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Topic: Methylcobalamin

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	Methylcobalamin
		Cyanocobalamin (the kind in vitamin supplements) is converted by the liver into methylcobalamin but not in therapeutically significant amounts.
		Vitamin B12 deficiency is caused by a wide range of factors including low gastric acidity (common in older people,) use of acid blockers such as Prilosec™ or excessive laxative use, lack of intrinsic factor, poor aborption from the intestines, lack of Calcium, heavy metal toxicity, or excessive Vitamin B12 degradation.
		Methylcobalamin donates methyl groups to the myelin sheath that insulates nerve fibers and regenerates damaged neurons.
	www.naturalhealthconsult.com /Monographs/Methylcobalamin.html (288 words)

	http://www.immunesupport.com
		The scientists who conducted the methylcobalamin studies emphasize that ongoing intake of methylcobalamin is necessary to protect against neurotoxicity.
		The scientists stated that ultra-high doses of methylcobalamin might be of clinical use for patients with peripheral neuropathies.
		Since methylcobalamin is not a drug, there is little economic incentive to conduct expensive clinical studies on it, so it may be a long time before we know just how effective this unique form of vitamin B12 is in slowing the progression of common diseases like Parkinson's disease.
	www.immunesupport.com /message/neurob12.htm (1258 words)

	METHYLCOBALAMIN (Site not responding. Last check: 2007-10-31)
		In a study in the European Journal of Pharmacology (1993 Sep.7; 7; 241 (1): 1-6), it was shown that methylcobalamin protected against glutamate-, aspartate- and nitroprusside- induced neurotoxicity in rat cortical neurons.
		The effects of methylcobalamin on human immune function was investigated in the Journal of Clinical Immunology (1982 Apr 2; [2]: 101-109).
		Since methylcobalamin is not a drug, there is little economic incentive to conduct expensive clinical studies on it, so it may be a long time before we know just how effective this form of vitamin B12 is in slowing the progression of common disorders like Parkinson's disease.
	www.internalhealth.com /methylcobalamin.htm (1293 words)

	Methylcobalamin and Diabetic Neuropathy (Site not responding. Last check: 2007-10-31)
		Methylcobalamin caused no side effects with respect to subjective symptoms or characteristics of spinal fluid.
		Methylcobalamin is a form of B12 that is sold as a drug in Japan.
		The liver converts about 1% of ingested cyanocobalamin into methylcobalamin, but it is far more efficient to dissolve a good tasting methylcobalamin lozenge in the mouth for immediately assimilation into the brain.
	laurieulrich.com /jasper/methylcobalaminarticle.htm (2173 words)

	Methylcobalamin - The Way Up
		Methylcobalamin is essential for cell growth and replication.
		Methylcobalamin may exert its neuroprotective effects through enhanced methylation, acceleration of nerve cell growth, or its ability to promote healthy homocysteine levels.
		For methylcobalamin to be available to the brain, it should be allowed to dissolve under the tongue or be taken by injection.
	www.thewayup.com /products/0339.cfm (434 words)

	Methylcobalamin Abstracts
		However, a daily injection of 500 mug/kg of methylcobalamin produced a significant increase in the weight of the soleus muscle which recovered to the extent of being the same weight of the contralateral 4 weeks after the nerve-crush.
		Cyanocobalamin, deoxyadenosylcobalamin and methylcobalamin were separately administered to mice sensitized with the ovalbumin antigen to investigate the allergic response.
		In a single turnover experiment, where enzyme-bound cob(I)alamin is generated from methylcobalamin by methyl transfer to the substrate homocysteine, the cob(I)alamin decays to cob(II)alamin, suggesting that the degradation of nitrous oxide involves one-electron reduction of nitrous oxide.
	www.integratedhealth.com /infoabstract/cobalab.html (5878 words)

	Methylcobalamin and Diabetic Neuropathy (Site not responding. Last check: 2007-10-31)
		Methylcobalamin caused no side effects with respect to subjective symptoms or characteristics of spinal fluid.
		Methylcobalamin is a form of B12 that is sold as a drug in Japan.
		The liver converts about 1% of ingested cyanocobalamin into methylcobalamin, but it is far more efficient to dissolve a good tasting methylcobalamin lozenge in the mouth for immediately assimilation into the brain.
	www.laurieulrich.com /jasper/methylcobalaminarticle.htm (2173 words)

