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Topic: Metastasis

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	Metastasis definition - Cancer Information (Cancers, Symptoms, Treatment) on MedicineNet.com
		The process by which cancer spreads from the place at which it first arose as a primary tumor to distant locations in the body.
		For example, someone with melanoma may have a metastasis in their brain.
		Metastasis depends on the cancer cells acquiring two separate abilities -- increased motility and invasiveness.
	www.medterms.com /script/main/art.asp?articlekey=4363 (282 words)

	Metastasis
		Cough, shortness of breath due to Lung metastasis
		An effort should be made to determine the extent of every cancer and the potential sites of metastasis must be studied.
		Depending on certain circumstances, treatment of metastatic disease may be accomplished by Surgery, Radiation or Chemotherapy.
	www.tirgan.com /metastasis.htm (192 words)

	ACS :: What Is Bone Metastasis?
		In some cases, the metastasis is discovered before the primary (original) tumor is found.
		Bone metastasis is not the same as cancer that starts in the bone, which is called primary bone cancer.
		Bone metastasis is one of the most frequent causes of pain in people with cancer.
	www.cancer.org /docroot/CRI/content/CRI_2_4_1X_What_Is_bone_metastasis_66.asp (653 words)

	Metastasis
		Metastasis is a very complicated process that still has yet to be completely understood.
		In late stages, patients with oral cancer for example, may succumb to a cancer in the lungs or the brain, which was not the location of the original, primary tumor.
		Metastasis most commonly occurs by way of the bloodstream or the lymphatic system.
	www.oralcancerfoundation.org /facts/metastasis.htm (1751 words)

	Endobronchial Metastasis from Breast Carcinoma (Site not responding. Last check: )
		The incidence of lung metastases is estimated to from 20 to 50% in nonpulmonary primary tumors.
		The incidence endobronchial metastasis is estimated to be approximately 2%.
		Endobronchial metastasis from nonpulmonary cancer is uncommon, occurring in 2-5% of patients with cancer at necropsy.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijpm/vol5n1/breast.xml (634 words)

	Breast cancer metastasis - Papers selected by SciMedWeb® (November-December 2004)
		PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer.
		The Drg-1 gene has been shown to suppress tumor metastasis in animal models of prostate and colon cancer, and the expression of this gene is significantly reduced with advancement of prostate and breast cancers in clinical setting.
		Metastasis is the major cause of mortality and morbidity for patients with cancer.
	www.geocities.com /m.lacroix/2004_6.htm (3400 words)

	BIO349 - Metastasis - Introduction (Site not responding. Last check: )
		Metastasis is the migration of cancer cells from their primary tumor formation site to secondary sites where they then invade normal tissue and begin to proliferate and form new tumors (Tepass, 2001).
		Studies in model organisms, such as the mouse and the fly, have revealed numerous molecules and genes that are involved in cancer formation and metastasis.
		This process, known as metastasis, is caused by changes in the cell-substrate and cell-cell adhesion properties of tumor cells (Tepass, 2001).
	dragon.zoo.utoronto.ca /~B03T9902A/introduction.htm (922 words)

	Breast cancer metastasis - Papers selected by SciMedWeb® (September-October 2002)
		Metastasis to bone occurs frequently in advanced breast cancer and is accompanied by debilitating skeletal complications.
		Maspin is known to be involved in invasion and metastasis, interact with the p53 tumor suppressor pathway, and act as an inhibitor of angiogenesis.
		Metastasis is the process by which tumor cells spread from their site of origin to distant sites after gaining access to the circulatory system.
	www.geocities.com /m.lacroix/2002_5.htm (5526 words)

	Genes That Mediate Breast Cancer Metastasis to Lung
		Metastasis is frequently a final and fatal step in the progression of solid malignancies.
		A biologically meaningful and clinically relevant gene profile that mediates lung metastasis might be expressed uniquely by a subgroup of patients that suffered relapse to the lung and it should be associated with the clinical outcome.
		For lung metastasis formation, 2 105 viable cells were washed and harvested in PBS and subsequently injected into the lateral tail vein in a volume of 0.1 ml.
	www.gordonresearch.com /articles_cancer/genes_mediate_breast_cancer_metastasis_lung.html (5512 words)

