| | MIT Department of Biology: Susumu Tonegawa (Site not responding. Last check: 2007-11-03) |
 | | Remote memory (very long term memory) is thought to be stored in the cortex and, once stored, its maintenance and retrieval are thought to be independent of the integrity of the hippocampus. |
 | | To study the relationships between synaptic structure and function in the cortex and consolidation of long-term memory, we have generated transgenic mice in which catalytic activity of PAK, a critical regulator of actin remodeling, is inhibited in the postnatal forebrain. |
 | | However, when the memory of the location of the hidden platform was tested following removal of three of the four major extramaze cues (partial cue conditions), the mutants exhibited a clear deficit of retrieval compared to the control animals. |
| web.mit.edu /biology/www/facultyareas/facresearch/tonegawa.shtml (1858 words) |