	NAP: Active B12
		Although methylcobalamin and adenosylcobalamin are both considered to be active forms of B12, they do appear to offer slightly different health advantages.
		Methylcobalamin has been shown to be an important vitamin in helping to establish and maintain an appropriate balance between these two opposing nervous systems.
		Because of methylcobalamin's impact on 24-hour clock and the cycles that feed of this, it is also an important vitamin to regulate your 24-hour release of the stress hormone cortisol.
	www.dadamo.com /napharm/store3/template2/b12.htm (2283 words)

	Dr. Michael T. Murray: Methyl-B12 Can Improve Alertness and Concentration (Site not responding. Last check: 2007-10-31)
		Methylcobalamin is preferred over adenosylcobalamin as 90% of the body's active B12 is in this form and methycobalamin is easily converted to adenosylcobalamin.
		Methylcobalamin supplementation led to a significantly improved sleep quality, shorter sleep cycles, increased feelings of alertness, better concentration, and a feeling of waking up refreshed in the morning.
		Methylcobalamin has also shown to help some people suffering from what is referred to as sleep-wake disorder.
	www.vitaminexpress.com /drmurray/drmurraymethylb-12canimprovealertnessandconcentration.htm (1121 words)

	Methylcobalamin: by Ray Sahelian, M.D., cobalamin benefits
		Methylcobalamin is the active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of homocysteine to methionine, thus lowering blood levels of homocysteine.
		Methylcobalamin taken orally is effective in the treatment of pernicious anemia, says a Japanese study.
		This Account focuses on the role of methylcobalamin and its structural homologues, the methylcorrinoids, as intermediaries in methyl transfer reactions, and particularly on the reaction catalyzed by cobalamin-dependent methionine synthase.
	www.raysahelian.com /methylcobalamin.html (2139 words)

	Methylcobalamin Concentrated Powder Printable Version
		Cyanocobalamin is converted to methylcobalamin in the liver, but not in amounts that are considered therapeutically significant.
		Methylcobalamin is also the form of B-12 which is most active and extremely important in folate chemistry and methylation processes in the body.
		Kirkman Methylcobalamin Concentrated Powder is a good tasting, quick dissolving powder which can be dissolved under the tongue or mixed in drinks if consumed immediately.
	www.kirkmanlabs.com /products/vitamins/print/methyl.html (215 words)

	Vitamins - Methylcobalamin (B-12) 5000mcg (5mg) (60 Sublingual Lozenges) - Health food store products from FeelGood ...
		Methylcobalamin is the neurologically active coenzyme form of vitamin B12.
		Safe at one half of one tablet daily.Adenosylcobalamin (the other coenzyme form of vitamin B12) in the liver and mitochondria, Methylcobalamin is located in fluids like the cerebrospinal fluid and plasma, and is urinated out rather than stored.
		In animal and test-tube studies, Methylcobalamin has been shown to protect nerve cells against a wide variety of hostile environmental situations, including lack of vital cellular fuel, thiamine deficiency (which normally causes degeneration of the nervous system), oxygen starvation, and exposure to toxins like methylmercury, botulin, or nitroprusside, and the excitotoxic nerotransmitter glutamate.
	www.feelgoodnatural.com /catalogue/JAR991.html (286 words)

	The Wonders of (methyl) Vitamin B 12 - The Compounder Pharmacy - Aurora, IL - 630-859-0333 (Site not responding. Last check: 2007-10-31)
		Methylcobalamin is one of the two coenzyme forms of vitamin B12 (the other being adenosylcobalamin).
		Although the exact mechanism of action is not yet elucidated, it is possible that Methylcobalamin is needed for the synthesis of melatonin, since the biosynthetic formation of melatonin requires the donation of a methyl group.
		Methylcobalamin has been administered orally, intramuscularly, and intravenously; however, positive clinical results have been reported irrespective of the method of administration.
	www.thecompounder.com /methylcobalamin.html (970 words)

