
	Where results make sense

Topic: Metalloproteinase

In the News (Thu 16 Feb 12)

EXECUTIVE POWER

Iran

ANALYSIS

Pakistan

Family compact

	Metalloproteinase - Wikipedia, the free encyclopedia
		Metalloproteinases (or metalloproteases) constitute a family of enzymes from the group of proteinases.
		Metalloproteinases bind a metal ion such as Zn2+ or Ca2+ in their active site.
		Important metalloproteinases are the bacterial enzyme thermolysin (which is a metalloendopeptidase), the digestive enzymes carboxypeptidase A or B (which are metallocarboxypeptidases), and the matrix metalloproteinases (MMP, also metalloendopeptidases).
	en.wikipedia.org /wiki/Metalloproteinase (306 words)

	Increased Expression of Membrane-Type Matrix Metalloproteinase and Preferential Localization of Matrix ...
		Increased Expression of Membrane-Type Matrix Metalloproteinase and Preferential Localization of Matrix Metalloproteinase-2 to the Neointima of Balloon-Injured Rat Carotid Arteries -- Jenkins et al.
		Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid artery.
		Metalloproteinase Inhibition and the Response to Angioplasty and Stenting in Atherosclerotic Primates
	circ.ahajournals.org /cgi/content/full/97/1/82 (5864 words)

	"RKKH" Peptides from the Snake Venom Metalloproteinase of Bothrops jararaca Bind Near the Metal Ion-dependent Adhesion ...
		in the rattlesnake metalloproteinase structure (31) and is
		of the aspartate (in the peptide derived from the jararhagin metalloproteinase)
		the conformation of the peptide or loop of the metalloproteinase.
	www.jbc.org /cgi/content/full/274/44/31493 (6695 words)

	BLAST Search Results
		Matrix metalloproteinase 1, mRNA 296 4e-78 dbjAB006779.1AB006779 Oryctolagus cuniculus mRNA for matr...
		278 1e-72 embZ12604.1MMSTRMLY3 M.musculus mRNA for stromelysin-3 278 1e-72 gbM25664.1RABSTROM Rabbit metalloproteinase synovial cell...
		4878, mRNA 60 8e-07 gbL36239.1MUSMAT05 Mus musculus metalloproteinase matrily...
	www.chickest.udel.edu /orthomouse/m483.html (2547 words)

	MMP2 - Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) - aka: CLG4A, CLG4 - Cancer ...
		Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma.
		Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis.
		S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme.
	www.cancerindex.org /geneweb/MMP2.htm (642 words)

	Matrix MetalloProteinase In Multiple Sclerosis Abstracts - 2g2
		We have previously demonstrated that Matrix MetalloProteinases (MMPs) are upregulated in Multiple Sclerosis Plaques and DTH lesions.
		Matrix MetalloProteinases (MMPs) are increasingly being implicated in the pathogenesis of several CNS diseases.
		Matrix-degrading MetalloProteinases (MMP) are ProteoLytic Enzymes, which are considered to be key Enzymes in ExtraCellular Matrix (ECM) turnover and mediators of cell migration.
	members.tripod.com /thjuland/mmp2g2.html (3043 words)

	InterPro: IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
		Tissue inhibitors of metalloproteinases (TIMPs, [ 1, 2, 3 ]) and their target matrix metalloproteinases (MMPs, MEROPS peptidase family M10A) are important in connective tissue re-modelling in diseases of the cardiovascular system and in the physiological degradation of connective tissue, as well as in pathological states such as tumor invasion and arthritis.
		IPR001820Proteinase inhibitor I35, tissue inhibitor of metalloproteinase 1-204
		IPR001820Proteinase inhibitor I35, tissue inhibitor of metalloproteinase 1-158
	www.ebi.ac.uk /interpro/IEntry?ac=IPR001820 (3372 words)

	METALLOPROTEINASE INHIBITORS (WO9535275A1)
		In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation.
		Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
		Metalloproteinase inhibitors and intermediates useful for their preparation
	www.delphion.com /details?pn=WO09535275A1 (736 words)

	Paradoxical Effects of a Synthetic Metalloproteinase Inhibitor That Blocks Both P55 and P75 TNF Receptor Shedding and ...
		Paradoxical Effects of a Synthetic Metalloproteinase Inhibitor That Blocks Both P55 and P75 TNF Receptor Shedding and TNFalpha Processing in RA Synovial Membrane Cell Cultures -- Williams et al.
		The metalloproteinase inhibitor BB-2275 blocks MMP activity in synovial joint mononuclear cell culture.
		Stimpson, A.B. McElroy, J.A. Menius, J.J. Jeffreys, R.L. Clark, G.M. McGeehan, and K.M. Connolly (1995) Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor.
	www.jci.org /cgi/content/full/97/12/2833 (6228 words)

