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Topic: Mercaptopurine

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	Mercaptopurine (Systemic) Seattle, Washington
		Mercaptopurine may also be used for other conditions as determined by your doctor.
		Mercaptopurine has been shown to cause damage to the fetus in rats and increases the risk of miscarriage or premature births in humans.
		Mercaptopurine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.swedish.org /18733.cfm (1969 words)

	Purinethol Online, Description, Chemistry, Ingredients - Mercaptopurine - RxList Monographs
		It should not be used unless a diagnosis of acute lymphatic leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy.
		PURINETHOL (mercaptopurine) was synthesized and developed by Hitchings, Elion, and associates at the Wellcome Research Laboratories.
		Mercaptopurine, known chemically as 1,7-dihydro-6 H -purine-6-thione monohydrate, is an analogue of the purine bases adenine and hypoxanthine.
	www.rxlist.com /cgi/generic2/mercaptopurine.htm (229 words)

	Purinethol Canada,Canadian Purinethol,Purinethol Side Effects,Buy Purinethol Online
		Mercaptopurine, as a single agent, is capable of significantly prolonging complete remission duration in children; however, combination therapy with multiple agents has produced results superior to that achieved with mercaptopurine alone.
		Contra-Indications: Mercaptopurine should not be used unless a diagnosis of acute leukemia or chronic myelogenous leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy.
		Mercaptopurine should not be used in patients whose disease has demonstrated prior resistance to this drug.
	www.candrug.com /DrugMoreInfo1938.aspx (539 words)

	mercaptopurine - [Medication]
		Mercaptopurine interferes with the growth of cancer cells and slows their growth and spread in the body.
		Mercaptopurine is used in the treatment of acute lymphatic leukemia and acute myelogenous leukemia.
		Mercaptopurine is in the FDA pregnancy category D. This means that mercaptopurine is known to be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d00289a1.htm (1013 words)

	ACS :: Cancer Drug Guide: mercaptopurine
		Mercaptopurine prevents cells from making DNA and RNA by interfering with the synthesis of nucleic acids, thus stopping the growth of cancer cells, and causing them to die.
		Mercaptopurine is a pill given once a day, usually for 5 days, with or without food.
		Mercaptopurine can decrease your white blood cell count, especially 5 days to 6 weeks after the drug is given.
	www.cancer.org /docroot/CDG/content/CDG_mercaptopurine.html?internal=1 (704 words)

	Mercaptopurine (Site not responding. Last check: 2007-10-20)
		Mercaptopurine is taken by mouth on an empty stomach (an hour before or 2 hours after meals).
		Mercaptopurine can decrease the number of white blood cells in your body, cells that usually help you fight infections.
		Mercaptopurine causes liver damage in a small number of patients and should be used very carefully in patients who have had liver disease.
	www.hci.utah.edu /patientdocs/hci/drugs/mercaptopurine.htm (456 words)

	Mercaptopurine Health Web Links (Site not responding. Last check: 2007-10-20)
		Mercaptopurine - Familydoctor.org - Information for patients in English and Spanish.
		If there is any reaction, both are transformed." (Carl Gustav Jung) Mercaptopurine We have children because we want immortality and this is the most reliable way of getting it.
		-- Ogden Nash Mercaptopurine "Now that we have everything we need, we discover that there is almost nothing that we have that we want." (John Cage, M, Writings 1967 - 1972) You can not apply mathematics as long as words still becloud reality.
	www.internet-health-directory.com /Pharmacy_Drugs_and_Medications_M_Mercaptopurine.html (1597 words)

	Mercaptopurine
		Mercaptopurine belongs to a group of drugs known as antimetabolites.
		Mercaptopurine may cause changes in the way that your liver works, which return to normal when the treatment is finished.
		Mercaptopurine can cause a rash, which may be itchy.
	www.cancer-symptoms.org /cancer-drugs.htm/mercaptopurine.htm (626 words)

	Mercaptopurine factsheet (Site not responding. Last check: 2007-10-20)
		Mercaptopurine is a drug which is used to treat certain types of cancer and leukaemia.
		Mercaptopurine is given by mouth in tablet form, once a day, at least one hour after food, in the evening.
		Mercaptopurine doses may be changed weekly according to your child’s blood count.
	www.ich.ucl.ac.uk /factsheets/families/F000255 (762 words)

	Data Sheet
		It acts as an immunosuppressant and anti-neoplastic agent with similar actions to those of mercaptopurine, to which it is converted in the body.
		Small amounts of unchanged drug and mercaptopurine are eliminated by the kidney.
		Mercaptopurine is widely distributed in body tissues, but only a small percentage enters the cerebrospinal fluid.
	www.medsafe.govt.nz /Profs/Datasheet/a/Azamuntab.htm (2735 words)

	Mercaptopurine, Purinethol, 6-Mercaptopurine, 6-MP Chemotherapy Drugs
		The amount of mercaptopurine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.
		Before starting mercaptopurine treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
		Mercaptopurine belongs to the class of chemotherapy drugs called antimetabolites.
	www.chemocare.com /bio/bio.sps?iBiographyID=7936 (1513 words)

