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Topic: Metabolic disease

In the News (Wed 23 Dec 09)

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	Metabolic Disease - Broad
		Diabetes, obesity and cardiovascular disease are among a group of devastating, common disorders of metabolism that afflict millions of people.
		Members of the Metabolic Disease Initiative are working with the Proteomics Platform to develop a mass spectrometry-based technology for metabolic profiling.
		Using this technology, scientists are dissecting metabolic pathways in cultured cells and discovering novel biomarkers for cardiovascular disease and for inborn errors of metabolism.
	www.broad.mit.edu /metabolic (231 words)

	Metabolic disorder - Wikipedia, the free encyclopedia
		A metabolic disorder is a medical disorder which affects the production of energy within individual human (or animal) cells.
		Most metabolic disorders are genetic, though a few are "acquired" as a result of diet, toxins, infections, etc. Genetic metabolic disorders are also known as inborn errors of metabolism.
		In general, the genetic metabolic disorders are caused by genetic defects that result in missing or improperly constructed enzymes necessary for some step in the metabolic process of the cell.
	en.wikipedia.org /wiki/Metabolic_disease (231 words)

	Metabolic Bone Disease in Exotic Pets
		Metabolic bone disease should be considered to be a disease caused by dietary and husbandry mismanagement.
		Metabolic bone disease occurs as a result of biochemical reactions regulated by the parathyroid glands, small glands located near the thyroid glands in the neck.
		Metabolic bone disease is a common nutritional disease in some birds, most commonly musophagids (turacos, Go-Away Birds and Plantain-Eaters.) MBD is most likely to occur when the natural diet of birds being kept is not known or only partially defined.
	www.exoticpetvet.net /dvms/mbd2.html (3326 words)

	Cardiovascular Disease and Metabolic Syndrome/Syndrome X
		Metabolic Syndrome is characterized by a group of risk factors for damage to the cardiovascular system.
		Compared to people with no Metabolic Syndrome factors, the risk of death from coronary heart disease or forms of Cardiovascular Disease was twice as high for those with one to two symptoms of Metabolic Syndrome and 3.5 times higher for people with full-blown Metabolic Syndrome (three or more symptoms).
		Action centers around managing Metabolic Syndrome to minimize the harmful effect of current symptoms and prevent or at least delay the worsening of underlying conditions that can lead to heart disease.
	www.metabolic-syndrome.insulitelabs.com /Cardiovascular-Disease-and-Metabolic-Syndrome.php (1745 words)

	Metabolic Disease - "Inborn Errors of Metabolism": A Scientist's Discovery
		The parents usually do not have the particular metabolic problem themselves; however, they both carry a "hidden" mutant (changed or abnormal) gene for the disorder that is passed on to the child.
		Metabolism actually is a series of chemical processes through which the body makes use of the nutrients in food to carry out its functions: growing, maintaining healthy tissues, disposing of wastes, producing the energy needed for moving, running, jumping, playing … and the list goes on.
		People who are born with metabolic diseases inherit a genetic mutation (a change) in a specific gene.
	www.humanillnesses.com /original/Men-Os/Metabolic-Disease.html (3361 words)

	Calcium metabolism and metabolic bone disease
		Less common is MBD caused by disease of the kidneys, liver, small intestine, or of the parathyroid or thyroid glands When any of these deficiencies, excesses or organ dysfunctions occur, the normal metabolic processes of the body are disrupted and, as they say, bad things happen.
		In addition, it is used in nearly all of the body's metabolic processes and is important in cellular function It is extracted from foods, and its use is controlled by vitamin D and calcium.
		Diseases which affect the way in which nutrients are extracted from food and metabolized may ultimately affect how calcium is processed in the body.
	www.anapsid.org /mbd2.html (2453 words)

	Metabolic Diseases
		Because three of the children with positive tandem MS metabolic screens did not have fat in their livers, performing postmortem metabolic disease screening on the basis of abnormal liver pathology might not have identified all affected children.
		Newborn screening programs considering including testing for metabolic diseases that can be detected by tandem MS (5) can use these results to estimate the number of children who might benefit from early identification and treatment.
		Second, the contribution of metabolic diseases that can be identified by tandem MS to unexpected deaths might be underestimated.
	www.vaccinetruth.org /metabolic_diseases.htm (1491 words)

