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Topic: Methuselah Mouse Prize

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Aubrey de Grey

University of Cambridge

England

	Methuselah Mouse Prize - Wikipedia, the free encyclopedia
		The Methuselah Mouse Prize or Mprize is a growing $3.5 million prize started in 2003 to accelerate research into slowing and eventually reversing cellular aging and breakdown in humans.
		The prize is named after Methuselah, a patriarch in the Bible said to have reached 969 years of age.
		For comparison: the mouse strain most often used for studies of lifespan, called "C57Bl/6", has a normal life-span of about 3 years, while mice whose grandparents have been caught in the wild are unharmed by inbreeding and live nearly 4 years on average.
	en.wikipedia.org /wiki/Methuselah_mouse_contest (620 words)

	Reason: Methuselah Mouse: Why you should care about old mice
		That's the goal of the Methuselah Mouse Prize.
		The Methuselah Mouse Prize is chiefly the brainchild of Cambridge University theoretical biogerontologist Aubrey de Grey.
		One is the Postponement Prize, which is awarded "whenever the world record lifespan for a mouse of the species most commonly used in scientific work, Mus musculus, is exceeded." The second one is the Reversal Prize, which will be awarded to researchers whose interventions keep a mature mouse alive significantly longer than expected.
	www.reason.com /rb/rb081804.shtml (671 words)

	Reason
		The prize is named after Methuselah -- the longest-lived human being, according to the Bible, which says he survived 969 years.
		If scientists can reliably lengthen the lives of mice, prize organizers believe, they will be well on their way to finding out how to do the same thing for people.
		But the aim of the Methuselah Mouse Prize is not just to encourage scientists to get involved with anti-aging research; it’s also a stunt aimed at capturing the public’s imagination.
	www.reason.com /0411/ci.rb.build.shtml (311 words)

	FuturePundit: Methuselah Mouse Prize Fund Reaches $1 Million
		Donations for the Methuselah Mouse Prize to extend the lives of mice have reached a commitment level of one million US dollars.
		The M Prize is attracting scientists enticed by the idea that they could simultaneously do scientifically and medically valuable research while also possibly making themselves rich.
		The Methuselah Foundation is a non-profit 501c(3) organization of professional and non-professional volunteers who are dedicated to raising the awareness of the potential for near-term science-based aging interventions using modern technologies.
	www.futurepundit.com /archives/002659.html (880 words)

	First Four Teams of world renowned scientists answer starting gun for competion to win the Methusela
		The prize is structured as a series where many winners are expected, each leap frogging the other as the ages of the mice grow longer and longerall along the way, serious, repeatable research of significant value to reversing human aging will be discovered and applied.
		The Methuselah Mouse competition, the first-ever life extension competition, follows in the footsteps of historical prizes which prove that the impossible can be done thru the right incentives, human genius and the support of visionary financiers.
		Each prize will be awarded from a fund to which everyone who might be aging is encouraged to contribute, initially $5,000 for each prize; the amount won depends on the margin by which the previous record has been broken.
	www.pressbox.co.uk /Detailed/9446.html (1141 words)

	On The Path To Building A Better Mouse -- And Man: Inaugural Methuselah Mouse Prize Awarded To Further Anti-Aging
		Each prize will be awarded from a fund to which anyone can contribute, initially $5,000 for each prize; the amount won depends on the margin by which the previous record has been broken.
		David Gobel, President of the Methuselah Foundation, explains, "The Methuselah Mouse Prize is meant to inspire and encourage serious scientific progress and innovation in extending the healthy human lifespan.
		Current prize sponsors are the Methuselah Foundation, HMX Inc., Dr. Peter Greenman and Diana Stackhouse of the Animal Health Institute.
	www.lef.org /featured-articles/jun2003_mouseandman.html (429 words)