	A Study of Vitamin B12 in Cancer Cells
		Methylcobalamin is one of the coenzymatically active cobalamin derivates and required for the activity of the cytoplasmic enzyme methionine synthetase catalyzing the methylation of homocysteine into methionine.
		Methylcobalamin inhibited the proliferation of androgen-sensitive SC-3 cells (a cloned cell line from Shionogi mouse mammary tumor, SC115) in culture at the concentration of 100-300 micrograms/ml.
		These results show that methylcobalamin inhibits the proliferation of malignant cells in culture and in vivo and propose the possibility of methylcobalamin as a candidate of potentially useful agents for the treatment for some malignant tumors.
	www.annieappleseedproject.org /studofvitb12.html (241 words)

	Global Healing Center
		Methylcobalamin is the active form of vitamin B-12 that is better absorbed than many of the other forms like cyanocobalamin.
		Methylcobalamin is important because it is delivered more efficiently to nerve tissues than regular B-12.
		In a sleep study it was shown that Methylcobalamin reduced the amount of time the subjects slept, but the sleep quality was better and subjects awakened refreshed with better alertness and concentration.
	www.natural-acne-treatment-solutions.com /jun-00.html (2933 words)

	Vitamin B12, methylcobalamin, Folic acid, B6, lower homocysteine level
		Methylcobalamin B-12 provides an infusion of B vitamins (B6, B12, and folic acid) directly into the bloodstream.
		Methylcobalamin B-12 is Sublingual Methylcobalamin B-12 with B-6 and Folic Acid.
		Methylcobalamin is a form of vitamin B-12 active in the central nervous system.
	www.ghchealth.com /methylcobalamin-sublingual-b12.php (709 words)

	Methylcobalamin B12
		Methylcobalamin (methyl B12) is the neurologically active, most bioavailable and best utilized form of vitamin B12.
		Effects of methylcobalamin on the proliferation of androgen-sensitive or estrogen-sensitive malignant cells in culture and in vivo.
		Effect of ultra high dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study.
	www.diabeticneuropathy.org /b12-reversing-tissue-damage.htm (1089 words)

	METH8 - Methylcobalamin 1000 mcg 60 - M - General Supplements - Vision Supplements - NaturalEyeCare
		Description: Methylcobalamin 60 vcaps The vitamin B12 family is generally referred to as the cobalamins, with cyanocobalamin as the most common form.
		Methylcobalamin helps moderate levels of glutamate in the brain, providing support for normal brain cell activity.
		As a result, methylcobalamin has been shown to encourage healthy cognitive, memory, emotional, and nerve function.
	www.naturaleyecare.com /store/detail.aspx?ID=1602 (122 words)

	Methylcobalamin
		Methylcobalamin is the neurologically active form of vitamin B12.
		Vitamin B12, methylcobalamin, and coenzyme B12 (methylcobalamin) were found to enhance significantly the de novo DNA methylation in the presence of S-adenosylmethionine for concentrations up to 1 microM, but at higher concentrations these compounds were found to inhibit DNA methylation.
		Methylcobalamin behaves as a competitive inhibitor of the enzymatic methylation reaction (Ki = 15 microM), the Km for S-adenosylmethionine being 8 microM.
	www.lifeextensionvitamins.com /lifeextensionvitamins/metcob1.html (1324 words)

	B12 Methylcobalamin Spray
		Methylcobalamin is the most absorbable form of B-12.
		Oral methylcobalamin works as well as injections, with the added feature of maintaining high levels in the blood over time.(3) Methylcobalamin is believed to help protect brain cells against glutamate toxicity.(5) Scientists emphasize ongoing intake of methylcobalamin is necessary to protect against neurological disease.(5) That means daily supplementation may be required.
		High doses of methylcobalamin have been used to treat degenerative neurological disease.(1) People with lateral sclerosis (Lou Gehrig’s disease) took 25mg of methylcobalamin for a month.
	www.vegfamily.com /b12-spray.htm (408 words)

	Amyotrophic Lateral Sclerosis (ALS), Part 4 - Protect and Regenerate Neurons
		A study investigated the daily administration of 60 mg of methylcobalamin to patients with chronic progressive multiple sclerosis (MS), a disease that has a poor prognosis and widespread demyelination in the central nervous system.
		In mice receiving methylcobalamin, nerve sprouts were more frequently observed, and the regeneration of motor nerve terminals occurred in sites that had previously been in a degenerating state (Yamazaki et al.
		Two studies showed that the administration of methylcobalamin caused significant increases in the in vivo incorporation of the amino acid leucine into the crushed sciatic nerve.
	www.lifeextensionvitamins.com /amlascapa4pr.html (3443 words)