	Cardiovascular and Metabolic Disease Research
		Cardiovascular diseases are the most frequent cause of death in Germany.
		Cardiovascular diseases are additionally responsible for enormous costs in the public health system.
		The "Cardiovascular and Metabolic Disease Research" programme is dedicated to finding more efficacious ways to prevent and treat such diseases.
	www.helmholtz.de /en/Research_Fields/Health/Cardiovascular_and_Metabolic_Disease_Research.html;jsessionid=7811D7C980E85576206788A64EB8FDA6 (142 words)

	Shaare Zedek Medical Center - Directors- METABOLIC DISEASE UNIT
		We have identified the disease in about 10 extended families and studied the biochemical abnormalities which are the result of deficiency of lipoamide dehydrogenase.
		We have recently sequenced the entire gene and have shown that the disease in Jews is caused by one common mutation and 2 rare ones.
		This metabolic disease is characterized by recurrent decompensation episodes with severe acidosis, brain damage and renal disease.
	www.szmc.org.il /index.asp?id=109&top=2&page_id=276 (382 words)

	UCSD Medical Center: Neurosciences : Mitochondrial and Metabolic Disease Center
		The Mitochondrial and Metabolic Disease Center (MMDC) at UCSD Medical Center is an international leader in the diagnosis, treatment and research of metabolic disorders.
		Although the words mitochondrial disease hold no meaning for most people, each year nearly 3,000 children are born with it; the mortality for the most severe forms in childhood is up to 50 percent per year.
		If metabolic diseases run in your family, or an infant in your family had an unexplained death or died of SIDS (sudden infant death syndrome), you may want to ask your pediatrician for a referral to our center so your newborn can be tested.
	health.ucsd.edu /specialties/Neuro/MMD.htm (418 words)

	Millennium and Abbott Laboratories Form Strategic Alliance in Metabolic Disease
		Both companies have committed to contributing their metabolic disease research pipelines exclusively to the new partnership with more than 35 projects in the alliance at the outset.
		Metabolic Disease Market More than $100 billion in health-related costs are associated with the morbid consequences of both obesity and type 2 diabetes in the United States.
		Leadership in Metabolic Disease Probably more than any other company in the health care industry, Abbott is uniquely positioned with multi-faceted strength in metabolic diseases.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/03-12-2001/0001445246&EDATE= (1591 words)

	Identification and treatment of metabolic bone disease
		Metabolic bone disease (MBD) is an umbrella term that covers a number of disorders related to the weakening of the bone or impaired systems function caused by an imbalance in vitamin D3, calcium and phosphorus.
		This imbalance may be caused by a lack of or too much of one of these three essential elements or the failure to provide one or more of them in a bioavailable form.
		Signs of metabolic bone disease include hard knobs in the long bones of the legs, bumps along the vertebral column of the back and tail, bilateral softening or hard swelling of the lower jaw, and softening of the plastron or carapace.
	www.anapsid.org /mbd.html (945 words)

	The Mitochondrial and Metabolic Disease Center
		Nonetheless, all of the children had serious mitochondrial and metabolic disease that required the specialized facilities of the Center and the UCSD Biochemical Genetics laboratories, directed by Dr. William Nyhan and Dr. Bruce Barshop, for proper diagnosis and treatment.
		If a child is stricken with a catastrophic disease affecting three or more organ systems, or if a child has been afflicted with a relapsing disease that affects two or more organ systems and leads to slow but measurable deterioration, he or she may have a mitochondrial disease.
		He is nationally known for his basic and clinical work in neurometabolic disease, and has carried out both clinical and bench research on the mitochondrial and metabolic diseases of children for over 20 years.
	biochemgen.ucsd.edu /MMDC/brochure.htm (2246 words)

	Lab Findings in Nutrition and Metabolic Disease
		PHENYLKETONURIA (PKU) is an inherited error of metabolism caused by a deficiency in the enzyme phenylalanine hydroxylase.
		Both diseases are the result of a variety of mutations in the PAH locus; in those cases where a patient is heterozygous for two mutations of PAH (ie each copy of the gene has a different mutation), the milder mutation will predominate.
		Wilson's disease is diagnosed through tests that measure the amount of copper in the blood, urine, and liver.
	www.hoslink.com /LabResults/Nutrition_Metabolic.htm (3909 words)

