and Cole-Calkins, J. (1997) Memory T cell tolerance to superantigens is not due to increased susceptibility to apoptosis.
www.wadsworth.org /resnres/bios/wtlee.htm   (408 words)

  
 Naive and Memory T cells inPeripheral Blood Reflect Levels inLymphoid Tissue   (Site not responding. Last check: 2007-10-16)
The naïve:memory ratio was positively correlated with CD4 cell counts and the patients with higher naïve:memory ratios had "more robust responses to CMV antigen." Furthermore, the viral load was several-fold higher in the lymph node compartment than in the blood, and inversely correlated with the naïve:memory ratio in both compartments.
Although the distribution pattern of T cells and their subsets differed in the lymph node and plasma compartments, the "plasma values were reflective of events in the lymph node tissue.
Homeostasis of Naïve and Memory T Cell Subpopulations in Peripheral Blood and Lymphoid Tissues in the Context of Human Immunodeficiency Virus Infection.
www.hivandhepatitis.com /recent/viral/043001.html   (502 words)

  
 Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs -- Chalasani et al. 99 ...
The allospecifc T cell population responding to a transplanted organ consists of both naïve and memory lymphocytes.
T cells that arise from the homeostatic proliferation of naive
T cells in the absence of antigenic stimulation are suboptimal
www.pnas.org /cgi/content/full/99/9/6175   (3625 words)

  
 Cutting Edge Commentary: Differential TCR Signaling and the Generation of Memory T Cells -- Farber 160 (2): 535 -- The ...
T cells in the absence of effector T cells.
T cells arise from activated effectors that have reverted to
Memory T cells are anergic to the superantigen staphylococcal enterotoxin B. Exp. Med.
www.jimmunol.org /cgi/content/full/160/2/535   (4665 words)

  
 Developmental Regulation of Lck Targeting to the CD8 Coreceptor Controls Signaling in Naive and Memory T Cells -- ...
T cells, whereas it was predominantly in the cell membrane in
Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model.
T cell responses are governed by avidity and costimulatory thresholds.
www.jem.org /cgi/content/full/189/10/1521   (5309 words)

  
 PHENOTYPIC AND FUNCTIONAL DIFFERENTIATION OF SYNOVIAL MEMORY T CELLS IN JIA   (Site not responding. Last check: 2007-10-16)
To investigate the differential role of CCR7 and CCR5 in the synovial recruitment of memory T cells in JIA.
T cells with effector characteristics are the prevalent synovial subpopulation.
Immunohistochemestry data may lead to postulate a differentiation of memory T cells in the synovial tissue.
www.pedrheumonlinejournal.org /June/115.htm   (278 words)

  
 IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells -- ...
T cells in vitro and in vivo (6,8–11,14,22,23,40,41).
T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis.
memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression.
intimm.oxfordjournals.org /cgi/content/full/15/1/49   (5042 words)

  
 Anergy in Peripheral Memory CD4+ T Cells Induced by Low Avidity Engagement of T Cell Receptor -- Mirshahidi et al. 194 ...
to the induction of T cell unresponsiveness in the periphery
proportion of cells with a naive/resting phenotype (58) that
T cell tolerance induction versus priming is independent of the rate and number of cell divisions.
www.jem.org /cgi/content/full/194/6/719   (6438 words)

  
 Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous ...
T cells from BM and PB of nine breast cancer patients are shown.
The migration of effector and memory T cells to inflamed tissues
ligands in the migration of murine memory and effector T cells
www.jci.org /cgi/content/full/114/1/67   (5746 words)

  
 85. HIV-1-Mediated Signal Transduction through CCR5 Allows Infection of Resting Memory T Cells
This may be because resting memory T cells are more susceptible to infection by R5 HIV-1 than by X4 HIV-1.
The resistance of resting memory T cells to infection with X4 HIV-1 maps to gp120, suggesting that CCR5 expressed on resting cells plays a role in determining susceptibility to infection.
32 T cells susceptible to infection by R5 HIV-1.
www.retroconference.org /2002/Abstract/13106.htm   (369 words)

  
 The impact of splenectomy on antiviral T cell memory in mice -- Mrusek et al. 17 (1): 27 -- International Immunology
The absolute number of RSV-specific T cells was determined by multiplying the percentage of tetramer-binding CD8+ T cells among total live cells as determined by a live gate in combination with microscopic cell counting.
T cells in the spleen than in lung or lymph nodes (4).
Ostler, T., Hussell, T., Surh, C. D., Openshaw, P. and Ehl, S. Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus.
intimm.oxfordjournals.org /cgi/content/full/17/1/27   (3681 words)

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