	ABSORB12 BIOSPRAY AND METHYLCOBALAMIN (Site not responding. Last check: 2007-10-31)
		Methylcobalamin in AbsorB12 Biospray is made available for absorption by the mucosa of the mouth.
		Methylcobalamin is the most potent form of Vitamin B12 found in nature.
		Methylcobalamin is the only active form of Vitamin B-12 in the brain outside the mitochondrion.
	www.mend.net /AbsorB12.html (1046 words)

	Sublingual Vitamin B 12 / B12 Methylcobalamin Supplements - Order
		The neurologically active form of vitamin B 12 (methylcobalamin), is the recommended form to consume.
		It is the methylcobalamin form of B12 that has been used in most European and Japanese studies showing efficacy.
		The liver converts about 1% of ingested cyanocobalamin into methylcobalamin, but it is far more efficient to dissolve a good tasting methylcobalamin lozenge or liquid in the mouth for immediate assimilation into the brain.
	www.smartbodyz.com /vitamin-B12-order.htm (881 words)

	B12 Sublingual (Methylcobalamin) 1,000 mcg
		A superior form of vitamin B12 called Methylcobalamin that simply dissolves under your tongue appears to have advantages over all other forms of B12, including injections given by your Doctor.
		Methylcobalamin is active immediately upon absorption, while other forms (ie; cyanocobalamin) must be converted to methylcobalamin in a two step process.
		Methylcobalamin demonstrates exceptional activity in areas where other forms are simply not active.
	www.betterlife.com /prod_home_page.asp?prod_id=14009 (111 words)

	Vitamin B12 - metal disturbs transport!
		In the south of Europe, however, methylcobalamin is generally used to treat disorders such as neuritis and polyneuropathia.
		Methylcobalamin should be obtained with dry substance and liquid packed separately to increase the shelf life.
		In Dr. Ahlrot-Westerlund's opinion, however, methylcobalamin for patients with metal-induced disorders should be given daily intramuscularly* in doses of 10 mg with 8 x 5 mg oral folic acid and 300 mg vitamin B6 for 6 days a week until a positive effect is achieved and then continued until no further peak is achieved.
	www.algonet.se /~leif/fub12kau.html (1912 words)

	Vitamin B12 (Site not responding. Last check: 2007-10-31)
		Methylcobalamin is a co-factor of methionine synthase, an enzyme that transfers methyl groups to homocysteine to regenerate methionine.
		Methylcobalamin was effective at elevated concentrations and cyanocobalamin had no effect in slowing the growth of any of the tumor cell lines studied.(6) In studies that show that vitamin B12 has no effect on cancer growth, we need to look closer at whether cyanocobalamin was used instead of the natural coenzyme forms (adenoxylcobalamin and methylcobalamin).
		In conclusion, methylcobalamin can be effective in cases of neuropathy, depression, cancer, optic atrophy, heart rate variability, homocysteinemia, and sleep disturbances.
	www.strokedoctor.com /vitamin_b12.htm (1811 words)

	Neuro B-12, Methylcobalamin
		A study published in the journal Neuropharmacology showed that methylcobalamin reduced the amount of time subjects slept; sleep quality was better, and subjects awoke feeling refreshed, with better alertness and concentration.
		Part of this effect was due to melatonin suppression during the daytime, because methylcobalamin supplementation reduces drowsiness by apparently decreasing daytime melatonin levels.
		In general, supplementation with methylcobalamin is an effective way to provide the bioactive form of B12 throughout your entire body for maximum benefits.
	www.immunesupport.com /shop/product.cfm?product__code=P279N (362 words)

	Vitamin B12
		Methylcobalamin is a cofactor for the enzyme methionine synthase, while adenosycobalamin is a cofactor for the enzyme L-methylmalonyl coenzyme A (methylmalonyl-CoA) mutase.
		Methylcobalamin is also available for nutritional supplementation and hydroxocobalamin is available for parenteral administration.
		Cobalamin is metabolized to methylcobalamin in the cytosol and to adenosylcobalamin in the mitochondria.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/vit_0262.shtml (5214 words)

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