	Medical Dictionary: Metabolic disease - WrongDiagnosis.com
		Metabolic disease (medical condition): Metabolic disorders refers to diseases or disorders of the internal body chemistry that causes the body's metabolism.
		The term metabolic disorders usually does not include hormonal disorders or endocrine disorders which refer to the interactions between body glands and hormones.
		Metabolic disease: A congenital (due to inherited enzyme abnormality) or acquired (due to failure of a metabolic important organ) disorder resulting from an abnormal metabolic process.
	www.wrongdiagnosis.com /medical/metabolic_disease.htm (225 words)

	Primate Center Aging and Metabolic Disease Research
		The next five years of the study should be even more insightful as the monkeys in the study enter late middle age: During this phase, age-related diseases and disorders appear more frequently, including adult-onset diabetes, osteoporosis, cancers, obesity, the loss of skeletal muscle mass and hypertension.
		A potential long-term application of this study may come through the development of drugs that slow aging by mimicking the biological effects of caloric restriction.
		Osteoporosis is a common disease in which bones become weak and consequently fracture occurs.
	www.primate.wisc.edu /WRPRC/aging.html (566 words)

	About the Center for Osteoporosis and Metabolic Bone Disease
		The Cleveland Clinic Center for Osteoporosis and Metabolic Bone Disease is devoted to the evaluation and treatment of patients with osteoporosis and other forms of diseases that affect bone.
		Since a woman has a greater than 50% chance of having a fracture, this is an important disease to evaluate and treat as early as possible.
		Delaney is a clinical endocrinologist, but solely sees patients with osteoporosis, disorders of calcium metabolism, and metabolic bone diseases.
	www.clevelandclinic.org /arthritis/osteo/about.htm (938 words)

	Genetic Mutations Linked To Rare Metabolic Disease
		It has taken nearly 40 years since the identification of the disease for researchers to trace its cause back to a faulty gene.
		Researchers have known that the disorder was autosomally recessive, that is, it occurs only when a child inherits a bad copy of the gene from each parent.
		This major Finnish mutation, called FM1, is responsible for 91 percent of the disease chromosomes studied during the project.
	www.eurekalert.org /pub_releases/1999-03/OSU-GMLT-030399.php (688 words)

	Facts About Metabolic Diseases of Muscle \| MDA Publications
		Knowing that my disease is rare and hard to diagnose helped me understand why I'd spent so many years believing I needed to "try harder" but only feeling weaker when I did.
		Metabolic muscle diseases affect each person differently, but for most of us, it doesn't limit our lives as much as you may fear.
		Those whose metabolic disease is more disabling will find much support today.
	www.mdausa.org /publications/fa-metab.html (488 words)

	Metabolic Syndrome -- familydoctor.org (Site not responding. Last check: 2007-10-20)
		Metabolic syndrome (also called syndrome X) is a group of risk factors for heart disease.
		Metabolic syndrome results from eating a diet that has too many calories and too much saturated fat, and not getting enough physical activity.
		Not being active is one of the biggest risk factors for heart disease.
	familydoctor.org /826.xml (392 words)

	Team 35: Metabolic Disease Group
		Traditionally thought of as a disease of old age, rather troublingly it is on the rise in the younger age groups (see BMJ 2001;322:377-378).
		The aim of the Metabolic Disease group is to understand the genetic aetiology of complex diseases such as type 2 diabetes, insulin resistance and obesity.
		SNP disease and intermediary phenotype association studies- DNA variants identified from mutation screening of extreme phenotypes and from other sources are tested for association with disease (diabetes and obesity case-control studies) and with intermediary phenotypes (Fig3).
	www.sanger.ac.uk /Teams/Team35 (1353 words)

	Institute of Metabolic Disease (IMD): Supporting the Institute for Metabolic Disease
		The Institute for Metabolic Disease is one of the few centers in the United States where new and effective treatments for inherited metabolic diseases are being developed.
		Metabolic Research funding supports the Institute’s current programs, clinical initiatives and research efforts in metabolic disease.
		The Institute of Metabolic Disease seeks to strengthen the area of expertise of molecular research to accelerate the development of new treatments.
	www.baylorhealth.edu /imd/support.htm (324 words)