	ImmInst.org -> Is the Methuselah Mouse Prize relevant? (Site not responding. Last check: 2007-11-03)
		Actually the primary goal of the prize is not to develop human aging interventions, although I'm sure many people would like to think that will be the end result. Rather, it is to develop aging interventions in MICE and in doing so, promote research and encourage funding that will lead to real human interventions.
		For me the amount of the Prize is important, and certainly its impact grows larger with that amount, but far more important is the seed of doubt that it sows in the average person's mind that they have to age and die.
		By clarifying that the reversal prize (or one category of the reversal prize) must specifically be performed using a method of gene manipulation that is safe to use with humans (such as somatic gene therapy) you make it very clear where you are going with this.
	www.imminst.org /forum/index.php?act=ST&f=44&t=3883&s= (5446 words)

	ImmInst.org -> Methuselah Mouse Prize (Site not responding. Last check: 2007-11-03)
		We at the Methuselah Foundation are committed to justifying his faith and that of everyone else who has so generously given to see an end to aging.
		This Methuselah Mouse prize is a first step towards engaging and interesting those with much, much more money: a later goal would be setting up multi-million-dollar prizes for proven interventions in the human aging process.
		The mouse prize is mentioned on the front page at the LEF (www.lef.org) as of today, and David tells me that they've been interviewed by Fortune.
	www.imminst.org /forum/index.php?act=ST&f=99&t=1236&hl=&s= (2107 words)

	The Chicago Methuselah Foundation Fund (CMFF)
		The Methuselah Mouse Prize, sponsored by the Foundation, is an effort funded by private donations in an attempt to inspire monumental breakthroughs in the extension of human lifespans.
		The first step toward this purpose is the development of the “Methuselah Mouse,” a mouse that can live up to 5 years, or the equivalent of 180 mouse-years, thereby demonstrating to the general public the feasibility and desirability of life extension technology for humans.
		The Methuselah Foundation is a non-profit endeavor, and all contributions shall be tax-deductible.
	www.geocities.com /chicagomethuselahfund (478 words)

	Anti-aging prize tops $1 million - LiveScience - MSNBC.com
		The Methuselah Mouse Prize, or M Prize as it is popularly known, offers awards to researchers who make significant advances in extending the lives of lab mice -- on the assumption that the work will lead eventually to extended human life.
		The Longevity Prize is for extending the life of a single mouse; the Rejuvenation Prize is for slowing aging in middle-aged mice.
		Funds for the M Prize are solicited from individuals, including a growing group that have pledged to contribute $1,000 a year for the next 25 years.
	www.msnbc.msn.com /id/7142669 (589 words)

	The Methuselah Mouse Prize
		Structured as an improvement on the X Prize model, and enjoying that organization's Peter Diamandis as a chief advisor, the Methuselah Mouse Prize (or M Prize) actually consists of two related prizes.
		The Longevity Prize is to be awarded for the next record in single-animal lifespan in the laboratory mouse, the second Rejuvenation Prize for the greatest extension of lifespan in a mouse that is already elderly.
		On the side of public opinion, the Prize structure, by its nature, captures public imagination and provides a dramatic way to educate the public and media that scientists are working on extending healthy lifespan in mammals.
	www.cron-web.org /m-prize.html (3405 words)

	Myspace.com
		These teams are competing for a prize, a reward for extending the life span of the common mouse from three years to five years.
		The Methuselah Foundation has already raised about 3.5 MILLION DOLLARS for this prize, but this is only the beginning.
		The Methuselah Foundation is asking you to follow in the footsteps of this noble Three Hundred, not to risk your lives, but to provide some of your treasure, so that others may liveand liveand live, so that the human species can beat back not just an army, but the Grim Reaper himself.
	groups.myspace.com /mprize (1071 words)