	Purinethol
		Mercaptopurine interferes with the growth of cancer cells, which are eventually destroyed.
		Children— Although there is no specific information comparing use of mercaptopurine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.
		While you are being treated with mercaptopurine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval.
	www.healthtouch.com /bin/EContent_HT/drugShowLfts.asp?fname=usp0537.htm&title=Purinethol&cid=L (2033 words)

	Mercaptopurine (6-MP, Purinethol )
		Mercaptopurine is a chemotherapy drug used in treating some types of cancers including acute lymphoblastic leukaemia.
		Mercaptopurine is one of a group of chemotherapy drugs known as anti metabolites.
		Mercaptopurine comes as fawn coloured 50mg tablets that you swallow with lots of water.
	www.cancerhelp.org.uk /help/default.asp?page=5199 (1026 words)

	CancerBACUP : Mercaptopurine (Puri-Nethol®)
		Mercaptopurine (pronounced mer cap toe pure een) is chemotherapy that is given as a treatment for some types of cancer.
		This information describes mercaptopurine, how it is given and some of its specific side effects.
		Mercaptopurine is available as fawn-coloured tablets of 50mg.
	www.cancerbacup.org.uk /Treatments/Chemotherapy/Individualchemotherapydrugs/Mercaptopurine (1041 words)

	Patient Education - Drugs - mercaptopurine (6-MP)
		Mercaptopurine may be taken with food or milk to reduce stomach irritation.
		It ranks drugs from A, where medical studies show no evidence for danger to the fetus or mother, to B, C, D and X, where the medical evidence indicates that the risk to the fetus outweighs any benefit to the mother.
		Mercaptopurine is ranked D. This drug can cause fetal harm or miscarriage so it should be used during pregnancy only if the benefit outweighs the risk to the fetus.
	www.gicare.com /pated/mercaptopurine.htm (852 words)

	Mercaptopurine - Patient UK
		Mercaptopurine works by preventing the growth and division of cells and therfore stops them increasing in numbers.
		Mercaptopurine lowers the body's resistance and there is a chance that you may get an infection from the vaccine.
		Mercaptopurine can lower the number of white cells in your blood, increasing the chance of getting an infection.
	www.patient.co.uk /showdoc/30002355 (746 words)

	Mercaptopurine What To Think About, Eastern Carolina
		Mercaptopurine is usually administered only under the supervision of a medical oncologist or hematologist.
		Mercaptopurine may increase the blood thinning effects of other medications, such as warfarin (Coumadin).
		You may not be able to become pregnant or father a child after taking mercaptopurine.
	www.uhseast.com /141090.cfm (196 words)

	Mercaptopurine at Absolute Authority :: Mercaptopurine Information, Products, Services, Resources ...
		This is your central hub for exploring the world of Mercaptopurine.
		If you would like to contribute any articles or resources on Mercaptopurine just use the submission form.
		Mercaptopurine - This is your central hub for exploring the world of Mercaptopurine on the web.
	www.absoluteauthority.com /on/mercaptopurine.htm (276 words)

	[No title]
		We prospectively assessed the pharmacokinetics of methotrexate, mercaptopurine, and erythrocyte thioguanine nucleotide levels in a homogenous population of children with lower risk acute lymphoblastic leukemia and correlated pharmacokinetic parameters with disease outcome.
		A Cox regression analysis showed that mercaptopurine AUC was a marginally significant (P =.043) predictor of outcome, but a direct comparison of mercaptopurine AUC in the remission and relapsed patient groups failed to show a significant difference.
		Methotrexate and mercaptopurine plasma concentrations and erythrocyte thioguanine nucleotide levels were highly variable, but measurement of these pharmacokinetic parameters at the start of maintenance will not distinguish patients who are more likely to relapse.
	home.vicnet.net.au /~koalaweb/ref/Methotrexate.html (11786 words)

	Drug Information: Mercaptopurine (Print Version)
		Mercaptopurine is also used to treat many types of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, acute idiopathic polyneuritis, acute idiopathic nephrotic syndrome, psoriatic arthritis, erythroid aplasia, or myelofibrosis; idiopathic hemolytic anemia; macroglobulinemia; idiopathic thrombocytopenia purpura; idiopathic pulmonary hemosiderosis; multiple sclerosis; myasthenia gravis; uveitis; and ulcerative colitis.
		you should know that mercaptopurine may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men.
		The most common side effect of mercaptopurine is a decrease in the number of blood cells.
	www.nlm.nih.gov /medlineplus/print/druginfo/medmaster/a682653.html (433 words)

	Inflammatory Bowel Disease: Serologic Markers and Pharmacogenomic and Metabolitic Assessment of Thiopurine Therapy (Site not responding. Last check: 2007-10-20)
		Azathioprine and mercaptopurine have had demonstrable adjunctive benefits to steroids in adults but may require up to 4 months to demonstrate a beneficial effect.
		Genetic polymorphisms for thiopurine methyltransferase, the primary enzyme metabolizing mercaptopurine, have been identified which may afford the potential to regulate therapy according to measurement of mercaptopurine metabolites (6-thioguanine).
		Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
	www.aetna.com /cpb/data/CPBA0249.html (4135 words)

