
	Where results make sense

Topic: Microcins

In the News (Fri 27 Nov 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	BioPortfolio News : Chromosome-encoded microcins may constitute a defined subgroup of peptide antibiotics
		"Microcins are ribosomally synthesized peptide antibiotics that are produced by Enterobacterial strains.
		Microcins thus acquire the ability to enter gram-negative cells through the catechol receptors.
		The researchers concluded: "The results presented herein lead us to propose that chromosome-encoded microcins constitute a defined subgroup of peptide antibiotics which are strictly related by their modes of synthesis, secretion, and uptake."
	www.bioportfolio.com /June_06/26_06_2006/Chromosome_encoded_microcins.html (374 words)

	Microcins Bacteria
		Microcins are very small bacteriocins, composed of a relatively few peptides.
		For this reason, they are distinct from their larger proteincousins.
		The classic example is microcin V, of E.
	www.lumrix.com /medical/bacteria/microcins.html (61 words)

	Laboratory of Gene Expression regulation
		Microcins are antibiotics of interesting and unusual structure having a broad spectrum of action directed predominantly against Gram-negative bacteria.
		The operon was sequenced, and polypeptides involved in the microcine biosynthesis and immunity to the microcin of strain producer cells were identified.
		The expression of this operon was found to be activated upon the culture transition to the stationary growth phase and to occur with the involvement of four global transcription regulators: the RNA polymerase sigma S subunit, CRP proteins (inducer), H-NS and Lrp (repressors).
	www.img.ras.ru /2-6-3-e.htm (704 words)

	IngentaConnect Posttranslationally modified microcins
		Microcins are antibacterial compounds that are encoded in the bacterial genome and synthesized via ribosomal translation.
		Microcins play an important role in microbial ecology and are promising as antibiotics.
		These microcins are unusual in structure and inhibit the grown of sensitive cells by entering their cytoplasm and affecting intracellular targets, such as DNA gyrase, DNA-dependent RNA polymerase, and aspartyl-tRNA synthase.
	www.ingentaconnect.com /content/maik/ruge/2006/00000042/00000012/00012004 (149 words)

	Bacteriocin - Wikipedia, the free encyclopedia
		These include the bacteriocins of gram-positive bacteria, the colicins, the microcins, and the bacteriocins of Archaea.
		They are a diverse group of bacteriocins and do not include all the bacteriocins produced by E.
		In fact, one of the oldest known so-called colicins was called colicin V and is now know as microcin V. It is much smaller and produced and secreted in a different manner than the classic colicins.
	en.wikipedia.org /wiki/Bacteriocin (957 words)

	Comparative Analysis of Chromosome-Encoded Microcins -- Poey et al. 50 (4): 1411 -- Antimicrobial Agents and ...
		Alignment of the amino acid sequences of microcins H47, E492, and M peptide precursors and of MchS2.
		Microcin H47, a chromosome-encoded microcin antibiotic of Escherichia coli.
		The structural gene for microcin H47 encodes a peptide precursor with antibiotic activity.
	aac.asm.org /cgi/content/full/50/4/1411 (4216 words)

	Antibacterial Activity Evaluation of Microcin J25 against Diarrheagenic Escherichia coli -- Sable et al. 66 (10): 4595 ...
		Microcins and colicins are classical bacteriocins produced by Enterobacteriaceae that inhibit E.
		The objective of the present study was to evaluate the inhibitory activity of microcins, particularly J25, against DEC strains.
		Purification of microcin J25 and analysis of its antagonistic properties against DEC. A culture (18 h, 37°C) of the J25 producer in M63 medium was centrifuged (13,000 × g, 30 min, 10°C) and heated (10 min, 120°C).
	aem.asm.org /cgi/content/full/66/10/4595 (1473 words)

	Biological control of food pathogens in livestock - Patent 6083500
		The term microcin is sometimes applied to antibiotic substances produced by diverse strains of Enterobacteriaceae able to pass through dialysis membranes having a molecular weight cut-off of about 10,000 daltons and produced during stationary phase culture.
		Microcin 24 is the same as "colicin 24" (O'Brien et al.
		Microcin 24 (also abbreviated Mcc24) is the term given to the bactericidal substance first characterized by O'Brien et al, supra, who called it "colicin 24."
	www.freepatentsonline.com /6083500.html (3603 words)