	Inherited Metabolic Storage Diseases and BMT - Blood and Marrow Transplantation, Medical School, at the University of ... (Site not responding. Last check: 2007-10-20)
		The International Storage Disease Collaborative Study Group, an international group of researchers and clinicians dedicated to advancing treatment for inherited metabolic storage diseases through collaborative studies and data sharing is based at the University of Minnesota.
		Inherited metabolic storage disease patients referred to Fairview-University Medical Center are assessed by our IMSD Team to customize a treatment plan based upon the patient’s diagnosis and stage of disease.
		In some cases this means monitoring the disease using serial brain scans, enzyme measurements and other tests until it is clear that the time for BMT is right.
	www.bmt.umn.edu /BMT/disease/Metabolic.html (1071 words)

	Metabolic Bone Disease (MBD)
		As the disease progresses further, the opossum may be unable to eat and drink.
		The rate of development of the disease is dependent upon the severity of the calcium deficiency and the age and health status of the opossum.
		Recovery may or may not be complete depending on a number of factors including duration of the disease, diet, overall health, age, parasite load, and any other complicating factors.
	www.opossumsocietyus.org /metabolic_bone_disease.htm (1424 words)

	What Causes Metabolic Syndrome/Syndrome X?
		Metabolic Syndrome creates an increased risk of Cardiovascular Disease, generating symptoms like hypertension (high blood pressure) that can lead to a heart attack and stroke.
		This latter condition is being increasingly identified as an underlying cause of obesity, which, in turn is a crucial factor in heart disease prevention because it inflicts major damage on the cardiovascular system.
		In addition, the imbalance of glucose and insulin can lead to a greater risk of developing Cardiovascular Disease because it causes increased levels of triglycerides, which are fat-storing substances carried through the blood stream to the tissues.
	metabolic-syndrome.insulitelabs.com /What-Causes-Metabolic-Syndrome.php (1466 words)

	Metabolic Disease: Sirna Therapeutics (Site not responding. Last check: 2007-10-20)
		Insulin is necessary for the body to be able to regulate glucose,glucoseA simple sugar that is the main source of energy for the body.
		It is transported in the blood and metabolized in the tissues.
		Of these 20.8 million, 14.6 million people have been diagnosed with the disease and 6.2 million are undiagnosed.
	www.sirna.com /wt/page/metabolic_disease (417 words)

	RepVet - Metabolic Bone Disease (MBD) In Reptiles & Amphibians (Site not responding. Last check: 2007-10-20)
		Metabolic bone disease (MBD) has become a very important issue in the South African lizard market over the last few years.
		MBD is defined as a syndrome including a range of bone diseases associated with metabolic diseases, e.g.
		It is generally a chronic, or long-term result, or combination of a dietary deficiency of calcium or vitamin D, a negative dietary calcium to phosphorus ratio or the lack of exposure to ultraviolet light.
	www.repvet.co.za /health_metabolic_bone_disease_mbd.htm (2248 words)

	Congenital/Metabolic
		There is little information in the literature regarding the usefulness of ultrastructural examination of axillary skin biopsies in the evaluation of metabolic diseases.
		This is a retrospective clinicopathologic review of 143 patients who underwent axillary skin biopsies as part of evaluations for metabolic disease.
		In conclusion, axillary skin biopsy is helpful in the evaluation of some causes of metabolic disease, but often the findings are nonspecific.
	www.thedoctorsdoctor.com /diseases/congenital_metabolic.htm (1414 words)

	eMedicine - Metabolic Disease & Stroke: Methylmalonic Acidemia : Article by Pitchaiah Mandava, MD, PhD (Site not responding. Last check: 2007-10-20)
		Liver transplantation meant to address the issue of metabolic derangement in methylmalonic acidemia did not prevent further neurologic worsening in 1 case or a new metabolic stroke in another case.
		Diabetes, alcoholic ketoacidosis, liver disease, shock, anoxic and/or ischemic injury of tissues, and seizures are often associated with acidosis.
		As mentioned in Mortality/Morbidity, outcomes are better in patients with cobalamin-responsive disease than in those with the cobalamin-nonresponsive disease, in association with dietary changes and supplementation of carnitine and cobalamin.
	www.emedicine.com /neuro/topic576.htm (2582 words)

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