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Topic: Metabolic acidosis


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  Metabolic acidosis - Wikipedia, the free encyclopedia
Metabolic acidosis is either due to increased generation of acid or an inability to generate sufficient bicarbonate.
The elevated bicarbonate that distinguishes metabolic acidosis is therefore due to two separate processes: the buffer (from water and carbon dioxide) and additional renal generation.
If the acidosis is particularly severe and/or there may be intoxication, consultation with the nephrology team is considered useful, as dialysis may clear both the intoxication and the acidosis.
en.wikipedia.org /wiki/Metabolic_acidosis   (964 words)

  
 MedlinePlus Medical Encyclopedia: Acidosis
Acidosis is a condition characterized by excessive acid in the body fluids.
Acidosis is caused by an accumulation of acid or a significant loss of bicarbonate.
Lactic acidosis is an accumulation of lactic acid.
www.nlm.nih.gov /medlineplus/ency/article/001181.htm   (497 words)

  
 Metabolic Acidosis | aHealthyAdvantage   (Site not responding. Last check: 2007-11-07)
Metabolic acidosis is a pH imbalance in which the body has accumulated too much acid and does not have enough bicarbonate to effectively neutralize the effects of the acid.
Metabolic acidosis, as a disruption of the body's acid/base balance, can be a mild symptom brought on by a lack of insulin, a starvation diet, or a gastrointestinal disorder like vomiting and diarrhea.
Metabolic acidosis is suspected based on symptoms, but is usually confirmed by laboratory tests on blood and urine samples.
www.ahealthyadvantage.com /topic/topic100587147   (838 words)

  
 infos for: metabolic acidosis symptoms pediatric
Metabolic acidosis is a condition in which the acid level within the blood is higher than...
Metabolic acidosis is a disturbance of the body acid-base balance in which there...
Metabolic acidosis is a disturbance of the body acid-base balance in which there is excessive acidity of...
www.das-werbefoto.de /metabolic_acidosis_symptoms_pediatric.html   (267 words)

  
 Acid Base Disorders in Critical Care MEDSTUDENTS-INTENSIVE CARE
Metabolic acidosis is characterized by a primary decrease in bicarbonate (HCO3) concentration and a compensatory decrease in the CO2 concentration.
Metabolic alkalosis is characterized by a primary increase in HCO3 concentration and a compensatory increase in Pa CO2.
Respiratory acidosis is characterized by a primary increase in Pa CO2 and a compensatory increase in HCO3.
www.medstudents.com.br /terin/terin5.htm   (2297 words)

  
 eMedicine - Metabolic Acidosis : Article by Karen L Stavile, MD   (Site not responding. Last check: 2007-11-07)
Metabolic acidosis most commonly stimulates the central and peripheral chemoreceptors that control respiration, resulting in an increase in alveolar ventilation, which results in a compensatory respiratory alkalosis.
Metabolic acidosis with a high AG is associated with the addition of endogenously- or exogenously-generated acids.
Since metabolic acidosis is a condition that occurs in response to a variety of disease states, the prognosis is directly related to the underlying etiology and the ability to treat or correct that particular disorder.
www.emedicine.com /emerg/topic312.htm   (3498 words)

  
 Critical Care | Full text | Conventional or physicochemical approach in intensive care unit patients with metabolic ...
Metabolic acidosis is the most frequent acid–base disorder in the intensive care unit.
Metabolic acidosis is one of the most frequent acid–base disorders occurring in the intensive care unit (ICU) [1].
The contributions of the three main causes of metabolic acidosis (hyperchloremia, hyperlactatemia and increased levels of other unmeasured strong anions) are presented in Table 3.
ccforum.com /content/7/3/R41   (2696 words)

  
 Metabolic Acidosis   (Site not responding. Last check: 2007-11-07)
Metabolic acidosis occurs in a number of diseases and even certain normal activities such as heavy exercise.
Although the magnitude of acidosis is important, the ultimate pathophysiological impact of any metabolic acidosis is defined by the rate of change and the specific cause of the acidosis.
Metabolic acidosis is a common problem accompanying and complicating a large number of diseases, especially those in critically ill patients, whose care routinely involves respiratory therapists.
www.rcjournal.com /contents/04.01/04.01.0342.asp   (308 words)