	TIMP2 - Tissue inhibitor of metalloproteinase 2 - Cancer GeneticsWeb
		Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma.
		In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis.
		Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
	www.cancerindex.org /geneweb/TIMP2.htm (360 words)

	matrix metalloproteinase
		A member of a group of enzymes that can break down proteins, such as collagen, that are normally found in the spaces between cells in tissues (i.e., extracellular matrix proteins).
		Because these enzymes need zinc or calcium atoms to work properly, they are called metalloproteinases.
		Matrix metalloproteinases are involved in wound healing, angiogenesis, and tumor cell metastasis.
	www.cancersource.com /LibraryAndResources/Dictionary/36,CDR0000044211 (80 words)

	Matrix Metalloproteinase-9 in Lung Remodeling -- Atkinson and Senior 28 (1): 12 -- American Journal of Respiratory Cell ...
		Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones.
		Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin.
		The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between tumor necrosis factor-alpha and interleukin-10.
	ajrcmb.atsjournals.org /cgi/content/full/28/1/12 (7584 words)

	Recombinant Matrix Metalloproteinase-7 (Matrilysin) - ENZ-271 (Site not responding. Last check: 2007-11-01)
		Clinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma.
		The role of matrix metalloproteinase 7 in innate immunity.
		Inhibitory effects of lignans on the activity of human matrix metalloproteinase 7 (matrilysin).
	www.prospec.co.il /~prospec/cart/catalog/rMMP7.html (443 words)

	METALLOPROTEINASE INHIBITORS (WO9535276A1)
		Compounds of general formula (II), wherein X is a hydroxamic or carboxylic acid group, Y is sulphonyl and R1 and R2 as defined in the claims are matrix metalloproteinase inhibitors.
		Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
		Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
	www.delphion.com /details?pn=WO09535276A1 (673 words)

	EMD Biosciences - Calbiochem: Matrix Metalloproteinases (MMPs)
		Matrix Metalloproteinases (MMPs) are a family of zinc metalloendopeptidases secreted by cells, and are responsible for much of the turnover of matrix components.
		The MT-MMPs (Membrane Type Matrix Metalloproteinases) are localized to the cell surface.
		TIMP-3 is localized in the extracellular matrix (ECM), and TIMP-4 is localized mostly in vascular tissue.
	www.emdbiosciences.com /html/cbc/matrix_metalloproteinase_MMP.htm (1236 words)

	ALZET® Bibliography - Administration of Metalloproteinase Inhibitors
		P6498 Nakamura,E.S., Koizumi,K., Kobayashi,M., Saiki,I. Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270.
		P5454 Charoenrat,P., Rhys-Evans,P., Eccles,S. A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
		P4285 Prescott,M.F., Sawyer,W.K., Von Linden-Reed,J., Jeune,M., Chou,M., Caplan,S.L., Jeng,A.Y. Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
	www.alzet.com /bibliography/METALLO.php (808 words)

	Activation of Matrix-Metalloproteinase-2 and Membrane-Type-1-Matrix-Metalloproteinase in Endothelial Cells and ...
		Andersen, K., Maelandsmo, G.M., Hovig, E., Fostad, O., Loennechen, T., and Winberg, J.O. Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associate protein CAPL.
		Lamoreaux, W.J., Fitzgerald, M.E.C., Reiner, A., Hasty, K.A., and Charles, S.T. Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro.
		Lehti, K., Lohi, J., Valtanen, H., and Keski-Oja, J. Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface.
	www.molbiolcell.org /cgi/content/full/12/10/2934 (8014 words)

	Human Endometrial Matrix Metalloproteinase-2, a Putative Menstrual Proteinase . Hormonal Regulation in Cultured Stromal ...
		Woessner (1980) The extraction of a neutral metalloproteinase from the involuting rat uterus, and its action on cartilage proteoglycan.
		Werb (1986) Secretion of metalloproteinases by stimulated capillary endothelial cells II: expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.
		Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts: purification and activation of the precursor and enzymic properties.
	www.jci.org /cgi/content/full/97/2/438 (6534 words)

	Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma ... (Site not responding. Last check: 2007-11-01)
		The effect of age and duration of disease on airway structure in fatal asthma.
		Woessner FJ Jr Matrix metalloproteinases and their inhibitors in connective tissue remodeling.
		Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophages of asthmatics.
	www.arabmedmag.com /issue-31-05-2005/pneumology/main03.htm (2571 words)

	Matrix Metalloproteinase-9 and Tensile Strength of Fetal Membranes in Uncomplicated Labor -- UCHIDE et al. 95 (6): 851 ...
		of tissue inhibitors of metalloproteinases in the rupture of
		Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases-1 levels in amniotic fluids from pregnancies complicated by premature rupture of membranes.
		Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.
	www.greenjournal.org /cgi/content/full/95/6/851 (2404 words)

