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Topic: Methotrexate

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Malignancy

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Antimetabolite

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	Methotrexate - Wikipedia, the free encyclopedia
		Methotrexate (rINN) (IPA: [mɛθəˈtrɛkseɪt]), abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases.
		Methotrexate competitively and reversibly inhibits dihydrofolate reductase (DHFR), an enzyme that is part of the folate synthesis metabolic pathway.
		Methotrexate is cell cycle S-phase selective, and has a greater negative effect on rapidly dividing cells (such as malignant and myeloid cells), which are replicating their DNA, and thus inhibits the growth and proliferation of these cells.
	en.wikipedia.org /wiki/Methotrexate (693 words)

	Methotrexate Information on Healthline
		Methotrexate is a folic acid derivative that interferes with folic acid metabolism (folate antagonist).
		Methotrexate is a highly effective chemical compound that targets a specific enzyme required by cells for normalfunction.
		Methotrexate may also be administered in a combination regimen with steroids to produce and maintain rapid remission of certain cancers or as part of an adjuvant therapy regimen with doxorubicin, cisplatin, or the BCD combination of bleomycin, cyclophosphamide, and dactinomycin.
	www.healthline.com /galecontent/methotrexate (1062 words)

	Reproductive Health Technologies Project - Abortion - Methotrexate (Site not responding. Last check: 2007-11-07)
		Methotrexate has been used in the United States since 1953, when it was approved by the FDA to treat certain types of cancer.
		Methotrexate can be taken to end a pregnancy from the time a woman knows she is pregnant up to 49 days after the beginning of her last menstrual cycle.
		Methotrexate should be considered an additional option for women, not as a substitute for either mifepristone or surgical abortion.
	www.rhtp.org /abortion/methotrexate (721 words)

	Patient Education - Methotrexate
		Methotrexate (Rheumatrex) is one of the most effective and commonly used medicines to treat various forms of arthritis and other rheumatic conditions.
		Methotrexate has been associated with cirrhosis (scarring) of the liver, but this side effect is rare and most likely to occur in patients who have underlying liver problems or are taking other drugs that are toxic to the liver.
		Methotrexate can cause serious birth defects and complications during pregnancy, so it is important that you discuss birth control and pregnancy plans with your physician while taking this medication.
	www.rheumatology.org /public/factsheets/methotrexate.asp?aud=pat (883 words)

	Trexall Side Effects, and Drug Interactions - Methotrexate - RxList Monographs
		Methotrexate is partially bound to serum albumin, and toxicity may be increased because of displacement by certain drugs, such as salicylates, phenylbutazone, phenytoin, and sulfonamides.
		Oral antibiotics such as tetracycline, chloramphenicol, and nonabsorbable broad spectrum antibiotics, may decrease intestinal absorption of methotrexate or interfere with the enterohepatic circulation by inhibiting bowel flora and suppressing metabolism of the drug by bacteria.
		Methotrexate may decrease the clearance of theophylline; theophylline levels should be monitored when used concurrently with methotrexate.
	www.rxlist.com /cgi/generic/mtx_ad.htm (1006 words)

	methotrexate (Trexall, Rheumatrex) - drug class, medical uses, medication side effects, and drug interactions by ...
		Recently, methotrexate has been shown to be effective in inducing miscarriage, for example in patients with ectopic pregnancy.
		This effect of methotrexate is attributed to its action of killing the rapidly growing cells of the placenta.
		Methotrexate is used to treat psoriasis, an inflammatory skin disease, as well as the arthritis that occurs in 10 percent of these patients (psoriatic arthritis).
	www.medicinenet.com /methotrexate/article.htm (798 words)

	Methotrexate
		Methotrexate is an anticancer drug used in the treatment of lymphoma (cancer of the lymph nodes) and certain forms of leukemia.
		Methotrexate is also given to treat rheumatoid arthritis when other treatments have proved ineffective, and is sometimes used to treat very severe and disabling psoriasis (a skin disease characterized by thickened patches of red, inflamed skin often covered by silver scales).
		Methotrexate should not be taken by a woman who is breastfeeding; it does pass into breast milk and may harm a nursing baby.
	www.healthsquare.com /newrx/MET1257.HTM (1061 words)

	Methotrexate
		Methotrexate has varying patterns of use for different conditions and the relationship of folic acid to the drug mechanism changes accordingly.
		Initially researchers assumed that methotrexate's effects on folic acid were the source of its presumed benefits in cases of rheumatoid arthritis, as in chemotherapeutic uses.
		Beyond the prevention of methotrexate toxicity, the prevention or treatment of folate deficiency and the prevention of hyperhomocysteinemia further contribute to the therapeutic value of supplementation with high doses of folic acid.
	home.caregroup.org /clinical/altmed/interactions/Drugs/Methotrexate.htm (3748 words)