	Expression level of integrin 5 on tumour cells affects the rate of metastasis to the kidney
		Tumour metastasis is known clinically to have organ specificity.
		We hypothesised that integrins might be involved in determining the organ specificity of tumour metastasis.
		Kidney metastasis in vivo and the adhesion of
	www.nature.com /bjc/journal/v88/n2/abs/6600710a.html (342 words)

	Information on Symptoms, Diagnosis & Treatment of Bone Metastasis \| NovartisOncology.com
		If bone metastasis affects the bone marrow, other symptoms may be experienced, depending on the type of blood cell affected.
		Conditions other than metastasis, such as arthritis, infections, or previous fractures that have healed, may also be picked up on a bone scan, although the patterns they produce are often different from those produced by cancer.
		Bone metastasis can cause a number of substances, such as calcium and an enzyme called alkaline phosphatase, to be released into the blood in amounts that are higher than normal.
	www.novartisoncology.com /page/bone_metastases.jsp (1900 words)

	CancerQuest : Tumor Biology : Angiogenesis and Metastasis
		The majority of mortality associated with cancer is due to the metastasis of the original tumor cells to sites distant from the initial or primary tumor.
		Metastasis is the process by which cancer cells migrate throughout the body.
		The process of metastasis formation is very inefficient process but leads to the majority of deaths associated with cancer.
	www.cancerquest.org /index.cfm?page=408 (569 words)

	Metastasis (Site not responding. Last check: )
		Metastasis describes when cancer spreads from the organ where it began.
		Overall for metastasis to the lungs, one quarter to one third of patients whose lung tumor is operated on live for five years or longer.
		Doctors reduce the chance of metastasis through removal of a margin of healthy tissue around a tumor, and often chemotherapy and/or radiation.
	tjsamson.client.web-health.com /web-health/topics/GeneralHealth/generalhealthsub/generalhealth/cancer/metastasis.html (819 words)

	Bone Metastasis
		Bone metastasis is one of the most frequent causes of pain in people with cancer.
		Although surgery to remove a primary bone tumor (one that started in the bone) is often done with the intent to cure, the purpose of treating a bone metastasis surgically is to relieve symptoms.
		If you can’t have surgery to reinforce a bone affected by metastasis (because of poor general state of health, other complications of the cancers, or side effects of other treatments) a cast may help stabilize leg bones to reduce pain and avoid the need to stay in bed.
	www.her2support.org /bone2.htm (5231 words)

	Brain-surgery.us ~ Brain surgery, Brain surgeon, Neurosurgery, Neurosurgeon, Brain tumor, Brain tumour, Brain aneurysm, ...
		Metastases (plural of metastasis) are "secondary" tumors that grow at a separate location from the cancer (the "primary" tumor) from which they detached.
		A metastasis arises from a cancer cell that seeded away or detached from the original cancer.
		Pathology studies confirmed metastasis from an esophageal primary.
	www.brain-surgery.us /metastasis.html (3121 words)

	NeurosurgeryToday.org \| What is Neurosurgery \| Patient Education Materials \| brain metastasis
		There is a lower incidence of brain metastasis in children than in adults, with frequencies ranging from 6 percent to 13 percent in children.
		Although brain metastasis occurs at a similar frequency among men and women some differences are seen in the types of primaries responsible for the brain metastasis in the two genders.
		Lung cancer is the most common source of brain metastasis in males, whereas breast cancer is the most common source in females.
	www.neurosurgerytoday.org /what/patient_e/brain1.asp (1000 words)

	Cancer control Journal: Melanoma Metastasis
		The fact that only a small number of cells in a primary tumor can produce metastasis led to the question of whether the development of metastases is due to random survival of few tumor cells or whether it represents the selective growth of unique subpopulations of tumor cells endowed with special properties.
		This pattern of metastasis is determined by interactions between the metastatic cells and the organ environment, possibly in terms of response to local growth factors or inhibitors.
		Site-specific metastasis of mouse melanomas and a fibrosarcoma in the brain or meninges of syngeneic animals.
	www.moffitt.org /moffittapps/ccj/v2n5/article3.html (4134 words)

