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Topic: Mesenchymal cell

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Intramembranous ossification

Endochondral ossification

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Diaphysis

	Chondrocyte - Wikipedia, the free encyclopedia
		When referring to bone or cartilage, mesenchymal stem cells (MSC) are commonly known as osteochondrogenic (or osteogenic, chondrogenic, osteoprogenitor, etc.) cells since a single MSC has shown the ability to differentiate into chondrocytes or osteoblasts, depending on the medium.
		In vivo, differentiation of a MSC in a vascularized area (such as bone) yields an osteoblasts while differentiation of a MSC in a non-vascularized area (such as cartilage) yields a chondrocyte.
		This terminology is technically inaccurate, since the progenitor of chondrocytes (which are mesenchymal stem cells) can also differentiate into osteoblasts.
	en.wikipedia.org /wiki/Chondrocyte (203 words)

	NIH Guide: BASIC RESEARCH ON MESENCHYMAL STEM CELL BIOLOGY
		In addition, mesenchymal stem cells have been demonstrated to differentiate into a variety of non-hematopoietic tissues including bone, cartilage, tendon, fat, skeletal and cardiac muscle, and early progenitors of neural cells.
		Preclinical and early clinical safety studies are paving the way for further applications of these cells in the field of transplantation with respect to hematopoietic support, immunoregulation, graft facilitation, and potentially gene therapy.
		Preclinical studies suggest mesenchymal stem cells may enhance the ability of the bone marrow microenviornment to support hematopoiesis after stem cell transplantation.
	grants.nih.gov /grants/guide/rfa-files/rfa-hl-02-018.html (2676 words)

	Mesenchymal Stem Cells -- Minguell et al. 226 (6): 507 -- Experimental Biology and Medicine
		stem cells (MSC)'' (23), or mesenchymal progenitor cells (30).
		Stem cell is a stem cell is a stem cell.
		Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta.
	www.ebmonline.org /cgi/content/full/226/6/507 (7938 words)

	VIT1 Primary Pancreatic Mesenchymal Cell Line: SCR014
		Frozen cells were subsequently rapidly thawed at 37°C, washed with 10 mL of PBS and plated at a low density (~200/cm2) in growth medium.
		Rapid achievement of a homogeneous cell suspension within the tissue culture flask containing growth medium is necessary to establish uniform cell distribution within the culture.
		All cell lines are extensively tested to assure: a) sterility, b) absence of common human viruses (HBV, HCV and HIV1), c) absence of mycoplasma and, d) achievement of performance specifications prior to QC release.
	www.chemicon.com /Product/ProductDatasheet.asp?ProductItem=SCR014 (1153 words)

	Mesenchymal Cell Precursors of Peritubular Smooth Muscle Cells of the Mouse Testis Can Be Identified by the Presence of ...
		that the interstitial population of mesenchymal cells in fetal
		Likewise, in the testis of the 12.5-dpc mouse embryo, intense
		At 11.25 dpc (d), cells immunostained with the anti-p75NTR antibody appear to be mainly distributed in the mesonephric region abutting on the gonadal bud.
	www.biolreprod.org /cgi/content/full/64/2/464 (5400 words)

	StemCell :: products & services :: Products for Mesenchymal Stem Cells
		Since then, it has become well established that the stroma consists of a heterogeneous population of cells, a subset of which exerts both positive and negative regulatory effects on the proliferation and differentiation of hematopoietic stem cells (HSC) in the marrow through a combination of physical and chemical signals.
		The cultured cells derived from the fibroblast colonies can be further expanded over a number of passages, after which they retain their ability to differentiate into a variety of mature cell types.
		Additionally, MesenCult can be used to expand MSC in vitro, after which the cells retain their ability to differentiate along various lineages upon the addition of the appropriate stimulatory supplements.
	www.stemcell.com /product_catalog/mscproducts.asp (457 words)

	Syntaxin 1A is transiently expressed in fetal lung mesenchymal cells: potential developmental roles -- Brimhall et al. ...
		Lane 1, mixture of fetal pulmonary cells; lane 2, fetal pulmonary fibroblasts; lane 3, fetal pulmonary epithelial cells (enriched for type II pneumocytes); lane 4, intact pulmonary explants grown in culture.
		Distribution of loose mesenchymal cells positive for Stx1A is reminiscent of lipid fibroblasts in developing lung.
		Subpopulations of stromal cells from long-term human bone marrow cultures: ontogeny of progenitor cells and expression of growth hormone receptors.
	ajplung.physiology.org /cgi/content/full/277/2/L401 (5592 words)

	Fibrogenesis IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models -- Pucilowska et al. 279 ...
		of the activated stellate cell population and fibrosis (12).
		Acute injury causes normal mesenchymal cells to be activated to a fibrogenic phenotype but may be followed by normal healing or fibrosis.
		1(I) are co-expressed in a subset of mesenchymal cells in active Crohn's disease.
	ajpgi.physiology.org /cgi/content/full/279/4/G653 (3990 words)