	Mercaptopurine (Site not responding. Last check: 2007-10-20)
		Dosage of mercaptopurine should be reduced to 1/4 of the usual dose if allopurinol is given concurrently.
		Dose of mercaptopurine should be reduced to one third to one quarter of usual dose.
		Other myelosuppressive agents: Enhance anti-neoplastic effect of mercaptopurine, dose of mercaptoppurine may need ot be reudced.
	www.mdbrowse.com /Druginf/M/mercaptopurine.htm (163 words)

	Mercaptopurine.
		Mercaptopurine kills cancer cells by interfering with the synthesis of their genetic material, which prevents the cells from reproducing.
		Among common side effects of mercaptopurine are unusual fatigue, yellowish tinge to skin and eyes ( jaundice).
		Doses must be reduced to 33% or even as low as 25% of the usual dose if these two medicines are to be combined.
	www.herbs2000.com /drugs/mercaptopurine.htm (346 words)

	Genesis Health System - Drug Info - Mercaptopurine
		Mercaptopurine is an anti-cancer drug that stops cells from dividing.
		This drug is used to treat acute and chronic leukemias.
		Mercaptopurine may increase the blood thinning effects of Coumadin.
	www.genesishealth.com /druginfo/Mercaptopurine.aspx (257 words)

	Data Sheet
		Studies carried out in children with acute lymphoblastic leukemia suggested that administration of mercaptopurine in the evening lowered the risk of relapse compared with morning administration.
		When allopurinol and 6-mercaptopurine are administered concomitantly it is essential that only a quarter of the usual dose of mercaptopurine is given since allopurinol decreases the rate of catabolism of mercaptopurine.
		For mercaptopurine there is a lack of modern clinical documentation which can serve as support for accurately determining the frequency of undesirable effects.
	www.medsafe.govt.nz /profs/Datasheet/p/Puri-netholtab.htm (1998 words)

	Purinethol Indications, Dosage, Storage, Stability - Mercaptopurine - RxList Monographs (Site not responding. Last check: 2007-10-20)
		PURINETHOL (mercaptopurine) is indicated for remission induction and maintenance therapy of acute lymphatic leukemia.
		The response to this agent depends upon the particular subclassification of acute lymphatic leukemia and the age of the patient (pediatric patient or adult).
		Dosage in Hepatic Impairment: Consideration should be given to reducing the dosage in patients with impaired hepatic function.
	www.rxlist.com /cgi/generic2/mercaptopurine_ids.htm (795 words)

	Differing Contribution of Thiopurine Methyltransferase to Mercaptopurine versus Thioguanine Effects in Human Leukemic ...
		Not shown is inactivation of mercaptopurine and thioguanine by TPMT to their respective methylated bases and by xanthine oxidase in the gastrointestinal tract and liver.
		the delayed effect of mercaptopurine or thioguanine (4, 26).
		Evans W. E., Relling M. Mercaptopurine vs thioguanine for the treatment of acute lymphoblastic leukemia.
	cancerres.aacrjournals.org /cgi/content/full/61/15/5810 (5402 words)

	[No title]
		Mercaptopurine in childhood leukaemia: the effects of dose escalation on thioguanine nucleotide metabolites.
		Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia.
		As part of a programme assessing the pharmacokinetics of oral thiopurines given for lymphoblastic leukaemia, we assayed intracellular metabolites of mercaptopurine in children from all over the United Kingdom who were given a standard dose of the drug.
	home.vicnet.net.au /~koalaweb/ref/6mp.html (13101 words)

	Pharmacokinetics and Pharmacodynamics of Oral Methotrexate and Mercaptopurine in Children With Lower Risk Acute ...
		Pharmacokinetics and Pharmacodynamics of Oral Methotrexate and Mercaptopurine in Children With Lower Risk Acute Lymphoblastic Leukemia: A Joint Children's Cancer Group and Pediatric Oncology Branch Study -- Balis et al.
		We prospectively assessed the pharmacokinetics of methotrexate, mercaptopurine, and erythrocyte thioguanine nucleotide levels
		Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group
	www.bloodjournal.org /cgi/content/abstract/92/10/3569 (546 words)

	Mercaptopurine: A guide to Mercaptopurine side effects
		Mercaptopurine is converted in the body to corresponding monoribonucleotides which inhibits the conversion of inosine monophosphate to adenine and guanine nucleotides.
		There is also feed back inhibition of de novo purine synthesis.
		anticoagulant action of warfarin may be inhibited by mercaptopurine,
	www.asbestos-mesothelioma-guide.com /mercaptopurine.htm (79 words)

	mercaptopurine - references in online news media (Site not responding. Last check: 2007-10-20)
		We have received reports of three serious medication errors involving confusion between mercaptamine and mercaptopurine.
		The strong performance of the base business resulted, in part, from the first- quarter introduction of mercaptopurine, the generic form of PurinetholÂ®, and...
		The strong performance of the base business resulted, in part, from the first- quarter introduction of mercaptopurine, the generic form of Purinethol(R), and...
	www.linkmorgue.org /DRUGS/nov03-nov04/mercaptopurine.html (219 words)

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