	Could Massage Therapy Promote Cancer Metastasis
		The processes involved in metastasis are highly complex, and still incompletely understood despite a great deal of research.
		Currently, there is a good prognosis with prompt treatment in cancers limited to local lymph node spread, but with increasingly distant lymphogenous metastasis the survival rate decreases, especially as the neoplastic cells eventually join the bloodstream.
		We will consider the metastasis process to be occurring in three principal stages, and examine the potential impact of massage therapy at each stage.
	www.amtamassage.org /journal/fa_00_journal/cancer_metastasis_1.html (742 words)

	CancerGuide: Brain Metastasis
		The diagnosis of brain metastasis is usually triggered by your reporting symptoms since brain scans are not normally included in routine follow-up testing.
		Treating the Brain Metastasis is The Top Priority: Even if there are tumors elsewhere in the body, the brain metastasis will usually be treated first, both because brain metastasis is life threatening and because the treatment is different from and often incompatible with treatment of tumors elsewhere.
		Appearance of a new brain metastasis would be considered progression in almost all clinical trials and is likely to mean you will be taken off study because of it.
	www.cancerguide.org /rcc_metbrain.html (2885 words)

	UM Comprehensive Cancer Center: Bone Metastasis
		Bone metastasis or "bone mets" occurs when cancer cells from the primary tumor relocate to the bone.
		For the majority of bone metastasis patients, it is still possible to maintain a good quality of life.
		Depending upon where the bone metastasis is located, certain activities may be more difficult or even unsafe.
	www.cancer.med.umich.edu /cancertreat/tissue_bone/bonegeneral.shtml (1023 words)

	Isolated Splenic Metastasis of Sigmoid Colon Cancer: a Case Report -- Okuyama et al. 31 (7): 341 -- Japanese Journal of ...
		Immunohistochemical staining of urokinase-type plasminogen activator (u-PA) of the primary lesion (A), lymph node metastasis (B) and splenic metastasis (C).
		The primary lesion and splenic metastasis were positive for u-PA, whereas lymph node metastasis was negative.
		the incidence of splenic metastasis of colorectal carcinoma
	jjco.oxfordjournals.org /cgi/content/full/31/7/341 (1869 words)

	Cancer Metastasis Research Center - M. D. Anderson Cancer Center
		“The major cause of death from cancer is due to metastases that are resistant to conventional therapeutics; therefore, the primary focus of research in the Cancer Metastasis Research Center is to understand the biology of metastasis.
		To reach this goal, the Center must study the mechanisms responsible for metastasis and for the biological heterogeneity of tumor cells so that more effective treatments can be designed.
		Research has been conducted at the Cancer Metastasis Research Center in the R. “Bob” Smith Research Building for more than two decades, and more than 100 basic researchers and clinical investigators are involved in the effort.
	www.mdanderson.org /Departments/newsroom/display.cfm?id=D5022CB0-50FC-4230-9CCE163B416C373C&method=displayFull&pn=7816F628-61D7-4B3C-88E76EAC5072A6FE (419 words)

	UM Comprehensive Cancer Center: Bone Metastasis
		Bone metastasis or "bone mets" occurs when cancerous cells from the primary tumor relocate to the bone.
		As well as to provide bone metastasis patients and community oncologists a clinic visit where all the opinions necessary and appropriate for this patient population will be given.
		Bone metastasis to the long bones of the arms and legs can cause pain with activity and occasionally that pain can be relieved with rest.
	www.cancer.med.umich.edu /cancertreat/tissue_bone/frequentquestions.shtml (776 words)

	Invasion and Metastases
		Invasion and metastasis are the most insidious and life-threatening aspects of cancer.
		The capacity for invasion may not be expressed initially or in all tumors, hence our ability to cure most in situ lesions with a local intervention.
		Thus, further understanding and molecular dissection of the processes of invasion and metastasis are needed to speed up our progress against cancer (Table 8.1).
	www.ncbi.nlm.nih.gov /books/bv.fcgi?rid=cmed.chapter.2030 (620 words)

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