	The colicin G, H and X determinants encode microcins M and H47, which might utilize the catecholate siderophore ...
		Export of colicin V is mediated by CvaA/B, of microcins H47 and M by MchE/F, of microcin E 492 by MceH/G, and of microcin 24 by MtfA/B. Downstream of mchF, the genes encoding microcin M, mcmA [the
		McmA is microcin M, and McmI is the immunity protein; MchB is microcin H47, and MchI is the immunity protein; CvaC is colicin V, and Cvi is the immunity protein; MceA is microcin E492, and MceB is the immunity protein; MtfS is microcin 24, and MtfI is the immunity protein.
		microcin M/H47 gene cluster from the colicin-G- and colicin
	mic.sgmjournals.org /cgi/content/full/149/9/2557 (6361 words)

	Natural Biologically Active Products from Microbes (Site not responding. Last check: 2007-10-12)
		Lantibiotics are produced by Gram-positive bacteria and microcins are produced by Gram-negative bacteria.
		Both lantibiotics and microcins possess an ability to form pores or punch holes in membranes of susceptible microorganisms.
		This property is of interest to the food industry, as bacteriocins are produced by Lactococcus spp., which are used in the preservation of various foodstuffs.
	www.naturalbioskincare.com /allnaturalskincareproduct/microbes.html (891 words)

	micbio2_4p150abs (Site not responding. Last check: 2007-10-12)
		Microcin biosynthesis was stimulated by a deficiency of nutrients in the
		The microcins were found to be resistant to thermolysin but were degraded by pronase, pro-
		This indicated that the microcins are peptides or
	www.maik.rssi.ru /cgi-bin/search.pl?type=abstract&name=micbio&number=2&year=4&page=150 (201 words)

	[No title]
		The nature of microcin production in E. coli is fundamentally different from the nature of colicin production in that the cell secretes microcins and microcin production is intimately associated with iron uptake.
		The host’s ability to sequester iron is an important defence against bacterial infection and the traits that bacteria have evolved to acquire this sequestered iron are vital determinants of a strain’s ability to cause disease.
		The differences between colicins and microcins are such that our conceptual model of colicin dynamics is not a suitable paradigm for understanding the role that microcins play in E. coli populations.
	www.anu.edu.au /BoZo/staffandstudents/staffprofiles/gordon/Theme1.doc (514 words)

	Possible New Pathway To Multidrug Resistance Found
		The compound, known as microcin 24, is an antimicrobial peptide secreted by a strain of E. coli that causes urinary tract infections.
		Many bacteria produce microcins as a means of disabling and competing with nearby bacteria.
		In this study, the researchers were testing Salmonella to see if they developed resistance to microcin 24.
	unisci.com /stories/20013/0815012.htm (214 words)

	mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks ...
		mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid.The position of the gene responsible for suppression, designated mprA, was determined by insertional mutagenesis and deletion analysis.
		A well-characterized deficient-immunity phenotype is exhibited by microcin B17-producing cells in the absence of the immunity gene mcbG (M.C. Garrido, M. Herrero, R. Kolter, and F. Moreno, EMBO J. Increased mprA gene dosage also caused a decrease in microcin C7 production and blocked the osmoinduction of the proU locus in high-osmolarity media.
		Microcins B17 and C7 are plasmid-determined, peptide antibiotics produced by Escherichia coli when cells enter the stationary phase of growth.
	www.ihop-net.org /UniPub/iHOP/gp/2087.html (244 words)

	Antibiotic Resistance: Bacterial 'Insults' Induce Drug Resistance, August 20-27, 2001 (Site not responding. Last check: 2007-10-12)
		Researchers from the U.S. Department of Agriculture and the University of Iowa report in the August 2001 issue of the journal Applied and Environmental Microbiology that Salmonella bacteria exposed to a compound secreted by a strain of Escherichia coli can develop multidrug resistance.
		The compound, known as microcin 24, is an antimicrobial peptide secreted by a strain of E.
		Many bacteria produce microcins as a means of disabling and competing with nearby bacteria.
	www.obgyn.net /NewsRX/general_health-Antibiotic_Resistance-20010827-3.asp (255 words)