  
 Disease - Metabolic acidosis - Hartford, Connecticut
Metabolic acidosis is a disturbance of the body acid-base balance in which there is excessive acidity of the blood.
Metabolic acidosis can occur as a result of many different diseases, such as kidney failure, poisoning, diabetic ketoacidosis (DKA), and shock.
Usually, the symptoms of the disease which causes metabolic acidosis are the main symptoms.
www.saintfranciscare.com /12884.cfm   (395 words)

  
 Critical Care | Full text | Determinants of blood pH in health and disease   (Site not responding. Last check: 2007-11-07)
Metabolic acidoses and alkaloses are categorized according to the ions that are responsible.
In the intensive care unit acidosis is usually more of a problem than alkalosis, and in the critically ill the most common sources of metabolic acidosis are disorders of chloride homeostasis, lactate, and other anions.
Hyperchloremic metabolic acidosis occurs either as a result of chloride administration or secondary to abnormalities in chloride handling or related to movements of chloride from one compartment to another.
dx.doi.org /10.1186/cc644   (6166 words)

  
 eMedicine - Lactic Acidosis : Article by Stephen W Borron, MD, MS   (Site not responding. Last check: 2007-11-07)
Metabolic acidosis is defined by an arterial blood pH of less than 7.35 with a plasma bicarbonate concentration of less than 22 mmol/L (see related article Metabolic Acidosis).
Lactic acidosis also may occur in association with an underlying disease, such as diabetes mellitus, severe iron-deficiency anemia, liver diseases, alcoholic ketoacidosis, pancreatitis, malignancy (eg, leukemias, lymphomas, lung cancer), alkalosis, infections (malaria, cholera), renal failure, pheochromocytoma, thiamine deficiency, short gut syndrome and other carbohydrate malabsorption syndromes (eg, d-lactic acidosis), and milk protein intolerance.
Severe metabolic acidosis with arterial pH of less that 7.20 is associated with impaired cardiac contractility and altered responses to exogenous catecholamines.
www.emedicine.com /emerg/topic291.htm   (1933 words)

  
 Department of Neonatal Medicine Protocol Book: acidosis   (Site not responding. Last check: 2007-11-07)
Metabolic acidosis in preterm infants may be associated with hypoxaemia, hypotension or poor tissue perfusion, anaemia, infection or sepsis, or strenuous activity (respiratory distress).
The incidence of postnatal acidosis has not been documented in the overall population of neonates born at KGV Hospital.
Metabolic acidosis is most often corrected by attention to its cause.
www.cs.nsw.gov.au /rpa/neonatal/html/newprot/acidosis.htm   (1238 words)

  
 Postgraduate Medicine: A stepwise approach to acid-base disorders
Metabolic acidosis is characterized by a decrease in serum HCO
Causes of high-anion-gap metabolic acidosis can be further divided into (1) acidosis with an organic source (ie, lactic acidosis, ketoacidosis [whether diabetic, alcoholic, or starvation], and renal failure) and (2) acidosis resulting from ingestion of a toxin (eg, methanol, ethylene glycol, salicylate).
In metabolic acidosis, NH excretion should increase dramatically if renal acidification is intact (as in diarrhea), resulting in a large negative urine anion gap (ie, -20 to -50 mEq/L).
www.postgradmed.com /issues/2000/03_00/fall.htm   (3123 words)

  
 Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats -- ...
B: regional increase of induction of SN1 mRNA in kidney regions in response to metabolic acidosis, on the basis of the densitometric scan of the blot in A.
Glutamine metabolism in the kidney during induction of, and recovery from, metabolic acidosis in the rat.
Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral Na(HCO
ajprenal.physiology.org /cgi/content/full/283/5/F1011   (5972 words)