	Methotrexate
		Methotrexate should only be administered under the supervision of a qualified healthcare provider experienced in the use of this medication.
		Methotrexate is in the FDA pregnancy category X. This means that it is known to cause birth defects in an unborn baby.
		Methotrexate is used to treat certain types of cancer, psoriasis, and rheumatoid arthritis.
	www.drugs.com /methotrexate.html (1526 words)

	Methotrexate for psoriasis - [Medication]
		Methotrexate is a drug taken orally once a week or in 3 divided doses taken at 12-hour intervals during a 24-hour period (for instance, taken at 8 a.m., at 8 p.m., and then again at 8 a.m.).
		Methotrexate slows the rapid growth of skin cells in psoriasis.
		Methotrexate is used to treat severe psoriasis (more than 20% of the skin is affected) when creams, ointments, tar products, and phototherapy have not worked or cannot be used.
	www.bchealthguide.org /kbase/topic/detail/drug/hw58213/detail.htm (372 words)

	Methotrexate. DermNet NZ
		Methotrexate is a successful and popular medicine used for treating severe psoriasis, atopic dermatitis and some other serious or extensive skin conditions.
		Methotrexate is a folate antagonist - this means it prevents the action of an essential B vitamin, folic acid, on cellular function.
		Methotrexate is known to cause birth defects and may cause miscarriage or stillbirth, especially in the first 3 months of pregnancy.
	dermnetnz.org /treatments/methotrexate.html (1270 words)

	Methotrexate - [Medication]
		Methotrexate may be given as a pill or as a shot in the vein (intravenously, or IV) or in the muscle (intramuscularly, or IM).
		Methotrexate may be used alone or with other medicines to control the progression of rheumatoid arthritis.
		Methotrexate is used with leucovorin to end an ectopic pregnancy or to prevent the growth of any fetal cells that are left behind after surgery to end an ectopic pregnancy.
	www.peacehealth.org /kbase/topic/detail/drug/tv6579/detail.htm (449 words)

	Arthritis Research Campaign \| Drugs for Arthritis: Methotrexate (Site not responding. Last check: 2007-11-07)
		Methotrexate is used to treat several different types of rheumatic disease, including rheumatoid arthritis and psoriatic arthritis.
		Methotrexate may also be given once a week by injection – either subcutaneous (an injection under the skin, like insulin injections for diabetes), or intramuscular (into the buttock or thigh).
		Taking methotrexate can affect the blood count (one of the effects is that fewer blood cells are made) and can make you more likely to develop infections.
	www.arc.org.uk /about_arth/infosheets/6247/6247.htm (981 words)

	ACS :: Cancer Drug Guide: methotrexate
		Methotrexate prevents cells from making DNA and RNA by interfering with the synthesis of nucleic acids, thus stopping the growth of cancer cells.
		Methotrexate is given as a pill by mouth, as an injection in a vein for up to 20 minutes, or as an injection into a muscle.
		Methotrexate is an effective drug for many cancers, and is given at doses that are low, medium, and high.
	www.cancer.org /docroot/CDG/content/CDG_methotrexate.asp (964 words)

	Methotrexate for ectopic pregnancy
		Methotrexate stops the growth of rapidly dividing cells, such as embryonic, fetal, and early placenta cells.
		Methotrexate is sometimes used just after surgical treatment to stop the growth of any remaining fetal cells.
		Methotrexate treatment avoids the risks of surgery, may be less likely to damage the fallopian tube than surgery, and may offer a better chance of maintaining your fertility after treatment.
	www.webmd.com /hw/being_pregnant/aa84234.asp (893 words)

	Methotrexate (MTX) for Early Abortion
		In a Methotrexate (MTX) Abortion, it stops embryonic cells from dividing and multiplying and is a non-surgical method of ending pregnancy in its early stages.Within a few days or weeks of receing an injection of Methotrexate (MTX) at the clinic the, the pregnancy ends through an experience similar to an early miscarriage.
		Methotrexate is a FDA approved drug, but is not labeled for use in the termination of pregnancy.
		Methotrexate is given by injection the amount of which is individually calculated by each woman’s weight and height.
	www.fwhc.org /abortion/mtxinfo.htm (1200 words)