	Identification and Properties of the Genes Encoding Microcin E492 and Its Immunity Protein -- Lagos et al. 181 (1): 212 ...
		Microcin E492 is a low-molecular-weight channel-forming bacteriocin (21) produced by Klebsiella pneumoniae that is active
		Hydropathy was calculated by the method of Kyte and Doolittle (20) with a span length of 13 amino acid residues and by using a linear weight variation model.
		The activity of microcin E492 from Klebsiella pneumoniae is regulated by a microcin-antagonist.
	jb.asm.org /cgi/content/full/181/1/212 (4458 words)

	Tips from the Journals of the American Society for Microbiology: August 2001
		The compound, known as microcin 24, is an antimicrobial peptide secreted by a strain of E. coli that causes urinary tract infections.
		In this study, the researchers were testing Salmonella to see if they developed resistance to microcin 24.
		Not only did they develop resistance to the microcin but also to multiple antibiotics.
	www.eurekalert.org /pub_releases/2001-08/asfm-tft080701.php (719 words)

	Microcins at AllExperts
		Microcins are very small bacteriocins, composed of a relatively few peptides.
		For this reason, they are distinct from their larger protein cousins.
		The classic example is microcin V, of E.
	en.allexperts.com /e/m/mi/microcins.htm (104 words)

	Siderophore Peptide, a New Type of Post-translationally Modified Antibacterial Peptide with Potent Activity -- Thomas ...
		belonged to a class of unmodified microcins (2).
		Compositions are calculated from duplicate (MccE492-(74–84) and MccE492m-(74–84) fragments) or quintuplicate (microcins) 24-h HCl hydrolysates.
		The presence in the microcin gene cluster of the mceD gene,
	www.jbc.org /cgi/content/full/279/27/28233 (5411 words)

	Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays ...
		Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity -- Blond et al.
		Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity
		Milne, J.C., Roy, R.S., Eliot, A.C., Kelleher, N.L., Wokhlu, A., Nickels, B. and Walsh, C.T. (1999) Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17.
	content.febsjournal.org /cgi/content/full/269/24/6212 (5932 words)

	Microbe Magazine
		They propose a new model to explain how this toxin of Klebsiella pneumoniae, microcin E492, enters cells, inserts itself into inner membranes, and exerts its toxic effects against various Enterobacteriaceae.
		Ordinarily, many microcins target other bacterial species, producing ion channels and depolarizing target cell membranes.
		A sidelight from earlier research by Biéler is that this microcin is an amyloid-like protein, meaning it resembles proteins that form plaques in the brains of people with Alzheimer’s disease.
	www.asm.org /news/index.asp?bid=46543 (460 words)

	Amazon.com: Bacteriocins, Microcins and Lantibiotics (Nato a S I Series Series H, Cell Biology): Books: Richard ... (Site not responding. Last check: 2007-10-12)
		Presented here are recent findings on bacteriocins: plasmid-encoded toxins produced by bacteria, which differ from traditional antibiotics in killing only bacteria that are closely related to the producing strain.
		Included are introductory chapters on bacteriocins, microcins (low molecular weight bacteriocins), and lantibiotics (peptide antibiotics containing lanthionine), further, contributions on pore forming bacteriocins, the mechanisms of immunity to bacteriocins, uptake and secretion, as well as evolution of bacteriocins.
		It is of particular interest that the lantibiotic nisin is approved for use as food preservative and another lantibiotic, epidermin, has potential as a therapeutic drug against acne.
	www.amazon.com /Bacteriocins-Microcins-Lantibiotics-Nato-Biology/dp/0387546049 (685 words)

	[No title] (Site not responding. Last check: 2007-10-12)
		The story explains that a team led by microbiologist Steve Carlson at the U.S. Department of Agriculture's Agricultural Research Service lab in Ames, Iowa, was interested in harnessing microcins as antibiotics but wondered whether bacteria would eventually learn how to evade these too.
		To test this, the researchers used two bacteria that both live in the gut: a strain of Escherichia coli that secretes microcin 24 and a Salmonella enterica strain that is susceptible to it.
		The explanation, the team figured, could be that the microcin turned on the so-called multiple antibiotic resistance system, a pump that some bacteria use to get rid of almost anything harmful.
	archives.foodsafetynetwork.ca /animalnet/2001/8-2001/an-08-29-01-01.txt (3650 words)

	microcinas - microcins (Spanish to English translation glossary) Medical: Pharmaceuticals,Medical
		The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.
		A number of gram-negative bacteria are capable of synthesizing the low molecular mass antibiotics microcins, the substances with molecular masses up to 10...
		Sorry, the correct spelling is microcins, as given by Marina.
	www.proz.com /kudoz/1293054 (190 words)

