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Topic: Meperidine

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	MedlinePlus Drug Information: Meperidine
		Meperidine is used to relieve moderate to severe pain.
		Meperidine is in a class of medications called narcotic analgesics, a group of pain medications similar to morphine.
		Meperidine may cause serious side effects or death if it is taken in these ways.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682117.html (985 words)

	MEPERIDINE HYDROCHLORIDE Drug Information MEPERIDINE HYDROCHLORIDE
		Meperidine hydrochloride, a white crystalline substance with a melting point of 186° C to 189° C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste.
		Meperidine, in 60 mg to 80 mg parenteral doses, is approximately equivalent in analgesic effect to 10 mg of morphine.
		Meperidine is an opioid agonist of the morphine-type.
	www.drugs.com /pdr/MEPERIDINE_HYDROCHLORIDE.html (3794 words)

	Meperidine Encyclopedia of Cancer - Find Articles
		Meperidine is not recommended for long-term management of chronic pain, such as pain caused by cancer, because of its potential for psychological and physical dependence.
		Meperidine is a synthetic compound that acts as an agonist-meaning it attaches to opioid receptors in the central nervous system and stimulates physiologic activity normally stimulated by naturally occurring substances such as endorphins (short for endogenous morphine).
		Meperidine is available in a banana-flavored syrup, in a tablet, and in a liquid form for injection.
	www.findarticles.com /p/articles/mi_gGEC/is_0012/ai_2699001284 (782 words)

	A
		Meperidine should not be used for longer than 48 hours or at doses greater than 600 mg/24 hours in patients with normal renal function.
		Meperidine is not recommended for this use because of its very short duration, its toxic metabolite, and because it is painful to inject.
		Meperidine should be used with extreme caution in patients with pre-existing convulsive disorders, and in patients receiving drugs that are known to predispose patients to seizures (e.g., imipenem).
	www2.kumc.edu /pharmacy/meperidine.htm (735 words)

	Meperidine
		Introduced as an analgesic in the 1930s, meperidine produces effects that are similar, but not identical, to morphine (shorter duration of action and reduced antitussive and antidiarrheal actions).
		Currently it is used for pre-anesthesia and the relief of moderate to severe pain, particularly in obstetrics and post-operative situations.
		Meperidine is available in tablets, syrups, and injectable forms under generic and brand name (Demerol®, Mepergan®, etc.) Schedule II preparations.
	www.streetdrugs.org /meperidine.htm (137 words)

	Meperidine
		Meperidine (Demerol) IM or IV is a highly addictive narcotic which has been heavily used by the field of medicine for many years for pain control.
		Oral ketamine/midazolam is superior to intramuscular meperidine, promethazine, and chlorpromazine for pediatric cardiac catheterization.
		Meperidine had significantly greater reduction in heart rate, a lower degree of motor block, shorter period before requests for postoperative analgesia but a higher incidence of sedation, nausea and vomiting.
	www.modern-psychiatry.com /meperidine.htm (5034 words)

	Meperidine
		Meperidine is reported to be physically incompatible with the following agents: aminophylline, amobarbital sodium, heparin sodium, hydrocortisone sodium succinate, methicillin, methylprednisolone sodium succinate, morphine sulfate, nitrofurantoin sodium, oxytetracycline HCl, pentobarbital sodium, phenobarbital sodium, phenytoin sodium, sodium iodide, tetracycline HCl, thiopental sodium and thiamylal sodium.
		Meperidine is contraindicated in cases where the patient is hypersensitive to narcotic analgesics, or in patients taking monamine oxidase inhibitors (MAOIs).
		Meperidine should be used with caution in patients with head injuries or increased intracranial pressure and acute abdominal conditions (e.g., colic) as it may obscure the diagnosis or clinical course of these conditions.
	www.elephantcare.org /Drugs/meperidi.htm (1219 words)

	Parkinsn's List Drug DataBase meperidine, pethidine / Demerol
		Meperidine is recommended for relief of moderate to severe pain but also has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B. Meperidine is metabolized to normeperidine, a compound capable of inducing seizures if it accumulates.
		Meperidine should be used cautiously in patients with pulmonary depression or pulmonary disease such as acute bronchial asthma or upper airway obstruction.
		Meperidine should be prescribed cautiously to patients undergoing biliary tract surgery, although meperidine reportedly causes less biliary tract spasm than does morphine.
	www.parkinsons-information-exchange-network-online.com /drugdb/079.html (2168 words)

	EHS: WOW-Notes on Meperidine
		Meperidine is commonly underdosed and administered too infrequently even by physicians aware of its pharmacokinetics (Marks and Sachar, 1973).
		Meperidine produces clinical analgesia for only 2.5-3.5 hours, and a dose of 75 mg every 4 hours is equivalent to only 5-7.5 mg of morphine.
		Therefore, meperidine should be reserved for very brief courses in otherwise healthy patients who have demonstrated an unusual reaction (e.g., local histamine release at the infusion site) or allergic response during treatment with other opioids such as morphine or hydromorphone.
	www3.us.elsevierhealth.com /WOW/op024.html (474 words)

	Demerol/Meperidine
		Psychic dependence, physical dependence, and tolerance may develop upon repeated administration of meperidine, and it should be prescribed and administered with the same degree of caution appropriate to the use of morphine.
		Meperidine should not be administered intravenously in less a narcotic antagonist and the facilities for assisted or controlled respiration are immediately available.
		Usage in Pregnancy and Lactation: Meperidine should not be used in pregnant women prior to the labor period, unless in the judgment of the physician the potential benefits outweigh the possible hazards, because safe use in pregnancy prior to labor has not been established relative to possible adverse effects on fetal development.
	www.ncpainmanagement.com /Meperidine.htm (826 words)

	Demerol (Meperidine) drug description - prescription drugs and medications at RxList
		Meperidine hydrochloride is ethyl 1-methyl-4-phenylisonipecotate hydrochloride, a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste.
		Meperidine hydrochloride injectable is supplied in Carpuject with InterLink and Carpuject Sterile Cartridge-Needle Units, SmartPak Injection Delivery System of 2.5% (25 mg/1 ml), 5% (50 mg/1 ml), 7.5% (75 mg/1 ml), and 10% (100 mg/1 ml).
		Meperidine hydrochloride, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C. Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc.
	www.rxlist.com /cgi/generic/meper.htm (341 words)

	Drug Profiles: Demerol® for Migraines
		Meperidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B. Meperidine has also been used for intravenous regional anesthesia, peripheral nerve blocks and intraarticular, epidural and spinal analgesia.
		Meperidine is not recommended for the treatment of chronic pain because of the risk of seizures with repetitive dosing and its short duration of action.
		Meperidine is often used as a rescue medication for treatment of Migraine, meaning used for controlling severe Migraine when a Migraineur dose not respond to abortive treatments or the Migraineur cannot use effective abortive regimes when they are contraindicated.
	www.migraines.org /treatment/prodemrl.htm (1410 words)

	meperidine - [Medication]
		Meperidine may increase the effects of other drugs that cause drowsiness, including other pain relievers, alcohol, antihistamines, sedatives (used to treat insomnia), antidepressants, anxiety medicines, and muscle relaxants.
		Meperidine may be habit forming and should only be used under close supervision if there is a history of alcohol or drug addiction.
		Meperidine may cause addiction and withdrawal symptoms as well as other harmful effects in an unborn baby.
	www.peacehealth.org /kbase/multum/d00017a1.htm (1276 words)

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