	Telegraph \| News \| Oldest mouse may give clue to youth
		The dwarf mouse, from a naturally-occurring strain, lives in quiet seclusion and, to ensure he does not get chilled at night, has a large "babysitter" mouse, Princess Leia.
		However, "Yoda is only the second mouse I know to have made it to his fourth birthday without the rigours of a severe calorie-restricted diet", said Prof Miller.
		There is a prize - the Methuselah Mouse Prize - for the oldest lab mouse but Yoda has some way to go.
	www.telegraph.co.uk /news/main.jhtml?xml=/news/2004/04/14/wmice14.xml (276 words)

	A $1,000,000 Mystery Donation in the Fight to Cure Aging : ArriveNet Press Releases : Health (Site not responding. Last check: 2007-11-03)
		The Mprize is a research prize modeled after the successful and influential Ansari X Prize.
		Prizes are awarded to scientists who succeed in extending the healthy life span of mice, or -- perhaps more importantly -- discovering a better method of rejuvenation for already aged mice while repairing the ravages of time and leading to longer, healthier lives.
		This is the true power of the Methuselah Mouse Prize, to demonstrate a proof of principle, and give hope to the world that decline in function and age-related disease are no longer guarantees, for us, or for future generations, if we work together now.
	press.arrivenet.com /health/article.php/717742.html (709 words)

	Fight Aging!: Discussing the Methuselah Mouse Prize Structure
		- a "Postponement Prize" (PP) for the oldest-ever Mus musculus;
		- a "Reversal Prize" (RP) for the best-ever late-onset intervention.
		Donors are given the option of contributing to either prize, and to date most have voted for the Reversal Prize.
	www.fightaging.org /archives/000184.php (897 words)

	Time to Donate to the Methuselah Mouse Prize
		The X Prize (http://www.xprize.org) is a current example of a very successful prize - it grew from $10,000 to $10 million over the past 7 years and is expected to be won in 2004.
		More on this topic here: http://www.longevitymeme.org/topics/research_prizes.cfm Here is my pitch for donations: giving a small donation to the Methuselah Mouse prize is a better long-term use of a few dollars for your health than anything else I can think of.
		The Methuselah Mouse prize is currently the only research prize aimed squarely at the new fields of regenerative medicine and healthy life extension.
	www.usenet.com /newsgroups/sci.med/msg05659.html (403 words)

	Brian.Carnell.Com (Site not responding. Last check: 2007-11-03)
		The Methuselah Mouse Prize is modeled on the X Prize, which set a $10 million prize for the first private craft to make it into space.
		The Methuselah Mouse Prize is targeted at life extension technologies.
		According to the Methuselah Mouse Prize web site, "The intervention must have commenced at an age at least half of the eventual mean age at death of the longest-lived 10% of the control group."
	brian.carnell.com /8255 (271 words)

	FuturePundit: Methuselah Mouse Prize Reaches Half Million Dollar Mark
		The Methuselah Foundation has announced that their Methuselah Mouse Prize award offered to scientists who break records in lab mouse longevity has reached the half million dollar mark in funding.
		Currently, six teams around the world are vying for the prize, and this new contribution is expected to swell that number.
		Your support of the Methuselah Mouse Prize is the best and most effective way that you can help ensure that human biological rejuvenation technologies are developed and widely available as quickly as possible.
	www.futurepundit.com /archives/002372.html (822 words)

	Half-million dollar landmark achieved for the Methuselah Mouse Prize
		The Methuselah Mouse Prize is being offered to scientific research teams who develop the longest living Mus musculus, the breed of mouse most commonly used in scientific research.
		The Methuselah Foundation, a non-profit 501(c)(3) registered organization, is a group of dedicated professional and non-professional volunteers who believe that the control of aging is foreseeable, preserving health and wisdom in a world that sorely needs it.
		The X PRIZE Foundation is a not-for-profit educational organization with headquarters in St. Louis, Missouri.
	www.eurekalert.org /pub_releases/2004-09/mf-hdl092904.php (548 words)