	Appendix E: Stem Cell Markers [Stem Cell Information]
		Normally, cells use these receptors and the molecules that bind to them as a way of communicating with other cells and to carry out their proper functions in the body.
		Stem cell markers are given short-hand names based on the molecules that bind to the stem cell surface receptors.
		With this technique, a suspension of tagged cells (i.e., bound to the cell surface markers are fluorescent tags) is sent under pressure through a very narrow nozzle—so narrow that cells must pass through one at a time.
	stemcells.nih.gov /info/scireport/appendixE.asp (2221 words)

	beta -Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes ...
		-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds
		The regulation of transgene expression in primary cell cultures is shown.
		A larger size to the mesenchymal component of the wound in the mouse treated with doxycycline (A) is illustrated compared with a transgenic mouse not treated with doxycycline (B).
	www.pnas.org /cgi/content/full/99/10/6973 (3997 words)

	LT2 Immortalized Pancreatic Mesenchymal Cell Line: SCR013
		The LT2 Immortalized Pancreatic Mesenchymal cell line is an attachment-dependent human cell line derived from isolated primary cultures of human fetal pancreatic fibroblasts.
		The CD90 positive cells were then cultured in Pancreatic Cell Culture Supplement (SCR015) and transfected with an expression vector containing the large T antigen sequence.
		We suggest establishing the initial culture of LT2 cells derived from frozen stock at a plating density of about 15,000 cells/cm2, followed by two successive passages where the cells are plated at 3,000 cells/cm2.
	www.chemicon.com /Product/ProductDatasheet.asp?ProductItem=SCR013 (1102 words)

	Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis ...
		Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone -- Horwitz et al.
		Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
		Stem Cells, September 1, 2005; 23(9): 1357 - 1366.
	www.pnas.org /cgi/content/abstract/99/13/8932 (1015 words)

	NF-{kappa}B mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing ...
		B mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
		the differentiation of mesenchymal cells and down-regulate the
		Cells were stained with alcian blue to determine extent of matrix formation containing sulfated glycosaminoglycans, an indicator of chondrocytic differentiation.
	www.genesdev.org /cgi/content/full/17/19/2368 (3049 words)

	The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2 -- ...
		Cells secrete chondrocyte-specific collagen 2 but not collagen X, which is specific for hypertrophic chondrocytes.
		With transverse sections at the level of the upper lumbar vertebra, expression of Brachyury is also detectable in distinct cells of the neural arch (h), whereas Col 1a1 is expressed in the outer annulus (i) and Col 2a1 in the cartilage primordium (j).
		is sufficient for the onset of chondrogenesis in the mesenchymal
	jcs.biologists.org /cgi/content/full/115/4/769 (7608 words)

	Cell Differentiation and Matrix Gene Expression in Mesenchymal Chondrosarcomas -- Aigner et al. 156 (4): 1327 -- ...
		Cell Differentiation and Matrix Gene Expression in Mesenchymal Chondrosarcomas -- Aigner et al.
		Mesenchymal chondrosarcoma is an uncommon malignant chondrogenic neoplasm
		The notion of mesenchymal chondrosarcoma as a neoplasm
	ajp.amjpathol.org /cgi/content/full/156/4/1327 (3682 words)

	Malignant Mesenchymal Spindle Cell Tumor
		Solid tumors of pleural origin can be either benign, such as a fibrous tumor of the pleura, mesenchymal tumors such as fibroma, neurofibroma, neurinoma or schwannoma, and leiomyoma, or malignant, including rare conditions like pleural osteosarcoma or pleural squamous cell carcinoma.
		The presence of the same types of connective tissue structures in both the pleura and the lung parenchyma may give rise to the same spectrum of tumors.
		Malignant mesenchymal spindle cell tumor most consistent with leiomyosarcoma with myoblastic differentiation of either pleural or lung origin.
	brighamrad.harvard.edu /Cases/bwh/hcache/145/full.html (613 words)

	Table of contents for Rise and fall of epithelial phenotype (Site not responding. Last check: 2007-09-29)
		EMT Concept and Examples from the Vertebrate Embryo 1 Elizabeth D. Hay Formation of the Mesenchymal Cell in the Embryo 2 Definition of the Mesenchymal Cell 4 Examples of EMT in Higher Vertebrate Embryos 4 2.
		Epithelial Cell Plasticity by Dynamic Transcriptional Regulation of E-Cadherin 178 Geert Berx and Frans Van Roy E-Cadherin Transcriptional Regulation 179 Transcriptional Up-Regulation of E-Cadherin 180 Transcriptional Down-Regulation of E-Cadherin 181 E-Cadherin Transrepression in Human Tumors 185 E-Cadherin Gene Silencing by CpG Hypermethylation 185 12.
		The Ras and Src Signaling Cascades Involved in Epithelial Cell Scattering 245 Brigitte Boyer The Signaling Pathways Leading to EMT 245 Src Involvement in EMT 247 17.
	www.loc.gov /catdir/toc/ecip058/2005005382.html (488 words)

	biology - Mesenchymal cell
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		Mesenchymal cells also known as mesenchymal stem cells or marrow stromal cells (MSC) are stem cells that can differentiate into osteoblasts, chondrocytes, myocytes and adipocytes.
		MSCs cultured without serum in the presence of transformation growth factor (TGF) will differentiate into chondrocytes while MSCs cultured in serum with ascorbic acid and dexamethasone will differentiate into osteoblasts.
	www.biologydaily.com /biology/Mesenchymal_cell (78 words)

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