	[No title] (Site not responding. Last check: 2007-10-12)
		Furthermore, a DNA microarray-based comparison of this strain with 9a5c, a CVC strain which is highly pathogenic and had its genome completely sequenced, revealed that 56 coding sequences (CDS) of strain 9a5c are absent from strain J1a12.
		Among these, 10 CDS can be directly related to the successful establishment and spreading of bacteria in the plant xylem, as they encode two fimbrial adhesin precursors, one fimbrial structural protein, two hemolysin-like calcium binding proteins, three colicin V-like microcins, an arginase and a secreted serine protease.
		Three CDS absent in strain J1a12 may explain its reported suitability for genetic transformation: two S subunits from type I restriction-modification enzymes and a methyltransferase from a type III restriction-modification system.
	verjo19.iq.usp.br /cagexylella/private/abstract.htm (193 words)

	PAQR7 - progestin and adipoQ receptor family member VII (Site not responding. Last check: 2007-10-12)
		mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid.
		Increased mprA gene dosage also caused a decrease in microcin C7 production and blocked the osmoinduction of the proU locus in high-osmolarity media.
		To begin to characterize the role of this system in M. tuberculosis physiology and virulence, a functional analysis of the mprA and mprB gene products was initiated.
	www.ihop-net.org /UniPub/iHOP/gg/108050.html (315 words)

	[No title]
		AB - Ton-dependent colicins and microcins are actively taken up into sensitive cells at the expense of energy which is provided by the proton motive force of the cytoplasmic membrane.
		Six TonB-dependent microcins with different primary structures are processed and exported by highly homologous proteins.
		Three of these microcins are modified in an unknown way and they have in common specificity for catecholate siderophore receptors.
	www-u.life.uiuc.edu /labs/crofts/arc-lit/200212/17042125 (15076 words)

	FORIMMUN: Research projects
		This is achieved by the current analysis of the EcN genome.
		An important property regarding EcN’s probiotic effect is - among other things - the production of microcins.
		These compounds are able to kill other bacteria, also pathogenic ones.
	www.abayfor.de /forimmun/en/projekte_detail.php?pk=720 (416 words)

	Forschungsdatenbank: Structure and function of Salmochelins and Microcins M/H47 (Site not responding. Last check: 2007-10-12)
		Forschungsdatenbank: Structure and function of Salmochelins and Microcins M/H47
		Structure and function of Salmochelins and Microcins M/H47
		For many pathogenic bacteria iron supply is an critical factor since in their host is bound to Proteins.
	www.tu-berlin.de /zuv/IIIC/cgi/new_druckscript.pl?page=fordat/02/35/13841.htm (213 words)

	Faculty and Staff
		Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae.
		Signal sequence-independent protein secretion in Gram-negative bacteria: Colicin V and Microcin B17.
		The secretion of Colicin V. In Bacteriocins, Microcins, and Lantibiotics.
	www.bio.umb.edu /facstaff/faculty_Skvirsky.html (456 words)

	The probiotic Escherichia coli strain Nissle 1917 interferes with invasion of human intestinal epith
		Furthermore, invasion of Yersinia enterocolitica, Shigella flexneri, Legionella pneumophila and even of Listeria monocytogenes were inhibited by the probiotic E. coli strain Nissle 1917 without affecting the viability of the invasive bacteria.
		The observed inhibition of invasion was not due to the production of microcins by the Nissle 1917 strain because its isogenic microcin-negative mutant SK22D was as effective as the parent strain.
		Reduced invasion rates were also achieved if strain Nissle 1917 was separated from the invasive bacteria as well as from the INT407 monolayer by a membrane non-permeable for bacteria.
	www.findyourhope.com /Article/18602/Page_Article.aspx (265 words)

Try your search on: Qwika (all wikis)