	Antiaging - Prize to End Aging Gets First Media Sponsor...
		TORONTO March 12, 2004--As the well-known X PRIZE comes close to awarding a winner in the private space race, a new prize to spur real antiaging breakthroughs is picking up momentum with its first media sponsor.
		The $10 million X PRIZE will be awarded to the first nongovernmental organization to launch three people into space, return them to Earth and repeat the feat with the same ship in two weeks.
		The Methuselah Mouse Prize is the premier effort of the Methuselah Foundation.
	www.antiagingu.com /newsletters/issue3.html (577 words)

	ScienceDaily: Riverside Professor Receives First Age-Reversal Prize (Site not responding. Last check: 2007-11-03)
		The Methuselah Foundation of Lorton, Va. presented Spindler the prize at a Nov. 21 ceremony during the 2004 Gerontological Society of America Conference in Washington, D.C. The foundation is a nonprofit organization of professional and nonprofessional volunteers who believe that the control of aging is foreseeable.
		The aim of the prize is to speed the development of anti-aging interventions and promote public awareness of the prospects for them.
		Mouse -- The mouse is a mammal that belongs to one of numerous species of small rodents in the genus Mus and various related genera of the family MuridÃ¦ (Old World...
	www.sciencedaily.com /releases/2005/01/050107070512.htm (1917 words)

	Life Enhancement:: The Methuselah Mouse Prize - July 2005
		You may not have heard of the Methuselah Mouse Prize, although Durk Pearson & Sandy Shaw mentioned it in a recent Life Extension News, but you soon will, because MMouse (as he is affectionately called) is coming to a newsstand, TV listing, and even a theater near you (a film is underway).
		It is the hope of the sponsoring organization, the Methuselah Foundation, that whatever the winning interventions are that work in mice will presage the development of interventions that can extend human lifespans as well.
		It is entirely fitting that a prize, the MPrize, should give liftoff to what we believe will be the greatest achievement in human history: the end and reversal of human aging.
	www.life-enhancement.com /LE/article_template.asp?ID=1096 (842 words)

	CNN.com - Mice may hold key to longevity - May 31, 2005
		The M Prize is offered by the Methuselah Project, a privately-funded foundation created to encourage research into aging in the same way the Ansari X Prize spurred the development of privately-funded spacecraft such as SpaceShipOne.
		The prize has two categories: a longevity prize for research in developing mice that live much longer; and a rejuvenation prize for finding ways to extend the life of an adult mouse, which Spindler won.
		Methuselah Foundation co-founder Aubrey de Grey, a biomedical gerontologist at Cambridge University in England, told CNN that he believed human life span could be extended by hundreds of years by the middle of the 21st century.
	www.cnn.com /2005/TECH/05/31/Vision.spindler?section=cnn_space (719 words)

	The Methuselah Mouse Prize (Site not responding. Last check: 2007-11-03)
		The Methuselah Mouse Prize is the premiere effort of The Methuselah Foundation; a scientific competition designed to draw attention to the ability of new technologies to slow and even reverse the damage of the aging process, preserving health and wisdom in a world that sorely needs it.
		A financial award derived from private donations is won by the research team that breaks the record for the world's oldest mouse.
		The Prize will use the ancient incentives of competition, money and fame to harness the power of human ingenuity to fight an ancient problem.
	explorersfoundation.org /glyphery/73.html (142 words)

	Mysteries of the Universe BBS
		The Methuselah Mouse Prize is a growing $3 million prize started in 2003 to accelerate research into slowing and eventually reversing cellular aging and breakdown in humans.
		The prize has been covered in many news sources, including the BBC, the New York Times, and Fortune Magazine, and doubled from $1.5 million USD in August 2005 to $3 million in November 2005.
		The prize is modelled after the highly successful Ansari X Prize, which accelerated efforts to launch a reusable manned spacecraft into space, and did so using orders of magnitude less money than comparable NASA projects.
	disc.server.com /discussion.cgi?disc=159729;article=65586;show_parent=1 (378 words)

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