  
 5.2 Metabolic Acidosis - Causes   (Site not responding. Last check: 2007-11-07)
An alternative to the above, is to classify the causes of metabolic acidosis into two groups depending on whether the anion gap is elevated or normal.
The term 'hyperchloraemic metabolic acidosis' is also often used for the 'normal anion gap' group but the terms are not really synonomous (as discussed in section 8.4).
This is the most clinically useful way to classify metabolic acidosis and it is used extensively when assessing metabolic acidosis.
www.anaesthesiamcq.com /AcidBaseBook/ab5_2.php   (161 words)

  
 eMedicine - Metabolic Acidosis : Article by Christie Thomas, MD, FACP, FAHA, FASN
Mortality/Morbidity: The causes of metabolic acidosis are varied, and the morbidity and mortality of this disorder are primarily related to the underlying condition.
Metabolic acidosis is usual in patients with renal failure, and, in early to moderate stages of renal failure (eg, glomerular filtration rate of 20-50 mL/min), it is associated with a normal AG (hyperchloremic).
The metabolic acidosis in DKA is commonly a high-AG acidosis secondary to the presence of ketones in the blood.
www.emedicine.com /med/topic1458.htm   (9921 words)

  
 Chronic Metabolic Acidosis Enhances NHE-3 Protein Abundance and Transport Activity in the Rat Thick Ascending Limb by ...
Metabolic acidosis is associated with a number of adaptive changes in renal tubules that contribute to increased urinary net
Akiba, T.,V.K. Rocco, andD.G. Warnock(1987)Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis.
Preisig, P.A., andR.J. Alpern(1988)Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO
www.jci.org /cgi/content/full/99/1/24   (5645 words)

  
 8.7 Use of Bicarbonate in Metabolic Acidosis   (Site not responding. Last check: 2007-11-07)
Metabolic acidosis causes adverse metabolic effects (see Section 5.4).
The main goal of alkali therapy is to counteract the extracellular acidaemia with the aim of reversing or avoiding the adverse clinical effects of the acidosis (esp the adverse cardiovascular effects).
The preferred management of metabolic acidosis is to correct the primary cause and to use specific treatment for any potentially dangerous complications
www.qldanaesthesia.com /AcidBaseBook/AB8_7.htm   (540 words)

  
 Upregulation of the Secretory-Type Na+/K+/2Cl--Cotransporter in the Kidney by Metabolic Acidosis and Dehydration in ...
Upregulation of the Secretory-Type Na+/K+/2Cl--Cotransporter in the Kidney by Metabolic Acidosis and Dehydration in Rats -- IKEBE et al.
NKCC1 protein abundance in the membrane fraction from the outer medulla was significantly increased by metabolic acidosis and dehydration.
NKCC1 protein expression in the OMCD was significantly stimulated by 2 d of dehydration and chronic metabolic acidosis.
www.jasn.org /cgi/content/full/12/3/423   (4784 words)

  
 Med&Tech-MuscleWasting
Muscle wasting or weakness in CRF cats is generally caused by three things: (1) potassium deficiency (hypokalemia), (2) metabolic acidosis, or (3) long-term use of a low-protein diet.
Signs of muscle wasting from either potassium deficiency or metabolic acidosis include: (a) muscle weakness, though in the early stages of muscle wasting this would be easy to confuse with low potassium; and (b) increased bony prominences.
If you view your cat from behind when s/he is standing, is s/he "knock-kneed?" (The joint you are really looking at is the ankle.) Cats that lose their muscle mass not only lose the ability to run and jump, but they also lose proper posture.
www.mindspring.com /~kerspin/Med&Tech-MuscleWasting.htm   (523 words)

  
 Metabolic acidosis
She had explo-lap /cholecystectomy a month ago and was intubated prior to surgery because of her acidosis.
This last 3 days, she has worsening metabolic acidosis, was brought back to OR today for exploration due to increasing abdominal distention but no dead bowels were found, only inflammation and some redness in the bowels and pancreas.
The metabolic acidosis in your patient may represent 1) hypoperfusion of tissues due to sepsis related to pancreatic inflammation, 2) hypoperfusion due to pancreatic necrosis, or 3) ketoacidosis due to the diabetes.
www.medhelp.org /perl6/gastro/archive/1124.html   (258 words)

