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Topic: Metabolite

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	Make Light Work of Metabolite ID with LightSight™ Software
		Calculate and display all data associated with a given metabolite in a single workspace.
		LightSight™ software’s MS/MS comparison tool enables you to compare metabolite and parent MS/MS spectra more rapidly and to display fragments and neutral losses common to both spectra.
		The animation walks you through the entire metabolite identification workflow using actual data.
	www.drugresearcher.com /news-by-product/productpresentation.asp?id=682&k=LightSight-Metabolite-ID (465 words)

	mslib
		The committee was set up to coordinate the generation of reliable mass spectra of new drugs and metabolite standards, and to make these available to the profession on a timely basis.
		newer drugs, metabolites and some breakdown products was created March 2006.
		It is the responsibility of any end-user of the information, regardless of profession, to ensure that decisions regarding the final identification of drugs or their metabolites are independently verified.
	rd.business.com /index.asp?epm=s.1&bdcq=metabolite&bdcr=2&bdcu=http://www.ualberta.ca/~gjones/mslib.htm&bdcp=&partner=2662601&bdcs=nwuuid-2662601-5A738303-ACB0-FA37-6987-3E7E7578D55D-ym (350 words)

	BioMed Central \| Abstract \| Metabolite coupling in genome-scale metabolic networks
		Metabolite coupling in the studied networks was found to be dominated by a relatively small group of highly interacting pairs of metabolites.
		For metabolite pairs that are not highly coupled, we show that the number of reactions a pair of metabolites shares across a metabolic network closely approximates a line on a log-log scale.
		We provide a measure for determining which metabolite pairs couple more often than would be expected based on their individual connectivity in the network and show that these metabolites often derive their principal biological functions from existing in pairs.
	www.biomedcentral.com /1471-2105/7/111/abstract (373 words)

	Reference.com/Encyclopedia/Secondary metabolite
		Secondary metabolites are those chemical compounds in organisms that are not directly involved in the normal growth, development or reproduction of organisms.
		Secondary metabolites, by contrast, are often species-specific (or found in only a small set of species in a narrow phylogenetic group), and without these compounds the organism suffers from only a mild impairment, lowered survivability/fecundity, aesthetic differences, or else no change in phenotype at all, especially when observed in controlled and optimized laboratory conditions.
		Since secondary metabolites are often created by modified primary metabolite synthases, or "borrow" substrates of primary metabolite origin, these categories should not be interpreted as saying that all molecules in the category are secondary metabolites (for example the steroid category), but rather that there are secondary metabolites in these categories.
	www.reference.com /browse/wiki/Secondary_metabolite (434 words)

	metabolite. The Columbia Encyclopedia, Sixth Edition. 2001-05
		Intermediary metabolites are by far the most common; they may be synthesized from other metabolites, perhaps used to make more complex substances, or broken down into simpler compounds, often with the release of chemical energy.
		A compound that closely resembles a metabolite in molecular structure but is metabolically inactive is called an antimetabolite; such a substance is often used as a drug in the treatment of malignant disease.
		When introduced into the body, it is mistaken by the cell for the metabolite it simulates, thus preventing the cell from using the genuine substance necessary to its life and growth.
	www.bartleby.com /65/me/metabolit.html (488 words)

	metabolite (Site not responding. Last check: )
		A metabolite is a chemical substance in the body that is the product of change or breakdown of another substance by the body's chemical "machinery," that is, something produced by the body's metabolism.
		For example, salicylic acid is a metabolite of aspirin (acetylsalicylic acid), and as is sometimes the case, it is the metabolite - what the body transforms the drug into - that is the active ingredient.
		Another example is the antibiotic amoxicillin - "the pink stuff;" it is metabolized to the metabolite ampicillin, which is the active antibiotic.
	www.drhull.com /EncyMaster/M/metabolite.html (134 words)

	Biotransformation, Excretion Kinetics, and Tissue Distribution of an N-Pyrrolo[1,2-c]imidazolylphenyl Sulfonamide ...
		Because the high-dose male urine (0-48 h) was inclusive of all significant metabolites, it was used for metabolite identification.
		the acidic metabolite (3) and its diastereomer on the HPLC.
		Metabolites 6 and 7 yielded a m/z of
	dmd.aspetjournals.org /cgi/content/full/29/8/1162 (5282 words)

	British Journal of Pharmacology - Abstract of article: Hepatic structure-pharmacokinetic relationships: The hepatic ...
		The hepatic disposition and metabolite kinetics of a homologous series of O-acyl (acetyl, propionyl, butanoyl, pentanoyl, hexanoyl and octanoyl) esters of salicylic acid (C2SA, C3SA, C4SA, C5SA, C6SA and C8SA, respectively) was determined using a single-pass, in-situ rat liver preparation.
		The overall recovery of ester plus metabolite was 89% of the ester dose injected and independent of the ester carbon number, suggesting that ester extraction was due to hepatic metabolism to salicylic acid.
		The metabolite AUC' value increased directly with the lipophilicity of the parent ester (from 0.12 for C2SA to 0.95 for C8SA).
	www.nature.com /bjp/journal/v124/n7/abs/0701961a.html (495 words)

	Dr. Koop - Cozaar Clinical Pharmacology
		Both losartan and its active metabolite are highly bound to plasma proteins, primarily albumin, with plasma free fractions of 1.3% and 0.2%, respectively.
		Following oral and intravenous administration of 14 C-labeled losartan potassium, circulating plasma radioactivity is primarily attributed to losartan and its active metabolite.
		Minimal conversion of losartan to the active metabolite (less than 1% of the dose compared to 14% of the dose in normal subjects) was seen in about one percent of individuals studied.
	www.drkoop.com /druglibrary/43/cozaar-clinical_pharmacology_2.html (517 words)

	metabolite — FactMonster.com
		Intermediary metabolites are by far the most common; they may be synthesized from other metabolites, perhaps used to make more complex substances, or broken down into simpler compounds, often with the release of chemical energy.
		A compound that closely resembles a metabolite in molecular structure but is metabolically inactive is called an antimetabolite; such a substance is often used as a drug in the treatment of malignant disease.
		When introduced into the body, it is mistaken by the cell for the metabolite it simulates, thus preventing the cell from using the genuine substance necessary to its life and growth.
	www.factmonster.com /ce6/sci/A0832877.html (433 words)

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