	Methotrexate an arthritis drug (Site not responding. Last check: 2007-11-07)
		Originally used as a chemotherapy drug to treat certain kinds of cancer, methotrexate was found to be beneficial in those with inflammatory arthritis and/or psoriasis.
		Injectable methotrexate may usually be self injected after proper instruction from a health care professional.
		Methotrexate should be avoided in those with a history of liver disease.
	www.arthritisinsight.com /medical/meds/mtx.html (528 words)

	Methotrexate
		Methotrexate alters the way in which diseases such as rheumatoid arthritis affect the joints by decreasing the function of the immune system which reduces pain, joint swelling and damage to the cartilage and bone inside the joints.
		Methotrexate can cause a drop in the numbers of white blood cells which are needed to fight infection.
		Methotrexate may decrease fertility and should be avoided in pregnancy and whilst breast-feeding.
	www.rheumatology.org.nz /nz09004.htm (770 words)

	Methotrexate
		An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.
		Methotrexate is in widespread use as second-line therapy for rheumatoid arthritis.
		It is likely that the occurrence of AML in patients with rheumatoid arthritis in the setting of methotrexate therapy represents the coincidence of these two diseases, and does not reflect a causal relationship.
	www.whale.to /a/methotrexate.html (1632 words)

	Methotrexate
		Methotrexate is a yellow powder which, when prepared for use, becomes a clear, yellow liquid, and is given by intravenous route.
		Methotrexate exerts its chemotherapeutic effect by its ability to counteract and compete with folic acid in cancer cells resulting in folic acid deficiency within the cells and causing their demise.
		Most of these complications and side effects of Methotrexate can be either prevented or treated by using Leucovorin, which is normally administered 24 hours after the Methotrexate is given.
	www.tirgan.com /methot.htm (231 words)

	MedlinePlus Drug Information: Methotrexate For Cancer (Systemic) (Site not responding. Last check: 2007-11-07)
		Because methotrexate may cause serious side effects, breast-feeding is generally not recommended while you are taking it.
		The dose that is used may depend on a number of things, including what the medicine is being used for, the patient's size, whether the medicine is being given by mouth or by injection, and whether or not other medicines are also being taken.
		Methotrexate may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202355.html (2096 words)

	Methotrexate for rheumatoid arthritis - [Medication] (Site not responding. Last check: 2007-11-07)
		Methotrexate is given weekly either as a shot (injection) or by mouth (orally).
		Methotrexate is often the first DMARD prescribed for rheumatoid arthritis and usually provides relatively rapid relief of at least some symptoms.
		Methotrexate should not be used by pregnant women or women of childbearing age who are not using reliable contraception.
	www.bcbswny.com /kbase/topic/detail/drug/aa18961/detail.htm (806 words)

	Methotrexate: Facts and details from Encyclopedia Topic (Site not responding. Last check: 2007-11-07)
		Methotrexate (abbreviated MTX; formerly known as amethopterin) is an antimetabolite antimetabolite quick summary:
		An antimetabolite is a chemical with a similar structural to a substance (a metabolite) required for normal biochemical reactions, yet different enough to interfere...
		Pregnancy is the process by which a mammalian female carries a live offspring from conception until it develops to the point where the offspring is capable...
	www.absoluteastronomy.com /encyclopedia/m/me/methotrexate.htm (1775 words)

	Methotrexate : BC Cancer Agency (Site not responding. Last check: 2007-11-07)
		Methotrexate powder is classified as dangerous goods under the Transportation of Dangerous Goods Act and must be declared as such for the purposes of transportation.
		Clearance of methotrexate is delayed in the presence of fluid in the third space (eg, pleural effusions, ascites), and toxicity may be enhanced.
		Cheung reported that mixtures of methotrexate 12 mg, cytarabine 30 or 50 mg, and hydrocortisone sodium succinate 15 or 25 mg in 12 mL of NS, D5W, Ringer's injection or lactated Ringer's were found to be physically compatible in disposable syringes at 25°C for at least 10 hours.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/Methotrexate.htm (2118 words)

	Trexall Online, Description, Chemistry, Ingredients - Methotrexate - RxList Monographs
		Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis.
		Methotrexate tablets, for oral administration, are available in 5 mg, 7.5 mg, 10 mg and 15 mg strengths.
		Each tablet contains methotrexate sodium in an amount equivalent to the labeled amount of methotrexate, and contains the following inactive ingredients: anhydrous lactose, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, pregelatinized starch, sodium carbonate monohydrate, talc and titanium dioxide.
	www.rxlist.com /cgi/generic/mtx.htm (186 words)

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