  
 Editorial Letters: Metabolic Acidosis in Restraint-associated Cardiac Arrest
First, a good portion of the metabolic acidosis may have simply been due to cardiopulmonary arrest, as blood gas sampling seems to have taken place after the initial arrest and resuscitation efforts on these patients.
We agree with Dr. Chan and colleagues that the acidosis observed in our patients almost certainly had its genesis in the profound physical exertion before and during their restraint process, and concur that the restraint position itself is unlikely to generate a profound acidosis.
Additionally, cocaine was likely pivotal in the development of severe metabolic acidosis in our series, but without serum evidence of concurrent cocaine intoxication in two of our five cases of cardiopulmonary arrest, we did not wish to overstate this association.
www.charlydmiller.com /LIB/1999acidosiscomments.html   (2078 words)

  
 Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats -- ...
Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats -- Karinch et al.
Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats
During chronic metabolic acidosis, renal glutamine utilization increases markedly.
ajprenal.physiology.org /cgi/content/abstract/283/5/F1011   (405 words)

  
 Metabolic Acidosis And Diabetes Mellitus - DiabeticGourmet.biz   (Site not responding. Last check: 2007-11-07)
Acidosis definition - Diabetes Mellitus, Type 2, Type 1, and Metabolic...
In acidosis, the pH of the blood is abnormally...
Metabolic Acidosis - Understanding the regulation of acid-base balance requires appreciation of the...
www.diabeticgourmet.biz /metabolic-acidosis-and-diabetes-mellitus.htm   (385 words)

  
 Chronic Metabolic Acidosis Enhances NHE-3 Protein Abundance and Transport Activity in the Rat Thick Ascending Limb by ...
Chronic Metabolic Acidosis Enhances NHE-3 Protein Abundance and Transport Activity in the Rat Thick Ascending Limb by Increasing NHE-3 mRNA -- Laghmani et al.
Chronic Metabolic Acidosis Enhances NHE-3 Protein Abundance and Transport Activity in the Rat Thick Ascending Limb by Increasing NHE-3 mRNA
Chronic metabolic acidosis (CMA) is associated with an adaptive increase in the bicarbonate absorptive capacity of the rat
www.jci.org /cgi/content/abstract/99/1/24   (1097 words)

  
 Upregulation of collecting duct aquaporin-2 by metabolic acidosis: role of vasopressin -- Amlal et al. 286 (5): C1019 ...
Upregulation of collecting duct aquaporin-2 by metabolic acidosis: role of vasopressin -- Amlal et al.
Metabolic acidosis is associated with alteration in fluid and
the effects of metabolic acidosis on urine osmolality and aquaporin-2
ajpcell.physiology.org /cgi/content/abstract/286/5/C1019   (347 words)

  
 ACTOplus met(TM) (pioglitazone HCl and metformin HCl) Now Available in U.S. Pharmacies
Lactic acidosis, a buildup of lactic acid in the blood, can be fatal in about half the cases.
Because lactic acidosis occurs most frequently in people with kidney problems, ACTOplus met should not be used in people with kidney disease or in people 80 years of age and older whose kidneys do not work properly.
ACTOplus met should not be taken by people with metabolic acidosis or with hypersensitivity to pioglitazone, metformin or any other component of ACTOplus met.
www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/11-01-2005/0004205309&EDATE=   (856 words)

  
 Lasix Metabolic Acidosis Results And Resource   (Site not responding. Last check: 2007-11-07)
Bicarbonate concentration, metabolic acidosis, chronic metabolic acidosis, bicarbonatewasting acidosis, hyperchloremic name.
Renal trauma and metabolic acidosis do not affect calcium levels.
Glycolic acid is the major cause of the metabolic acidosis that is seen in ethylene glycol toxicity, although patient has been well hydrated lasix may be used to help maintain.
www.myeyeguru.com /lasix-metabolic-acidosis.html   (1035 words)

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