	Interleukin-13-Dependent Expression of Matrix Metalloproteinase-12 Is Required for the Development of Airway ...
		Coordinate regulation of matrix metalloproteases and tissue inhibitor of metalloproteinase expression in human synovial fibroblasts.
		Inhibition of matrix metalloproteinases prevents allergen-induced airways inflammation in a murine model of asthma.
		Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.
	ajrcmb.atsjournals.org /cgi/content/full/30/1/84 (4539 words)

	Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the ... (Site not responding. Last check: 2007-11-01)
		Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface -- Remacle et al.
		Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase.
		Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
	jcs.biologists.org /cgi/content/full/116/19/3905 (7127 words)

	Matrix Metalloproteinase-26 Is Associated with Estrogen-Dependent Malignancies and Targets {alpha}1-Antitrypsin Serpin ...
		by the enzymes from the Ser and metalloproteinases superfamilies.
		Uria JA, Lopez-Otin C Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity.
		Tunuguntla R, Ripley D, Sang QX, Chegini N Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer.
	cancerres.aacrjournals.org /cgi/content/full/64/23/8657 (6634 words)

	Arch Surg -- Abstract: Prestorage Leukoreduction Prevents Accumulation of Matrix Metalloproteinase 9 in Stored Blood, ...
		tissue inhibitor of metalloproteinase 1 but not matrix metalloproteinase
		Matrix metalloproteinase 9 accumulated in an active form.
		the effects of matrix metalloproteinase 9 on neutrophil apoptosis.
	archsurg.ama-assn.org /cgi/content/abstract/141/4/396 (240 words)

	Amniotic Fluid Matrix Metalloproteinase-9 Levels in Women With Preterm Labor and Suspected Intra-amniotic Infection -- ...
		The matrix metalloproteinases are a family of enzymes that use
		Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases levels in amniotic fluids from pregnancies complicated by premature rupture of membranes.
		Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.
	www.greenjournal.org /cgi/content/full/94/1/1 (2523 words)

	Disruption of the Tissue Inhibitor of Metalloproteinase-1 Gene Results in Altered Reproductive Cyclicity and Uterine ...
		Hampton AL, Butt AR, Riley SC, Salamonsen LA. Tissue inhibitors of metalloproteinases in endometrium of ovariectomized steroid-treated ewes during the estrous cycle and early pregnancy.
		Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the periimplantation period.
		Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1 deficient mice.
	www.biolreprod.org /cgi/content/full/63/3/905 (5481 words)

	Bovine Membrane-Type 1 Matrix Metalloproteinase: Molecular Cloning and Expression in the Corpus Luteum -- Zhang et al. ...
		Identification of matrix metalloproteinases and metalloproteinase inhibitors in bovine corpora lutea and their variation during the estrous cycle.
		Expression of matrix metalloproteinases and their tissue inhibitor messenger ribonucleic acids in macaque periovulatory granulosa cells: time course and steroid regulation.
		Are matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinases 2 (TIMP-2) coordinately expressed with membrane type 1 metalloproteinase (MT1-MMP) in the bovine corpus luteum (CL) during the estrous cycle?.
	www.biolreprod.org /cgi/content/full/67/1/99 (5284 words)

	Matrix Metalloproteinase-9 Expression in Asthma: Effect of Asthma Severity, Allergen Challenge, and Inhaled ...
		Okada, Y, Gonoji, Y, Naka, K, et al Matrix metalloproteinase 9 (92-kd gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells: purification and activation of the precursor and enzymic properties.
		Di Girolamo, N, Tedla, N, Lloyd, A, et al Expression of matrix metalloproteinases by human plasma cells and B lymphocytes.
		Dahlen, B, Shute, J, Howarth, P Immunohistochemical localisation of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma.
	www.chestjournal.org /cgi/content/full/122/5/1543 (4270 words)

	Mature Human Thymocytes Migrate on Laminin-5 with Activation of Metalloproteinase-14 and Cleavage of CD44 -- ...
		Mammalian tolloid metalloproteinase, and not matrix metalloproteinase 2 nor membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin.
		A matrix metalloproteinase expressed on the surface of invasive tumor cells.
		The TIMP2 membrane type 1 metalloproteinase receptor regulates the concentration and efficient activation of progelatinase A: a kinetic study.
	www.jimmunol.org /cgi/content/full/172/3/1397 (6675 words)

	Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis -- Ii et ...
		Burke B. The role of matrix metalloproteinase 7 in innate immunity.
		Jones LE, Humphreys MJ, Campbell F, Neoptolemos JP, Boyd MT. Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival.
		Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.
	www.ebmonline.org /cgi/content/full/231/1/20 (4156 words)

Try your search on: Qwika (all wikis)